Publications by authors named "Kirandeep Kaur"

111 Publications

Comparative contribution of magnetoencephalography (MEG) and single-photon emission computed tomography (SPECT) in pre-operative localization for epilepsy surgery: A prospective blinded study.

Seizure 2021 Feb 15;86:181-188. Epub 2021 Feb 15.

Dept of Neurology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Purpose: The aim of this study was to compare the diagnostic value and accuracy of ictal SPECT and inter-ictal magnetoencephalography (MEG) in localizing the site for surgery in persons with drug resistant epilepsy.

Method: This was a prospective observational study. Patients expected to undergo epilepsy surgery were enrolled consecutively and the localization results from different imaging modalities were discussed in an epilepsy surgery meet. Odds ratio of good outcome (Engel I) were calculated in patients who underwent surgery in concordance with MEG and SPECT findings. Post-surgical seizure freedom lasting at least 36 months or more was considered the gold standard for determining the diagnostic output of SPECT and MEG.

Results: MEG and SPECT were performed in 101 and 57 patients respectively. In 45 patients SPECT could not be done due to delay in injection or technical factors. The accuracy of MEG and SPECT in localizing the epileptogenic zone was found to be 74.26 % and 78.57 % respectively. The diagnostic odds ratio for Engel I surgical outcome was reported as 2.43 and 5.0 for MEG and SPECT respectively. The diagnostic odds ratio for MEG in whom SPECT was non-informative was found to be 6.57 [95 % CI 1.1, 39.24], although it was not significantly associated with good surgical outcome. MEG was useful in indicating sites for SEEG implantation.

Conclusion: SPECT was found to be non-informative for most patients, but reported better diagnostic output than MEG. MEG may be a useful alternative for patients in whom SPECT cannot be done or was non-localizing.
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http://dx.doi.org/10.1016/j.seizure.2021.02.005DOI Listing
February 2021

The development and efficacy of a mobile phone application to improve medication adherence for persons with epilepsy in limited resource settings: A preliminary study.

Epilepsy Behav 2021 Feb 9;116:107794. Epub 2021 Feb 9.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Objective: Persons with epilepsy (PWE), especially those with limited education backgrounds from developing countries, are challenged by complicated medication regimens, debilitating seizures, and stigmatization in their daily life. Consequently, it is difficult for physicians to ensure medication adherence. This study validates a novel mobile application which was hypothesized to increase medication adherence and self-management skills in PWE. Created by medical professionals, the application included behavioral and educational components and was built to be easy-to-understand for those of socio-economically disadvantaged backgrounds.

Methods: This was a parallel, two-armed randomized controlled trial in which a total of 96 participants were enrolled from a Neurology Outpatient Department into a control standard care group and a mobile application group that used the smartphone application (app) in addition to the standard medical treatment. The app was intuitive and easy to understand for those coming from a socio-economically disadvantaged background. Medication adherence and self-efficacy were assessed with the Morisky Green and Levine Scale (MGLS) and the Epilepsy Self Efficacy Scale (ESES). Patients were reassessed 12 weeks later. Change in seizure frequency following administration of the application was a secondary outcome.

Results: In an intent-to-treat analysis, the mobile application interventional group showed over a 60% increase in the proportion of medication adherence (P < 0.0001). The mean self-efficacy score for the mobile application group was increased from 269.5 to 289.75 (P < 0.0001). The control group showed no statistically significant increases in either the proportion adherent or mean self-efficacy scores.

Significance: This study demonstrated the statistically significant performance of a mobile application in improving medication adherence and self-management skills in Indian persons with epilepsy.
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http://dx.doi.org/10.1016/j.yebeh.2021.107794DOI Listing
February 2021

Maintaining infliximab induced clinical remission with azathioprine and 5-aminosalicylates in acute severe steroid-refractory ulcerative colitis has lower cost and high efficacy (MIRACLE): a multicenter study.

Intest Res 2021 Feb 3. Epub 2021 Feb 3.

Department of Gastroenterology, Dayanand Medical College, Ludhiana, India.

Background/aims: Infliximab (IFX) has been used to induce and maintain remission in patients with severe steroid-refractory ulcerative colitis (UC). Long-term use of biologics in developing countries is limited by high cost and frequent side effects. An optimal maintenance strategy in these patients needs to be established.

