Publications by authors named "Kim Nasmyth"

100Publications

Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA.

Mol Cell 2020 07 23;79(2):234-250.e9. Epub 2020 Jun 23.

Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, School of Life Sciences, THU-PKU Center for Life Science, Tsinghua University, Beijing 100084, China. Electronic address:

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July 2020

Organization of Chromosomal DNA by SMC Complexes.

Annu Rev Genet 2019 12 2;53:445-482. Epub 2019 Oct 2.

Department of Biochemistry, Oxford University, Oxford OX1 3QU, United Kingdom; email:

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December 2019

Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex.

Mol Cell 2019 07 11;75(2):224-237.e5. Epub 2019 Jun 11.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address:

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July 2019

A folded conformation of MukBEF and cohesin.

Nat Struct Mol Biol 2019 03 4;26(3):227-236. Epub 2019 Mar 4.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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March 2019

How are DNAs woven into chromosomes?

Authors:
Kim Nasmyth

Science 2017 11;358(6363):589-590

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

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November 2017

Cohesin Can Remain Associated with Chromosomes during DNA Replication.

Cell Rep 2017 Sep;20(12):2749-2755

Department of Biochemistry, Oxford University, South Parks Road, Oxford, OX1 3QU, UK. Electronic address:

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September 2017

Scc2/Nipbl hops between chromosomal cohesin rings after loading.

Elife 2017 09 15;6. Epub 2017 Sep 15.

Department of Biochemistry, Oxford University, Oxford, United Kingdom.

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September 2017

Evolution of condensin and cohesin complexes driven by replacement of Kite by Hawk proteins.

Curr Biol 2017 Jan;27(1):R17-R18

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Electronic address:

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January 2017

Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1.

Cell Rep 2016 Mar 25;14(9):2108-2115. Epub 2016 Feb 25.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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March 2016

Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening.

Mol Cell 2016 Feb;61(4):575-588

Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address:

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February 2016

Biological chromodynamics: a general method for measuring protein occupancy across the genome by calibrating ChIP-seq.

Nucleic Acids Res 2015 Nov 30;43(20):e132. Epub 2015 Jun 30.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK

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November 2015

Condensin confers the longitudinal rigidity of chromosomes.

Nat Cell Biol 2015 Jun 11;17(6):771-81. Epub 2015 May 11.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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June 2015

A meiotic mystery: How sister kinetochores avoid being pulled in opposite directions during the first division.

Authors:
Kim Nasmyth

Bioessays 2015 Jun 15;37(6):657-65. Epub 2015 Apr 15.

Department of Biochemistry, Oxford University, Oxford, UK.

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June 2015

Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase.

PLoS Biol 2014 Oct 7;12(10):e1001962. Epub 2014 Oct 7.

Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California.

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October 2014

Structure and function of cohesin's Scc3/SA regulatory subunit.

FEBS Lett 2014 Oct 27;588(20):3692-702. Epub 2014 Aug 27.

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom. Electronic address:

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October 2014

Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible.

Curr Biol 2014 Mar 27;24(6):630-7. Epub 2014 Feb 27.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address:

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March 2014

Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.

Curr Biol 2013 Dec 27;23(24):2534-9. Epub 2013 Nov 27.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address:

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December 2013

Pds5 promotes and protects cohesin acetylation.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):13020-5. Epub 2013 Jul 22.

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.

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August 2013

Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis.

Cell Rep 2012 Nov 1;2(5):1077-87. Epub 2012 Nov 1.

UPMC Université Paris 06, UMR7622 Laboratoire de Biologie du Développement, 9 quai St. Bernard, Paris 75005, France.

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November 2012

Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation.

Cell 2012 Aug 14;150(5):961-74. Epub 2012 Aug 14.

University of Oxford, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK.

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August 2012

The cell cycle.

Philos Trans R Soc Lond B Biol Sci 2011 Dec;366(1584):3494-7

Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK.

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December 2011

Cohesin's concatenation of sister DNAs maintains their intertwining.

Mol Cell 2011 Oct;44(1):97-107

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

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October 2011

Cohesin: a catenase with separate entry and exit gates?

Authors:
Kim Nasmyth

Nat Cell Biol 2011 Oct 3;13(10):1170-7. Epub 2011 Oct 3.

University of Oxford, Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK.

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October 2011

The anaphase promoting complex is required for memory function in mice.

Learn Mem 2011 Jan 22;18(1):49-57. Epub 2010 Dec 22.

Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Göttingen D-37077, Germany.

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January 2011

ATP hydrolysis is required for relocating cohesin from sites occupied by its Scc2/4 loading complex.

Curr Biol 2011 Jan 23;21(1):12-24. Epub 2010 Dec 23.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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January 2011

Getting through anaphase: splitting the sisters and beyond.

Biochem Soc Trans 2010 Dec;38(6):1639-44

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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December 2010

How far will we see in the future?

