Publications by authors named "Kim D Janda"

99Publications

Evaluation of a Series of Lipidated Tucaresol Adjuvants in a Hepatitis C Virus Vaccine Model.

ACS Med Chem Lett 2020 Dec 29;11(12):2428-2432. Epub 2020 Oct 29.

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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December 2020

Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability.

Mol Pharm 2021 Jan 10;18(1):228-235. Epub 2020 Dec 10.

Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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January 2021

A synthetic opioid vaccine attenuates fentanyl-vs-food choice in male and female rhesus monkeys.

Drug Alcohol Depend 2021 Jan 20;218:108348. Epub 2020 Oct 20.

Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.

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January 2021

Anti-Opioid Antibodies in Individuals Using Chronic Opioid Therapy for Lower Back Pain.

ACS Pharmacol Transl Sci 2020 Oct 25;3(5):896-906. Epub 2020 Aug 25.

School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, United States.

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October 2020

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A.

J Med Chem 2020 10 18;63(19):11100-11120. Epub 2020 Sep 18.

Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.

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October 2020

Sulfonate-isosteric replacement examined within heroin-hapten vaccine design.

Bioorg Med Chem Lett 2020 09 4;30(17):127388. Epub 2020 Jul 4.

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address:

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September 2020

Enhancement of a Heroin Vaccine through Hapten Deuteration.

J Am Chem Soc 2020 08 27;142(31):13294-13298. Epub 2020 Jul 27.

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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August 2020

Salicylanilide Analog Minimizes Relapse of Infection in Mice.

J Med Chem 2020 07 16;63(13):6898-6908. Epub 2020 Jun 16.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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July 2020

A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1-3Gal epitope.

Chem Commun (Camb) 2020 Jun 12;56(48):6551-6554. Epub 2020 May 12.

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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June 2020

Standing out from the crowd in treating COVID-19.

Med Drug Discov 2020 Jun 3;6:100034. Epub 2020 Apr 3.

Department of Perioperative Medicine,Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

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June 2020

Evaluation of a Dual Fentanyl/Heroin Vaccine on the Antinociceptive and Reinforcing Effects of a Fentanyl/Heroin Mixture in Male and Female Rats.

ACS Chem Neurosci 2020 05 22;11(9):1300-1310. Epub 2020 Apr 22.

Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, United States.

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May 2020

Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory-Impairing Anti-Parallel Aβ Dimers.

Angew Chem Int Ed Engl 2020 07 7;59(28):11491-11500. Epub 2020 May 7.

Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea.

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July 2020

Consequence of Hapten Stereochemistry: An Efficacious Methamphetamine Vaccine.

J Am Chem Soc 2019 09 3;141(36):14089-14092. Epub 2019 Sep 3.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, and Worm Institute of Research and Medicine (WIRM) , The Scripps Research Institute , 10550 N. Torrey Pines Road , La Jolla , California 92037 , United States of America.

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September 2019

Vaccine blunts fentanyl potency in male rhesus monkeys.

Neuropharmacology 2019 11 29;158:107730. Epub 2019 Jul 29.

Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. Electronic address:

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November 2019

Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.

Acc Chem Res 2019 08 19;52(8):2322-2331. Epub 2019 Jul 19.

Department of Chemistry, Department of Immunology and Microbial Science , The Skaggs Institute for Chemical Biology, The WIRM Institute for Research & Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.

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August 2019

Monoclonal Antibodies for Combating Synthetic Opioid Intoxication.

J Am Chem Soc 2019 07 25;141(26):10489-10503. Epub 2019 Jun 25.

Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , 10550 N Torrey Pines Road , La Jolla , California 92037 , United States.

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July 2019

Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences.

Vaccine 2019 07 5;37(30):4155-4163. Epub 2019 Jun 5.

Department of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. Electronic address:

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July 2019

A chemically contiguous hapten approach for a heroin-fentanyl vaccine.

Beilstein J Org Chem 2019 3;15:1020-1031. Epub 2019 May 3.

Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology; The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA, 92037, USA.

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May 2019

Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats.

Neuropsychopharmacology 2019 09 2;44(10):1681-1689. Epub 2019 May 2.

Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.

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September 2019

Δ-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions.

Neuropharmacology 2019 06 11;151:127-135. Epub 2019 Apr 11.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. Electronic address:

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June 2019

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin.

Sci Rep 2019 02 12;9(1):1841. Epub 2019 Feb 12.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

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February 2019

Chemical Interventions for the Opioid Crisis: Key Advances and Remaining Challenges.

J Am Chem Soc 2019 02 11;141(5):1798-1806. Epub 2018 Dec 11.

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and WIRM Institute for Research and Medicine , The Scripps Research Institute , La Jolla , California 92037 , United States.

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February 2019

Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin.

Bioorg Med Chem 2019 01 20;27(1):125-132. Epub 2018 Nov 20.

Department of Chemistry, Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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January 2019

Lateral Flow Assessment and Unanticipated Toxicity of Kratom.

Chem Res Toxicol 2019 01 16;32(1):113-121. Epub 2018 Nov 16.

ABiox Company, 720 East First Street , Newberg , Oregon 97132 , United States.

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January 2019

An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse.

Sci Adv 2018 10 17;4(10):eaat4751. Epub 2018 Oct 17.

Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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October 2018

Immunopharmacotherapies for Treating Opioid Use Disorder.

Trends Pharmacol Sci 2018 11;39(11):908-911

Department of Chemistry, Department of Immunology and Microbial Science, Skaggs Institute for Chemical Biology, Worm Institute for Research and Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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November 2018

Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin.

ACS Omega 2018 Sep 20;3(9):11537-11543. Epub 2018 Sep 20.

Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology, and Department of Neuroscience, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037 United States.

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September 2018

Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis.

ACS Infect Dis 2018 10 21;4(10):1423-1431. Epub 2018 Sep 21.

Department of Chemistry , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.

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October 2018

Synthetic molecules for disruption of the MYC protein-protein interface.

Bioorg Med Chem 2018 08 11;26(14):4234-4239. Epub 2018 Jul 11.

Department of Chemistry, BCC-582, 10550 N Torrey Pines Road, The Scripps Research Institute, La Jolla, CA 92037, United States. Electronic address:

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August 2018

Introduction.

Bioorg Med Chem Lett 2018 09 10;28(16):2661-2662. Epub 2018 Jul 10.

Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, United States.

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September 2018

Prophylactic vaccination protects against the development of oxycodone self-administration.

Neuropharmacology 2018 08 22;138:292-303. Epub 2018 Jun 22.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA. Electronic address:

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August 2018

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.

Biochemistry 2018 07 13;57(26):3741-3751. Epub 2018 Jun 13.

Program in Biomolecular Pharmacology , Boston University School of Medicine , 72 East Concord Street , Boston , Massachusetts 02118 , United States.

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July 2018

Efficient Syntheses of Cocaine Vaccines and Their Evaluation.

ACS Med Chem Lett 2018 May 16;9(5):411-416. Epub 2018 Apr 16.

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and WIRM Institute for Research and Medicine, The Scripps Research Institute, La Jolla, California 92037, United States.

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May 2018

Efficacious Vaccine against Heroin Contaminated with Fentanyl.

ACS Chem Neurosci 2018 06 23;9(6):1269-1275. Epub 2018 Mar 23.

Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.

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June 2018

Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality.

Mol Pharm 2018 03 19;15(3):1062-1072. Epub 2018 Feb 19.

Departments of Chemistry, Immunology, and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.

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March 2018

Investigations into the efficacy of multi-component cocaine vaccines.

Bioorg Med Chem Lett 2018 09 20;28(16):2779-2783. Epub 2017 Dec 20.

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology and the Worm Institute of Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address:

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September 2018

An enzymatic advance in nicotine cessation therapy.

