Publications by authors named "Kingston Mills"

100Publications

UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation.

PLoS One 2020 19;15(11):e0239713. Epub 2020 Nov 19.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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January 2021

Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract.

Vaccines (Basel) 2020 Oct 21;8(4). Epub 2020 Oct 21.

School of Biochemistry and Immunology, Trinity College Dublin, 2, D02 PN40 Dublin, Ireland.

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October 2020

IL-33-Stimulated Murine Mast Cells Polarize Alternatively Activated Macrophages, Which Suppress T Cells That Mediate Experimental Autoimmune Encephalomyelitis.

J Immunol 2020 Oct 28;205(7):1909-1919. Epub 2020 Aug 28.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

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October 2020

Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner.

Biomaterials 2020 05 31;239:119833. Epub 2020 Jan 31.

School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland; School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address:

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May 2020

Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells.

Immunity 2020 02 4;52(2):342-356.e6. Epub 2020 Feb 4.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

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February 2020

The microbiota and immune-mediated diseases: Opportunities for therapeutic intervention.

Eur J Immunol 2020 03 6;50(3):326-337. Epub 2020 Feb 6.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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March 2020

Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells.

Brain Behav Immun 2020 07 21;87:413-428. Epub 2020 Jan 21.

Trinity College Institute for Neuroscience, Trinity College, Dublin 2, Ireland. Electronic address:

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July 2020

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4 T Cell Pathogenicity and Suppresses Autoimmunity.

Cell Metab 2020 02 21;31(2):391-405.e8. Epub 2019 Nov 21.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin D02 R590, Ireland. Electronic address:

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February 2020

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages William W Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Francesco Annunziato Achille Anselmo Petra Bacher Cosima T Baldari Sudipto Bari Vincenzo Barnaba Joana Barros-Martins Luca Battistini Wolfgang Bauer Sabine Baumgart Nicole Baumgarth Dirk Baumjohann Bianka Baying Mary Bebawy Burkhard Becher Wolfgang Beisker Vladimir Benes Rudi Beyaert Alfonso Blanco Dominic A Boardman Christian Bogdan Jessica G Borger Giovanna Borsellino Philip E Boulais Jolene A Bradford Dirk Brenner Ryan R Brinkman Anna E S Brooks Dirk H Busch Martin Büscher Timothy P Bushnell Federica Calzetti Garth Cameron Ilenia Cammarata Xuetao Cao Susanna L Cardell Stefano Casola Marco A Cassatella Andrea Cavani Antonio Celada Lucienne Chatenoud Pratip K Chattopadhyay Sue Chow Eleni Christakou Luka Čičin-Šain Mario Clerici Federico S Colombo Laura Cook Anne Cooke Andrea M Cooper Alexandra J Corbett Antonio Cosma Lorenzo Cosmi Pierre G Coulie Ana Cumano Ljiljana Cvetkovic Van Duc Dang Chantip Dang-Heine Martin S Davey Derek Davies Sara De Biasi Genny Del Zotto Gelo Victoriano Dela Cruz Michael Delacher Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing James P Di Santo Andreas Diefenbach Francesco Dieli Andreas Dolf Thomas Dörner Regine J Dress Diana Dudziak Michael Dustin Charles-Antoine Dutertre Friederike Ebner Sidonia B G Eckle Matthias Edinger Pascale Eede Götz R A Ehrhardt Marcus Eich Pablo Engel Britta Engelhardt Anna Erdei Charlotte Esser Bart Everts Maximilien Evrard Christine S Falk Todd A Fehniger Mar Felipo-Benavent Helen Ferry Markus Feuerer Andrew Filby Kata Filkor Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Britta Frehse Paul S Frenette Stefan Frischbutter Wolfgang Fritzsche David W Galbraith Anastasia Gangaev Natalio Garbi Brice Gaudilliere Ricardo T Gazzinelli Jens Geginat Wilhelm Gerner Nicholas A Gherardin Kamran Ghoreschi Lara Gibellini Florent Ginhoux Keisuke Goda Dale I Godfrey Christoph Goettlinger Jose M González-Navajas Carl S Goodyear Andrea Gori Jane L Grogan Daryl Grummitt Andreas Grützkau Claudia Haftmann Jonas Hahn Hamida Hammad Günter Hämmerling Leo Hansmann Goran Hansson Christopher M Harpur Susanne Hartmann Andrea Hauser Anja E Hauser David L Haviland David Hedley Daniela C Hernández Guadalupe Herrera Martin Herrmann Christoph Hess Thomas Höfer Petra Hoffmann Kristin Hogquist Tristan Holland Thomas Höllt Rikard Holmdahl Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Fang-Ping Huang Johanna E Huber Jochen Huehn Michael Hundemer Christopher A Hunter William Y K Hwang Anna Iannone Florian Ingelfinger Sabine M Ivison Hans-Martin Jäck Peter K Jani Beatriz Jávega Stipan Jonjic Toralf Kaiser Tomas Kalina Thomas Kamradt Stefan H E Kaufmann Baerbel Keller Steven L C Ketelaars Ahad Khalilnezhad Srijit Khan Jan Kisielow Paul Klenerman Jasmin Knopf Hui-Fern Koay Katja Kobow Jay K Kolls Wan Ting Kong Manfred Kopf Thomas Korn Katharina Kriegsmann Hendy Kristyanto Thomas Kroneis Andreas Krueger Jenny Kühne Christian Kukat Désirée Kunkel Heike Kunze-Schumacher Tomohiro Kurosaki Christian Kurts Pia Kvistborg Immanuel Kwok Jonathan Landry Olivier Lantz Paola Lanuti Francesca LaRosa Agnès Lehuen Salomé LeibundGut-Landmann Michael D Leipold Leslie Y T Leung Megan K Levings Andreia C Lino Francesco Liotta Virginia Litwin Yanling Liu Hans-Gustaf Ljunggren Michael Lohoff Giovanna Lombardi Lilly Lopez Miguel López-Botet Amy E Lovett-Racke Erik Lubberts Herve Luche Burkhard Ludewig Enrico Lugli Sebastian Lunemann Holden T Maecker Laura Maggi Orla Maguire Florian Mair Kerstin H Mair Alberto Mantovani Rudolf A Manz Aaron J Marshall Alicia Martínez-Romero Glòria Martrus Ivana Marventano Wlodzimierz Maslinski Giuseppe Matarese Anna Vittoria Mattioli Christian Maueröder Alessio Mazzoni James McCluskey Mairi McGrath Helen M McGuire Iain B McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Stephen D Miller Kingston H G Mills Hans Minderman Jenny Mjösberg Jonni Moore Barry Moran Lorenzo Moretta Tim R Mosmann Susann Müller Gabriele Multhoff Luis Enrique Muñoz Christian Münz Toshinori Nakayama Milena Nasi Katrin Neumann Lai Guan Ng Antonia Niedobitek Sussan Nourshargh Gabriel Núñez José-Enrique O'Connor Aaron Ochel Anna Oja Diana Ordonez Alberto Orfao Eva Orlowski-Oliver Wenjun Ouyang Annette Oxenius Raghavendra Palankar Isabel Panse Kovit Pattanapanyasat Malte Paulsen Dinko Pavlinic Livius Penter Pärt Peterson Christian Peth Jordi Petriz Federica Piancone Winfried F Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Zhiyong Poon Katharina Pracht Immo Prinz Carlo E M Pucillo Sally A Quataert Linda Quatrini Kylie M Quinn Helena Radbruch Tim R D J Radstake Susann Rahmig Hans-Peter Rahn Bartek Rajwa Gevitha Ravichandran Yotam Raz Jonathan A Rebhahn Diether Recktenwald Dorothea Reimer Caetano Reis e Sousa Ester B M Remmerswaal Lisa Richter Laura G Rico Andy Riddell Aja M Rieger J Paul Robinson Chiara Romagnani Anna Rubartelli Jürgen Ruland Armin Saalmüller Yvan Saeys Takashi Saito Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Inga Sandrock Angela Santoni Ramon Bellmàs Sanz Marina Saresella Catherine Sautes-Fridman Birgit Sawitzki Linda Schadt Alexander Scheffold Hans U Scherer Matthias Schiemann Frank A Schildberg Esther Schimisky Andreas Schlitzer Josephine Schlosser Stephan Schmid Steffen Schmitt Kilian Schober Daniel Schraivogel Wolfgang Schuh Thomas Schüler Reiner Schulte Axel Ronald Schulz Sebastian R Schulz Cristiano Scottá Daniel Scott-Algara David P Sester T Vincent Shankey Bruno Silva-Santos Anna Katharina Simon Katarzyna M Sitnik Silvano Sozzani Daniel E Speiser Josef Spidlen Anders Stahlberg Alan M Stall Natalie Stanley Regina Stark Christina Stehle Tobit Steinmetz Hannes Stockinger Yousuke Takahama Kiyoshi Takeda Leonard Tan Attila Tárnok Gisa Tiegs Gergely Toldi Julia Tornack Elisabetta Traggiai Mohamed Trebak Timothy I M Tree Joe Trotter John Trowsdale Maria Tsoumakidou Henning Ulrich Sophia Urbanczyk Willem van de Veen Maries van den Broek Edwin van der Pol Sofie Van Gassen Gert Van Isterdael René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Anouk von Borstel Konrad von Volkmann Ari Waisman Rachael V Walker Paul K Wallace Sa A Wang Xin M Wang Michael D Ward Kirsten A Ward-Hartstonge Klaus Warnatz Gary Warnes Sarah Warth Claudia Waskow James V Watson Carsten Watzl Leonie Wegener Thomas Weisenburger Annika Wiedemann Jürgen Wienands Anneke Wilharm Robert John Wilkinson Gerald Willimsky James B Wing Rieke Winkelmann Thomas H Winkler Oliver F Wirz Alicia Wong Peter Wurst Jennie H M Yang Juhao Yang Maria Yazdanbakhsh Liping Yu Alice Yue Hanlin Zhang Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky

Eur J Immunol 2019 Oct;49(10):1457-1973

Max Planck Institute for Infection Biology, Berlin, Germany.

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October 2019

Anti-inflammatory Trained Immunity Mediated by Helminth Products Attenuates the Induction of T Cell-Mediated Autoimmune Disease.

Front Immunol 2019 21;10:1109. Epub 2019 May 21.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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September 2020

A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against , Including Pertactin Deficient Strains.

Front Cell Infect Microbiol 2019 26;9:125. Epub 2019 Apr 26.

Laboratorio VacSal, Facultad de Ciencias Exactas, Instituto de Biotecnología y Biología Molecular (IBBM), CCT-CONICET La Plata, Universidad Nacional de La Plata, La Plata, Argentina.

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January 2020

Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis.

Eur J Immunol 2019 08 2;49(8):1291-1294. Epub 2019 May 2.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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August 2019

Immunization with whole cell but not acellular pertussis vaccines primes CD4 T cells that sustain protective immunity against nasal colonization with Bordetella pertussis.

Emerg Microbes Infect 2019 ;8(1):169-185

a Immune Regulation Research Group, School of Biochemistry and Immunology , Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin , Ireland.

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July 2019

Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis.

Oncogene 2019 04 11;38(14):2658-2674. Epub 2018 Dec 11.

Trinity Biomedical Sciences Institute, School of Biochemistry & Immunology, Trinity College Dublin, Dublin 2, Ireland.

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April 2019

CD4 T Cells Following Infection and Immunization: Implications for More Effective Vaccine Design.

Front Immunol 2018 10;9:1860. Epub 2018 Aug 10.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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September 2019

Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T cells.