Methods: A retrospective analysis of maintenance of clinical remission with combination of azathioprine (AZA) and 5-aminosalicylates (5-ASA) in patients with severe steroidrefractory UC where IFX (5 mg/kg intravenously at weeks 0, 2, 6) had been used only as an induction therapy was done at 2 centers in India. Primary outcome was the proportion of patients maintaining corticosteroid-free sustained clinical remission (SCR) at the end of study period. Rates of relapse and cost of therapy were also analyzed.

Results: Of the 137 patients who received rescue IFX induction therapy, 77 (56.2%) achieved clinical remission (mean age 34.81 ± 13.32 years, 68.83% males, median follow-up 4 years, range 3 months to 6 years) and were included. Cumulative corticosteroid-free SCR was maintained in 68%, 59%, 42%, and 35% patients at 1, 2, 4, and 6 years respectively. Sixty-seven relapses were observed in 33 patients. Majority of the relapses (45/67, 67.16%) occurred within first 2 years of follow-up. Two relapses were managed with re-induction with IFX, one required colectomy, whereas all other responded to repeat course(s) of corticosteroids. Annual per capita maintenance therapy with 5-ASA and AZA was cheaper by US$ 4,526 compared to maintaining remission with IFX.

Conclusions: Clinical remission achieved with IFX induction therapy in severe steroid-refractory UC can be sustained over long time with a combination of AZA and 5-ASA.
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http://dx.doi.org/10.5217/ir.2020.00100DOI Listing
February 2021

Impact of the COVID-19 pandemic on clinical ophthalmology.

Indian J Med Res 2021 Jan 21. Epub 2021 Jan 21.

Department of Pediatric Ophthalmology & Squint Service, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Puducherry 605 007, India.

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http://dx.doi.org/10.4103/ijmr.IJMR_3883_20DOI Listing
January 2021

Comments on: Are we treating the effect and neglecting the cause of keratoconus?

Indian J Ophthalmol 2021 Feb;69(2):462-463

Fellow Pediatric Ophthalmology and Squint Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_3280_20DOI Listing
February 2021

Comments on: Senior residency: An opportunity missed?

Indian J Ophthalmol 2021 Feb;69(2):458-459

Pediatric and Squint Fellow, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_3306_20DOI Listing
February 2021

Comments on: Academic quality of incoming ophthalmology residents in India: Concerns for the future.

Indian J Ophthalmol 2021 Feb;69(2):457

Pediatric and Squint Fellow, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_3090_20DOI Listing
February 2021

On-scalp magnetoencephalography: A long but promising road ahead?

Clin Neurophysiol 2021 Feb 30;132(2):696-697. Epub 2020 Dec 30.

Dept. of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2020.12.011DOI Listing
February 2021

Comments on: Clinical profile and prevalence of conjunctivitis in mild COVID-19 patients in a tertiary care COVID-19 hospital: A retrospective cross-sectional study.

Indian J Ophthalmol 2021 01;69(1):165

Pediatric and Squint Fellow, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Cuddalore Main Road, Thavalukuppam, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_2571_20DOI Listing
January 2021

Comments on: Teleconsultation at a tertiary care government medical university during COVID-19 lockdown in India - A pilot study.

Indian J Ophthalmol 2021 01;69(1):161-162

Consultant Cornea and Refractive Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Cuddalore Main Road, Thavalukuppam, Puducherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_2701_20DOI Listing
January 2021

Changing drug regimen during COVID-19 pandemic lockdown: An experience from a Tertiary Eye Care Hospital as a cornea specialist.

Indian J Pharmacol 2020 Sep-Oct;52(5):435-436

Department of Pediatric Ophthalmology and Strabismus, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Puducherry, India.

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http://dx.doi.org/10.4103/ijp.IJP_688_20DOI Listing
December 2020

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles.

Front Plant Sci 2020 22;11:585212. Epub 2020 Oct 22.

Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.

Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl isomerase (PPIase) activity that catalyzes the isomerization of the peptide bond preceding a proline residue, essential for correct folding of the proteins. Compared to prokaryotes and other eukaryotes studied until now, the cyclophilin gene families in plants exhibit considerable expansion. With few exceptions, the role of the majority of these proteins in plants is still a matter of conjecture. However, recent studies suggest that cyclophilins are highly versatile proteins with multiple functionalities, and regulate a plethora of growth and development processes in plants, ranging from hormone signaling to the stress response. The present review discusses the implications of cyclophilins in different facets of cellular processes, particularly in the context of plants, and provides a glimpse into the molecular mechanisms by which these proteins fine-tune the diverse physiological pathways.
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http://dx.doi.org/10.3389/fpls.2020.585212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641896PMC
October 2020

Computational identification of maize miRNA and their gene targets involved in biotic and abiotic stresses.

