Kimme Hyrich

Kimme Hyrich

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Kimme Hyrich

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Predicting disease outcomes in juvenile idiopathic arthritis: challenges, evidence, and new directions.

Lancet Child Adolesc Health 2019 Oct 19;3(10):725-733. Epub 2019 Jul 19.

UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Centre for Adolescent Rheumatology Versus Arthritis at University College London, University College London Hospital, and Great Ormond Street Hospital, University College London, London, UK; National Institute of Health Research Biomedical Research Centre at Great Ormond Street Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(19)30188-9DOI Listing
October 2019

A UK study: vocational experiences of young adults with juvenile idiopathic arthritis.

Pediatr Rheumatol Online J 2019 08 6;17(1):54. Epub 2019 Aug 6.

Centre for Epidemiology Versus Arthritis, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s12969-019-0357-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683541PMC
August 2019

The predictors of and reasons for non-adherence in an observational cohort of patients with rheumatoid arthritis commencing methotrexate.

Rheumatology (Oxford) 2019 Jul 13. Epub 2019 Jul 13.

NIHR Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/kez274DOI Listing
July 2019

Predicting Remission Remains a Challenge in Patients with Juvenile Idiopathic Arthritis.

J Rheumatol 2019 Jun;46(6):552-554

Arthritis Research UK Centre for Epidemiology, The University of Manchester, and the UK National Institute for Health Research Manchester Biomedical Research Centre, Manchester University Hospitals, National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.3899/jrheum.181245DOI Listing
June 2019

Predictors, demographics and frequency of sustained remission and low disease activity in anti-tumour necrosis factor-treated rheumatoid arthritis patients.

Rheumatology (Oxford) 2019 Jun 1. Epub 2019 Jun 1.

Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/kez188DOI Listing
June 2019

Prediction of infection risk in rheumatoid arthritis patients treated with biologics: are we any closer to risk stratification?

Curr Opin Rheumatol 2019 May;31(3):285-292

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester.

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http://dx.doi.org/10.1097/BOR.0000000000000598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443047PMC
May 2019

Not all moderate disease is the same - Identification of disability trajectories among patients with rheumatoid arthritis and moderate disease activity.

PLoS One 2019 20;14(5):e0215999. Epub 2019 May 20.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215999PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527224PMC
May 2019

Comparing Proxy, Adolescent and Adult Assessments of Functional Ability in Adolescents with Juvenile Idiopathic Arthritis.

Arthritis Care Res (Hoboken) 2019 Mar 15. Epub 2019 Mar 15.

NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/acr.23877DOI Listing
March 2019

Short-term outcomes in patients with systemic juvenile idiopathic arthritis treated with either tocilizumab or anakinra.

Rheumatology (Oxford) 2019 Jan;58(1):94-102

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/key262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293481PMC
January 2019

Malignancy and rheumatoid arthritis: Epidemiology, risk factors and management.

Best Pract Res Clin Rheumatol 2018 12 15;32(6):869-886. Epub 2019 Apr 15.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom; National Institute of Health Research Manchester Biomedical Research Centre, Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.berh.2019.03.011DOI Listing
December 2018

Biologic refractory disease in rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Ann Rheum Dis 2018 10 6;77(10):1405-1412. Epub 2018 Jul 6.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2018-213378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161665PMC
October 2018

Long-Term Outcomes Following Achievement of Clinically Inactive Disease in Juvenile Idiopathic Arthritis: The Importance of Definition.

Arthritis Rheumatol 2018 09 22;70(9):1519-1529. Epub 2018 Jul 22.

The University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://doi.wiley.com/10.1002/art.40519
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http://dx.doi.org/10.1002/art.40519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175118PMC
September 2018

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Pharmacogenomics J 2018 09 31;18(5):657-664. Epub 2018 Aug 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41397-018-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150911PMC
September 2018

Growth patterns in early juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study (CAPS).

Semin Arthritis Rheum 2018 08 7;48(1):53-60. Epub 2017 Nov 7.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Division of Musculoskeletal & Dermatological Sciences. Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2017.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089842PMC
August 2018

Prediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS).

