Kirk R Schultz

Kirk R Schultz

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Kirk R Schultz

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Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children's Oncology Group CML Working Group.

Pediatr Blood Cancer 2019 Sep 10;66(9):e27827. Epub 2019 Jun 10.

Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27827DOI Listing
September 2019

Too stressed for tests? Challenges of diagnosing psychological distress in pediatric cancer patients and survivors.

Authors:
Kirk R Schultz

Pediatr Hematol Oncol 2019 Apr;36(3):123-124

a BC Childrens Hospital , Vancouver , British Columbia , Canada.

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http://dx.doi.org/10.1080/08880018.2019.1632398DOI Listing
April 2019

Comprehensive B Cell Phenotyping Profile for Chronic Graft-versus-Host Disease Diagnosis.

Biol Blood Marrow Transplant 2019 Mar 14;25(3):451-458. Epub 2018 Nov 14.

Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, Canada; Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10838791183070
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http://dx.doi.org/10.1016/j.bbmt.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445755PMC
March 2019

Practice Patterns of Physician Treatment for Pediatric Chronic Myelogenous Leukemia.

Biol Blood Marrow Transplant 2019 Feb 26;25(2):321-327. Epub 2018 Sep 26.

Department of Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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https://linkinghub.elsevier.com/retrieve/pii/S10838791183059
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http://dx.doi.org/10.1016/j.bbmt.2018.09.029DOI Listing
February 2019

The case for plerixafor to replace filgrastim as the optimal agent to mobilize peripheral blood donors for allogeneic hematopoietic cell transplantation.

Exp Hematol 2019 02 11;70:1-9. Epub 2018 Nov 11.

Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Michael Cuccione Childhood Cancer Research Program, British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X183087
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http://dx.doi.org/10.1016/j.exphem.2018.11.003DOI Listing
February 2019

Generic formulations of imatinib for treatment of Philadelphia chromosome-positive leukemia in pediatric patients.

Pediatr Blood Cancer 2018 12 30;65(12):e27431. Epub 2018 Aug 30.

Department of General Pediatrics, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Universitäts-Kinderklinik, Kiel, Germany.

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http://dx.doi.org/10.1002/pbc.27431DOI Listing
December 2018

Higher levels of free plasma mitochondrial DNA are associated with the onset of chronic GvHD.

Bone Marrow Transplant 2018 10 21;53(10):1263-1269. Epub 2018 Mar 21.

Michael Cuccione Childhood Cancer Research Program, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://www.nature.com/articles/s41409-018-0156-y
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http://dx.doi.org/10.1038/s41409-018-0156-yDOI Listing
October 2018

Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622.

J Clin Oncol 2018 Aug 29;36(22):2306-2314. Epub 2018 May 29.

William B. Slayton, John A. Kairalla, Meenakshi Devidas, Xinlei Mi, and Sherri L. Mizrahy, University of Florida, Gainesville, FL; Kirk R. Schultz, BC Children's Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Michael A. Pulsipher, Children's Hospital of Los Angeles, Los Angeles; Lance Sieger, University of California Los Angles-Harbor, Torrance; Mignon L. Loh, University of California San Francisco, San Francisco, CA; Bill H. Chang, Oregon Health and Science University, Portland, OR; Charles Mullighan, Ilaria Iacobucci, and Thomas Merchant, St Jude's Research Hospital, Memphis, TN; Lewis B. Silverman, Dana-Farber Cancer Institute, Boston, MA; Michael J. Borowitz, Johns Hopkins University, Baltimore, MD; Andrew J. Carroll, University of Alabama at Birmingham, Birmingham, AL; Nyla A. Heerema, Ohio State University; Julie M. Gastier-Foster, Nationwide Children's Hospital, Columbus, OH; Brent L. Wood, University of Washington Seattle, Seattle, WA; Valerie I. Brown, Penn State Health Children's Hospital, Hershey; Stephen P. Hunger, Children's Hospital of Philadelphia, Philadelphia, PA; Marilyn J. Siegel, Washington University School of Medicine, St Louis, MO; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; Naomi J. Winick, University of Texas Southwestern Medical Center, Dallas, TX; and William L. Carroll, New York University Langone Health Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2017.76.7228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067800PMC
August 2018

Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group.

Pediatr Hematol Oncol 2017 Sep - Oct;34(6-7):355-364. Epub 2017 Nov 30.

h Division of Pediatric Hematology and Oncology, Department of Pediatrics and OHSU Knight Cancer Institute , Oregon Health and Sciences University , Portland , OR , USA.

