Kieran Clarke

Kieran Clarke

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Kieran Clarke

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Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology.

Authors:
Christoph Maack Michael Lehrke Johannes Backs Frank R Heinzel Jean-Sebastien Hulot Nikolaus Marx Walter J Paulus Patrick Rossignol Heinrich Taegtmeyer Johann Bauersachs Antoni Bayes-Genis Dirk Brutsaert Heiko Bugger Kieran Clarke Francesco Cosentino Gilles De Keulenaer Alessandra Dei Cas Arantxa González Martin Huelsmann Guido Iaccarino Ida Gjervold Lunde Alexander R Lyon Piero Pollesello Graham Rena Niels P Riksen Giuseppe Rosano Bart Staels Linda W van Laake Christoph Wanner Dimitrios Farmakis Gerasimos Filippatos Frank Ruschitzka Petar Seferovic Rudolf A de Boer Stephane Heymans

Eur Heart J 2018 Dec;39(48):4243-4254

Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.

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https://academic.oup.com/eurheartj/advance-article/doi/10.10
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http://dx.doi.org/10.1093/eurheartj/ehy596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302261PMC
December 2018

Data on triiodothyronine treated peroxisome proliferator-activated receptor-alpha-null mouse hearts using magnetic resonance imaging and magnetic resonance spectroscopy.

Authors:
Wen Zhang Michiel Ten Hove Jürgen E Schneider Kieran Clarke

Data Brief 2018 Oct 8;20:250-253. Epub 2018 Aug 8.

Department of Physiology, Anatomy and Genetics University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.dib.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104556PMC
October 2018

Data on uncoupling protein-3 levels, hypoxia, low flow ischemia, and insulin stimulation in dystrophin-deficient mouse hearts.

Authors:
Wen Zhang A Elizabeth Sang Michiel Ten Hove Stefan Neubauer Kieran Clarke

Data Brief 2018 Oct 8;20:277-280. Epub 2018 Aug 8.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S23523409183086
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http://dx.doi.org/10.1016/j.dib.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106704PMC
October 2018

Prior ingestion of exogenous ketone monoester attenuates the glycaemic response to an oral glucose tolerance test in healthy young individuals.

Authors:
Étienne Myette-Côté Helena Neudorf Hossein Rafiei Kieran Clarke Jonathan Peter Little

J Physiol 2018 Apr 2;596(8):1385-1395. Epub 2018 Mar 2.

School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.

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http://dx.doi.org/10.1113/JP275709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899975PMC
April 2018

A Ketone Ester Drink Lowers Human Ghrelin and Appetite.

Authors:
Brianna J Stubbs Pete J Cox Rhys D Evans Malgorzata Cyranka Kieran Clarke Heidi de Wet

Obesity (Silver Spring) 2018 02 6;26(2):269-273. Epub 2017 Nov 6.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1002/oby.22051
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http://dx.doi.org/10.1002/oby.22051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813183PMC
February 2018

The Importance of Calcium Ions for Determining Mitochondrial Glycerol-3-Phosphate Dehydrogenase Activity When Measuring Uncoupling Protein 1 (UCP1) Function in Mitochondria Isolated from Brown Adipose Tissue.

Authors:
Kieran J Clarke Richard K Porter

Methods Mol Biol 2018 ;1782:325-336

Trinity Biomedical Science Institute (TBSI), School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/978-1-4939-7831-1_19DOI Listing
January 2018

Weighted averaging in spectroscopic studies improves statistical power.

Authors:
Jack J Miller Lowri Cochlin Kieran Clarke Damian J Tyler

Magn Reson Med 2017 Dec 26;78(6):2082-2094. Epub 2017 Jan 26.

Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/mrm.26615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697704PMC
December 2017

Correction to: Adenosine stress CMR T1-mapping detects early microvascular dysfunction in patients with type 2 diabetes mellitus without obstructive coronary artery disease.

Authors:
Eylem Levelt Stefan K Piechnik Alexander Liu Rohan S Wijesurendra Masliza Mahmod Rina Ariga Jane M Francis Andreas Greiser Kieran Clarke Stefan Neubauer Vanessa M Ferreira Theodoros D Karamitsos

J Cardiovasc Magn Reson 2017 12 7;19(1):99. Epub 2017 Dec 7.

