Kim Orth

Kim Orth

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High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers.

PLoS One 2019 2;14(5):e0213423. Epub 2019 May 2.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213423PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497250PMC
May 2019

Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection.

J Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836193020
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http://dx.doi.org/10.1016/j.jmb.2019.04.008DOI Listing
April 2019

Protein AMPylation by an Evolutionarily Conserved Pseudokinase.

Cell 2018 Oct 27;175(3):809-821.e19. Epub 2018 Sep 27.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183110
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http://dx.doi.org/10.1016/j.cell.2018.08.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524645PMC
October 2018

Natural Transformation in Vibrio parahaemolyticus: a Rapid Method To Create Genetic Deletions.

J Bacteriol 2018 Aug 10;200(15). Epub 2018 Jul 10.

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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http://dx.doi.org/10.1128/JB.00032-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040184PMC
August 2018

Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth.

Trends Microbiol 2018 07 24;26(7):582-597. Epub 2018 Jan 24.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0966842X173028
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http://dx.doi.org/10.1016/j.tim.2017.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003838PMC
July 2018

My winding trail while fulfilling my love for science and family.

Authors:
Kim Orth

J Biol Chem 2018 07 11;293(27):10435-10437. Epub 2018 Apr 11.

From the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390

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http://dx.doi.org/10.1074/jbc.AW118.003225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036213PMC
July 2018

Enzymes Involved in AMPylation and deAMPylation.

Chem Rev 2018 02 18;118(3):1199-1215. Epub 2017 Aug 18.

Department of Molecular Biology, University of Texas Southwestern Medical Center , 6000 Harry Hines Boulevard NA5.120F, Dallas, Texas 75390-9148, United States.

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http://dx.doi.org/10.1021/acs.chemrev.7b00145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896785PMC
February 2018

The Biochemistry of Sensing: Enteric Pathogens Regulate Type III Secretion in Response to Environmental and Host Cues.

MBio 2018 01 16;9(1). Epub 2018 Jan 16.

Department of Molecular Biology, University of Texas Southwestern Medical School, Dallas, Texas, USA

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http://mbio.asm.org/lookup/doi/10.1128/mBio.02122-17
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http://dx.doi.org/10.1128/mBio.02122-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770552PMC
January 2018

Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities.

EMBO Rep 2017 11 14;18(11):1978-1990. Epub 2017 Sep 14.

Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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http://dx.doi.org/10.15252/embr.201744226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666596PMC
November 2017

Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus.

Gut Microbes 2017 07 27;8(4):366-373. Epub 2017 Jan 27.

a Department of Molecular Biology , University of Texas Southwestern Medical Center , Dallas , Texas , USA.

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http://dx.doi.org/10.1080/19490976.2017.1287655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570421PMC
July 2017

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus.

PLoS Pathog 2017 Jun 22;13(6):e1006438. Epub 2017 Jun 22.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481031PMC
June 2017

The cytotoxic type 3 secretion system 1 of rewires host gene expression to subvert cell death and activate cell survival pathways.

Sci Signal 2017 May 16;10(479). Epub 2017 May 16.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/scisignal.aal4501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662193PMC
May 2017

Podcast for 16 May 2017: rewires host cells.

Sci Signal 2017 May 16;10(479). Epub 2017 May 16.

Associate Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

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http://dx.doi.org/10.1126/scisignal.aan5621DOI Listing
May 2017

Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury.

Sci Rep 2016 12 20;6:39341. Epub 2016 Dec 20.

Department of Microbiology and Molecular Genetics, University of Texas McGovern Medical School at Houston, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/srep39341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171828PMC
December 2016

Bile salt receptor complex activates a pathogenic type III secretion system.

Elife 2016 07 5;5. Epub 2016 Jul 5.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, United States.

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http://dx.doi.org/10.7554/eLife.15718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933562PMC
July 2016

Proteomics Analysis Reveals Previously Uncharacterized Virulence Factors in Vibrio proteolyticus.