Mucosal Immunol 2018 11 20;11(6):1763-1776. Epub 2018 Aug 20.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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November 2018

Azithromycin Clears Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory.

Front Immunol 2018 30;9:1764. Epub 2018 Jul 30.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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September 2019

Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis.

J Autoimmun 2018 Jan 21. Epub 2018 Jan 21.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

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January 2018

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.

Nat Commun 2017 12 12;8(1):1923. Epub 2017 Dec 12.

Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephens Green, D02 YN77, Dublin, Ireland.

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December 2017

Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.

Front Immunol 2017 13;8:1300. Epub 2017 Oct 13.

School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Science Institute, Dublin, Ireland.

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October 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Mübeccel Akdis Immanuel Andrä Francesco Annunziato Petra Bacher Vincenzo Barnaba Luca Battistini Wolfgang M Bauer Sabine Baumgart Burkhard Becher Wolfgang Beisker Claudia Berek Alfonso Blanco Giovanna Borsellino Philip E Boulais Ryan R Brinkman Martin Büscher Dirk H Busch Timothy P Bushnell Xuetao Cao Andrea Cavani Pratip K Chattopadhyay Qingyu Cheng Sue Chow Mario Clerici Anne Cooke Antonio Cosma Lorenzo Cosmi Ana Cumano Van Duc Dang Derek Davies Sara De Biasi Genny Del Zotto Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing Andreas Diefenbach James Di Santo Francesco Dieli Andreas Dolf Vera S Donnenberg Thomas Dörner Götz R A Ehrhardt Elmar Endl Pablo Engel Britta Engelhardt Charlotte Esser Bart Everts Anita Dreher Christine S Falk Todd A Fehniger Andrew Filby Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Paul S Frenette David Galbraith Natalio Garbi Maria Dolores García-Godoy Jens Geginat Kamran Ghoreschi Lara Gibellini Christoph Goettlinger Carl S Goodyear Andrea Gori Jane Grogan Mor Gross Andreas Grützkau Daryl Grummitt Jonas Hahn Quirin Hammer Anja E Hauser David L Haviland David Hedley Guadalupe Herrera Martin Herrmann Falk Hiepe Tristan Holland Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Christopher A Hunter Anna Iannone Hans-Martin Jäck Beatriz Jávega Stipan Jonjic Kerstin Juelke Steffen Jung Toralf Kaiser Tomas Kalina Baerbel Keller Srijit Khan Deborah Kienhöfer Thomas Kroneis Désirée Kunkel Christian Kurts Pia Kvistborg Joanne Lannigan Olivier Lantz Anis Larbi Salome LeibundGut-Landmann Michael D Leipold Megan K Levings Virginia Litwin Yanling Liu Michael Lohoff Giovanna Lombardi Lilly Lopez Amy Lovett-Racke Erik Lubberts Burkhard Ludewig Enrico Lugli Holden T Maecker Glòria Martrus Giuseppe Matarese Christian Maueröder Mairi McGrath Iain McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Kingston Mills David Mirrer Jenny Mjösberg Jonni Moore Barry Moran Alessandro Moretta Lorenzo Moretta Tim R Mosmann Susann Müller Werner Müller Christian Münz Gabriele Multhoff Luis Enrique Munoz Kenneth M Murphy Toshinori Nakayama Milena Nasi Christine Neudörfl John Nolan Sussan Nourshargh José-Enrique O'Connor Wenjun Ouyang Annette Oxenius Raghav Palankar Isabel Panse Pärt Peterson Christian Peth Jordi Petriz Daisy Philips Winfried Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Carlo Pucillo Sally A Quataert Timothy R D J Radstake Bartek Rajwa Jonathan A Rebhahn Diether Recktenwald Ester B M Remmerswaal Katy Rezvani Laura G Rico J Paul Robinson Chiara Romagnani Anna Rubartelli Beate Ruckert Jürgen Ruland Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Birgit Sawitzki Alexander Scheffold Matthias Schiemann Frank Schildberg Esther Schimisky Stephan A Schmid Steffen Schmitt Kilian Schober Thomas Schüler Axel Ronald Schulz Ton Schumacher Cristiano Scotta T Vincent Shankey Anat Shemer Anna-Katharina Simon Josef Spidlen Alan M Stall Regina Stark Christina Stehle Merle Stein Tobit Steinmetz Hannes Stockinger Yousuke Takahama Attila Tarnok ZhiGang Tian Gergely Toldi Julia Tornack Elisabetta Traggiai Joe Trotter Henning Ulrich Marlous van der Braber René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Konrad von Volkmann Ari Waisman Rachael Walker Michael D Ward Klaus Warnatz Sarah Warth James V Watson Carsten Watzl Leonie Wegener Annika Wiedemann Jürgen Wienands Gerald Willimsky James Wing Peter Wurst Liping Yu Alice Yue Qianjun Zhang Yi Zhao Susanne Ziegler Jakob Zimmermann

