Publications by authors named "Kimberly B Kegel"

23Publications

Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.

Hum Mol Genet 2013 Mar 7;22(6):1112-31. Epub 2012 Dec 7.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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March 2013

The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.

Acta Pharmacol Sin 2012 Jun 30;33(6):743-51. Epub 2012 Apr 30.

Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China.

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June 2012

Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice.

Biochem Biophys Res Commun 2012 May 20;421(4):727-30. Epub 2012 Apr 20.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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May 2012

Multiple phenotypes in Huntington disease mouse neural stem cells.

Mol Cell Neurosci 2012 May 6;50(1):70-81. Epub 2012 Apr 6.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, United States.

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May 2012

Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.

J Biol Chem 2012 Apr 27;287(16):13487-99. Epub 2012 Feb 27.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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April 2012

Reagents that block neuronal death from Huntington's disease also curb oxidative stress.

Neuroreport 2012 Jan;23(1):10-5

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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January 2012

Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease.

PLoS Curr 2010 Dec 29;2:RRN1205. Epub 2010 Dec 29.

Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Novartis Institutes for Biomedical Research, Neuroscience; Boston University; Massachusetts General Hospital/Harvard Medical School; Massachusetts General Hospital; Neuroscience Research, Head Neurodegeneration at Novartis, Basel, Switzerland; Novartis Institutes for Biomedical Research and AC Immune SA.

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December 2010

Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.

J Neurosci 2010 Mar;30(13):4552-61

Cellular Neurobiology Laboratory and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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March 2010

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.

Neurobiol Dis 2009 Nov 20;36(2):374-83. Epub 2009 Aug 20.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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November 2009

Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers.

Biochem Biophys Res Commun 2009 Sep 14;387(3):472-5. Epub 2009 Jul 14.

Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

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September 2009

Polyglutamine expansion in huntingtin alters its interaction with phospholipids.

J Neurochem 2009 Sep 29;110(5):1585-97. Epub 2009 Jun 29.

Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, 11416th Street, Room 2150, Charlestown, MA 02129, USA.

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September 2009

A function of huntingtin in guanine nucleotide exchange on Rab11.

Neuroreport 2008 Oct;19(16):1643-7

Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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October 2008

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.

Neurobiol Dis 2006 May 19;22(2):346-56. Epub 2006 Jan 19.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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May 2006