Dr Kimitoshi Kohno, MD, PhD - University of Occupational and Environmental Health - former president, professor emeritous

Dr Kimitoshi Kohno

MD, PhD

University of Occupational and Environmental Health

former president, professor emeritous

kitakyushu, fukuoka | Japan

Main Specialties: Oncology

Additional Specialties: molecular biology

Dr Kimitoshi Kohno, MD, PhD - University of Occupational and Environmental Health - former president, professor emeritous

Dr Kimitoshi Kohno

MD, PhD

Introduction

Primary Affiliation: University of Occupational and Environmental Health - kitakyushu, fukuoka , Japan

Specialties:

Additional Specialties:

Research Interests:


View Dr Kimitoshi Kohno’s Resume / CV

Publications

100Publications

1661Reads

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1190PubMed Central Citations

Polypeptide N-acetylgalactosaminyltransferase-6 expression independently predicts poor overall survival in patients with lung adenocarcinoma after curative resection.

Oncotarget 2016 Aug;7(34):54463-54473

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

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http://dx.doi.org/10.18632/oncotarget.9810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342355PMC
August 2016
12 Reads
4 Citations
6.360 Impact Factor

Role of WNT10A-expressing kidney fibroblasts in acute interstitial nephritis.

PLoS One 2014 23;9(7):e103240. Epub 2014 Jul 23.

The President Laboratory, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103240PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108433PMC
November 2015
23 Reads
5 Citations
3.234 Impact Factor

Mitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer Chemotherapy.

Int J Mol Sci 2015 Aug 20;16(8):19836-50. Epub 2015 Aug 20.

Asahi Matsumoto Hospital, Kokuramimami-ku Tsuda, Kitakyushu-shi 800-0242, Japan.

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http://dx.doi.org/10.3390/ijms160819836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581328PMC
August 2015
19 Reads
4 Citations
2.862 Impact Factor

Hypersensitivity to aurora kinase inhibitors in cells resistant against platinum- containing anticancer agents.

Anticancer Agents Med Chem 2014 ;14(7):1042-50

President Laboratory, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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June 2015
20 Reads
3 Citations
2.470 Impact Factor

The combination of strong immunohistochemical mtTFA expression and a high survivin index predicts a shorter disease-specific survival in pancreatic ductal adenocarcinoma.

Histol Histopathol 2015 Feb 8;30(2):193-204. Epub 2014 Aug 8.

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.14670/HH-30.193DOI Listing
February 2015
40 Reads
3 Citations
2.100 Impact Factor

Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction.

J Exp Clin Cancer Res 2014 Dec 24;33:112. Epub 2014 Dec 24.

The President Laboratory, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

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http://dx.doi.org/10.1186/s13046-014-0112-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308875PMC
December 2014
4 Reads
2 Citations

MCL-1 dependency of cisplatin-resistant cancer cells.

Biochem Pharmacol 2014 Nov 12;92(1):55-61. Epub 2014 Aug 12.

Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, INSERM U1138, F-75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, F-75005 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, F-94805 Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.07.029DOI Listing
November 2014
68 Reads
20 Citations
5.010 Impact Factor

The combination of a nuclear HMGB1-positive and HMGB2-negative expression is potentially associated with a shortened survival in patients with pancreatic ductal adenocarcinoma.

Tumour Biol 2014 Oct 26;35(10):10555-69. Epub 2014 Jul 26.

Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1007/s13277-014-2328-8DOI Listing
October 2014
28 Reads
4 Citations
2.840 Impact Factor

Molecular mechanisms of cadmium-induced fibroblast growth factor 23 upregulation in osteoblast-like cells.

Toxicol Sci 2014 Jun 10;139(2):301-16. Epub 2014 Mar 10.

Department of Molecular Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan.

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http://dx.doi.org/10.1093/toxsci/kfu043DOI Listing
June 2014
4 Reads
1 Citation

Clinical significance of epithelial-mesenchymal transition-associated markers in malignant pleural mesothelioma.