J Biosci 2020 ;45

School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana 141 004, India.

Plant interactions with biotic and abiotic stresses are complex and entail changes at the transcriptional, cellular and physiological level. MicroRNAs (miRNAs) are small (∼20-24 nt), non-coding RNAs that play a vital role in wide range of biological processes involved in regulation of gene expression through translation inhibition or degradation of their target mRNAs during stress conditions. Therefore, identification of miRNAs and their targets are of immense value in understanding the regulatory networks triggered during stress. Advancement in computational approaches has opened up ways for the prediction of miRNAs and their possible targets with functional pathways. Our objective was to identify miRNA and their potential targets involved in both biotic and abiotic stresses in maize. A total of 2,019,524 downloaded ESTs from dbEST were processed and trimmed by Seq Clean. The program trashed 264,000 and trimmed 284,979 sequences and the resulting 1,755,534 sequences were submitted for clustering and assembled to RepeatMasker and TGICL. A total of 30 miRNAs were found to hybridize with the potential targets of gene families such as CoA ligase, lipoxygenase 1, Terpenoideyclases, Zn finger, transducing, etc. Ten of the identified miRNAs targeted cytochrome c1 family. Zm_miR23 class targeted 11 different genes. The identified targets are involved in the plant growth and development during biotic and abiotic stresses in maize. These miRNAs may be further used for functional analysis. Furthermore, four and two of the miRNA targets were validated in response to waterlogging tolerance and southern leaf blight resistance, respectively, to understand the miRNA-assisted regulation of target miRNAs. The functional annotation of the predicted targets indicated that these stress-responsive miRNAs regulate cellular function; molecular function and biological process in maize at the post-transcriptional level. The present results have paved way towards better understanding the role of miRNAs in the mechanism of stress tolerance in maize.
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January 2020

Rare traumatic anterior dislocation of capsular tension ring-intraocular lens complex in-toto.

Indian J Ophthalmol 2020 Nov;68(11):2529

Pediatric and Squint Fellow, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_807_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774167PMC
November 2020

Ruptured unilateral anterior lenticonus with congenital hypertrophy of retinal pigment epithelium: A rare association.

Indian J Ophthalmol 2020 Nov;68(11):2496-2497

Pediatric Ophthalmology and Strabismus, Aravind Eye Hospital, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_898_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774175PMC
November 2020

Knowledge, attitude and practise toward COVID-19 among patients presenting to five tertiary eye care hospitals in South India - A multicentre questionnaire-based survey.

Indian J Ophthalmol 2020 Nov;68(11):2385-2390

Department of Glaucoma, Aravind Eye Hospital, Pondicherry, India.

Purpose: The aim of this study was to assess the knowledge, attitude, and practice (KAP) pattern towards COVID-19, among patients presenting to eye care hospitals during the last phase of lockdown period.

Methods: A multicenter cross-sectional survey was conducted from May 15 to June 15, 2020 in five tertiary eye care hospitals in South India to assess the KAP towards COVID-19. Each of the hospitals belonged to one of the three different zones assigned in India based on number of infections. Red zones represent hotspots and orange/green zones represent regions with medium and lower caseloads, respectively. A validated questionnaire was administered through telephone and responses were recorded on a Google form.

Results: Out of the total (n = 6119) participants, 3081 were from hospitals in green zone, 2110 from the orange zone, and 928 from red zone. Majority of participants were above 50 years of age (42%) and 15.54% were illiterate. The mean (percentage) scores of knowledge, attitude, and practice were 21.26 (82%), 9.37 (92%), and 10.32 (86%), respectively. KAP among patients more than 50 years of age and in illiterate individuals was significantly less (P < 0.01) when compared with all other groups. Participants from red zone had a significantly better attitude (P < 0.01) compared to other centers.

Conclusion: Although the overall KAP regarding COVID-19 disease was robust (above 80% in all categories) in our participants, the high risk elderly population (>50 years) and illiterate individuals had a significantly lower KAP. These are populations in which education should be emphasized and appropriately delivered as a way to reduce COVID-19 risk.
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http://dx.doi.org/10.4103/ijo.IJO_2522_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774232PMC
November 2020

Therapeutic status of hydroxychloroquine in COVID-19: A review.