Arthritis Res Ther 2018 07 13;20(1):147. Epub 2018 Jul 13.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-018-1645-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044018PMC
July 2018

Long-term persistence with rituximab in patients with rheumatoid arthritis.

Rheumatology (Oxford) 2018 06;57(6):1089-1096

Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/key036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965076PMC
June 2018

Patterns of pain over time among children with juvenile idiopathic arthritis.

Arch Dis Child 2018 05 25;103(5):437-443. Epub 2017 Nov 25.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.1136/archdischild-2017-313337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916104PMC
May 2018

Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis.

Best Pract Res Clin Rheumatol 2018 04 19;32(2):206-222. Epub 2018 Nov 19.

ARUK Centre for Epidemiology, Stopford Building, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, M13 9PT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216942183006
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http://dx.doi.org/10.1016/j.berh.2018.10.004DOI Listing
April 2018

The influence of TNF inhibitors on dementia incidence in patients with rheumatoid arthritis; an analysis from the BSRBR-RA.

Int J Geriatr Psychiatry 2018 03;33(3):556-558

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/gps.4793DOI Listing
March 2018

The prioritization of symptom beliefs over illness beliefs: The development and validation of the Pain Perception Questionnaire for Young People.

Br J Health Psychol 2018 02 9;23(1):68-87. Epub 2017 Oct 9.

Division of Musculoskeletal and Dermatological Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, UK.

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http://dx.doi.org/10.1111/bjhp.12275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765490PMC
February 2018

How common is remission in juvenile idiopathic arthritis: A systematic review.

Semin Arthritis Rheum 2017 12 20;47(3):331-337. Epub 2017 May 20.

Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687936PMC
December 2017

How common is clinically inactive disease in a prospective cohort of patients with juvenile idiopathic arthritis? The importance of definition.

Ann Rheum Dis 2017 Aug 7;76(8):1381-1388. Epub 2017 Apr 7.

Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-210511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738598PMC
August 2017

Biologics registers in RA: methodological aspects, current role and future applications.

Nat Rev Rheumatol 2017 Aug 1;13(8):503-510. Epub 2017 Jun 1.

National Institute for Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust; and at the Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/nrrheum.2017.81DOI Listing
August 2017

Mortality in patients with interstitial lung disease treated with rituximab or TNFi as a first biologic.

RMD Open 2017 13;3(1):e000473. Epub 2017 Jul 13.

Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/rmdopen-2017-000473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604605PMC
July 2017

Factors Associated With Sustained Remission in Rheumatoid Arthritis in Patients Treated With Anti-Tumor Necrosis Factor.

Arthritis Care Res (Hoboken) 2017 06 8;69(6):783-793. Epub 2017 May 8.

University of Bath, Claverton Down, Bath, UK.

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http://dx.doi.org/10.1002/acr.23016DOI Listing
June 2017

The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort.

Rheumatology (Oxford) 2017 06;56(6):1019-1024

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester.

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http://dx.doi.org/10.1093/rheumatology/kew387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445600PMC
June 2017

Efficacy of biologic therapy across individual juvenile idiopathic arthritis subtypes: A systematic review.

Semin Arthritis Rheum 2017 04 1;46(5):584-593. Epub 2016 Nov 1.

Department of Paediatric Rheumatology, Alder Hey Children׳s NHS Foundation Trust, Eaton Rd, Liverpool L12 2AP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2016.10.008DOI Listing
April 2017

Does sex or ethnicity impact anti-tumour necrosis factor agent use in rheumatoid arthritis?

Rheumatology (Oxford) 2017 04;56(4):663-665

NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/rheumatology/kew466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401627PMC
April 2017

Relationship between exposure to tumour necrosis factor inhibitor therapy and incidence and severity of myocardial infarction in patients with rheumatoid arthritis.

Ann Rheum Dis 2017 04 10;76(4):654-660. Epub 2017 Jan 10.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-209784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530342PMC
April 2017

Pregnancy outcomes in women with rheumatoid arthritis ever treated with rituximab.

Rheumatology (Oxford) 2017 04;56(4):661-663

Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre.

