J Biol Chem 2018 Aug 14;293(31):12248-12258. Epub 2018 Jun 14.

From the Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065 and

Proc Natl Acad Sci U S A 2018 07 20;115(30):E7033-E7042. Epub 2018 Jun 20.

Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10065;

Andra, Biochem Anal Biochem 2015, 4:4

Biochemistry & Analytical Biochemistry

Fluorinated amino acids play a significant role in peptides and protein studies. These are known to enhance the stability of proteins folds and serve as valuable analogues for investigation of enzyme kinetics, protein-protein and ligand-receptor interactions. Due to the unique properties of fluorine, fluorinated amino acids are used as a powerful tool to study biological process and to develop anti-cancer reagent and vaccines. Previous reviews cover synthesis and applications of fluorinated amino acids in broad range; this short review provides the importance of fluorinated aromatic amino acids and the impact of fluorine substitution in its aromatic rings that facilitate the study of structure, function and stability of therapeutic proteins and peptides which have great potential for future therapeutic applications.

Hum Vaccin Immunother 2013 Nov 7;9(11):2362-70. Epub 2013 Aug 7.

Macromolecule and Vaccine Stabilization Center; Department of Pharmaceutical Chemistry; University of Kansas; Lawrence, KS USA; Bioengineering Graduate Program; University of Kansas; Lawrence, KS USA.

J Pharm Sci 2012 Nov 21;101(11):4118-28. Epub 2012 Aug 21.

Macromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.

Protein Sci 2012 Oct 22;21(10):1467-80. Epub 2012 Aug 22.

Department of Chemistry, Wichita State University, Wichita, Kansas 67260-0051, USA.

Acta Crystallogr Sect E Struct Rep Online 2010 Oct 2;66(Pt 11):o2713. Epub 2010 Oct 2.

Department of Chemistry, Wichita State University, 1845 Fairmount, Wichita, KS 67260-0051, USA.