University of Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s12968-017-0406-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719930PMC
December 2017

Adenosine stress CMR T1-mapping detects early microvascular dysfunction in patients with type 2 diabetes mellitus without obstructive coronary artery disease.

Authors:
Eylem Levelt Stefan K Piechnik Alexander Liu Rohan S Wijesurendra Masliza Mahmod Rina Ariga Jane M Francis Andreas Greiser Kieran Clarke Stefan Neubauer Vanessa M Ferreira Theodoros D Karamitsos

J Cardiovasc Magn Reson 2017 Oct 25;19(1):81. Epub 2017 Oct 25.

University of Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s12968-017-0397-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655826PMC
October 2017

On the Metabolism of Exogenous Ketones in Humans.

Authors:
Brianna J Stubbs Pete J Cox Rhys D Evans Peter Santer Jack J Miller Olivia K Faull Snapper Magor-Elliott Satoshi Hiyama Matthew Stirling Kieran Clarke

Front Physiol 2017 30;8:848. Epub 2017 Oct 30.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://journal.frontiersin.org/article/10.3389/fphys.2017.00
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http://dx.doi.org/10.3389/fphys.2017.00848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670148PMC
October 2017

A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans.

Authors:
David A Holdsworth Peter J Cox Tom Kirk Huw Stradling Samuel G Impey Kieran Clarke

Med Sci Sports Exerc 2017 09;49(9):1789-1795

1Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UNITED KINGDOM; and 2Research Institute for Sport and Exercise Sciences, Liverpool John Moore's University, Liverpool, UNITED KINGDOM.

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http://dx.doi.org/10.1249/MSS.0000000000001292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556006PMC
September 2017

Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species.

Authors:
Mary Board Colleen Lopez Christian van den Bos Richard Callaghan Kieran Clarke Carolyn Carr

Int J Biochem Cell Biol 2017 07 5;88:75-83. Epub 2017 May 5.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3 PG, United Kingdom.

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http://dx.doi.org/10.1016/j.biocel.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497396PMC
July 2017

Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation.

Authors:
Latt S Mansor Maria da Luz Sousa Fialho Georgina Yea Will A Coumans James A West Matthew Kerr Carolyn A Carr Joost J F P Luiken Jan F C Glatz Rhys D Evans Julian L Griffin Damian J Tyler Kieran Clarke Lisa C Heather

Cardiovasc Res 2017 Jun;113(7):737-748

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1093/cvr/cvx045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437367PMC
June 2017

Ketone bodies mimic the life span extending properties of caloric restriction.

Authors:
Richard L Veech Patrick C Bradshaw Kieran Clarke William Curtis Robert Pawlosky M Todd King

IUBMB Life 2017 05 3;69(5):305-314. Epub 2017 Apr 3.

Lab of Metabolic Control, NIH/NIAAA, Rockville, MD, USA.

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http://dx.doi.org/10.1002/iub.1627DOI Listing
May 2017

Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle.

Authors:
Tijs Vandoorne Stefan De Smet Monique Ramaekers Ruud Van Thienen Katrien De Bock Kieran Clarke Peter Hespel

Front Physiol 2017 23;8:310. Epub 2017 May 23.

Exercise Physiology Research Group, Department of Kinesiology, KU LeuvenLeuven, Belgium.

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http://dx.doi.org/10.3389/fphys.2017.00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440563PMC
May 2017

Metabolic Remodeling in Diabetic Cardiomyopathy.

Authors:
Cher-Rin Chong Kieran Clarke Eylem Levelt

Cardiovasc Res 2017 02 8. Epub 2017 Feb 8.

2 Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital.

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http://dx.doi.org/10.1093/cvr/cvx018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412022PMC
February 2017

Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus.

Authors:
Eylem Levelt Christopher T Rodgers William T Clarke Masliza Mahmod Rina Ariga Jane M Francis Alexander Liu Rohan S Wijesurendra Saira Dass Nikant Sabharwal Matthew D Robson Cameron J Holloway Oliver J Rider Kieran Clarke Theodoros D Karamitsos Stefan Neubauer

Eur Heart J 2016 12 20;37(46):3461-3469. Epub 2015 Sep 20.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK

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http://eurheartj.oxfordjournals.org/content/ehj/early/2015/0
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http://eurheartj.oxfordjournals.org/lookup/doi/10.1093/eurhe
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http://dx.doi.org/10.1093/eurheartj/ehv442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201143PMC
December 2016

Novel ketone diet enhances physical and cognitive performance.