Eur J Immunol 2017 10;47(10):1584-1797

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse, Bern.

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October 2017

Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model.

Vaccine 2017 09 18;35(39):5256-5263. Epub 2017 Aug 18.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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September 2017

FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation.

J Neuroimmune Pharmacol 2017 12 15;12(4):670-681. Epub 2017 Jun 15.

Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.

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December 2017

Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with .

J Immunol 2017 07 22;199(1):233-243. Epub 2017 May 22.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; and

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July 2017

Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases.

Clin Vaccine Immunol 2017 Jul 5;24(7). Epub 2017 Jul 5.

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

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July 2017

Immune checkpoints and their inhibition in cancer and infectious diseases.

Eur J Immunol 2017 05 24;47(5):765-779. Epub 2017 Apr 24.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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May 2017

In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis.

Nucleic Acids Res 2017 02;45(4):2029-2039

School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Trinity College Dublin, Ireland.

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February 2017

IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory γδ T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice.

J Immunol 2017 01 18;198(1):363-374. Epub 2016 Nov 18.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

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January 2017

Pertussis: Biology, epidemiology and prevention.

Vaccine 2016 11 22;34(48):5819-5826. Epub 2016 Oct 22.

Global Medical Affairs, Sanofi Pasteur, Swiftwater, PA, USA.

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November 2016

What rheumatologists need to know about innate lymphocytes.

Nat Rev Rheumatol 2016 11 2;12(11):658-668. Epub 2016 Sep 2.

Manchester Collaborative Centre for Inflammation Research (MCCIR), The University of Manchester, Grafton Street, Manchester M13 9NT, UK.

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November 2016

Anti-PD-1 inhibits Foxp3 Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model.

Cancer Immunol Immunother 2016 12 28;65(12):1491-1498. Epub 2016 Sep 28.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland.

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December 2016

Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages.

Autophagy 2016 06 10;12(6):907-16. Epub 2016 May 10.

a Lupus Research Group, Center for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University , Clayton , Victoria , Australia.

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June 2016

Trained immunity: A program of innate immune memory in health and disease.

Science 2016 Apr 21;352(6284):aaf1098. Epub 2016 Apr 21.

The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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April 2016

Retinoic acid suppresses IL-17 production and pathogenic activity of γδ T cells in CNS autoimmunity.

Immunol Cell Biol 2016 09 10;94(8):763-73. Epub 2016 May 10.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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September 2016

The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases.

Semin Immunol 2016 08 12;28(4):343-50. Epub 2016 Mar 12.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

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August 2016

Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia.

J Immunol 2016 Jan 16;196(2):703-14. Epub 2015 Dec 16.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland;

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January 2016

γδ T Cells and NK Cells - Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity.

Front Immunol 2015 8;6:455. Epub 2015 Sep 8.

Immune Regulation Research Group, Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin , Dublin , Ireland.

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October 2015

Roads to the development of improved pertussis vaccines paved by immunology.

Pathog Dis 2015 Nov 6;73(8):ftv067. Epub 2015 Sep 6.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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November 2015

Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction.