Oncology 2014 21;86(2):109-16. Epub 2014 Jan 21.

Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1159/000356874DOI Listing
April 2014
14 Reads
4 Citations
2.422 Impact Factor

Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necroinflammation and subsequent peribiliary fibrosis.

Am J Pathol 2014 Mar 9;184(3):644-61. Epub 2014 Jan 9.

Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1016/j.ajpath.2013.11.030DOI Listing
March 2014
20 Reads
10 Citations
4.591 Impact Factor

Circadian disruption and cancer risk: a new concept of stromal niche (review).

Int J Oncol 2014 Feb 29;44(2):364-70. Epub 2013 Nov 29.

The President Laboratory, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

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http://dx.doi.org/10.3892/ijo.2013.2201DOI Listing
February 2014
5 Reads
2 Citations
3.025 Impact Factor

Peroxiredoxin 4 protects against nonalcoholic steatohepatitis and type 2 diabetes in a nongenetic mouse model.

Antioxid Redox Signal 2013 Dec 3;19(17):1983-98. Epub 2013 May 3.

1 Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health , Kitakyushu, Japan .

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http://dx.doi.org/10.1089/ars.2012.4946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869472PMC
December 2013
23 Reads
19 Citations
7.410 Impact Factor

Expression of polypeptide N-acetylgalactosaminyl transferase-3 and its association with clinicopathological factors in thyroid carcinomas.

Thyroid 2013 Dec 4;23(12):1553-60. Epub 2013 Sep 4.

1 Division of Breast and Endocrine Surgery, Shinshu University School of Medicine , Matsumoto, Nagano, Japan .

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http://dx.doi.org/10.1089/thy.2012.0613DOI Listing
December 2013
2 Reads
7 Citations
4.493 Impact Factor

Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma.

Virchows Arch 2013 Oct 2;463(4):553-62. Epub 2013 Aug 2.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan.

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http://dx.doi.org/10.1007/s00428-013-1460-yDOI Listing
October 2013
6 Reads
2 Citations
2.651 Impact Factor

Thoughts for special issue.

Authors:
Kimitoshi Kohno

J UOEH 2013 Oct;35 Suppl:ii-iii

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October 2013
43 Reads

How Occupational Health can contribute in a disaster and what we should prepare for the future--lessons learned through support activities of a medical school at the Fukushima Daiichi Nuclear Power Plant in Summer 2011.

J Occup Health 2013 27;55(1):6-10. Epub 2012 Nov 27.

Department of Occupational Health Practice and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan.

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http://dx.doi.org/10.1539/joh.12-0134-csDOI Listing
September 2013
6 Reads
3 Citations
1.100 Impact Factor

Apoptosis signal-regulating kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis in smooth muscle cells.

Am J Pathol 2013 Feb 22;182(2):597-609. Epub 2012 Nov 22.

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1016/j.ajpath.2012.10.008DOI Listing
February 2013
6 Reads
12 Citations
4.591 Impact Factor

Overexpression of peroxiredoxin 4 attenuates atherosclerosis in apolipoprotein E knockout mice.

Antioxid Redox Signal 2012 Nov 12;17(10):1362-75. Epub 2012 Jun 12.

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1089/ars.2012.4549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437049PMC
November 2012
44 Reads
17 Citations
7.410 Impact Factor

Association of nuclear YB-1 localization with lung resistance-related protein and epidermal growth factor receptor expression in lung cancer.

Clin Lung Cancer 2012 Sep 27;13(5):375-84. Epub 2012 Jan 27.

Department of Surgery II, Shinshu University School of Medicine, Matsumoto, Japan.

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http://ac.els-cdn.com/S1525730411002944/1-s2.0-S152573041100
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http://linkinghub.elsevier.com/retrieve/pii/S152573041100294
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http://dx.doi.org/10.1016/j.cllc.2011.11.006DOI Listing
September 2012
20 Reads
4 Citations
3.104 Impact Factor

TLX controls angiogenesis through interaction with the von Hippel-Lindau protein.