MBio 2016 07 26;7(4). Epub 2016 Jul 26.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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http://dx.doi.org/10.1128/mBio.01077-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981721PMC
July 2016

Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins.

PLoS One 2014 6;9(8):e104387. Epub 2014 Aug 6.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104387PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123922PMC
November 2015

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria.

PLoS Pathog 2015 Aug 25;11(8):e1005128. Epub 2015 Aug 25.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549250PMC
August 2015

Type VI secretion system.

Curr Biol 2015 Mar;25(7):R265-6

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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http://dx.doi.org/10.1016/j.cub.2015.02.031DOI Listing
March 2015

Subversion of the cytoskeleton by intracellular bacteria: lessons from Listeria, Salmonella and Vibrio.

Cell Microbiol 2015 Feb 8;17(2):164-73. Epub 2015 Jan 8.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1111/cmi.12399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806695PMC
February 2015

Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes.

Proc Natl Acad Sci U S A 2015 Jan 1;112(1):100-5. Epub 2014 Dec 1.

Departments of Microbiology and Infectious Diseases, University of Georgia, Athens, GA 30602

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http://dx.doi.org/10.1073/pnas.1413764111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291640PMC
January 2015

AMPylation of Rho GTPases subverts multiple host signaling processes.

J Biol Chem 2014 Nov 9;289(47):32977-88. Epub 2014 Oct 9.

From the Department of Molecular Biology, UT Southwestern Medical Center, Dallas, Texas 75390-9148 and

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http://www.jbc.org/content/289/47/32977.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M114.601310
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http://dx.doi.org/10.1074/jbc.M114.601310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239643PMC
November 2014

H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1.

Microbiology 2014 Sep 1;160(Pt 9):1867-73. Epub 2014 Jul 1.

Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8816, USA

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http://dx.doi.org/10.1099/mic.0.080028-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148687PMC
September 2014

Intracellular Vibrio parahaemolyticus escapes the vacuole and establishes a replicative niche in the cytosol of epithelial cells.

MBio 2014 Sep 9;5(5):e01506-14. Epub 2014 Sep 9.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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http://dx.doi.org/10.1128/mBio.01506-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173779PMC
September 2014

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides.

Nat Commun 2013 ;4:2973

Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.

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http://www.nature.com/articles/ncomms3973
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http://dx.doi.org/10.1038/ncomms3973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981085PMC
July 2014

Marker for type VI secretion system effectors.

Proc Natl Acad Sci U S A 2014 Jun 9;111(25):9271-6. Epub 2014 Jun 9.

Department of Molecular Biology,Department of Biochemistry, and

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http://dx.doi.org/10.1073/pnas.1406110111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078801PMC
June 2014

Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.

ACS Chem Biol 2014 Feb 25;9(2):433-42. Epub 2013 Nov 25.

Department of Chemistry, The Scripps Research Institute, Scripps Florida , 120 Scripps Way, Jupiter, Florida 33458, United States.

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http://dx.doi.org/10.1021/cb4006886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944102PMC
February 2014

The pore-forming bacterial effector, VopQ, halts autophagic turnover.

Autophagy 2013 Dec 8;9(12):2169-70. Epub 2013 Oct 8.

Department of Molecular Biology; UT Southwestern Medical Center; Dallas, TX USA.

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http://dx.doi.org/10.4161/auto.26449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028346PMC
December 2013

Vibrio parahaemolyticus type VI secretion system 1 is activated in marine conditions to target bacteria, and is differentially regulated from system 2.

PLoS One 2013 16;8(4):e61086. Epub 2013 Apr 16.

Department of Molecular Biology, University of Texas Southwestern, Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061086PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628861PMC
November 2013

What pathogens have taught us about posttranslational modifications.

Cell Host Microbe 2013 Sep;14(3):269-79

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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http://dx.doi.org/10.1016/j.chom.2013.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785091PMC
September 2013

An interview with Kim Orth.