Chem Commun (Camb) 2018 Feb;54(14):1686-1689

Departments of Chemistry, Immunology, Microbiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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February 2018

A Vision for Vaccines: Combating the Opioid Epidemic.

Biochemistry 2017 10 10;56(42):5625-5627. Epub 2017 Oct 10.

Departments of Chemistry, Immunology, and Microbial Science, Skaggs Institute for Chemical Biology, The Scripps Research Institute , La Jolla, California 92037, United States.

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October 2017

Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity.

Nature 2017 08 16;548(7668):476-479. Epub 2017 Aug 16.

Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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August 2017

Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination.

Bioorg Med Chem Lett 2017 08 5;27(16):3666-3668. Epub 2017 Jul 5.

Departments of Chemistry and Immunology, The Scripps Research Institute, La Jolla, CA 92037, United States. Electronic address:

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August 2017

A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior.

Chem Commun (Camb) 2017 Jul;53(58):8156-8159

Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.

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July 2017

Conjugate Vaccine Immunotherapy for Substance Use Disorder.

Pharmacol Rev 2017 07;69(3):298-315

Departments of Chemistry and Immunology, The Scripps Research Institute, La Jolla, California

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July 2017

Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG).

Bioorg Med Chem Lett 2017 08 29;27(15):3436-3440. Epub 2017 May 29.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Department of Immunology, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey, La Jolla, CA 92037, United States.

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August 2017

Development of a Clinically Viable Heroin Vaccine.

J Am Chem Soc 2017 06 20;139(25):8601-8611. Epub 2017 Jun 20.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute , 10550 N Torrey Pines Road, La Jolla, California 92037, United States.

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June 2017

Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.

J Am Chem Soc 2017 05 19;139(21):7264-7272. Epub 2017 May 19.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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May 2017

The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response.

Org Biomol Chem 2017 Apr;15(14):2979-2992

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 N Torrey Pines Rd BCC-582, La Jolla, CA 92037, USA.

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April 2017

An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life.

ACS Chem Biol 2017 01 29;12(1):36-40. Epub 2016 Nov 29.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute , La Jolla, California 92037, United States.

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January 2017

Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.

J Med Chem 2017 01 3;60(1):338-348. Epub 2017 Jan 3.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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January 2017

Influencing Antibody-Mediated Attenuation of Methamphetamine CNS Distribution through Vaccine Linker Design.

ACS Chem Neurosci 2017 03 16;8(3):468-472. Epub 2016 Dec 16.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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March 2017

Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats.

Neuropharmacology 2017 04 9;116:1-8. Epub 2016 Dec 9.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, La Jolla, CA, USA.

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April 2017

Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.

Biochemistry 2016 Dec 18;55(48):6595-6598. Epub 2016 Nov 18.

Program in Biomolecular Pharmacology, Boston University School of Medicine , 72 East Concord Street, Boston, Massachusetts 02118, United States.

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December 2016

Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain.

Chem Commun (Camb) 2016 Oct;52(84):12521-12524

Departments of Chemistry, Immunology and Microbial Sciences, Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.

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October 2016

Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations That Activate Multiple Toll-Like Receptors.

Mol Pharm 2016 11 18;13(11):3884-3890. Epub 2016 Oct 18.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute , La Jolla, California 92037, United States.

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November 2016

Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile.

Sci Rep 2016 09 16;6:33642. Epub 2016 Sep 16.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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September 2016

Modulation of the Surface-Layer Protein of Clostridium difficile through Cwp84 Inhibition.

ACS Infect Dis 2016 07 31;2(7):465-70. Epub 2016 May 31.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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July 2016

Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose.

Bioorg Med Chem Lett 2016 10 25;26(20):5078-5081. Epub 2016 Aug 25.

Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Immunology and Microbial Sciences, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Worm Institute of Medical Research (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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October 2016

Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis.

Tetrahedron 2015 Jun;72(25):3593-3598

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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June 2015

Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis.

Tetrahedron 2015 Jun;72(25):3593-3598

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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June 2015

Methamphetamine Vaccines: Improvement through Hapten Design.

