Kim Zarse

Kim Zarse

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Kim Zarse

Kim Zarse

Publications by authors named "Kim Zarse"

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Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.

Redox Biol 2020 Feb 4;32:101448. Epub 2020 Feb 4.

Energy Metabolism Laboratory, Institute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH) Zurich, Schwerzenbach, CH-8603, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2020.101448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096751PMC
February 2020

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.

Cell Metab 2018 04 15;27(4):914-925.e5. Epub 2018 Mar 15.

Energy Metabolism Laboratory, Institute of Translational Medicine, D-HEST, Swiss Federal Institute of Technology (ETH) Zürich, Schwerzenbach 8603, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.02.004DOI Listing
April 2018

Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

Aging Cell 2017 08 22;16(4):761-772. Epub 2017 May 22.

Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH) Zurich-Schwerzenbach, Schwerzenbach, Zurich, Switzerland.

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http://dx.doi.org/10.1111/acel.12610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506415PMC
August 2017

A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism.

Cell Syst 2016 05 19;2(5):312-22. Epub 2016 May 19.

Research Group Medical Systems Biology, Christian-Albrechts-University Kiel, 24105 Kiel, Germany; Research Group Theoretical Systems Biology, Friedrich Schiller-University (FSU) Jena, 07745 Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.04.017DOI Listing
May 2016

A mitochondrially encoded hormone ameliorates obesity and insulin resistance.

Cell Metab 2015 Mar;21(3):355-6

Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH), 8603 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.02.013DOI Listing
March 2015

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.

Proc Natl Acad Sci U S A 2014 Oct 22;111(40):14512-7. Epub 2014 Sep 22.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1415475111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209990PMC
October 2014

Extension of life span by impaired glucose metabolism in Caenorhabditis elegans is accompanied by structural rearrangements of the transcriptomic network.

PLoS One 2013 30;8(10):e77776. Epub 2013 Oct 30.

Systems Biology and Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, Jena, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813781PMC
September 2014

D-Glucosamine supplementation extends life span of nematodes and of ageing mice.

Nat Commun 2014 Apr 8;5:3563. Epub 2014 Apr 8.

1] Energy Metabolism Laboratory, ETH Zürich (Swiss Federal Institute of Technology Zurich), Zürich CH-8603, Switzerland [2] German Institute of Human Nutrition Potsdam-Rehbrücke, D-14558 Nuthetal, Germany [3] Department of Human Nutrition, Institute of Nutrition, University of Jena, D-07743 Jena, Germany.

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http://dx.doi.org/10.1038/ncomms4563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988823PMC
April 2014

Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner.

Aging (Albany NY) 2013 Apr;5(4):270-5

Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D-07743, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651519PMC
http://dx.doi.org/10.18632/aging.100548DOI Listing
April 2013

L-Theanine extends lifespan of adult Caenorhabditis elegans.

Eur J Nutr 2012 Sep 16;51(6):765-8. Epub 2012 Mar 16.

Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany.

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http://dx.doi.org/10.1007/s00394-012-0341-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419347PMC
September 2012

Dual role of the mitochondrial protein frataxin in astrocytic tumors.

Lab Invest 2011 Dec 22;91(12):1766-76. Epub 2011 Aug 22.

Department of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1038/labinvest.2011.130DOI Listing
December 2011

Low-dose lithium uptake promotes longevity in humans and metazoans.

Eur J Nutr 2011 Aug 8;50(5):387-9. Epub 2011 Feb 8.

Department of Human Nutrition, Institute of Nutrition, University of Jena, Germany.

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http://dx.doi.org/10.1007/s00394-011-0171-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151375PMC
August 2011

Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.

J Biol Chem 2011 Jun 3;286(25):22323-30. Epub 2011 May 3.

Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D-07743, Germany.

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http://dx.doi.org/10.1074/jbc.M110.205229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121379PMC
June 2011

Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice.

Eur J Nutr 2010 Oct 10;49(7):417-27. Epub 2010 Mar 10.

Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena, Germany.

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http://dx.doi.org/10.1007/s00394-010-0100-4DOI Listing
October 2010

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis).

Exp Gerontol 2010 Jun 27;45(6):410-8. Epub 2010 Mar 27.

Dept. of Human Nutrition, Institute of Nutrition, University of Jena, Germany.

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http://dx.doi.org/10.1016/j.exger.2010.03.014DOI Listing
June 2010

Small-molecule targeting of the mitochondrial compartment with an endogenously cleaved reversible tag.

Chembiochem 2009 Jul;10(10):1689-96

Department of Human Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 29, Jena, Germany.

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http://dx.doi.org/10.1002/cbic.200900159DOI Listing
July 2009

Antioxidants prevent health-promoting effects of physical exercise in humans.

Proc Natl Acad Sci U S A 2009 May 11;106(21):8665-70. Epub 2009 May 11.

Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D-07743, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0903485106
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http://dx.doi.org/10.1073/pnas.0903485106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680430PMC
May 2009

Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells.

FEBS J 2008 Oct 13;275(19):4728-39. Epub 2008 Aug 13.

Department of Dermatology, IZKF Münster and Ludwig Boltzmann Institute for Cell and Immunobiology of the Skin, Germany.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06606.xDOI Listing
October 2008

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.

Cell Metab 2007 Oct;6(4):280-93

Department of Human Nutrition, Institute of Nutrition, University of Jena, D-07743 Jena, Germany.

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http://dx.doi.org/10.1016/j.cmet.2007.08.011DOI Listing
October 2007

Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia.

FASEB J 2007 Apr 10;21(4):1271-5. Epub 2007 Jan 10.

Department of Human Nutrition, Inst. of Nutrition, University of Jena, 29 Dornburger St., Jena D-07743, Germany.

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http://www.fasebj.org/doi/10.1096/fj.06-6994com
Publisher Site
http://dx.doi.org/10.1096/fj.06-6994comDOI Listing
April 2007

Development of peptide microarrays for epitope mapping of antibodies against the human TSH receptor.

J Immunol Methods 2006 Aug 14;315(1-2):11-8. Epub 2006 Jul 14.

Fraunhofer Institute for Biomedical Engineering, Department Molecular Bioanalytics and Bioelectronics, Arthur-Scheunert-Allee 114-116, D-14558 Potsdam-Nuthetal, Germany.

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http://dx.doi.org/10.1016/j.jim.2006.06.012DOI Listing
August 2006

Functional peptide microarrays for specific and sensitive antibody diagnostics.

Proteomics 2006 Mar;6(5):1376-84

Fraunhofer Institute for Biomedical Engineering, Department of Molecular Bioanalytics & Bioelectronics, Potsdam-Nuthetal, Germany.

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http://dx.doi.org/10.1002/pmic.200500343DOI Listing
March 2006