Biol Open 2012 Jun 18;1(6):527-35. Epub 2012 Apr 18.

Sahlgrenska Cancer Center, University of Gothenburg , Box 425, SE 405 30 Gothenburg , Sweden ; Molecular Biology Research Center, School of Biological Science and Technology, Central South University , Changsha 410078 , China.

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http://dx.doi.org/10.1242/bio.2012893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509445PMC
June 2012
12 Reads
5 Citations

Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer.

J Surg Oncol 2012 Jun 3;105(7):724-30. Epub 2012 Jan 3.

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu City, Fukuoka, Japan.

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http://dx.doi.org/10.1002/jso.23030DOI Listing
June 2012
1 Read
13 Citations
3.244 Impact Factor

Clinical significance of mitochondrial transcription factor A expression in patients with colorectal cancer.

Oncol Rep 2012 May 16;27(5):1325-30. Epub 2012 Jan 16.

Department of Surgery 1, School of Medicine, University of Occupational Environmental Health, and Department of Gastroenterological and General Surgery, Wakamatsu Hospital, Kitakyushu, Japan.

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http://dx.doi.org/10.3892/or.2012.1640DOI Listing
May 2012
3 Reads
5 Citations
2.191 Impact Factor

Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer.

Breast Cancer Res Treat 2012 May 24;133(1):145-59. Epub 2011 Aug 24.

Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

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http://dx.doi.org/10.1007/s10549-011-1731-8DOI Listing
May 2012
30 Reads
7 Citations
3.940 Impact Factor

Mitochondrial transcription factor A regulates BCL2L1 gene expression and is a prognostic factor in serous ovarian cancer.

Cancer Sci 2012 Feb 23;103(2):239-444. Epub 2011 Dec 23.

Departments of Obstetrics and Gynecology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2011.02156.xDOI Listing
February 2012
18 Reads
8 Citations

CA19-9-producing early gastric adenocarcinoma arising in hyperplastic foveolar polyp: a very unique resection case.

Diagn Pathol 2011 Nov 10;6:112. Epub 2011 Nov 10.

Department of Pathology and Cell Biology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1186/1746-1596-6-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285093PMC
November 2011
6 Reads
2 Citations
2.411 Impact Factor

Forced Expression of ZNF143 Restrains Cancer Cell Growth.

Cancers (Basel) 2011 Oct 19;3(4):3909-20. Epub 2011 Oct 19.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.3390/cancers3043909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763402PMC
October 2011
11 Reads
7 Citations

Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis.

Arterioscler Thromb Vasc Biol 2011 Jul 28;31(7):1555-64. Epub 2011 Apr 28.

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1161/ATVBAHA.111.227140DOI Listing
July 2011
2 Reads
9 Citations
6.000 Impact Factor

Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells.

Cancer Sci 2011 May 7;102(5):1007-13. Epub 2011 Mar 7.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2011.01908.xDOI Listing
May 2011
13 Reads
35 Citations

Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level.

Arterioscler Thromb Vasc Biol 2011 Apr 27;31(4):800-7. Epub 2011 Jan 27.

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1161/ATVBAHA.110.215228DOI Listing
April 2011
7 Reads
9 Citations
6.000 Impact Factor

Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth.

Biochem Biophys Res Commun 2011 Apr 29;408(1):45-51. Epub 2011 Mar 29.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. ; Department of Urology, School of Medicine, University of Occupational and

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http://dx.doi.org/10.1016/j.bbrc.2011.03.114DOI Listing
April 2011
14 Reads
11 Citations
2.300 Impact Factor

Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin.

Int J Oncol 2011 Apr 9;38(4):893-902. Epub 2011 Feb 9.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807-8555, Japan.

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http://dx.doi.org/10.3892/ijo.2011.938DOI Listing
April 2011
62 Reads
4 Citations
3.025 Impact Factor

Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells.