J Anaesthesiol Clin Pharmacol 2020 Aug 31;36(Suppl 1):S160-S165. Epub 2020 Jul 31.

Department of Emergency Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Hydroxychloroquine (HCQ), a 4-aminoquinoline, is used worldwide mainly for its role in management of malaria and rheumatoid arthritis. In the present pandemic of coronavirus disease (COVID)-2019, the drug is being repurposed, based on its evidence of efficacy against coronavirus. There has been a lot of information, for and against the drug, and this review is an effort to bring forth the evidence and current understanding regarding role of HCQ in COVID-19. Clinical studies, case reports, and studies have generated conflicting results. There are concerns for use of HCQ because of the variable results and the known adverse effects like QT prolongation and hypoglycemia. In the current scenario, recommendations from Indian Council of Medical Research for use of HCQ in the prophylaxis of COVID-19 are being followed.
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http://dx.doi.org/10.4103/joacp.JOACP_313_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573985PMC
August 2020

Pre-harvest application of hexanal formulations for improving post-harvest life and quality of mango ( L.) Dashehari.

J Food Sci Technol 2020 Nov 6;57(11):4257-4264. Epub 2020 May 6.

Department of Fruit Science, Punjab Agricultural University, Ludhiana, 141014 India.

The highly perishable nature of the mango fruit which leads to quick deterioration in quality is the major limiting factor for mango growers of north India. Studies were, therefore, planned to determine the role of 'enhanced freshness formulation' (EFF) having hexanal as the main component in extending the storage life and quality of mango fruits of cultivar Dashehari. Aqueous formulations of hexanal are known to retard the activity of phospholipase-D thereby increasing the shelf-life and quality of stored fruits. Mango trees were given pre-harvest sprays of hexanal @800 µM, 1200 µM, 1600 µM and 2000 µM at 30 and 15 days before harvesting of the fruit. After harvest at physiologically mature stage, fruits were stored in walk-in-cool chambers at a temperature of 12 ± 2 °C and 85-90% relative humidity. These fruits were analysed for different physiological and biochemical parameters at weekly intervals till the stipulated storage period of 35 days. The results of the research revealed that the hexanal treatments widened the storage period of fruits while maintaining their freshness in comparison to the untreated mango fruits. Hexanal formulation @1600 µM significantly reduced the decay incidence, pectin methyl esterase activity and respiratory rate of mango fruits. These fruits also exhibited increased firmness, total soluble solids, acidity and maintained acceptable palatability up to 28 days of storage. The lower doses of EFF did not showed significant effect in expanding the storage span of fruits beyond 21 days while the higher dose of hexanal @2000 µM did not showed a significant enhancement in quality and storage life of mango fruits in comparison to hexanal @1600 µM.
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http://dx.doi.org/10.1007/s13197-020-04464-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520494PMC
November 2020

Bridging the gap between analytical methods and their clinical interpretation.

Epilepsia 2020 11 16;61(11):2609-2610. Epub 2020 Oct 16.

Department of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

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http://dx.doi.org/10.1111/epi.16706DOI Listing
November 2020

Maximizing non-invasive investigations in the quest for identifying the epileptogenic zone.

Clin Neurophysiol 2020 Nov 23;131(11):2777-2778. Epub 2020 Sep 23.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2020.08.020DOI Listing
November 2020

To assess the accuracy of Plusoptix S12-C photoscreener in detecting amblyogenic risk factors in children aged 6 months to 6 years in remote areas of South India.

Indian J Ophthalmol 2020 Oct;68(10):2186-2189

Department of Pediatric Ophthalmology and Strabismus, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

Purpose: To assess the screening accuracy of a novel fourth generation, handheld Plusoptix S12 C photo screener in detecting amblyogenic risk factors in children aged 6 months to 6 years in remote areas of South India.

Methods: In this cross sectional study, 381 children aged 6 months to 6 years were screened by a trained fieldworker in Anganwadis and schools using the Plusoptix photoscreener. This was followed by complete ophthalmic evaluation including retinoscopy, subjective refraction, and strabismus evaluation by an optometrist and an orthoptist. All children further underwent complete ocular examination by the senior pediatric ophthalmologist for validation of the results.

Results: A total of 367 children were included in the study. The sensitivity and specificity of the photo screener were found to be 86.76% and 82.27%, respectively. Positive Predictive Value, Negative Predictive Value, and Receiver Operative Characteristics were 52.67%, 96.47%, and 83.11%, respectively. In subgroup younger than 3 years, sensitivity and specificity was 89.19% and 81.18%, respectively. Myopic astigmatism was the most common amblyogenic risk factor in our study group.