Brain Behav Immun 2015 Nov 19;50:41-46. Epub 2015 Jun 19.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

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November 2015

Innate immune memory: a paradigm shift in understanding host defense.

Nat Immunol 2015 Jul;16(7):675-9

School of Biochemistry and Immunology, Trinity College, Dublin, Ireland.

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July 2015

Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity.

J Immunol 2015 Jul 10;195(2):528-40. Epub 2015 Jun 10.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland

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July 2015

T Cells-Protective or Pathogenic in Alzheimer's Disease?

J Neuroimmune Pharmacol 2015 Dec 10;10(4):547-60. Epub 2015 May 10.

Trinity College Institute of Neuroscience, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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December 2015

Protective role for caspase-11 during acute experimental murine colitis.

J Immunol 2015 Feb 29;194(3):1252-60. Epub 2014 Dec 29.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland;

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February 2015

Innate IFN-γ promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages.

Eur J Immunol 2014 Oct 19;44(10):2903-17. Epub 2014 Aug 19.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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October 2014

Improved pertussis vaccines based on adjuvants that induce cell-mediated immunity.

Expert Rev Vaccines 2014 Oct 12;13(10):1253-64. Epub 2014 Jul 12.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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October 2014

Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses.

J Nutr Biochem 2014 Jul 27;25(7):741-9. Epub 2014 Mar 27.

Immunomodulation Research Group, School of Biotechnology, Dublin City University, Dublin 9, Ireland. Electronic address:

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July 2014

Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases.

Immunol Rev 2014 May;259(1):206-30

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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May 2014

Modulation of T cell and innate immune responses by retinoic Acid.

J Immunol 2014 Apr;192(7):2953-8

Immune Regulation Research Group and Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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April 2014

Mouse and pig models for studies of natural and vaccine-induced immunity to Bordetella pertussis.

J Infect Dis 2014 Apr;209 Suppl 1:S16-9

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.

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April 2014

Staphylococcus aureus infection of mice expands a population of memory γδ T cells that are protective against subsequent infection.

J Immunol 2014 Apr 12;192(8):3697-708. Epub 2014 Mar 12.

Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin 2, Ireland.

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April 2014

Do we need a new vaccine to control the re-emergence of pertussis?

Trends Microbiol 2014 Feb;22(2):49-52

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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February 2014

Prior exposure to bacteria attenuates viral disease of the respiratory tract: a role for IL-17 and innate immune memory?

Am J Respir Crit Care Med 2014 Jan;189(2):126-8

1 School of Biochemistry and Immunology Trinity College Dublin Dublin, Ireland.

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January 2014

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice.

Neurobiol Aging 2014 Jan 29;35(1):109-21. Epub 2013 Aug 29.

Trinity College Institute of Neuroscience, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Electronic address:

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January 2014

Dendritic cells and other innate determinants of T helper cell polarisation.

Trends Immunol 2013 Nov 21;34(11):521-30. Epub 2013 Aug 21.

Immune Regulation Research Group and Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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November 2013

Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells.

Cancer Immunol Immunother 2013 Jul 9;62(7):1273-82. Epub 2013 May 9.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, 152-160 Pearse St, Dublin 2, Ireland.

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July 2013

Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine.

PLoS Pathog 2013 4;9(4):e1003264. Epub 2013 Apr 4.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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January 2014

Alveolar macrophages contribute to respiratory tolerance by inducing FoxP3 expression in naive T cells.

Am J Respir Cell Mol Biol 2013 Jun;48(6):773-80

Immune Regulation Research Group, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.

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June 2013

IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease.

J Immunol 2013 Mar 30;190(5):2241-51. Epub 2013 Jan 30.

Trinity College Institute of Neuroscience, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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March 2013

Autophagy and inflammatory diseases.

Immunol Cell Biol 2013 Mar 15;91(3):250-8. Epub 2013 Jan 15.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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March 2013

The role of inflammasome-derived IL-1 in driving IL-17 responses.