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https://www.tandfonline.com/doi/full/10.1080/08880018.2017.1
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http://dx.doi.org/10.1080/08880018.2017.1395937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191173PMC
July 2018

Plerixafor effectively mobilizes CD56 NK cells in blood, providing an allograft predicted to protect against GVHD.

Blood 2018 06 4;131(25):2863-2866. Epub 2018 May 4.

Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, BC Children's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1182/blood-2018-03-836700DOI Listing
June 2018

Prolonged granulocyte colony stimulating factor use in glycogen storage disease type 1b associated with acute myeloid leukemia and with shortened telomere length.

Pediatr Hematol Oncol 2018 Feb 13;35(1):45-51. Epub 2018 Apr 13.

c Department of Pediatrics , University of British Columbia, BC Children's Hospital , Vancouver , BC . Canada.

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http://dx.doi.org/10.1080/08880018.2018.1440675DOI Listing
February 2018

National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Immune Dysregulation and Pathobiology Working Group Report.

Biol Blood Marrow Transplant 2017 Jun 14;23(6):870-881. Epub 2016 Oct 14.

University of Florida Health Cancer Center, Gainesville, Florida; Bone Marrow Transplant Program, Division of Hematology/Oncology, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.bbmt.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392182PMC
June 2017

Y-box-binding protein 1 contributes to IL-7-mediated survival signaling in B-cell precursor acute lymphoblastic leukemia.

Oncol Lett 2017 Jan 28;13(1):497-505. Epub 2016 Nov 28.

Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.3892/ol.2016.5437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244896PMC
January 2017

Quantitation of Human Cells that Produce Neutrophils and Platelets in Vivo Obtained from Normal Donors Treated with Granulocyte Colony-Stimulating Factor and/or Plerixafor.

Biol Blood Marrow Transplant 2016 11 2;22(11):1945-1952. Epub 2016 Aug 2.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2016.07.023DOI Listing
November 2016

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation.

Clin Immunol 2016 07 22;168:1-5. Epub 2016 Apr 22.

Department of Pediatrics, BC Children's Hospital, Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.04.011DOI Listing
July 2016

Exome Sequencing and the Management of Neurometabolic Disorders.

N Engl J Med 2016 Jun 25;374(23):2246-55. Epub 2016 May 25.

From the Centre for Molecular Medicine and Therapeutics (M.T.-G., C. Shyr, X.C.Y., L.-H.Z., J.J.Y.L., B.I.D., I.G., W.W.W., C.D.K.), the Departments of Medical Genetics (M.T.-G., C. Shyr, C.J.R., X.C.Y., J.J.Y.L., L.A., J.M.F., S.L., M.M., M.I.V.A., A.M.L., W.W.W.), Pediatrics (C.J.R., G.A.H., R.S., L.-H.Z., A.P.B., B.I.D., M.B.C., M.D., T.D., J.D., A. Michoulas, D.M., J.R., K.R.S., K.S., S.E.T., John Wu, S.S.-I., C.D.K.), and Pathology and Laboratory Medicine (B.R., P.E., H.V., G.S.), the Child and Family Research Institute (M.T.-G., C. Shyr, C.J.R., G.A.H., X.C.Y., A.P.B., J.J.Y.L., B.I.D., L.A., M.B.C., M.D., J.D., J.M.F., I.G., S.L., M.M., D.M., J.R., K.R.S., K.S., S.E.T., M.I.V.A., John Wu, P.E., A.M.L., H.V., S.S.-I., G.S., W.W.W., C.D.K.), and the Division of Endocrinology, Adult Metabolic Diseases Clinic (A. Mattman, S. Sirrs), University of British Columbia, and the Divisions of Biochemical Diseases (G.A.H., R.S., B.S., S.S.-I., C.D.K.), Pediatric Neurology (M.B.C., M.D., A. Michoulas, K.S.), Pediatric Nephrology (J.D.), Pediatric Endocrinology (D.M.), and Immunology (S.E.T.) and the Division of Hematology, Oncology and Transplantation, Michael Cuccione Childhood Cancer Research Program (J.R., K.R.S., John Wu), BC Children's Hospital, Vancouver, the Department of Pathology and Laboratory Medicine, Hospital for Sick Children, University of Toronto, Toronto (J.C.), the Department of Biological and Computing Sciences, University of Alberta (R.M., D.W.), and the National Institute for Nanotechnology (D.W.), Edmonton, AB, and the Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC (M. Abdelsayed, P.R.) - all in Canada; the Division of Genetics, Department of Pediatrics, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia (M. Alfadhel); the Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich (M.R.B., P.B.), and the Departmen

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http://dx.doi.org/10.1056/NEJMoa1515792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983272PMC
June 2016

In Vivo T Cell Depletion with Myeloablative Regimens on Outcomes after Cord Blood Transplantation for Acute Lymphoblastic Leukemia in Children.