Conclusion: In India, with a lack of adequate healthcare professionals and poor health-seeking behavior; photo screeners can play an important role. We recommend the use of photo screeners for screening children as young as 6 months, especially in remote low-resource settings. This will help in expanding reliable eye care services to previously underserved areas.
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http://dx.doi.org/10.4103/ijo.IJO_2046_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727995PMC
October 2020

Commentry: Ocular coinfections in human immunodeficiency virus infection-What is so different?

Indian J Ophthalmol 2020 09;68(9):1997-1998

Pediatric Ophthalmology Fellow, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_680_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690466PMC
September 2020

Interleukins and cytokine biomarkers in uveitis.

Indian J Ophthalmol 2020 09;68(9):1750-1763

Aravind Eye Hospital, Pondicherry, India.

Interleukins and cytokines are involved in the pathogenesis of uveitis of heterogeneous origin. Understanding the basics of the ocular immune privilege is a fulcrum to discern their specific role in diverse uveitis to potentially translate as therapeutic targets. This review attempts to cover these elements in uveitis of infectious, noninfectious and masquerade origin. Insights of the molecular targets in novel therapy along with the vision of future research are intriguing.
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http://dx.doi.org/10.4103/ijo.IJO_564_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7690463PMC
September 2020

Trends of inflammatory bowel disease at a tertiary care center in northern India.

Intest Res 2020 Aug 18. Epub 2020 Aug 18.

Research and Development Centre, Dayanand Medical College and Hospital, Ludhiana, India.

Background/aims: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is increasingly being reported from India and other Asian countries. This study looks into the changing trends of IBD at a tertiary care center in north India over last two decades.

Methods: Retrospective analysis of a prospectively maintained database of patients diagnosed with IBD between January 1991 and December 2015 was conducted. The study period was divided into five times cohorts (1991-1995, 1996-2000, 2001-2005, 2006-2010, 2011-2015).

Results: During the study period, 2,467 patients (UC [n = 2,137, 86.6%], CD [n = 330, 13.3%], mean age 38.5 ± 13.3 years; 55.9% males) were registered. The proportion of patients with CD increased (ratio of UC to CD declined from 15.7:1 to 4:1). The mean age at diagnosis decreased for UC (45.7 ± 12.1 years in 1991-1995 vs. 37.6 ± 13.0 years in 2011-2015; P= 0.001) and remained consistent for CD (41.3 ± 13.6 years in 1996-2000 vs. 41.3 ± 16.9 years in 2011-2015, P= 0.86). Patients with proctitis in UC and isolated ileal disease in CD increased over the study period (P= 0.001 and P= 0.007, respectively). Inflammatory CD increased (P= 0.009) whereas stricturing CD decreased (P= 0.01) across all cohorts. There was a trend towards less severe presentation of both UC and CD. The use of thiopurines (P= 0.02) and biologics increased (P= 0.001) with no significant change in trends for requirements of surgery (P= 0.9).

Conclusions: Increasing prevalence of CD, younger age at diagnosis, diagnosis at an earlier and milder stage, greater use of thiopurines and biologics were observed.
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http://dx.doi.org/10.5217/ir.2020.00010DOI Listing
August 2020

Clinical Predictors of response to Faecal Microbiota Transplantation in patients with active ulcerative colitis.

J Crohns Colitis 2020 Aug 9. Epub 2020 Aug 9.

School of Business Studies, Punjab Agricultural University, Ludhiana, Punjab, India.

Background: Fecal Microbiota Transplantation (FMT) has been shown to be effective for induction of remission in patients with active ulcerative colitis (UC). At present, clinical factors impacting the response to FMT in UC remain unclear.

Methods: Patients with active UC treated with multisession FMT via colonoscopy at weeks 0, 2, 6, 10, 14, 18, and 22, were analysed. Response to FMT was defined as achievement of corticosteroid free clinical remission at week 30. Patient and disease characteristics were evaluated to determine the predictors of response to FMT.

