Publications by authors named "Kirk C Hansen"

100Publications

Extracellular vesicles from young women's breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach.

Breast Cancer Res 2020 Nov 23;22(1):128. Epub 2020 Nov 23.

Young Women's Breast Cancer Translational Program, Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13058-020-01363-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681773PMC
November 2020

Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients.

J Proteome Res 2020 11 26;19(11):4455-4469. Epub 2020 Oct 26.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado 80045, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.0c00606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640979PMC
November 2020

Matrix reverses immortalization-mediated stem cell fate determination.

Biomaterials 2021 Jan 16;265:120387. Epub 2020 Sep 16.

Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA; WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2020.120387DOI Listing
January 2021

Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level.

J Proteome Res 2020 11 14;19(11):4417-4427. Epub 2020 Aug 14.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.0c00365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640953PMC
November 2020

Metabolomics of Endurance Capacity in World Tour Professional Cyclists.

Front Physiol 2020 5;11:578. Epub 2020 Jun 5.

Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2020.00578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291837PMC
June 2020

Inflammation, immunity, and vascular remodeling in pulmonary hypertension; Evidence for complement involvement?

Glob Cardiol Sci Pract 2020 Apr 30;2020(1):e202001. Epub 2020 Apr 30.

University of Colorado, Denver, Anschutz Medical Campus, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21542/gcsp.2020.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232865PMC
April 2020

Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis.

Front Physiol 2020 30;11:396. Epub 2020 Apr 30.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2020.00396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204509PMC
April 2020

Site-Dependent Lineage Preference of Adipose Stem Cells.

Front Cell Dev Biol 2020 15;8:237. Epub 2020 Apr 15.

Stem Cell and Tissue Engineering Laboratory, Department of Orthopedics, West Virginia University, Morgantown, WV, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcell.2020.00237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174673PMC
April 2020

A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice.

Blood 2020 May;135(19):1704-1717

Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019004267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205812PMC
May 2020

Biologically-engineered mechanical model of a calcified artery.

Acta Biomater 2020 07 16;110:164-174. Epub 2020 Apr 16.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States; Department of Chemical Engineering & Materials Science, University of Minnesota, Minneapolis, MN, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.04.018DOI Listing
July 2020

Postpartum breast cancer progression is driven by semaphorin 7a-mediated invasion and survival.

Oncogene 2020 03 4;39(13):2772-2785. Epub 2020 Feb 4.

Division of Medical Oncology, Department of Medicine, CU Anschutz Medical Campus, Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-020-1192-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103487PMC
March 2020

Role of lineage-specific matrix in stem cell chondrogenesis.

Biomaterials 2020 02 16;231:119681. Epub 2019 Dec 16.

Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, 26506, USA; WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2019.119681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958706PMC
February 2020

Manufacturing considerations for producing and assessing decellularized extracellular matrix hydrogels.

Methods 2020 01 20;171:20-27. Epub 2019 Sep 20.

Department of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2019.09.015DOI Listing
January 2020

A unified mechanism for intron and exon definition and back-splicing.

Nature 2019 09 4;573(7774):375-380. Epub 2019 Sep 4.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1523-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939996PMC
September 2019

Streptococcus pneumoniae G5 domains bind different ligands.

Protein Sci 2019 10 9;28(10):1797-1805. Epub 2019 Aug 9.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, School of Medicine, Aurora, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pro.3693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740092PMC
October 2019

Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells.

Nutrients 2019 Jun 14;11(6). Epub 2019 Jun 14.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, 12801 East 17th Ave RC1 South, Aurora, CO 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11061337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627295PMC
June 2019

Prospective assessment of fibrinolysis in morbid obesity: tissue plasminogen activator resistance improves after bariatric surgery.

Surg Obes Relat Dis 2019 Jul 10;15(7):1153-1159. Epub 2019 Apr 10.

Department of Surgery-Division of GI, Trauma, and Endocrine Surgery, University of Colorado Denver, Denver, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.soard.2019.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719338PMC
July 2019

High-Throughput Metabolomics: Isocratic and Gradient Mass Spectrometry-Based Methods.