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http://dx.doi.org/10.1093/rheumatology/kew493DOI Listing
April 2017

Risk of lymphoma in patients exposed to antitumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Ann Rheum Dis 2017 Mar 8;76(3):497-503. Epub 2016 Aug 8.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-209389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446004PMC
March 2017

Mortality rates are increased in patients with systemic juvenile idiopathic arthritis.

Arch Dis Child 2017 02 31;102(2):206-207. Epub 2016 Oct 31.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/archdischild-2016-311571DOI Listing
February 2017

Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: an observational study from the British Society for Rheumatology Biologics Register for rheumatoid arthritis.

Clin Rheumatol 2017 Feb 2;36(2):241-250. Epub 2016 Dec 2.

Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Room 2.800 Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1007/s10067-016-3485-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290047PMC
February 2017

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.

Ann Rheum Dis 2017 Jan 31;76(1):208-213. Epub 2016 May 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264213PMC
January 2017

Drug-specific risk and characteristics of lupus and vasculitis-like events in patients with rheumatoid arthritis treated with TNFi: results from BSRBR-RA.

RMD Open 2017 17;3(1):e000314. Epub 2017 Jan 17.

Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2016-00031
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http://dx.doi.org/10.1136/rmdopen-2016-000314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255894PMC
January 2017

The BSRBR-RA at 15 years.

Rheumatology (Oxford) 2016 12 24;55(12):2093-2095. Epub 2016 Mar 24.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester University and.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061081PMC
http://dx.doi.org/10.1093/rheumatology/kew053DOI Listing
December 2016

What is the impact of biologic therapies on common co-morbidities in patients with rheumatoid arthritis?

Arthritis Res Ther 2016 12 1;18(1):282. Epub 2016 Dec 1.

Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, UK.

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http://arthritis-research.biomedcentral.com/articles/10.1186
Publisher Site
http://dx.doi.org/10.1186/s13075-016-1176-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134078PMC
December 2016

Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.

Rheumatology (Oxford) 2016 Nov 25;55(11):2050-2055. Epub 2016 Aug 25.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088626PMC
November 2016

Melanoma risk in patients with rheumatoid arthritis treated with tumour necrosis factor alpha inhibitors: a systematic review and meta-analysis.

Melanoma Res 2016 10;26(5):517-23

aDepartment of Population Health, QIMR Berghofer Medical Research Institute, Herston, Australia bArthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester cNIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals Foundation Trust, Manchester Academic Health Science Centre dCancer Research UK Manchester Institute and Institute of Inflammation and Repair, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1097/CMR.0000000000000284DOI Listing
October 2016

Treatment prescribing patterns in patients with juvenile idiopathic arthritis (JIA): Analysis from the UK Childhood Arthritis Prospective Study (CAPS).

Semin Arthritis Rheum 2016 10 8;46(2):190-195. Epub 2016 Jun 8.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University, Hospitals NHS Foundation Trust and University of Manchester Partnership, Manchester, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052142PMC
http://dx.doi.org/10.1016/j.semarthrit.2016.06.001DOI Listing
October 2016

Patient global assessment in measuring disease activity in rheumatoid arthritis: a review of the literature.

Arthritis Res Ther 2016 10 28;18(1):251. Epub 2016 Oct 28.

Sorbonne Universités, UPMC University Paris 06, Institut Pierre Louis d'Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS), Paris, France.

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http://dx.doi.org/10.1186/s13075-016-1151-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086038PMC
October 2016

Effectiveness and safety of TNF inhibitors in adults with juvenile idiopathic arthritis.

RMD Open 2016 7;2(2):e000273. Epub 2016 Oct 7.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, Manchester, UK.

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http://dx.doi.org/10.1136/rmdopen-2016-000273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073611PMC
October 2016

Factors associated with choice of biologic among children with Juvenile Idiopathic Arthritis: results from two UK paediatric biologic registers.

Rheumatology (Oxford) 2016 09 4;55(9):1556-65. Epub 2016 Jan 4.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, Manchester, UK

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http://rheumatology.oxfordjournals.org/content/early/2016/03
Web Search
http://www.rheumatology.oxfordjournals.org/lookup/doi/10.109
Publisher Site
http://dx.doi.org/10.1093/rheumatology/kev429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993954PMC
September 2016

Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study.