Authors:
Andrew J Murray Nicholas S Knight Mark A Cole Lowri E Cochlin Emma Carter Kirill Tchabanenko Tica Pichulik Melanie K Gulston Helen J Atherton Marie A Schroeder Robert M J Deacon Yoshihiro Kashiwaya M Todd King Robert Pawlosky J Nicholas P Rawlins Damian J Tyler Julian L Griffin Jeremy Robertson Richard L Veech Kieran Clarke

FASEB J 2016 12 15;30(12):4021-4032. Epub 2016 Aug 15.

Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1096/fj.201600773RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102124PMC
December 2016

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.

Authors:
Samira Lakhal-Littleton Magda Wolna Yu Jin Chung Helen C Christian Lisa C Heather Marcella Brescia Vicky Ball Rebeca Diaz Ana Santos Daniel Biggs Kieran Clarke Benjamin Davies Peter A Robbins

Elife 2016 11 29;5. Epub 2016 Nov 29.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.19804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176354PMC
November 2016

Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism.

Authors:
Suat Cheng Tan Renata S M Gomes Kar Kheng Yeoh Filippo Perbellini Sophia Malandraki-Miller Lucy Ambrose Lisa C Heather Giuseppe Faggian Christopher J Schofield Kay E Davies Kieran Clarke Carolyn A Carr

Cell Transplant 2016 6;25(1):35-53. Epub 2015 Mar 6.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.3727/096368915X687697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042641PMC
October 2016

The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.

Authors:
Mary Slingo Mark Cole Carolyn Carr Mary K Curtis Michael Dodd Lucia Giles Lisa C Heather Damian Tyler Kieran Clarke Peter A Robbins

Am J Physiol Heart Circ Physiol 2016 09 15;311(3):H759-67. Epub 2016 Jul 15.

Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

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http://dx.doi.org/10.1152/ajpheart.00912.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142182PMC
September 2016

On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

Authors:
Mark A Cole Amira H Abd Jamil Lisa C Heather Andrew J Murray Elizabeth R Sutton Mary Slingo Liam Sebag-Montefiore Suat Cheng Tan Dunja Aksentijević Ottilie S Gildea Daniel J Stuckey Kar Kheng Yeoh Carolyn A Carr Rhys D Evans Ellen Aasum Christopher J Schofield Peter J Ratcliffe Stefan Neubauer Peter A Robbins Kieran Clarke

FASEB J 2016 08 21;30(8):2684-97. Epub 2016 Apr 21.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;

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http://dx.doi.org/10.1096/fj.201500094RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072355PMC
August 2016

Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes.

Authors:
Pete J Cox Tom Kirk Tom Ashmore Kristof Willerton Rhys Evans Alan Smith Andrew J Murray Brianna Stubbs James West Stewart W McLure M Todd King Michael S Dodd Cameron Holloway Stefan Neubauer Scott Drawer Richard L Veech Julian L Griffin Kieran Clarke

Cell Metab 2016 08 27;24(2):256-68. Epub 2016 Jul 27.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1016/j.cmet.2016.07.010DOI Listing
August 2016

Ectopic and Visceral Fat Deposition in Lean and Obese Patients With Type 2 Diabetes.

Authors:
Eylem Levelt Michael Pavlides Rajarshi Banerjee Masliza Mahmod Catherine Kelly Joanna Sellwood Rina Ariga Sheena Thomas Jane Francis Christopher Rodgers William Clarke Nikant Sabharwal Charalambos Antoniades Jurgen Schneider Matthew Robson Kieran Clarke Theodoros Karamitsos Oliver Rider Stefan Neubauer

J Am Coll Cardiol 2016 07;68(1):53-63

University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, Oxford, United Kingdom; Perspectum Diagnostics Ltd., Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.03.597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925621PMC
July 2016

The Population Pharmacokinetics of D-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate.

Authors:
Vittal Shivva Pete J Cox Kieran Clarke Richard L Veech Ian G Tucker Stephen B Duffull

AAPS J 2016 05 18;18(3):678-88. Epub 2016 Feb 18.

School of Pharmacy, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand.