Biol Blood Marrow Transplant 2015 Dec 29;21(12):2173-2179. Epub 2015 Aug 29.

Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1016/j.bbmt.2015.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639413PMC
December 2015

Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia.

Eur J Immunol 2015 Jul 6;45(7):1980-90. Epub 2015 May 6.

The Michael Cuccione Childhood Cancer Research Program, Child and Family Research Institute and Division of Pediatric Hem/Onc/BMT, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

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http://doi.wiley.com/10.1002/eji.201444874
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http://dx.doi.org/10.1002/eji.201444874DOI Listing
July 2015

IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients.

Blood 2015 May 10;125(22):3501-8. Epub 2015 Apr 10.

Division of Oncology, Children's Hospital of Philadelphia, and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Pathology, Children's Hospital of Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-12-61
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http://dx.doi.org/10.1182/blood-2014-12-615757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447864PMC
May 2015

Hematopoietic cell transplantation and cellular therapeutics in the treatment of childhood malignancies.

Pediatr Clin North Am 2015 Feb;62(1):257-73

Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, 3901 Beaubien, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.pcl.2014.10.001DOI Listing
February 2015

Is any donor too old?

Authors:
Kirk R Schultz

Biol Blood Marrow Transplant 2015 Jan 20;21(1):2-3. Epub 2014 Nov 20.

Childhood Cancer and Blood Research Cluster, Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.11.006DOI Listing
January 2015

One-unit versus two-unit cord-blood transplantation for hematologic cancers.

N Engl J Med 2014 Oct;371(18):1685-94

From the University of Minnesota Medical School, Minneapolis (J.E.W., M.R.V.); Medical College of Wisconsin, Milwaukee (M.E., D.M., M.M.H.); EMMES Corporation, Rockville, MD (S.C., Y.W.); BC Children's Hospital, Vancouver (K.R.S.), and University of Manitoba, Winnipeg (D.A.W.) - both in Canada; Children's Hospital of Philadelphia, Philadelphia (N.B.); Fred Hutchinson Cancer Research Center, Seattle (C.D.); Indiana University, Indianapolis (P.H.); University of Michigan, Ann Arbor (E.P.); University of California San Francisco Benioff Children's Hospital Oakland, Oakland (M.W.); and Duke University, Durham, NC (J.K.).

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http://dx.doi.org/10.1056/NEJMoa1405584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257059PMC
October 2014

Combined immunodeficiency associated with homozygous MALT1 mutations.

J Allergy Clin Immunol 2014 May 12;133(5):1458-62, 1462.e1-7. Epub 2013 Dec 12.

Department of Pediatrics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.10.045DOI Listing
May 2014

Paroxysmal nocturnal haemoglobinuria phenotype cells and leucocyte subset telomere length in childhood acquired aplastic anaemia.

Br J Haematol 2014 Mar 14;164(5):717-21. Epub 2013 Nov 14.

Division of Pediatric Hematology/Oncology/Bone Marrow Transplantation, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1111/bjh.12656DOI Listing
March 2014

STAT3 mutations and persistence of autoimmunity.

Authors:
Kirk R Schultz

Blood 2013 Oct;122(14):2295-6

BRITISH COLUMBIA CHILDREN'S HOSPITAL;

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http://dx.doi.org/10.1182/blood-2013-08-521138DOI Listing
October 2013

Prediction of area under the cyclosporine concentration versus time curve in children undergoing hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2013 Mar 2;19(3):418-23. Epub 2012 Nov 2.

Department of Pharmacy, SickKids, 555 University Ave., Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2012.10.031DOI Listing
March 2013

Excess of veno-occlusive disease in a randomized clinical trial on a higher trigger for red blood cell transfusion after bone marrow transplantation: a canadian blood and marrow transplant group trial.