J Leukoc Biol 2013 Apr 27;93(4):489-97. Epub 2012 Dec 27.

Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

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April 2013

Therapeutic potential of targeting IL-17.

Nat Immunol 2012 Nov;13(11):1022-5

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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November 2012

Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion.

J Immunol 2012 Oct 12;189(8):4144-53. Epub 2012 Sep 12.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.

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October 2012

IL-17-producing γδ T cells and innate lymphoid cells.

Eur J Immunol 2012 Sep;42(9):2221-31

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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September 2012

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance.

Mol Nutr Food Res 2012 Aug 15;56(8):1212-22. Epub 2012 Jun 15.

Nutrigenomics Research Group, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.

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August 2012

A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers.

Mult Scler 2012 Dec 28;18(12):1797-800. Epub 2012 Mar 28.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.

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December 2012

The immunoregulatory role of CD4⁺ FoxP3⁺ CD25⁻ regulatory T cells in lungs of mice infected with Bordetella pertussis.

FEMS Immunol Med Microbiol 2012 Apr 18;64(3):413-24. Epub 2012 Jan 18.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.

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April 2012

Gene silencing of TGF-β1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells.

Cancer Immunol Immunother 2012 Mar 23;61(3):425-31. Epub 2011 Dec 23.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Room 4.04, Pearse Street, Dublin 2, Ireland.

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March 2012

Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors.

Cancer Res 2012 Feb 9;72(3):581-91. Epub 2011 Dec 9.

Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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February 2012

TLR-dependent T cell activation in autoimmunity.

Nat Rev Immunol 2011 Nov 18;11(12):807-22. Epub 2011 Nov 18.

Immunology Research Centre and School of Biochemistry and Immunology, Trinity College Dublin, Ireland.

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November 2011

Targeting regulatory T cells in cancer.

Cancer Res 2011 Nov 8;71(22):6915-20. Epub 2011 Nov 8.

Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jnr. Laboratory, University College Cork, Cork, Ireland.

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November 2011

A deep rough type structure in Bordetella bronchiseptica lipopolysaccharide modulates host immune responses.

Microbiol Immunol 2011 Dec;55(12):847-54

VacSal Laboratory, Biotechnology and Molecular Biology Institute, Department of Biological Sciences, Faculty of Sciences, National University of La Plata, National Council of Scientific and Technical Research (CONICET), Calles 47 y 115 (1900) La Plata, Argentina.

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December 2011

Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction.

Kidney Int 2012 Feb 5;81(4):379-90. Epub 2011 Oct 5.

Regenerative Medicine Institute, National Centre for Biomedical Engineering Science and School of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.

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February 2012

Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17.

Cytokine 2011 Oct 6;56(1):126-32. Epub 2011 Aug 6.

School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.

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October 2011

Immunology meets neuroscience--opportunities for immune intervention in neurodegenerative diseases.

Brain Behav Immun 2012 Jan 31;26(1):1-10. Epub 2011 May 31.

Trinity Institute for Neuroscience, Trinity College, Dublin, Ireland.

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January 2012

Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.

Diabetes 2011 Jun 22;60(6):1688-98. Epub 2011 Apr 22.

Nutrigenomics Research Group, University College Dublin Conway Institute, School of Public Health & Population Science, University College Dublin, Dublin, Ireland.

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June 2011

TLR based therapeutics.

Curr Opin Pharmacol 2011 Aug 16;11(4):404-11. Epub 2011 Apr 16.

School of Biochemistry and Immunology, and Immunology Research Centre, Trinity College Dublin, Ireland.

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August 2011

Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma.

J Allergy Clin Immunol 2011 May 21;127(5):1097-107; quiz 1108-9. Epub 2011 Mar 21.

School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.

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May 2011

TLR, NLR Agonists, and Other Immune Modulators as Infectious Disease Vaccine Adjuvants.

Curr Infect Dis Rep 2010 Jan;12(1):4-12

School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.

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January 2010