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http://dx.doi.org/10.1208/s12248-016-9879-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256599PMC
May 2016

HIV-1-Related Cardiovascular Disease Is Associated With Chronic Inflammation, Frequent Pericardial Effusions, and Probable Myocardial Edema.

Authors:
Ntobeko Ntusi Eoin O'Dwyer Lucy Dorrell Emma Wainwright Stefan Piechnik Genevieve Clutton Gemma Hancock Vanessa Ferreira Pete Cox Motasim Badri Theodoros Karamitsos Sam Emmanuel Kieran Clarke Stefan Neubauer Cameron Holloway

Circ Cardiovasc Imaging 2016 Mar;9(3):e004430

From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom (N.N., S.P., V.F., T.K., S.N., C.H.); Division of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa (N.N., M.B.); Department of Cardiology, St.Vincent's Hospital, Darlinghurst, New South Wales, Australia (E.O., S.E., C.H.); Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia (E.O., S.E., C.H.); Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom (L.D., E.W., G.C., G.H.); Department of Physiology, Anatomy and Genetics (P.C., K.C., C.H.) and Oxford NIHR Biomedical Research Centre (S.N., C.H.), University of Oxford, Oxford, United Kingdom; and 1st Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece (T.K.).

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http://dx.doi.org/10.1161/CIRCIMAGING.115.004430DOI Listing
March 2016

Relationship Between Left Ventricular Structural and Metabolic Remodeling in Type 2 Diabetes.

Authors:
Eylem Levelt Masliza Mahmod Stefan K Piechnik Rina Ariga Jane M Francis Christopher T Rodgers William T Clarke Nikant Sabharwal Jurgen E Schneider Theodoros D Karamitsos Kieran Clarke Oliver J Rider Stefan Neubauer

Diabetes 2016 Jan 5;65(1):44-52. Epub 2015 Oct 5.

Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/db15-0627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890658PMC
January 2016

Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation.

Authors:
Latt S Mansor Keshavi Mehta Dunja Aksentijevic Carolyn A Carr Trine Lund Mark A Cole Lydia Le Page Maria da Luz Sousa Fialho Michael J Shattock Ellen Aasum Kieran Clarke Damian J Tyler Lisa C Heather

J Physiol 2016 Jan 20;594(2):307-20. Epub 2015 Dec 20.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1113/JP271242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713751PMC
January 2016

An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans.

Authors:
Martin F Kemper Shireesh Srivastava M Todd King Kieran Clarke Richard L Veech Robert J Pawlosky

Lipids 2015 Dec 26;50(12):1185-93. Epub 2015 Oct 26.

Laboratory of Metabolic Control, National Institute of Alcohol Abuse and Alcoholism, 5625 Fishers Ln 1S22, Rockville, MD, 20852, USA.

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http://dx.doi.org/10.1007/s11745-015-4085-xDOI Listing
December 2015

Chronic High-Fat Feeding Affects the Mesenchymal Cell Population Expanded From Adipose Tissue but Not Cardiac Atria.

Authors:
Filippo Perbellini Renata S M Gomes Silvia Vieira Dougal Buchanan Sophia Malandraki-Miller Arne A N Bruyneel Maria da Luz Sousa Fialho Vicky Ball Kieran Clarke Giuseppe Faggian Carolyn A Carr

Stem Cells Transl Med 2015 Dec 30;4(12):1403-14. Epub 2015 Oct 30.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.5966/sctm.2015-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675502PMC
December 2015

Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism.

Authors:
Tom Ashmore Lee D Roberts Andrea J Morash Aleksandra O Kotwica John Finnerty James A West Steven A Murfitt Bernadette O Fernandez Cristina Branco Andrew S Cowburn Kieran Clarke Randall S Johnson Martin Feelisch Julian L Griffin Andrew J Murray

BMC Biol 2015 Dec 22;13:110. Epub 2015 Dec 22.

Department of Physiology, Development & Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

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http://dx.doi.org/10.1186/s12915-015-0221-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688964PMC
December 2015

No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure.

Authors:
Sairia Dass Cameron J Holloway Lowri E Cochlin Oliver J Rider Masliza Mahmod Matthew Robson Emily Sever Kieran Clarke Hugh Watkins Houman Ashrafian Theodoros D Karamitsos Stefan Neubauer

Circ Heart Fail 2015 Nov 2;8(6):1088-93. Epub 2015 Sep 2.

