Kimberly M Christian

Kimberly M Christian

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Kimberly M Christian

Kimberly M Christian

Publications by authors named "Kimberly M Christian"

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Evaluating Neurodevelopmental Consequences of Perinatal Exposure to Antiretroviral Drugs: Current Challenges and New Approaches.

J Neuroimmune Pharmacol 2019 Sep 11. Epub 2019 Sep 11.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11481-019-09880-zDOI Listing
September 2019

Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance.

Cell Rep 2019 Aug;28(6):1419-1428.e3

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690484PMC
August 2019

Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders.

Mol Psychiatry 2019 Aug 23. Epub 2019 Aug 23.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41380-019-0485-2DOI Listing
August 2019

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System.

Annu Rev Neurosci 2019 Jul;42:249-269

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email:

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http://dx.doi.org/10.1146/annurev-neuro-080317-062231DOI Listing
July 2019

A previously undetected pathology of Zika virus infection.

Nat Med 2018 03;24(3):258-259

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nm.4510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190581PMC
March 2018

Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms.

Genome Med 2018 01 31;10(1). Epub 2018 Jan 31.

Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-018-0518-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793422PMC
January 2018

Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.

Cell Stem Cell 2017 09 17;21(3):349-358.e6. Epub 2017 Aug 17.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Bioengineering Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600197PMC
September 2017

Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus.

Neuron 2017 Feb 26;93(3):677-690.e5. Epub 2017 Jan 26.

Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300955PMC
February 2017

Using Induced Pluripotent Stem Cells to Investigate Complex Genetic Psychiatric Disorders.

Curr Behav Neurosci Rep 2016 Dec 14;3(4):275-284. Epub 2016 Oct 14.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/s40473-016-0100-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295811PMC
December 2016

Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus.

Neurogenesis (Austin) 2015 10;2(1):e1081715. Epub 2015 Nov 10.

Institute for Cell Engineering; Department of Neurology; The Solomon H. Snyder Department of Neuroscience; Graduate Program in Cellular and Molecular Medicine; Department of Psychiatry and Behavioral Sciences; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Neurology; The Solomon H. Snyder Department of Neuroscience; Graduate Program in Cellular and Molecular Medicine; Department of Psychiatry and Behavioral Sciences; Johns Hopkins University School of Medicine; Baltimore, MD USA; The Solomon H. Snyder Department of Neuroscience; Graduate Program in Cellular and Molecular Medicine; Department of Psychiatry and Behavioral Sciences; Johns Hopkins University School of Medicine; Baltimore, MD USA; Graduate Program in Cellular and Molecular Medicine; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Psychiatry and Behavioral Sciences; Johns Hopkins University School of Medicine; Baltimore, MD USA.

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http://dx.doi.org/10.1080/23262133.2015.1081715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973590PMC
September 2016

Adult Neurogenesis and Psychiatric Disorders.

Cold Spring Harb Perspect Biol 2016 Sep 1;8(9). Epub 2016 Sep 1.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

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http://dx.doi.org/10.1101/cshperspect.a019026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008067PMC
September 2016

Epigenetic mechanisms in neurogenesis.

Nat Rev Neurosci 2016 09 23;17(9):537-49. Epub 2016 Jun 23.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nrn.2016.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610421PMC
September 2016

Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice.

Nat Commun 2016 06 1;7. Epub 2016 Jun 1.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1038/ncomms11773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895353PMC
June 2016

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth.

Cell Stem Cell 2016 05 4;18(5):587-90. Epub 2016 Mar 4.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909160010
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http://dx.doi.org/10.1016/j.stem.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299540PMC
May 2016

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure.

Cell 2016 May 22;165(5):1238-1254. Epub 2016 Apr 22.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30467-6.pdf
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http://www.cell.com/cms/attachment/2054161004/2060541246/mmc
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http://dx.doi.org/10.1016/j.cell.2016.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900885PMC
May 2016

Modeling psychiatric disorders with patient-derived iPSCs.

Curr Opin Neurobiol 2016 Feb 17;36:118-27. Epub 2015 Dec 17.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738077PMC
February 2016

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis.

Cell Stem Cell 2015 Sep 20;17(3):360-72. Epub 2015 Aug 20.

Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.07.013DOI Listing
September 2015

DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats.

Front Syst Neurosci 2015 25;9:93. Epub 2015 Jun 25.

Institute for Cell Engineering, Johns Hopkins University School of Medicine Baltimore, MD, USA ; Department of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fnsys.2015.00093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479724PMC
July 2015

Functions and dysfunctions of adult hippocampal neurogenesis.

Annu Rev Neurosci 2014 29;37:243-62. Epub 2014 May 29.

Institute for Cell Engineering.

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http://dx.doi.org/10.1146/annurev-neuro-071013-014134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531058PMC
March 2015

Synaptic dysregulation in a human iPS cell model of mental disorders.

Nature 2014 Nov 17;515(7527):414-8. Epub 2014 Aug 17.

1] Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [3] Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [4] The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature13716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501856PMC
November 2014

Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.

Cell Stem Cell 2014 Jul;15(1):79-91

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237009PMC
July 2014

Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.

Nat Neurosci 2013 Dec 10;16(12):1728-30. Epub 2013 Nov 10.

1] Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [3] Department of Pharmacology and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nn.3572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096812PMC
December 2013

Seamless reconstruction of intact adult-born neurons by serial end-block imaging reveals complex axonal guidance and development in the adult hippocampus.

J Neurosci 2013 Jul;33(28):11400-11

Institute for Cell Engineering, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1374-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724551PMC
July 2013

Life or death: developing cortical interneurons make their own decision.

EMBO J 2012 Nov 16;31(23):4373-4. Epub 2012 Oct 16.

Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/emboj.2012.290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512393PMC
November 2012

Modification of hippocampal circuitry by adult neurogenesis.

Dev Neurobiol 2012 Jul;72(7):1032-43

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/dneu.22014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710549PMC
July 2012

Cellular reprogramming: recent advances in modeling neurological diseases.

J Neurosci 2011 Nov;31(45):16070-5

Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4218-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236609PMC
November 2011

CA3 NMDA receptors are crucial for rapid and automatic representation of context memory.

Eur J Neurosci 2006 Sep;24(6):1771-80

Unit on Genetics of Cognition and Behaviour, Mood and Anxiety Disorders Research Program, National Institute of Mental Health, Bethesda, MD 20892-3710, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2006.05044.xDOI Listing
September 2006

Long-term storage of an associative memory trace in the cerebellum.

Behav Neurosci 2005 Apr;119(2):526-37

Neuroscience Program, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1037/0735-7044.119.2.526DOI Listing
April 2005

Comment on "Cerebellar LTD and learning-dependent timing of conditioned eyelid responses".

Science 2004 Apr;304(5668):211; author reply 211

Neuroscience Program, University of Southern California, 3641 Watt Way, Los Angeles, CA 90089-2520, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1093706
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http://dx.doi.org/10.1126/science.1093706DOI Listing
April 2004

Neural substrates of eyeblink conditioning: acquisition and retention.

Learn Mem 2003 Nov-Dec;10(6):427-55

Neuroscience Program, University of Southern California, Los Angeles, California 90089-2520, USA.

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http://www.learnmem.org/cgi/doi/10.1101/lm.59603
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http://dx.doi.org/10.1101/lm.59603DOI Listing
January 2004