Authors:
Kim Orth

Trends Biochem Sci 2013 Jul 12;38(7):331-2. Epub 2013 Jun 12.

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http://dx.doi.org/10.1016/j.tibs.2013.05.002DOI Listing
July 2013

Vibrio effector protein, VopQ, forms a lysosomal gated channel that disrupts host ion homeostasis and autophagic flux.

Proc Natl Acad Sci U S A 2013 Jul 24;110(28):11559-64. Epub 2013 Jun 24.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.1307032110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710849PMC
July 2013

Targeting the bacteria-host interface: strategies in anti-adhesion therapy.

Virulence 2013 May;4(4):284-94

Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.4161/viru.24606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710331PMC
May 2013

Lost after translation: post-translational modifications by bacterial type III effectors.

Curr Opin Microbiol 2013 Apr;16(2):213-20

Department of Molecular Biology, University of Texas Southwestern, Medical Center, Dallas, TX 75390-9148, USA.

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http://dx.doi.org/10.1016/j.mib.2013.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798434PMC
April 2013

Virulence determinants for Vibrio parahaemolyticus infection.

Curr Opin Microbiol 2013 Feb 22;16(1):70-7. Epub 2013 Feb 22.

Department of Molecular Biology, Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.mib.2013.02.002DOI Listing
February 2013

The role of type III secretion system 2 in Vibrio parahaemolyticus pathogenicity.

J Microbiol 2012 Oct 4;50(5):719-25. Epub 2012 Nov 4.

Department of Molecular Biology, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1007/s12275-012-2550-2DOI Listing
October 2012

Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent.

Virulence 2012 Jan-Feb;3(1):68-71. Epub 2012 Jan 1.

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.4161/viru.3.1.18172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337152PMC
September 2012

Subversion of cell signaling by pathogens.

Cold Spring Harb Perspect Biol 2012 Sep 1;4(9):a006114. Epub 2012 Sep 1.

UT Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1101/cshperspect.a006114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428769PMC
September 2012

In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel.

Virulence 2012 Jul 22;3(4):389-99. Epub 2012 Jun 22.

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.4161/viru.20816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478241PMC
July 2012

Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections.

Nat Neurosci 2012 Jun;15(6):871-5

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/nn.3102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578554PMC
June 2012

Type III effector VopC mediates invasion for Vibrio species.

Cell Rep 2012 May 3;1(5):453-60. Epub 2012 May 3.

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.celrep.2012.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392014PMC
May 2012

Manipulation of kinase signaling by bacterial pathogens.

J Cell Biol 2011 Dec 28;195(7):1083-92. Epub 2011 Nov 28.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1083/jcb.201107132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246894PMC
December 2011

Vibrio parahaemolyticus cell biology and pathogenicity determinants.

Microbes Infect 2011 Nov 7;13(12-13):992-1001. Epub 2011 Jul 7.

Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas TX 75390-9148, USA.

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http://dx.doi.org/10.1016/j.micinf.2011.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384537PMC
November 2011

Functional characterization of the interaction between bacterial adhesin multivalent adhesion molecule 7 (MAM7) protein and its host cell ligands.

J Biol Chem 2011 Nov 20;286(45):38939-47. Epub 2011 Sep 20.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M111.291377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234719PMC
November 2011

A chemical reporter for protein AMPylation.

J Am Chem Soc 2011 Nov 7;133(43):17103-5. Epub 2011 Oct 7.

The Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1021/ja205137dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246509PMC
November 2011

De-AMPylation unmasked: modulation of host membrane trafficking.

Sci Signal 2011 Oct 11;4(194):pe42. Epub 2011 Oct 11.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/scisignal.2002458DOI Listing
October 2011

AMPylation: Something Old is New Again.

Front Microbiol 2010 19;1:113. Epub 2010 Oct 19.

Department of Molecular Biology, University of Texas Southwestern Medical Center Dallas, TX, USA.

