Mr Kingsley Miyanda Tembo, MSc/MMed Immunology, MSc Global Health* - School of Basic Medical Sciences, Wuhan University

Mr Kingsley Miyanda Tembo

MSc/MMed Immunology, MSc Global Health*

School of Basic Medical Sciences, Wuhan University

Wuhan, hubei | China

Main Specialties: Biology

Additional Specialties: Cancer Immunology, identification of potential diagnostic and prognostic biomakers

Mr Kingsley Miyanda Tembo, MSc/MMed Immunology, MSc Global Health* - School of Basic Medical Sciences, Wuhan University

Mr Kingsley Miyanda Tembo

MSc/MMed Immunology, MSc Global Health*

Introduction

Primary Affiliation: School of Basic Medical Sciences, Wuhan University - Wuhan, hubei , China

Specialties:

Additional Specialties:

Research Interests:

Education

Nov 2019
University of Aberdeen
Golabal health and management
Jun 2016
Wuhan University
MSc/MMed Immunology
Jun 2010
University of Zambia
BSc Biomedicine

Publications

9Publications

322Reads

21Profile Views

24PubMed Central Citations

PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression.

Cancer Cell Int 2018 13;18:112. Epub 2018 Aug 13.

1Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071 China.

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http://dx.doi.org/10.1186/s12935-018-0610-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090666PMC
August 2018
4 Reads
1.990 Impact Factor

NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia.

Oncol Lett 2017 Oct 3;14(4):4256-4262. Epub 2017 Aug 3.

Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China.

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http://dx.doi.org/10.3892/ol.2017.6716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592868PMC
October 2017
36 Reads
0.987 Impact Factor

Wnt5a and CCL25 promote adult T-cell acute lymphoblastic leukemia cell migration, invasion and metastasis.

Oncotarget 2017 Jun;8(24):39033-39047

Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China.

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http://dx.doi.org/10.18632/oncotarget.16559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503593PMC
June 2017
28 Reads
2 Citations
6.360 Impact Factor

Bioinformatics analysis of the prognostic value of Tripartite Motif 28 in breast cancer.

Oncol Lett 2017 Apr 22;13(4):2670-2678. Epub 2017 Feb 22.

Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, Hubei 430071, P.R. China.

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http://dx.doi.org/10.3892/ol.2017.5764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403292PMC
April 2017
16 Reads
0.990 Impact Factor

CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner.

Oncol Rep 2017 Feb 2;37(2):921-928. Epub 2016 Dec 2.

Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, Hubei 430071, P.R. China.

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http://dx.doi.org/10.3892/or.2016.5289DOI Listing
February 2017
22 Reads
2 Citations
2.191 Impact Factor

Angiogenesis in carcinogenesis, focus on angiopoietins and tyrosine kinase receptors (Tie1 & Tie2): Current perspectives

https://www.omicsonline.org/proceedings/angiogenesis-in-carcinogenesis-focus-on-angiopoietins-and-tyrosine-kinase-receptors-tie1--tie2-current-perspectives-47822.html

Immunotherapy: Open Access

Angiogenesis still remains as one of the most promising therapeutic targets in cancer as it has been linked to tumor metastasis and other cellular processes. Angiopoietin induced angiogenesis through the angiopoietin pathway (Ang-Tie) involves Angiopoietin 1 (Ang1) and Angiopoietin 2 (Ang2) among others as stimulating ligands and Tyrosine kinase receptor 1 and 2 (Tie1 and Tie2) as receptors. Ang1 is involved in vessel-sealing effects, pro-survival signaling and promotion of vascular quiescence in mature vessels, the effects of Ang1 in vivo in a tumor setting suggests that manipulation of this ligand could have therapeutic potential. Ang2 has been implicated in tumor angiogenesis as it has been found to be highly expressed in tumors and has been associated with progressive tumor growth and development of metastasis in many types of carcinomas. This high expression has been shown to be inversely related to the decreased expression levels of miR-126, which in turn has been linked to increased metastatic potential and poor prognosis in cancers. Therefore, understanding the cross-talk amongst Ang1:Ang2 ratio, Tie1:Tie2 balance and how Tie1 cleavage and miR-126 regulate angiogenesis holds great promise to rationally understand the complex multilayered control during angiopoietin induce angiogenesis. Hence, this provides a rationale for developing novel antiangiogenics therapies and combinations targeting Ang-Tie pathway and other pathways such as VEGF-VEGFR with the potential of overcoming therapeutic resistance. Antiangiogenic therapies such as Ang2 and Tie1 inhibitors which have been found to inhibit tumor angiogenesis and growth can be tested in combination with other VEGF inhibitors and conventional chemotherapies.

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July 2016
7 Reads

PEG10 promotes human breast cancer cell proliferation, migration and invasion.

Int J Oncol 2016 May 23;48(5):1933-42. Epub 2016 Feb 23.

Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China.

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http://dx.doi.org/10.3892/ijo.2016.3406DOI Listing
May 2016
20 Reads
6 Citations
3.025 Impact Factor

CCR9 in cancer: oncogenic role and therapeutic targeting.

J Hematol Oncol 2016 Feb 16;9:10. Epub 2016 Feb 16.

Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.

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http://dx.doi.org/10.1186/s13045-016-0236-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754913PMC
February 2016
56 Reads
7 Citations
4.812 Impact Factor