Publications by authors named "Kim Sooi Law"

4 Publications

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Depression and anxiety in the Malaysian urban population and their association with demographic characteristics, quality of life, and the emergence of the COVID-19 pandemic.

Curr Psychol 2021 Feb 19:1-12. Epub 2021 Feb 19.

Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang Malaysia.

The prevalence of depression and anxiety has been shown to be higher in the urban population compared with the rural population. The present study investigated the prevalence of depression symptoms, anxiety symptoms, and depression with comorbid anxiety symptoms and their associated factors in a random sample drawn from several urban communities in Malaysia. This study also determined the association between the emergence of the COVID-19 pandemic and depression symptoms, anxiety symptoms, and depression with comorbid anxiety symptoms. We recruited 326 participants, who were administered a sociodemographic characteristics questionnaire; the 21-item Depression, Anxiety, and Stress Scale (DASS-21) to assess the presence or absence of depression symptoms, anxiety symptoms, and depression with comorbid anxiety symptoms; and the World Health Organization Quality of Life-BREF (WHOQoL-BREF) to assess their QoL. The following prevalence values were obtained among the participants: depression symptoms, 23.9%; anxiety symptoms, 41.7%; and depression with comorbid anxiety symptoms, 19.9%. Those assessed after the declaration of COVID-19 as a global pandemic showed increased odds of depressive symptoms (adjusted OR = 2.99, 95% CI = 1.41-6.35,  = 0.006) and depressive with comorbid anxiety symptoms (adjusted OR = 3.19, 95% CI = 1.37-7.45,  = 0.005), while the presence of comorbid stress increased the odds of depressive symptoms (adjusted OR = 16.00, 95% CI = 7.84-32.63,  < 0.001), anxiety symptoms (adjusted OR = 19.72, 95% CI = 9.75-39.89,  < 0.001), and depressive with comorbid anxiety symptoms (adjusted OR = 40.44, 95% CI = 15.90-102.87,  < 0.001). Higher psychological QoL reduced the odds of depressive symptoms (adjusted OR = 0.83, 95% CI = 0.69-0.99,  = 0.032) and depressive with comorbid anxiety symptoms (adjusted OR = 0.82, 95% CI = 0.68-0.98,  = 0.041), whereas higher physical health QoL (adjusted OR = 0.85, 95% CI = 0.75-0.97,  = 0.021) and social relationship QoL (adjusted OR = 0.70, 95% CI = 0.55-0.90,  = 0.009) reduced the odds of anxiety symptoms. Based on our findings, we recommended several measures to curb psychological complications among the urban population, particularly as the battle to contain COVID-19 is ongoing.
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http://dx.doi.org/10.1007/s12144-021-01492-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892323PMC
February 2021

The effects of virgin coconut oil (VCO) as supplementation on quality of life (QOL) among breast cancer patients.

Lipids Health Dis 2014 Aug 27;13:139. Epub 2014 Aug 27.

Institut Perubatan dan Pergigian Termaju, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Pulau Pinang, Malaysia.

Background: Breast cancer is the most common cancer amongst Malaysian women. Both the disease and its treatment can disrupt the lives of the woman and adversely affect all aspects of life and thus can alter a woman's quality of life. The aim of this study was to examine the effect of virgin coconut oil (VCO) on the quality of life (QOL) of patients diagnosed with breast cancer.

Methods: This was a prospective study of breast cancer patients admitted into the Oncology Unit of Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. The sample consisted of 60 patients with stage III and IV breast cancer allocated to either an intervention group (n = 30) or a control group (n = 30) using a simple random table. QOL was evaluated from the first cycle of chemotherapy to the sixth cycle, and data were collected using a validated Bahasa Malaysia version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Breast Cancer Module (EORTC QLQ-C30) and its breast-specific module (QLQ-BR 23).

Results: The mean age of breast cancer patients was 50.2 (SD = 13.5) years. There were significant mean score differences for functioning and global QOL between groups (α < 0.01). The intervention group also had better scores for symptoms including fatigue, dyspnea, sleep difficulties, and loss of appetite compared to the control group. Although there are deteriorations for sexual enjoyment, the intervention group exhibited improvement in breast functioning and symptom scores for body image, sexual function, future perspective, breast symptoms, and systemic therapy side effects.

Conclusion: VCO consumption during chemotherapy helped improve the functional status and global QOL of breast cancer patients. In addition, it reduced the symptoms related to side effects of chemotherapy.
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http://dx.doi.org/10.1186/1476-511X-13-139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176590PMC
August 2014

Efficacy and safety of Labisia pumila var alata water extract among pre- and postmenopausal women.

J Med Food 2014 Aug 7;17(8):929-38. Epub 2014 Jul 7.

1 Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia .

This study evaluated the effectiveness and safety of Labisia pumila var alata (L. pumila) water extract for improving quality of life, cardiovascular and hormonal balance. A randomized, double-blind, placebo-controlled, parallel group, 16-week study in healthy pre- and postmenopausal women aged 40-60 years was conducted in Kelantan, Malaysia. The subjects were randomized to 400 mg propriety extract of L. pumila or placebo. A Women's Health Questionnaire was used to assess quality of life. Repeated-measures analysis of variance was used to evaluate the data. A total of 197 subjects (L. pumila: n=102 and placebo: n=95) were analyzed. Subjects in the herbal group showed improved memory/concentration, vasomotor symptoms, menstrual symptoms, and sleep problems by 8.3%, 15.9%, 11.8%, and 31.0%, respectively. The greatest improvement was observed for the question: "I get frightened or panic feelings for apparently no reason at all" with a 53% decrease as compared with placebo. Improvements were also seen in the cardiovascular parameters, and the safety profiles were normal. Postmenopausal women supplemented with L. pumila showed no changes in gynecological relevant hormones luteinizing hormone (LH), follicle-stimulating hormone (FSH), and 17β-Estradiol. Water extract of L. pumila was shown to be safe and effective for improving several parameters of quality of life and cardiovascular risks factors (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C]).
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http://dx.doi.org/10.1089/jmf.2013.2953DOI Listing
August 2014

Herbal Medicines: Malaysian Women's Knowledge and Practice.

Evid Based Complement Alternat Med 2013 5;2013:438139. Epub 2013 Sep 5.

Advanced Medical & Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia.

This is a cross-sectional, descriptive study among Malay women admitted in the antenatal and postnatal ward to determine the prevalence and use of herbal medicines during pregnancy and elemental analysis in the most popular herbs. A total of 460 women were surveyed. Herbal medicine use during pregnancy was 34.3%, while 73% utilized herbal medicines during labor, because of a belief that it may shorten and ease labor. The most commonly used herbal medicines in pregnancy were Anastatica hierochuntica L. (60.1%) followed by coconut oil (35.4%). The majority of women (89.2%) used only one type of herbal medicines and took one capsule/glass (38%) per day. Herbal medicines use by pregnant women is largely unsupervised (81%), with most women getting information from their parents (60.7%) and buying the products directly from traditional midwives (32.2%) and 77% agreed upon its efficacy and safety. From the 460 respondents, 89.8% women were in the low end of the herbs knowledge. There was a significant difference found between knowledge score and income (P < 0.05). Microdiffraction analysis revealed significant presence of carbon, oxygen, silica, calcium, magnesium, aluminium, potassium, zinc, and iron that were found in Anastatica hierochuntica L. and proved to have good benefits for pregnancy.
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http://dx.doi.org/10.1155/2013/438139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777224PMC
October 2013