Biol Blood Marrow Transplant 2013 Mar 7;19(3):468-73. Epub 2012 Dec 7.

Service d'Hématologie-Oncologie, Centre de Cancérologie Charles-Bruneau, Département de Pédiatrie, CHU Sainte-Justine, Université de Montréal, 3175 chemin de la Côte-Sainte-Catherine,Montréal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2012.12.002DOI Listing
March 2013

Inhibition of cathepsin S reduces allogeneic T cell priming but not graft-versus-host disease against minor histocompatibility antigens.

Biol Blood Marrow Transplant 2012 Apr 14;18(4):546-56. Epub 2011 Dec 14.

Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2011.11.027DOI Listing
April 2012

Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the Children's Oncology Group Study ASCT0031.

Biol Blood Marrow Transplant 2011 Dec 25;17(12):1804-13. Epub 2011 May 25.

Children's Oncology Group, Pediatric Hematology/Oncology/Bone Marrow Transplantation, British Columbia Children's Hospital/University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2011.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190042PMC
December 2011

Immunosuppressive therapy without hematopoietic growth factor exposure in pediatric acquired aplastic anemia.

Pediatr Hematol Oncol 2011 Sep 27;28(6):469-78. Epub 2011 Jun 27.

Division of Pediatric Hematology/Oncology/Bone Marrow Transplantation, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.3109/08880018.2011.568043DOI Listing
September 2011

Biomarkers in chronic graft-versus-host disease.

Expert Rev Hematol 2011 Jun;4(3):329-42

Division of Oncology, Hematology and BMT, Department of Pediatrics, BC Children's Hospital/University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1586/ehm.11.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132532PMC
June 2011

Controversies in the treatment of CML in children and adolescents: TKIs versus BMT?

Biol Blood Marrow Transplant 2011 Jan;17(1 Suppl):S115-22

Division of Pediatric Hematology-Oncology-Blood and Marrow Transplantation, University Hospital Carl Gustav Carus, Fetscherstr. 74, Dresden, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2010.09.003DOI Listing
January 2011

Philadelphia chromosome-positive acute lymphoblastic leukemia in children: new and emerging treatment options.

Expert Rev Hematol 2010 Dec;3(6):731-42

Division of Pedatric Hematology, Oncology, Blood and Marrow Transplantation, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1586/ehm.10.60DOI Listing
December 2010

Haploidentical transplantation in children.

Authors:
Kirk R Schultz

Blood 2010 Apr;115(17):3420-1

University of British Columbia, Canada.

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http://dx.doi.org/10.1182/blood-2010-01-263657DOI Listing
April 2010

Chronic graft-versus-host disease (GVHD) in children.

Pediatr Clin North Am 2010 Feb;57(1):297-322

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1-3750, 9000 Rockville Pike, MSC 1104, Bethesda, MD 20892-1104, USA.

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http://dx.doi.org/10.1016/j.pcl.2009.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872081PMC
February 2010

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.

Clin Immunol 2009 May 13;131(2):179-88. Epub 2009 Feb 13.

University of British Columbia Federation of Clinical Immunology Societies Center of Excellence, Department of Pediatrics, University of British Columbia, BC, Canada.

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http://dx.doi.org/10.1016/j.clim.2009.01.003DOI Listing
May 2009

Controversies of and unique issues in hematopoietic cell transplantation for infant leukemia.

Biol Blood Marrow Transplant 2009 Jan;15(1 Suppl):79-83

University of Colorado School of Medicine and The Children's Hospital, Aurora, Colorado, USA.

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http://dx.doi.org/10.1016/j.bbmt.2008.10.015DOI Listing
January 2009

Chronic Graft-versus-Host Disease--implementation of the National Institutes of Health Consensus Criteria for Clinical Trials.

Biol Blood Marrow Transplant 2008 Apr;14(4):379-84

Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1016/j.bbmt.2008.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293302PMC
April 2008

Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the Children's Oncology Group.

Blood 2008 Mar 9;111(6):3276-85. Epub 2007 Oct 9.

Children's Oncology Group, Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Pediatrics, BC Children's Hospital/University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1182/blood-2007-08-106286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265463PMC
March 2008

Altered Toll-like receptor 9 responses in circulating B cells at the onset of extensive chronic graft-versus-host disease.

Biol Blood Marrow Transplant 2007 Apr 15;13(4):386-97. Epub 2007 Feb 15.

Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2006.12.441DOI Listing
April 2007