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http://dx.doi.org/10.3389/fmicb.2010.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095399PMC
July 2011

Outer membrane adhesion factor multivalent adhesion molecule 7 initiates host cell binding during infection by gram-negative pathogens.

Proc Natl Acad Sci U S A 2011 Jul 27;108(28):11614-9. Epub 2011 Jun 27.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.1102360108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136308PMC
July 2011

Manipulation of host membranes by bacterial effectors.

Nat Rev Microbiol 2011 Jul 18;9(9):635-46. Epub 2011 Jul 18.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/nrmicro2602DOI Listing
July 2011

Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry.

J Am Soc Mass Spectrom 2011 Apr 24;22(4):752-61. Epub 2011 Feb 24.

Protein Chemistry Technology Center, Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/s13361-011-0084-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391576PMC
April 2011

Characterization of a rabbit polyclonal antibody against threonine-AMPylation.

J Biotechnol 2011 Feb 23;151(3):251-4. Epub 2010 Dec 23.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.jbiotec.2010.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391625PMC
February 2011

A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity.

Science 2010 Sep 19;329(5999):1660-2. Epub 2010 Aug 19.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/science.1192850DOI Listing
September 2010

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain.

J Biol Chem 2010 Jun 21;285(26):20155-63. Epub 2010 Apr 21.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M110.114884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888428PMC
June 2010

Tipping the balance by manipulating post-translational modifications.

Curr Opin Microbiol 2010 Feb 12;13(1):34-40. Epub 2010 Jan 12.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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http://dx.doi.org/10.1016/j.mib.2009.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018334PMC
February 2010

Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis.

Mol Microbiol 2009 Aug 14;73(4):639-49. Epub 2009 Jul 14.

Department of Molecular Biology, University of Texas South-western Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06798.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733864PMC
August 2009

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse.

Blood 2009 Jul 3;114(5):1016-25. Epub 2009 Jun 3.

Department of Immunology, Wright-Fleming Institute, Imperial College, Norfolk Pl, London W2 1PG London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2008-03-136770DOI Listing
July 2009

AMPylation is a new post-translational modiFICation.

Nat Chem Biol 2009 Jun;5(6):378-9

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http://dx.doi.org/10.1038/nchembio0609-378DOI Listing
June 2009

Fido, a novel AMPylation domain common to fic, doc, and AvrB.

PLoS One 2009 Jun 5;4(6):e5818. Epub 2009 Jun 5.

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005818PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686095PMC
June 2009

Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death.

Autophagy 2009 Jan 25;5(1):100-2. Epub 2009 Jan 25.

Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788499PMC
http://dx.doi.org/10.4161/auto.5.1.7264DOI Listing
January 2009

AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.

Science 2009 Jan 27;323(5911):269-72. Epub 2008 Nov 27.

Department of Molecular Biology, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/science.1166382DOI Listing
January 2009

Acanthamoeba castellanii promotes the survival of Vibrio parahaemolyticus.

Appl Environ Microbiol 2008 Dec 10;74(23):7183-8. Epub 2008 Oct 10.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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http://dx.doi.org/10.1128/AEM.01332-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592933PMC
December 2008

Microbiology. A protein pupylation paradigm.

Science 2008 Nov;322(5904):1062-3

Department of Immunology, University of Texas Southwestern Medical School, Dallas, TX 75230, USA.

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http://dx.doi.org/10.1126/science.1166485DOI Listing
November 2008

Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis.

Proc Natl Acad Sci U S A 2008 Aug 19;105(34):12497-502. Epub 2008 Aug 19.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0802773105
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http://dx.doi.org/10.1073/pnas.0802773105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527940PMC
August 2008

In vitro signaling by MAPK and NFkappaB pathways inhibited by Yersinia YopJ.

Methods Enzymol 2008 ;438:343-53

University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)38024-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432501PMC
June 2008

In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax.