Invest Ophthalmol Vis Sci 2011 Mar 2;52(3):1226-34. Epub 2011 Mar 2.

Department of Molecular Biology, University of Occupational and Environmental Health, Japan, Fukuoka, Japan.

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http://dx.doi.org/10.1167/iovs.10-5775DOI Listing
March 2011
21 Reads
18 Citations
3.404 Impact Factor

Enhanced expression of nuclear factor I/B in oxaliplatin-resistant human cancer cell lines.

Cancer Sci 2011 Feb 19;102(2):382-6. Epub 2010 Nov 19.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01784.xDOI Listing
February 2011
21 Reads
7 Citations

Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway.

Invest Ophthalmol Vis Sci 2011 Feb 22;52(2):1055-63. Epub 2011 Feb 22.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.

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http://dx.doi.org/10.1167/iovs.10-5777DOI Listing
February 2011
14 Reads
15 Citations
3.404 Impact Factor

Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes.

Cancer Sci 2010 Dec 23;101(12):2538-45. Epub 2010 Sep 23.

Department of Molecular Biology Otorhinolaryngology Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01725.xDOI Listing
December 2010
15 Reads
15 Citations

Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations.

Cancer Res 2010 Nov 19;70(21):8715-25. Epub 2010 Oct 19.

Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0043DOI Listing
November 2010
17 Reads
47 Citations
9.330 Impact Factor

Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice.

Antioxid Redox Signal 2010 Nov;13(10):1477-90

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan.

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http://dx.doi.org/10.1089/ars.2010.3137DOI Listing
November 2010
2 Reads
29 Citations
7.410 Impact Factor

Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice.

Am J Pathol 2010 Aug 21;177(2):713-23. Epub 2010 Jun 21.

Department of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.2353/ajpath.2010.091198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913336PMC
August 2010
4 Reads
15 Citations
4.591 Impact Factor

Y-box binding protein-1 is a novel molecular target for tumor vessels.

Cancer Sci 2010 Jun 16;101(6):1367-73. Epub 2010 Feb 16.

Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01534.xDOI Listing
June 2010
4 Reads
9 Citations

Enhanced expression of PCAF endows apoptosis resistance in cisplatin-resistant cells.

Mol Cancer Res 2010 Jun 8;8(6):864-72. Epub 2010 Jun 8.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

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http://dx.doi.org/10.1158/1541-7786.MCR-09-0458DOI Listing
June 2010
22 Reads
10 Citations
4.380 Impact Factor

Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status.

J Thorac Oncol 2010 May;5(5):591-6

Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1097/JTO.0b013e3181d0a4dbDOI Listing
May 2010
29 Reads
25 Citations
5.282 Impact Factor

Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.

Biochem Biophys Res Commun 2010 May 21;396(2):376-81. Epub 2010 Apr 21.

Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.04.100DOI Listing
May 2010
21 Reads
18 Citations
2.300 Impact Factor

Expression of mitochondrial transcription factor A in endometrial carcinomas: clinicopathologic correlations and prognostic significance.

Virchows Arch 2010 Apr 16;456(4):387-93. Epub 2010 Mar 16.

Department of Obstetrics and Gynecology, University of Occupational and Environmental Health School of Medicine, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1007/s00428-010-0895-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852529PMC
April 2010
7 Reads
6 Citations
2.651 Impact Factor

Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells.

Eur J Cancer 2010 Mar 14;46(5):954-65. Epub 2010 Jan 14.

Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.ejca.2009.12.024DOI Listing
March 2010
22 Reads
16 Citations
5.420 Impact Factor

Involvement of Wnt signaling in dermal fibroblasts.

Am J Pathol 2010 Feb 30;176(2):721-32. Epub 2009 Dec 30.

Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.2353/ajpath.2010.090454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808079PMC
February 2010
5 Reads
9 Citations
4.591 Impact Factor

Thioredoxin2 enhances the damaged DNA binding activity of mtTFA through direct interaction.