Methods Mol Biol 2019 ;1978:13-26

Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9236-2_2DOI Listing
November 2019

Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.

Clin Cancer Res 2019 07 2;25(13):4079-4090. Epub 2019 Apr 2.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-3223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642698PMC
July 2019

Does Tranexamic Acid Improve Clot Strength in Severely Injured Patients Who Have Elevated Fibrin Degradation Products and Low Fibrinolytic Activity, Measured by Thrombelastography?

J Am Coll Surg 2019 07 29;229(1):92-101. Epub 2019 Mar 29.

School of Public Health, University of Colorado, Denver, CO; Department of Surgery, Ernest E Moore Shock and Trauma Center at Denver Health, Denver, CO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jamcollsurg.2019.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874093PMC
July 2019

Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix.

J Proteome Res 2019 04 25;18(4):1657-1668. Epub 2019 Mar 25.

Aroa Biosurgery Limited , Airport Oaks , Auckland 2022 , New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.8b00908DOI Listing
April 2019

Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel.

J Proteome Res 2019 04 28;18(4):1827-1841. Epub 2019 Feb 28.

Department of Biochemistry and Molecular Genetics , University of Colorado Denver - Anschutz Medical Campus , Aurora , Colorado 80045 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.9b00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219541PMC
April 2019

Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma.

Sci Rep 2018 08 28;8(1):12941. Epub 2018 Aug 28.

Department of Cell and Regenerative Biology, University of Wisconsin-Madison, 1111 Highland Ave., WIMR II Rm. 4528, Madison, WI, 53705, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-31126-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113240PMC
August 2018

Author Correction: CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.

Nat Commun 2018 04 11;9(1):1495. Epub 2018 Apr 11.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-03708-9
Publisher Site
http://dx.doi.org/10.1038/s41467-018-03708-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895711PMC
April 2018

When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies.

Expert Rev Proteomics 2018 04 21;15(4):293-309. Epub 2018 Mar 21.

a Department of Biochemistry and Molecular Genetics , University of Colorado Denver - Anschutz Medical Campus , Aurora , CO , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14789450.2018.1453362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174679PMC
April 2018

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.

J Trauma Acute Care Surg 2017 12;83(6):1014-1022

From the Department of Surgery (H.B.M., E.E.M., B.R.H., M.D., G.R.S., G.R.N., P.J.L., A.B., C.S., A.S., K.C.H.), University of Colorado; Denver Health Medical Center (E.E.M., A.G., J.C.); and University of Colorado School of Public Health (A.S.), Denver, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000001718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726780PMC
December 2017

Structure of the yeast spliceosomal postcatalytic P complex.

Science 2017 12 16;358(6368):1278-1283. Epub 2017 Nov 16.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver (UCD), Anschutz Medical Campus, Aurora, CO 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aar3462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828012PMC
December 2017

All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.

J Trauma Acute Care Surg 2018 03;84(3):537-541

From the Department of Biochemistry and Molecular Genetics (J.A.R., M.J.W., K.C.H., A.D.), University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado; Denver Health Hospital - (E.E.M., A.G., J.C.), Denver, Colorado; Department of Surgery (A.L.S., H.B.M., M.F., G.N., A.B.), University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado; Naval Medical Research Unit San Antonio (L.J.S., F.R.S.), JBSA-Ft. Sam Houston, Texas; Department of Paediatrics (C.C.S.), University of Colorado Denver - Anschutz Medical Campus, Aurora, Colorado; and Bonfils Blood Center (C.C.S.), Denver, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000001721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820217PMC
March 2018

Metabolism of Citrate and Other Carboxylic Acids in Erythrocytes As a Function of Oxygen Saturation and Refrigerated Storage.

Front Med (Lausanne) 2017 17;4:175. Epub 2017 Oct 17.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2017.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650965PMC
October 2017

CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.

Nat Commun 2017 10 19;8(1):1035. Epub 2017 Oct 19.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-01241-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648754PMC
October 2017

Hydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization.