J Biol Chem 2008 May 26;283(22):15127-33. Epub 2008 Jan 26.

Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1074/jbc.M704831200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397464PMC
May 2008

Yersinia outer proteins: Yops.

Cell Microbiol 2008 Mar 11;10(3):557-65. Epub 2007 Dec 11.

Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild Science Building, D300, 299 Campus Drive, Stanford, CA 94305-5124, USA.

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http://dx.doi.org/10.1111/j.1462-5822.2007.01109.xDOI Listing
March 2008

Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways.

PLoS One 2008 Jan 2;3(1):e1375. Epub 2008 Jan 2.

Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001375PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147050PMC
January 2008

VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases.

J Biol Chem 2007 Nov 19;282(47):34299-305. Epub 2007 Sep 19.

Department of Molecular Biology, Protein Chemistry Technology Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1074/jbc.M706970200DOI Listing
November 2007

The elusive activity of the Yersinia protein kinase A kinase domain is revealed.

Trends Microbiol 2007 Oct 24;15(10):437-40. Epub 2007 Oct 24.

Department of Molecular Biology, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-9148, USA.

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http://dx.doi.org/10.1016/j.tim.2007.09.002DOI Listing
October 2007

Arp2/3-independent assembly of actin by Vibrio type III effector VopL.

Proc Natl Acad Sci U S A 2007 Oct 17;104(43):17117-22. Epub 2007 Oct 17.

Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0703196104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040399PMC
October 2007

A newly discovered post-translational modification--the acetylation of serine and threonine residues.

Trends Biochem Sci 2007 May 6;32(5):210-6. Epub 2007 Apr 6.

Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.tibs.2007.03.007DOI Listing
May 2007

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases.

J Biol Chem 2007 Mar 3;282(9):6773-82. Epub 2007 Jan 3.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA.

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http://dx.doi.org/10.1074/jbc.M608730200DOI Listing
March 2007

Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation.

Biochem J 2006 Sep;398(3):521-9

Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1042/BJ20060426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559452PMC
September 2006

AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-kappaB signalling pathway.

Microbiology 2006 Sep;152(Pt 9):2809-18

Institute of Veterinary Bacteriology, Vetsuisse Faculty, Universität Bern, Länggassstrasse 122, Postfach, CH-3001 Bern, Switzerland.

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http://dx.doi.org/10.1099/mic.0.28889-0DOI Listing
September 2006

Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.

Science 2006 May;312(5777):1211-4

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/science.1126867DOI Listing
May 2006

Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus.

J Biol Chem 2004 Dec 30;279(50):51953-7. Epub 2004 Sep 30.

Department of Molecular Biology, University of Texas Southwestern Medical School, Dallas, Texas 75390-9148, USA.

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http://dx.doi.org/10.1074/jbc.M407001200DOI Listing
December 2004

Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta.

Mol Microbiol 2003 Oct;50(2):377-89

Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.

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October 2003

Yersinia effector YopJ inhibits yeast MAPK signaling pathways by an evolutionarily conserved mechanism.

J Biol Chem 2003 Jan 13;278(4):2131-5. Epub 2002 Nov 13.

Department of Molecular Biology, University of Texas Southwestern Medical School, Dallas 75390-9148, USA.

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http://dx.doi.org/10.1074/jbc.M209905200DOI Listing
January 2003

Hijacking of host cell IKK signalosomes by the transforming parasite Theileria.

Science 2002 Nov;298(5595):1033-6

Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, CH-3012 Bern, Switzerland.

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http://dx.doi.org/10.1126/science.1075462DOI Listing
November 2002

Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway.

J Immunol 2002 Sep;169(6):2846-50

Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.4049/jimmunol.169.6.2846DOI Listing
September 2002

Function of the Yersinia effector YopJ.

Authors:
Kim Orth

Curr Opin Microbiol 2002 Feb;5(1):38-43

Department of Molecular Biology, 5323 Harry Hines Boulevard, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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February 2002