Kirk Beebe

Kirk Beebe

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Kirk Beebe

Kirk Beebe

Publications by authors named "Kirk Beebe"

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21Publications

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Metabolomic Profiling of Human Urine as a Screen for Multiple Inborn Errors of Metabolism.

Genet Test Mol Biomarkers 2016 Sep 22;20(9):485-95. Epub 2016 Jul 22.

2 Medical Genetics Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine , Houston, Texas.

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http://dx.doi.org/10.1089/gtmb.2015.0291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314726PMC
September 2016

Metabolomics as a key integrator for "omic" advancement of personalized medicine and future therapies.

Clin Transl Sci 2012 Jun;5(3):285-8

Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2011.00388.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439875PMC
June 2012

Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers.

Genome Med 2012 Feb 23;4(2):14. Epub 2012 Feb 23.

Stanford University School of Medicine, Department of Dermatology, 450 Broadway Street, C 5334, Redwood City, CA 94603, USA.

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http://dx.doi.org/10.1186/gm313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392760PMC
February 2012

Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.

Nature 2009 Dec;462(7274):808-12

The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, BCC-379, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature08612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799227PMC
December 2009

The C-Ala domain brings together editing and aminoacylation functions on one tRNA.

Science 2009 Aug;325(5941):744-7

The Skaggs Institute for Chemical Biology and the Department of Molecular Biology, The Scripps Research Institute, BCC-379, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1174343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559334PMC
August 2009

Distinct domains of tRNA synthetase recognize the same base pair.

Nature 2008 Jan;451(7174):90-3

Department of Molecular Biology and Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://www.nature.com/articles/nature06454
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http://dx.doi.org/10.1038/nature06454DOI Listing
January 2008

A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities.

Anal Biochem 2007 Sep 18;368(1):111-21. Epub 2007 May 18.

Department of Molecular Biology and Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ab.2007.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833075PMC
September 2007

Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.

Nature 2006 Sep 13;443(7107):50-5. Epub 2006 Aug 13.

The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/nature05096DOI Listing
September 2006

Molecular biology: genetic code seizes pyrrolysine.

Nature 2004 Sep;431(7006):257-8

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http://dx.doi.org/10.1038/431257aDOI Listing
September 2004

A domain for editing by an archaebacterial tRNA synthetase.

Proc Natl Acad Sci U S A 2004 Apr 12;101(16):5958-63. Epub 2004 Apr 12.

The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Beckman Center, BCC379, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0401530101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395905PMC
April 2004

Structure-specific tRNA determinants for editing a mischarged amino acid.

J Biol Chem 2003 Nov 28;278(46):45056-61. Epub 2003 Aug 28.

Department of Molecular Biology and Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M307080200DOI Listing
November 2003

Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability.

EMBO J 2003 Feb;22(3):668-75

The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Beckman Center, BCC379, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/emboj/cdg065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140749PMC
February 2003

Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase.

Proc Natl Acad Sci U S A 2003 Jan 6;100(2):490-4. Epub 2003 Jan 6.

The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Beckman Center, BCC379, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0237335100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC141022PMC
January 2003

alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship.

Bioorg Med Chem Lett 2002 Nov;12(21):3047-50

Department of Chemistry and Ohio State Biochemistry Program, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/s0960-894x(02)00681-9DOI Listing
November 2002