Int J Oncol 2009 Dec;35(6):1435-40

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.3892/ijo_00000462DOI Listing
December 2009
13 Reads
4 Citations
3.025 Impact Factor

Human synapsin I mediates the function of nuclear respiratory factor 1 in neurite outgrowth in neuroblastoma IMR-32 cells.

J Neurosci Res 2009 Aug;87(10):2255-63

Institute of Basic Medical Sciences, National Cheng Kung University, College of Medicine, Taiwan.

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http://dx.doi.org/10.1002/jnr.22059DOI Listing
August 2009
4 Reads
3 Citations
2.594 Impact Factor

Nipradilol and timolol induce Foxo3a and peroxiredoxin 2 expression and protect trabecular meshwork cells from oxidative stress.

Invest Ophthalmol Vis Sci 2009 Jun 17;50(6):2777-84. Epub 2009 Jan 17.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

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http://dx.doi.org/10.1167/iovs.08-3061DOI Listing
June 2009
33 Reads
9 Citations
3.404 Impact Factor

N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression.

Cancer Res 2009 Jun 2;69(12):4983-91. Epub 2009 Jun 2.

Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4882DOI Listing
June 2009
2 Reads
18 Citations
9.330 Impact Factor

Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth.

Cancer Res 2009 Apr 24;69(7):3148-56. Epub 2009 Mar 24.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2334DOI Listing
April 2009
4 Reads
29 Citations
9.330 Impact Factor

GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity.

Biochim Biophys Acta 2009 Jan 11;1792(1):61-7. Epub 2008 Oct 11.

Laboratory of Molecular Dermatology and Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

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http://dx.doi.org/10.1016/j.bbadis.2008.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169302PMC
January 2009
14 Reads
11 Citations

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.

Mol Cell Biol 2008 Dec 22;28(23):7066-80. Epub 2008 Sep 22.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-1079, USA.

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http://dx.doi.org/10.1128/MCB.00244-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593380PMC
December 2008
4 Reads
45 Citations
4.780 Impact Factor

Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1.

Cancer Sci 2008 Oct;99(10):1950-9

Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00912.xDOI Listing
October 2008
15 Reads
15 Citations

Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.

J Biol Chem 2008 Jun 5;283(26):18218-26. Epub 2008 May 5.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1074/jbc.M802332200DOI Listing
June 2008
7 Reads
23 Citations
4.573 Impact Factor

Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell.

Endocrinology 2008 May 14;149(5):2219-29. Epub 2008 Feb 14.

The Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1210/en.2007-1320DOI Listing
May 2008
13 Reads
12 Citations
4.503 Impact Factor

Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma.

Cancer Sci 2008 Apr;99(4):726-32

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00748.xDOI Listing
April 2008
1 Read
3 Citations

Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.

J Biol Chem 2008 Apr 7;283(14):9113-26. Epub 2008 Feb 7.

Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1074/jbc.M708205200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2431041PMC
April 2008
3 Reads
43 Citations
4.573 Impact Factor

Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers.

Cancer Res 2008 Mar;68(5):1504-12

Center for Innovative Cancer Therapy of the 21st Century Center of Excellence Program for Medical Science, Department of Surgery, Kurume University School of Medicine, Kurume, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2362DOI Listing
March 2008
21 Reads
18 Citations
9.330 Impact Factor

Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells.

J Biol Chem 2008 Feb 18;283(8):4643-51. Epub 2007 Dec 18.

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1074/jbc.M708853200DOI Listing
February 2008
8 Reads
9 Citations
4.573 Impact Factor

Twist promotes tumor cell growth through YB-1 expression.

Cancer Res 2008 Jan;68(1):98-105

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2981DOI Listing
January 2008
27 Reads
33 Citations
9.330 Impact Factor

Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1.