J Med Chem 2016 04 19;59(8):3878-85. Epub 2016 Apr 19.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM) and ‡Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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April 2016

Investigations of Enantiopure Nicotine Haptens Using an Adjuvanting Carrier in Anti-Nicotine Vaccine Development.

J Med Chem 2016 Mar 7;59(6):2523-9. Epub 2016 Mar 7.

Departments of Chemistry and Immunology, Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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March 2016

Glycation Reactivity of a Quorum-Sensing Signaling Molecule.

Angew Chem Int Ed Engl 2016 Mar 17;55(12):4002-6. Epub 2016 Feb 17.

The Skaggs Institute for Chemical Biology and Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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March 2016

Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs.

Angew Chem Int Ed Engl 2016 Mar 16;55(11):3772-5. Epub 2016 Feb 16.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 N Torrey Pines Rd BCC-582, La Jolla, CA, 92037, USA.

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March 2016

MINCR is not a MYC-induced lncRNA.

Proc Natl Acad Sci U S A 2016 Feb 25;113(5):E496-7. Epub 2016 Jan 25.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037;

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February 2016

Litomosoides sigmodontis: a jird urine metabolome study.

Bioorg Med Chem Lett 2015 Dec 23;25(24):5804-7. Epub 2015 Oct 23.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Department of Immunology, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address:

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December 2015

A New Strategy for Smoking Cessation: Characterization of a Bacterial Enzyme for the Degradation of Nicotine.

J Am Chem Soc 2015 Aug 6;137(32):10136-9. Epub 2015 Aug 6.

†Departments of Chemistry and Immunology and The Skaggs Institute for Chemical Biology, and ‡Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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August 2015

Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping.

ACS Infect Dis 2015 May 18;1(5):198-202. Epub 2015 Mar 18.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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May 2015

Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model.

Chem Biol 2015 Apr 16;22(4):483-491. Epub 2015 Apr 16.

The Skaggs Institute for Chemical Biology and Departments of Chemistry and Immunology and the Worm Institute for Research and Medicine (WIRM), La Jolla, CA 92037, USA. Electronic address:

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April 2015

Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting.

ACS Med Chem Lett 2015 Mar 20;6(3):339-43. Epub 2015 Jan 20.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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March 2015

Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity.

Chem Commun (Camb) 2015 Apr;51(28):6226-9

Departments of Chemistry and Immunology and Microbial Sciences, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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April 2015

Flagellin as carrier and adjuvant in cocaine vaccine development.

Mol Pharm 2015 Feb 7;12(2):653-62. Epub 2015 Jan 7.

Departments of Chemistry, Integrative Structural and Computational Biology, and Immunology and Microbial Science, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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February 2015

A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity.

J Med Chem 2015 Jan 17;58(2):1005-11. Epub 2014 Dec 17.

Departments of Chemistry and Immunology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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January 2015

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.

Oncotarget 2014 Oct;5(19):8869-78

Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.

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October 2014

Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity.

Biochemistry 2014 Nov 21;53(43):6820-4. Epub 2014 Oct 21.

Departments of Chemistry and Immunology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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November 2014

A human recombinant monoclonal antibody to cocaine: Preparation, characterization and behavioral studies.

Bioorg Med Chem Lett 2014 Oct 21;24(19):4664-4666. Epub 2014 Aug 21.

Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Immunology and Microbial Sciences, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Worm Institute of Medical Research (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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October 2014

Inhibitor of MYC identified in a Kröhnke pyridine library.

Proc Natl Acad Sci U S A 2014 Aug 11;111(34):12556-61. Epub 2014 Aug 11.

Chemistry, The Scripps Research Institute, La Jolla, CA 92037; and

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August 2014

A platform stratifying a sequestering agent and a pharmacological antagonist as a means to negate botulinum neurotoxicity.

ACS Chem Neurosci 2014 Aug 11;5(8):632-6. Epub 2014 Jul 11.