Authors:
Kim Nasmyth

Mol Biol Cell 2010 Nov;21(22):3813-4

University of Oxford, Department of Biochemistry, Oxford OX1 3QU, United Kingdom.

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November 2010

A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands.

Curr Biol 2010 Oct 7;20(20):1787-98. Epub 2010 Oct 7.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.

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October 2010

ParticleStats: open source software for the analysis of particle motility and cytoskeletal polarity.

Nucleic Acids Res 2010 Jul 11;38(Web Server issue):W641-6. Epub 2010 Jun 11.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

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July 2010

Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei.

Nat Cell Biol 2010 Feb 17;12(2):185-92. Epub 2010 Jan 17.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

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February 2010

Cohesin: its roles and mechanisms.

Annu Rev Genet 2009 ;43:525-58

Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.

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December 2009

Structure and function of the PP2A-shugoshin interaction.

Mol Cell 2009 Aug;35(4):426-41

Department of Biological Structure, University of Washington, Seattle, WA 98195, USA.

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August 2009

The cohesin ring concatenates sister DNA molecules.

Nature 2008 Jul 2;454(7202):297-301. Epub 2008 Jul 2.

University of Oxford, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK.

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July 2008

Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe.

Nat Protoc 2007 ;2(11):2996-3000

Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Dr. Bohr-Gasse 1, 1030 Vienna, Austria.

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February 2008

A physical assay for sister chromatid cohesion in vitro.

Mol Cell 2007 Jul;27(2):300-10

Research Institute of Molecular Pathology, Dr Bohr-Gasse 7, Vienna, Austria.

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July 2007

Tandem affinity purification of functional TAP-tagged proteins from human cells.

Nat Protoc 2007 ;2(5):1145-51

Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Dr Bohr-Gasse 1, 1030 Vienna, Austria.

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January 2008

High-throughput knockout screen in fission yeast.

Nat Protoc 2006 ;1(5):2457-64

Research Institute of Molecular Pathology, Dr Bohr-Gasse 7, 1030 Vienna, Austria.

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October 2007

Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.

Curr Biol 2006 Oct;16(20):1998-2008

Research Institute of Molecular Pathology, Dr. Bohr Gasse 7, A-1030 Vienna, Austria.

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October 2006

Control of Shugoshin function during fission-yeast meiosis.

Curr Biol 2005 Dec;15(24):2263-70

Centre National de la Recherche Scientifique, Institut de Biochimie et Génétique Cellulaires, Unité mixte de recherche 5095, Bordeaux, F-33077, France.

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December 2005

A topological interaction between cohesin rings and a circular minichromosome.

Cell 2005 Sep;122(6):849-60

Research Institute of Molecular Pathology, Vienna, Austria.

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September 2005

The structure and function of SMC and kleisin complexes.

Annu Rev Biochem 2005 ;74:595-648

Institute of Molecular Pathology, A-1030 Vienna, Austria.

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September 2005

How might cohesin hold sister chromatids together?

Authors:
Kim Nasmyth

Philos Trans R Soc Lond B Biol Sci 2005 Mar;360(1455):483-96

IMP (Research Institute of Molecular Pathology), Dr Bohr-Gasse 7, A-1030 Vienna, Austria.

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March 2005

Introduction: dissection and simplification of chromosome segregation.

Philos Trans R Soc Lond B Biol Sci 2005 Mar;360(1455):481

Department of Gene Mechanism, Graduate School of Biostudies, Kyoto University, Yoshida-Honmachi, Kyoto 606-8501, Japan.

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March 2005

How do so few control so many?

Authors:
Kim Nasmyth

Cell 2005 Mar;120(6):739-46

Research Institute of Molecular Pathology, Vienna,

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March 2005

Structure and stability of cohesin's Smc1-kleisin interaction.

Mol Cell 2004 Sep;15(6):951-64

Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

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September 2004

The Drosophila meiotic kleisin C(2)M functions before the meiotic divisions.

Chromosoma 2004 Oct 30;113(4):177-87. Epub 2004 Jul 30.

Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany.

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October 2004

Is chromatin remodeling required to build sister-chromatid cohesion?

Trends Biochem Sci 2004 Aug;29(8):389-92

Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

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August 2004

From a single double helix to paired double helices and back.

Philos Trans R Soc Lond B Biol Sci 2004 Jan;359(1441):99-108

Research Institute for Molecular Biology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria.

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January 2004

Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle.

Nature 2004 Mar 11;428(6978):93-7. Epub 2004 Feb 11.

School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee DD1 5EH, UK.

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March 2004

Building and breaking bridges between sister chromatids.

Bioessays 2003 Dec;25(12):1178-91

Institute of Molecular Pathology, Dr. Bohr Gasse 7, A-1030 Vienna, Austria.

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December 2003

ATP hydrolysis is required for cohesin's association with chromosomes.

Curr Biol 2003 Nov;13(22):1941-53

Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, 1030 Vienna, Austria.

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November 2003

Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.

Mol Cell 2003 Mar;11(3):571-5

Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria.

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March 2003