Rheumatology (Oxford) 2016 07 25;55(7):1225-34. Epub 2016 Mar 25.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Faculty of Medical and Human Sciences, University of Manchester, Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911538PMC
July 2016

Risk of Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis treated with inhibitors of tumour necrosis factor α: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Rheumatology (Oxford) 2016 07 26;55(7):1336-7. Epub 2016 Apr 26.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew200DOI Listing
July 2016

Association Between Ischemic Stroke and Tumor Necrosis Factor Inhibitor Therapy in Patients With Rheumatoid Arthritis.

Arthritis Rheumatol 2016 06;68(6):1337-45

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester and NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/art.39582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982051PMC
June 2016

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis.

Arthritis Rheumatol 2016 06 21;68(6):1353-60. Epub 2016 Apr 21.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, and Central Manchester NHS Trust, and Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.39590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914881PMC
June 2016

Factors associated with improvement in disease activity following initiation of etanercept in children and young people with Juvenile Idiopathic Arthritis: results from the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study.

Rheumatology (Oxford) 2016 May 31;55(5):840-7. Epub 2015 Dec 31.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, The University of Manchester, Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kev434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830911PMC
May 2016

Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

Pharmacogenomics 2016 05 16;17(7):715-20. Epub 2016 May 16.

Arthritis Research UK, Centre for Genetics & Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2217/pgs.16.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996314PMC
May 2016

Influence of past breast feeding on pattern and severity of presentation of juvenile idiopathic arthritis.

Arch Dis Child 2016 Apr 14;101(4):348-51. Epub 2015 Sep 14.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.

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http://dx.doi.org/10.1136/archdischild-2014-308117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819639PMC
April 2016

Psychological factors predict adherence to methotrexate in rheumatoid arthritis; findings from a systematic review of rates, predictors and associations with patient-reported and clinical outcomes.

RMD Open 2016 20;2(1):e000171. Epub 2016 Jan 20.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester , Manchester , UK.

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http://dx.doi.org/10.1136/rmdopen-2015-000171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731843PMC
February 2016

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples.

Arthritis Res Ther 2015 Dec 14;17:359. Epub 2015 Dec 14.

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, the University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-015-0868-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704535PMC
December 2015

The influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: a study in the biologics era.

Rheumatology (Oxford) 2015 Oct 13;54(10):1780-91. Epub 2015 May 13.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kev105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571488PMC
October 2015

Consistency and Utility of Data Items Across European Rheumatoid Arthritis Clinical Cohorts and Registers.

Arthritis Care Res (Hoboken) 2015 Sep;67(9):1219-29

Karolinska Institute, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/acr.22602
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http://dx.doi.org/10.1002/acr.22602DOI Listing
September 2015

Growth in children and adolescents with juvenile idiopathic arthritis over 2 years of treatment with etanercept: results from the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study.

Rheumatology (Oxford) 2015 Jul 30;54(7):1279-85. Epub 2015 Jan 30.

Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Sciences Centre and Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, UK

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/keu489DOI Listing
July 2015

Risk of solid cancer in patients exposed to anti-tumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Ann Rheum Dis 2015 Jun 31;74(6):1087-93. Epub 2014 Mar 31.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2013-204851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431340PMC
June 2015

The EULAR Study Group for Registers and Observational Drug Studies: comparability of the patient case mix in the European biologic disease modifying anti-rheumatic drug registers.