Departments of Chemistry, Immunology and Microbial Sciences, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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August 2014

Benzoquinones as inhibitors of botulinum neurotoxin serotype A.

Bioorg Med Chem 2014 Aug 16;22(15):3971-81. Epub 2014 Jun 16.

Departments of Chemistry and Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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August 2014

Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.

J Med Chem 2014 Jul 20;57(13):5792-9. Epub 2014 Jun 20.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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July 2014

Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL.

Angew Chem Int Ed Engl 2014 Jun 18;53(26):6628-31. Epub 2014 May 18.

Department of Chemistry, Dept. of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).

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June 2014

Investigating hapten clustering as a strategy to enhance vaccines against drugs of abuse.

Bioconjug Chem 2014 Mar 25;25(3):593-600. Epub 2014 Feb 25.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, Worm Institute of Research and Medicine (WIRM), The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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March 2014

Injection route and TLR9 agonist addition significantly impact heroin vaccine efficacy.

Mol Pharm 2014 Mar 19;11(3):1075-80. Epub 2014 Feb 19.

Departments of Chemistry, Immunology, and Microbial Science, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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March 2014

Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.

Bioorg Med Chem 2014 Feb 8;22(3):1208-17. Epub 2013 Dec 8.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address:

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February 2014

Scorpion toxins for the reversal of BoNT-induced paralysis.

Bioorg Med Chem Lett 2013 Dec 25;23(24):6743-6. Epub 2013 Oct 25.

Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Immunology and Microbial Sciences, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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December 2013

Targeting botulinum A cellular toxicity: a prodrug approach.

J Med Chem 2013 Oct 15;56(20):7870-9. Epub 2013 Oct 15.

Departments of Chemistry and Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and The Worm Institute for Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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October 2013

Probing the effects of hapten stability on cocaine vaccine immunogenicity.

Mol Pharm 2013 Nov 4;10(11):4176-84. Epub 2013 Oct 4.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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November 2013

A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level.

Chem Biol 2013 Jul;20(7):903-11

The Skaggs Institute for Chemical Biology, Departments of Chemistry, Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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July 2013

Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors.

J Am Chem Soc 2013 Jul 28;135(27):10014-7. Epub 2013 Jun 28.

Department of Chemistry, The Skaggs Institute for Chemical Biology, and The Worm Institute for Research and Medicine, The Scripps Research Institute, University of California, San Diego, La Jolla, California 92037, USA.

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July 2013

Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.

J Am Chem Soc 2013 May 16;135(21):7827-30. Epub 2013 May 16.

The Skaggs Institute for Chemical Biology and Department of Chemistry and the Worm Institute for Research and Medicine (WIRM), the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA.

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May 2013

Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter.

Neuropsychopharmacology 2013 Oct 10;38(11):2170-8. Epub 2013 May 10.

1] Division of Nuclear Medicine and Molecular Imaging, Weill Cornell Medical College, New York, NY, USA [2] Citigroup Biomedical Imaging Center, Department of Radiology, Weill Cornell Medical College, New York, NY, USA.

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October 2013

Dynamic vaccine blocks relapse to compulsive intake of heroin.

Proc Natl Acad Sci U S A 2013 May 6;110(22):9036-41. Epub 2013 May 6.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.

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May 2013

Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design.

J Med Chem 2013 May 29;56(9):3701-9. Epub 2013 Apr 29.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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May 2013

Liposomes containing monophosphoryl lipid A: a potent adjuvant system for inducing antibodies to heroin hapten analogs.

Vaccine 2013 Jun 23;31(26):2804-10. Epub 2013 Apr 23.

Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.

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June 2013

The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.

ACS Med Chem Lett 2013 Feb 23;4(2):283-287. Epub 2012 Dec 23.

Departments of Chemistry and Immunology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA, 92037, USA.

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February 2013

Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.

ACS Chem Biol 2013 21;8(6):1117-20. Epub 2013 Mar 21.

Department of Immunology and Microbial Sciences and ‡Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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August 2014