Eur J Haematol 2008 Jan;80(1):10-9

The first Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/j.1600-0609.2007.00981.xDOI Listing
January 2008
2 Reads
11 Citations
2.070 Impact Factor

Oncogenic Ras-induced morphologic change is through MEK/ERK signaling pathway to downregulate Stat3 at a posttranslational level in NIH3T3 cells.

Neoplasia 2008 Jan;10(1):52-60

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213899PMC
http://dx.doi.org/10.1593/neo.07691DOI Listing
January 2008
34 Reads
12 Citations

Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.

Cancer Sci 2007 Dec 9;98(12):2009-18. Epub 2007 Oct 9.

Research Center for Innovative Cancer Therapy and Department of Surgery, Kurume University, Kurume 830-0011, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2007.00633.xDOI Listing
December 2007
22 Reads
35 Citations

Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia.

Leuk Res 2007 Dec 12;31(12):1633-40. Epub 2007 Jun 12.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.leukres.2007.04.009DOI Listing
December 2007
10 Citations
2.351 Impact Factor

A new mechanism for primary resistance to gefitinib in lung adenocarcinoma: the role of a novel G796A mutation in exon 20 of EGFR.

Anticancer Res 2007 Jul-Aug;27(4B):2297-303

Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

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September 2007
2 Reads
1 Citation
1.872 Impact Factor

Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress.

J Biol Chem 2007 Sep 7;282(39):28474-84. Epub 2007 Aug 7.

Sealy Center for Molecular Medicine and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA.

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http://dx.doi.org/10.1074/jbc.M704672200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679419PMC
September 2007
6 Reads
49 Citations
4.573 Impact Factor

p73gamma transactivates the p21 promoter through preferential interaction with the p300/CBP-associated factor in human prostate cancer cells.

Oncol Rep 2007 Aug;18(2):411-6

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health Japan, Fukuoka 807-8555, Japan.

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August 2007
2 Reads
1 Citation
2.191 Impact Factor

DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation.

Cancer Sci 2007 Jun 18;98(6):858-63. Epub 2007 Apr 18.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Fukuoka, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2007.00476.xDOI Listing
June 2007
6 Reads
2 Citations

Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells.

J Cell Physiol 2007 May;211(2):513-21

Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan.

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http://dx.doi.org/10.1002/jcp.20961DOI Listing
May 2007
1 Read
16 Citations
3.840 Impact Factor

Fragmented hyaluronan induces transcriptional up-regulation of the multidrug resistance-1 gene in CD4+ T cells.

J Biol Chem 2006 Dec 12;281(49):38089-97. Epub 2006 Oct 12.

First Department of Internal Medicine and Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1074/jbc.M601030200DOI Listing
December 2006
4 Citations
4.573 Impact Factor

YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation.

J Biol Chem 2006 Dec 2;281(52):40440-9. Epub 2006 Nov 2.

Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1074/jbc.M605948200DOI Listing
December 2006
11 Reads
22 Citations
4.573 Impact Factor

Expression and cellular localization of dbpC/Contrin in germ cell tumor cell lines.

Biochim Biophys Acta 2006 Jan-Feb;1759(1-2):80-8. Epub 2006 Mar 27.

Department of Molecular Biology, University of Occupational and Environmental Health School of Medicine, Iseigaoka, Kitakyushu 807-8555, Japan.

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http://dx.doi.org/10.1016/j.bbaexp.2006.02.005DOI Listing
July 2006
7 Reads

Increased nuclear localization of transcription factor Y-box binding protein 1 accompanied by up-regulation of P-glycoprotein in breast cancer pretreated with paclitaxel.

Clin Cancer Res 2005 Dec;11(24 Pt 1):8837-44

Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, and Department of Surgery, Niigata Cancer Center Hospital, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0945DOI Listing
December 2005
13 Reads
17 Citations
8.722 Impact Factor

Transcription factors and drug resistance.

Eur J Cancer 2005 Nov 4;41(16):2577-86. Epub 2005 Oct 4.

Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka 807-8555, Japan.

