SUNY at Buffalo
Buffalo, New York | United States
Primary Affiliation: SUNY at Buffalo - Buffalo, New York , United States
PubMed Central Citations
21PubMed Central Citations
J Biol Chem 2018 Aug 14;293(31):12248-12258. Epub 2018 Jun 14.
From the Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065 and
Andra, Biochem Anal Biochem 2015, 4:4
Biochemistry & Analytical Biochemistry
Fluorinated amino acids play a significant role in peptides and protein studies. These are known to enhance the stability of proteins folds and serve as valuable analogues for investigation of enzyme kinetics, protein-protein and ligand-receptor interactions. Due to the unique properties of fluorine, fluorinated amino acids are used as a powerful tool to study biological process and to develop anti-cancer reagent and vaccines. Previous reviews cover synthesis and applications of fluorinated amino acids in broad range; this short review provides the importance of fluorinated aromatic amino acids and the impact of fluorine substitution in its aromatic rings that facilitate the study of structure, function and stability of therapeutic proteins and peptides which have great potential for future therapeutic applications.
Hum Vaccin Immunother 2013 Nov 7;9(11):2362-70. Epub 2013 Aug 7.
Macromolecule and Vaccine Stabilization Center; Department of Pharmaceutical Chemistry; University of Kansas; Lawrence, KS USA; Bioengineering Graduate Program; University of Kansas; Lawrence, KS USA.