Rheumatology (Oxford) 2015 Jun 27;54(6):1074-1079. Epub 2014 Nov 27.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK, 2Institute of Rheumatology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 3DANBIO, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, 4Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 5 Department of Medicine, Helsinki University Central Hospital, 6Faculties of Pharmacy and Medicine, University of Helsinki, Helsinki, Finland, 7German Rheumatism Research Centre, Epidemiology Unit, Berlin, 8German Rheumatism Research Centre, Epidemiology Unit and Charité University Medicine, Berlin, Germany, 9Department of Rheumatology, Semmelweis University, Polyclinic of the Hospitaller Brothers of St John of God, Budapest, Hungary,10Rheumatology Unit, Interdisciplinary Department of Medicine, School of Medicine, University of Bari, Italy, 11Institute of Rheumatology and Affine Sciences, Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, 12Radboud University Medical Center, Rheumatology, Nijmegen, 13Arthritis Centre Twente, Medisch Spectrum Twente & University Twente, Department of Psychology Health and Technology, Enschede, The Netherlands, 14Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 15Rheumatology Research Group, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Portugal, 16Hospital de Santa Maria, Lisbon Academic Medical Centre, Portugal,17Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 18Institute for Musculoskeletal Health, Madrid, Spain,19Karolinska Institutet, Clinical Epidemiology Unit, Department of Medicine Solna, Stockholm, Sweden and 20Division of Rheumatology, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1093/rheumatology/keu446DOI Listing
June 2015

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

JAMA 2015 Apr;313(16):1645-56

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, England2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manches.

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http://dx.doi.org/10.1001/jama.2015.3435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928097PMC
April 2015

The association between low socioeconomic status with high physical limitations and low illness self-perception in patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study.

Arthritis Care Res (Hoboken) 2015 Mar;67(3):382-9

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1002/acr.22466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737227PMC
March 2015

Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort.

Rheumatology (Oxford) 2015 Mar 10;54(3):494-9. Epub 2014 Sep 10.

Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK. Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/keu358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334684PMC
March 2015

Clinical utility of random anti-tumour necrosis factor drug testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis.

Lancet 2015 Feb;385 Suppl 1:S48

Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://linkinghub.elsevier.com/retrieve/pii/S014067361560363
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http://dx.doi.org/10.1016/S0140-6736(15)60363-4DOI Listing
February 2015

Biologic therapies and pregnancy: the story so far.

Rheumatology (Oxford) 2014 Aug 17;53(8):1377-85. Epub 2013 Dec 17.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/ket409DOI Listing
August 2014

Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach.

Ann Rheum Dis 2014 May 9;73(5):938-40. Epub 2013 Dec 9.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, , Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20444
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http://dx.doi.org/10.1136/annrheumdis-2013-204443DOI Listing
May 2014

Rheumatoid arthritis: When TNF inhibitors fail in RA--weighing up the options.

Nat Rev Rheumatol 2014 May 11;10(5):262-4. Epub 2014 Mar 11.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, the University of Manchester, Manchester Academic Health Science Centre, Room 2.800 Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/nrrheum.2014.34DOI Listing
May 2014

The risk of gastrointestinal perforations in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the BSRBR-RA.

Ann Rheum Dis 2014 Jan 5;73(1):252-5. Epub 2013 May 5.

Arthritis Research UK Epidemiology Unit, The University of Manchester, , Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2012-203102DOI Listing
January 2014

Recent developments in disease activity indices and outcome measures for juvenile idiopathic arthritis.

Rheumatology (Oxford) 2013 Nov 28;52(11):1941-51. Epub 2013 Apr 28.

Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/rheumatology/ket150DOI Listing
November 2013

Biologic treatment response among adults with juvenile idiopathic arthritis: results from the British Society for Rheumatology Biologics Register.

Rheumatology (Oxford) 2013 Oct 19;52(10):1905-13. Epub 2013 Jul 19.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Room 2.800 Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/rheumatology/ket248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775296PMC
October 2013

A threshold hazard model for estimating serious infection risk following anti-tumor necrosis factor therapy in rheumatoid arthritis patients.

J Biopharm Stat 2013 Mar;23(2):461-76

Arthritis Research UK Epidemiology Unit , University of Manchester , Manchester , United Kingdom.

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http://dx.doi.org/10.1080/10543406.2011.616973DOI Listing
March 2013

Risk of cancer in patients receiving non-biologic disease-modifying therapy for rheumatoid arthritis compared with the UK general population.

Rheumatology (Oxford) 2013 Jan;52(1):91-8

Arthritis Research UK Epidemiology Unit, Stopford Building, University of Manchester, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/rheumatology/kes350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521445PMC
January 2013