Results: Out of 140 patients with active UC treated with FMT, 93 patients [mean age 34.96±11.27 years, 62.36% males (n=58), mean Mayo clinic score 8.07±2.00] who completed the multi-session FMT protocol were analysed. Fifty-seven (61.29%) patients achieved clinical remission. Younger age (OR for age 0.93, 95% CI 0.89-0.97, p=0.001), moderate (Mayo clinic score 6-9) disease severity (OR 3.01, 95% CI 1.12 to 8.06, p=0.025) and endoscopic Mayo score 2 (OR 5.55, 95% CI 2.18-14.06, p<0.001) were significant predictors of remission on univariate analysis. Younger age, disease extent E2 and endoscopic mayo score 2 (OR 0.925, 95% CI 0.88-0.97, p=0.002; OR 2.89, 95% CI 1.01-8.25, p=0.04 and OR 8.43, 95% CI 2.38-29.84, p=0.001, respectively) were associated with clinical remission on multivariate logistic regression. A mathematical model (nomogram) was developed for estimating the probability of remission with FMT protocol.

Conclusion: Younger age, disease extent E2, and endoscopic mayo score 2 significantly predict achievement of clinical remission with FMT in active UC. The prediction model can help in selecting individuals for FMT. Validation in larger cohorts is needed.
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http://dx.doi.org/10.1093/ecco-jcc/jjaa163DOI Listing
August 2020

Spontaneous Adverse Drug Reaction Monitoring in a Tertiary Care Centre.

Curr Drug Saf 2020 ;15(3):215-221

Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, India.

Background And Objective: Adverse drug reactions (ADRs) are associated with increased economic burden on the society. Monitoring of ADRs can help in decreasing the incidence of preventable adverse reactions.

Methods: Under Pharmacovigilance Program of India, collection and reporting of ADRs has been going on at Dayanand Medical College and Hospital since January 2011. Here, we have analyzed the individual case safety reports (ICSRs) reported and uploaded between January 2017 and June 2019 from our centre. The ADR form provided by PvPI was used for collecting information, and the causality assessment was done according to the WHO-UMC scale.

Results: A total of 498 ICSRs were uploaded through Vigiflow software during this period. Highest number of ADRs were recorded in the age group of 31-45 years (29.01%) and the least number of ADRs were recorded in the children less than 15 years of age (6.76%). General Medicine ward reported the highest number of ADRs and the antibiotics were most commonly associated with ADRs (26.21%), followed by antipsychotics (13.83%) and NSAIDs (12.14%). More than 90% of ADRs were non-serious (93.17%) and most of the ADRs were skin and soft tissue related (49.20%).

Conclusion: Spontaneous reporting among indoor patients shows highest number of ADRs with use of antibiotics and almost all of the ADRs were non-serious in nature. Almost half of the total ADRs were skin and subcutaneous tissue related. Continuous efforts are required for further strengthening of the pharmacovigilance program of India.
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http://dx.doi.org/10.2174/1574886315666200731172405DOI Listing
January 2020

Innovative application of ultraviolet rays and hydrogen peroxide vapor for decontamination of respirators during COVID-19 pandemic- An experience from a tertiary eye care hospital.

Indian J Ophthalmol 2020 Aug;68(8):1714-1715

Department of Microbiology, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, India.

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http://dx.doi.org/10.4103/ijo.IJO_2160_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640840PMC
August 2020

A simple solution to prevent microscope eyepiece fogging and spectacle fogging in COVID-19 era.

Indian J Ophthalmol 2020 Aug;68(8):1712-1713

Glaucoma Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_1500_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640865PMC
August 2020

Contact lens warpage: Lost but found.

Indian J Ophthalmol 2020 Aug;68(8):1662

Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

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http://dx.doi.org/10.4103/ijo.IJO_2034_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640866PMC
August 2020

Innovative intraocular lens loading magnified.

Indian J Ophthalmol 2020 08;68(8):1640-1642

Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

Cataract surgery continues to evolve and advance in terms of new technology and improved techniques, offering a final result of better visual quality and faster visual recovery for our patients. Intraocular lens (IOL) delivery into the eye is a critical step in cataract surgery. Currently, eye surgeons load the IOL into the cartridge under the operating microscope or ophthalmic assistants load the IOL under their own direct vision. Because ophthalmic assistants load the IOL unaided, the IOL may be mishandled and lead to challenges such as IOL slippage, breakage, or incorrect orientation. In order to overcome these challenges and facilitate the surgical process, here we describe a novel technique by introducing a magnifier to the surgical table to aid ophthalmic assistants during this crucial step in cataract surgery. This not only saves time but also improves precision while loading IOL into the cartridge during cataract surgery.
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Source
http://dx.doi.org/10.4103/ijo.IJO_2217_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640858PMC
August 2020