J Proteome Res 2017 11;16(11):4177-4184

Department of Biochemistry and Molecular Genetics, and ‡Biological Mass Spectrometry Facility, University of Colorado Denver , Aurora, Colorado 80045, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.7b00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802359PMC
November 2017

Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.

Exp Hematol 2018 02 22;58:52-58. Epub 2017 Sep 22.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2017.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815916PMC
February 2018

Investigation of the effects of storage and freezing on mixes of heavy-labeled metabolite and amino acid standards.

Rapid Commun Mass Spectrom 2017 Dec;31(23):2030-2034

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, 12801 East 17th Ave, Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.7989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673535PMC
December 2017

Blood and Plasma Proteomics: Targeted Quantitation and Posttranslational Redox Modifications.

Methods Mol Biol 2017 ;1619:353-371

Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, 12801 E. 17th Ave., Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-7057-5_24DOI Listing
March 2018

An autonomous metabolic role for Spen.

PLoS Genet 2017 Jun 22;13(6):e1006859. Epub 2017 Jun 22.

Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1006859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501677PMC
June 2017

Plasma succinate is a predictor of mortality in critically injured patients.

J Trauma Acute Care Surg 2017 09;83(3):491-495

From the Department of Biochemistry and Molecular Genetics (A.D.A., J.A.R., M.J.W., K.C.H.), University of Colorado Denver-Anschutz Medical Campus; Denver Health Hospital (H.B.M., E.E.M., A.G., J.C.), Denver; Department of Surgery (E.E.M., A.B.), Department of Pediatrics (C.C.S.), University of Colorado Denver-Anschutz Medical Campus, Aurora; and Bonfils Blood Center (C.C.S.), Denver, CO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000001565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573618PMC
September 2017

Characterization of rapid extraction protocols for high-throughput metabolomics.

Rapid Commun Mass Spectrom 2017 Sep;31(17):1445-1452

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, 12801 East 17th Ave, Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.7916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547002PMC
September 2017

Erythrocyte purinergic signaling components underlie hypoxia adaptation.

J Appl Physiol (1985) 2017 Oct 1;123(4):951-956. Epub 2017 Jun 1.

Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00155.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668449PMC
October 2017

Red blood cell proteomics update: is there more to discover?

Blood Transfus 2017 03;15(2):182-187

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2450/2017.0293-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336341PMC
March 2017

Omics markers of the red cell storage lesion and metabolic linkage.

Blood Transfus 2017 Mar;15(2):137-144

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2450/2017.0341-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336335PMC
March 2017

A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways.

Rapid Commun Mass Spectrom 2017 Apr;31(8):663-673

Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, 12801 East 17th Ave, Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.7834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364945PMC
April 2017

Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.

J Proteome Res 2017 02 29;16(2):958-969. Epub 2016 Dec 29.

Department of Biochemistry and Molecular Genetics and ‡Department of Cell and Developmental Biology, University of Colorado Denver - Anschutz Medical Campus , Aurora, Colorado 80045, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.6b00884DOI Listing
February 2017

The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis.

Cancer Discov 2017 02 14;7(2):177-187. Epub 2016 Dec 14.

Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-16-0822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459606PMC
February 2017

Citrate metabolism in red blood cells stored in additive solution-3.

Transfusion 2017 02 4;57(2):325-336. Epub 2016 Nov 4.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.13892DOI Listing
February 2017

Mass Spectrometry-Based Bottom-Up Proteomics: Sample Preparation, LC-MS/MS Analysis, and Database Query Strategies.

Curr Protoc Protein Sci 2016 Nov 1;86:16.4.1-16.4.20. Epub 2016 Nov 1.

Biological Mass Spectrometry Core, Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpps.18DOI Listing
November 2016

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

Proc Natl Acad Sci U S A 2016 10 10;113(43):E6669-E6678. Epub 2016 Oct 10.

Department of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO 80045; School of Medicine, University of Colorado, Aurora, CO 80045; Integrated Department of Immunology, University of Colorado, Aurora, CO 80045; Cancer Biology Program, University of Colorado, Aurora, CO 80045; Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado, Aurora, CO 80045

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1603876113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086999PMC
October 2016

Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments.

Int J Biochem Cell Biol 2016 12 24;81(Pt A):223-232. Epub 2016 Oct 24.

Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA; Young Women's Breast Cancer Translational Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2016.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459605PMC
December 2016

Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.

Circulation 2016 10 25;134(15):1105-1121. Epub 2016 Aug 25.

From Cardiovascular Pulmonary Research Laboratories, Department of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (M.L., S.R., H.Z., A.F., B.A.M., M.F., S.K., M.A.F., K.R.S.); Department of Biochemistry and Molecular Genetics and Biological Mass Spectrometry Shared Resource (A.D., K.C.H.), Department of Anesthesiology (N.J.S.), Advanced Light Microscopy Core Facility (R.M.), Department of Dermatology (H.L., H.L., Q.Z.), and Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition (K.C.E.K.), University of Colorado, Denver; Department of Mitochondrial Physiology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic (L.P.-H., P.J.); Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany (D.I., S.P.); Center for Genetic Improvement of Livestock, Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada (A.C.); Department of Animal Science, University of California-Davis, Davis (J.F.M.); and Department of Animal Science, Colorado State University, Fort Collins (M.G.T.).

View Article

Download full-text PDF

Source
http://circ.ahajournals.org/content/134/15/1105.full.pdf?dow
Web Search
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069179PMC
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023171DOI Listing
October 2016

Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices.

Acta Biomater 2016 12 29;46:91-100. Epub 2016 Sep 29.

Department of Biomedical Engineering, Yale University, New Haven, CT 06519, USA; Department of Anesthesiology, Yale University, New Haven, CT 06519, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2016.09.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451113PMC
December 2016

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia.

J Proteome Res 2016 10 27;15(10):3883-3895. Epub 2016 Sep 27.

Altitude Research Center, Department of Emergency Medicine, University of Colorado , Anschutz Medical Campus, Aurora, Colorado, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.6b00733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512539PMC
October 2016

Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock.

J Trauma Acute Care Surg 2016 12;81(6):1012-1019

From the Department of Surgery, University of Colorado Denver, Aurora, Colorado (A.L.S., E.E.M., A.B., C.C.S., M.F. A.W.B., H.B.M., E.D.P.); Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, Colorado (A.D., K.C.H., J.A.R., M.J.W.); Denver Health Medical Center, Denver, Colorado (E.E.M., M.F.); Department of Pediatrics, University of Colorado Denver, Aurora, Colorado (C.C.S.); and Bonfils Blood Center, Denver, Colorado (C.C.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TA.0000000000001256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121066PMC
December 2016

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.

Circulation 2016 Aug;134(5):405-21

From the Department of Biochemistry and Molecular Biology (H.L., Y.Z., H.W., A.S., K.S., J.L., N.-Y.C., A.H., Y.E.W., T.T.W., F.L., R.E.K., H.K.-Q., M.R.B., Y.X.), Graduate School of Biomedical Sciences (H.L., K.S., R.E.K., M.R.B., Y.X.), and Department of Pathology (B.Z.), University of Texas Health Science Center at Houston; Departments of Otolaryngology (H.L., H.S.) and Nephrology (Y.X.), Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora (A.D., T.N., K.C.H.); Medicity Research Laboratory, University of Turku, Turku, Finland (G.G.Y.); Altitude Research Center, Department of Emergency Medicine (A.W.S., S.J.-V.H., C.G.J., R.C.R.), and Organ Protection Program, Department of Anesthesiology (H.K.E.), University of Colorado School of Medicine, Aurora; and Department of Human Physiology, University of Oregon, Eugene (A.TL.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168195PMC
August 2016

Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells.

Blood 2016 09 12;128(12):e32-42. Epub 2016 Jul 12.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Aurora, CO; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-05-714816DOI Listing
September 2016

Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph.

Blood Transfus 2016 05 22;14(2):185-94. Epub 2016 Apr 22.

Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, University of Colorado Denver, Aurora, CO, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2450/2016.0208-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918547PMC
May 2016

Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine.

Exp Biol Med (Maywood) 2016 Apr 27;241(7):772-81. Epub 2016 Mar 27.

Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1535370216640150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950385PMC
April 2016