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http://dx.doi.org/10.1016/j.ejca.2005.08.007DOI Listing
November 2005
22 Reads
11 Citations
5.420 Impact Factor

Y-box-binding protein-1 expression is not correlated with p53 expression but with proliferating cell nuclear antigen expression in non-small cell lung cancer.

Anticancer Res 2005 Sep-Oct;25(5):3437-43

Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

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October 2005
16 Reads
6 Citations
1.872 Impact Factor

Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells.

Oncol Res 2005 ;15(3):139-49

Department of Neurosurgery, Oita University School of Medicine, 1-1, Idaigaoka, Hasama-machi, Oita, 879-5593 Japan.

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September 2005
3 Reads
2 Citations
0.920 Impact Factor

4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) induces apoptosis in colon cancer partially through the induction of Fas expression.

In Vivo 2005 Jan-Feb;19(1):125-32

Department of Surgery 1, University of Occupational and Environmental Health, School of Medicine, Yahatanisi-ku, Kitakyushu 807-8555, Japan.

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August 2005
8 Reads
1 Citation
1.150 Impact Factor

The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus.

Pathobiology 2005 ;72(3):139-45

Department of Surgery, Division of Surgical Oncology, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1159/000084117DOI Listing
June 2005
3 Reads
4 Citations
2.320 Impact Factor

Significance of hypoxia in cervical cancer.

Authors:
Kimitoshi Kohno

Int J Clin Oncol 2005 Feb;10(1)

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http://dx.doi.org/10.1007/s10147-004-0461-xDOI Listing
February 2005
2 Reads
2.170 Impact Factor

4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid inhibits angiogenesis in colon cancer through reduced expression of vascular endothelial growth factor.

Oncol Res 2004 ;14(9):407-14

Department of Surgery 1, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kita-kyushu 807-8555, Japan.

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February 2005
3 Reads
3 Citations
0.920 Impact Factor

Cisplatin resistance and transcription factors.

Curr Med Chem Anticancer Agents 2005 Jan;5(1):15-27

Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan.

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January 2005
21 Reads
26 Citations

The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.

Oncogene 2005 Jan;24(1):148-56

Department of Gastroenterology, Charité-Universitaetsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.

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http://dx.doi.org/10.1038/sj.onc.1207842DOI Listing
January 2005
4 Reads
6 Citations
8.460 Impact Factor

DNA topoisomerase II poison TAS-103 transactivates GC-box-dependent transcription via acetylation of Sp1.

J Biol Chem 2005 Jan 8;280(2):1179-85. Epub 2004 Nov 8.

Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Fukuka, Japan.

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http://dx.doi.org/10.1074/jbc.M410499200DOI Listing
January 2005
9 Reads
5 Citations
4.573 Impact Factor

Transcriptional regulation of multidrug resistance-1 gene by interleukin-2 in lymphocytes.

Genes Cells 2004 Dec;9(12):1265-73

First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Yahata-nishi, Kitakyushu, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2004.00803.xDOI Listing
December 2004
2 Reads
6 Citations
2.810 Impact Factor

The role of nuclear Y-box binding protein 1 as a global marker in drug resistance.

Mol Cancer Ther 2004 Nov;3(11):1485-92

Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka, Japan.

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November 2004
1 Read
22 Citations
5.683 Impact Factor

ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA.

Int J Cancer 2004 Oct;111(6):900-9

Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan.

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http://dx.doi.org/10.1002/ijc.20358DOI Listing
October 2004
8 Reads
12 Citations
5.085 Impact Factor

[Molecular targeting drugs--present status and future development].

Nihon Rinsho 2004 Jul;62(7):1211-5

Research Center for Innovative Cancer Therapy, Kurume University.

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July 2004
6 Reads

Interleukin-1beta represses MRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells.

Hepatology 2004 Jun;39(6):1574-82

Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1002/hep.20216DOI Listing
June 2004
2 Reads
4 Citations
11.055 Impact Factor