From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine (S.D., O.J.R., M.M., M.R., E.S., H.W., H.A., T.D.K., S.N.) and Department of Physiology, Anatomy, and Genetics (C.J.H., L.E.C., K.C.), Oxford University, Oxford, United Kingdom.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.002169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645953PMC
November 2015

Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study.

Authors:
Lydia M Le Page Oliver J Rider Andrew J Lewis Vicky Ball Kieran Clarke Edvin Johansson Carolyn A Carr Lisa C Heather Damian J Tyler

Diabetes 2015 Aug 20;64(8):2735-43. Epub 2015 Mar 20.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K.

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http://diabetes.diabetesjournals.org/content/early/2015/03/1
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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-1560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516266PMC
August 2015

Detection of UCP1 protein and measurements of dependent GDP-sensitive proton leak in non-phosphorylating thymus mitochondria.

Authors:
Kieran J Clarke Audrey M Carroll Gemma O'Brien Richard K Porter

Methods Mol Biol 2015 ;1241:123-35

School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.

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http://link.springer.com/10.1007/978-1-4939-1875-1_11
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http://dx.doi.org/10.1007/978-1-4939-1875-1_11DOI Listing
June 2015

Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction.

Authors:
Sairia Dass Lowri E Cochlin Joseph J Suttie Cameron J Holloway Oliver J Rider Leah Carden Damian J Tyler Theodoros D Karamitsos Kieran Clarke Stefan Neubauer Hugh Watkins

Eur Heart J 2015 Jun 18;36(24):1547-54. Epub 2015 May 18.

Division of Cardiovascular Medicine, Anatomy and Genetics, Oxford University, Oxford, UK

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehv120DOI Listing
June 2015

Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy.

Authors:
Corinne A Betts Amer F Saleh Carolyn A Carr Sofia Muses Kim E Wells Suzan M Hammond Caroline Godfrey Graham McClorey Caroline Woffindale Kieran Clarke Dominic J Wells Michael J Gait Matthew J A Wood

Sci Rep 2015 Jun 26;5:11632. Epub 2015 Jun 26.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK, OX1 3QX.

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http://dx.doi.org/10.1038/srep11632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586900PMC
June 2015

In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy.

Authors:
Anne-Marie L Seymour Lucia Giles Vicky Ball Jack J Miller Kieran Clarke Carolyn A Carr Damian J Tyler

Cardiovasc Res 2015 May 5;106(2):249-60. Epub 2015 Mar 5.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK

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http://dx.doi.org/10.1093/cvr/cvv101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400188PMC
May 2015

iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.

Authors:
Mario Notari Ying Hu Gopinath Sutendra Zinaida Dedeić Min Lu Laurent Dupays Arash Yavari Carolyn A Carr Shan Zhong Aaisha Opel Andrew Tinker Kieran Clarke Hugh Watkins David J P Ferguson David P Kelsell Sofia de Noronha Mary N Sheppard Mike Hollinshead Timothy J Mohun Xin Lu

Proc Natl Acad Sci U S A 2015 Mar 17;112(9):E973-81. Epub 2015 Feb 17.

Ludwig Institute for Cancer Research Ltd., Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1408111112
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352828PMC
March 2015

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.

Authors:
Samira Lakhal-Littleton Magda Wolna Carolyn A Carr Jack J J Miller Helen C Christian Vicky Ball Ana Santos Rebeca Diaz Daniel Biggs Richard Stillion Philip Holdship Fiona Larner Damian J Tyler Kieran Clarke Benjamin Davies Peter A Robbins

Proc Natl Acad Sci U S A 2015 Mar 23;112(10):3164-9. Epub 2015 Feb 23.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1422373112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364209PMC
March 2015

Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice.

Authors:
Corinne A Betts Amer F Saleh Carolyn A Carr Suzan M Hammond Anna M L Coenen-Stass Caroline Godfrey Graham McClorey Miguel A Varela Thomas C Roberts Kieran Clarke Michael J Gait Matthew J A Wood

Sci Rep 2015 Mar 11;5:8986. Epub 2015 Mar 11.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK, OX1 3QX.

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http://dx.doi.org/10.1038/srep08986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355666PMC
March 2015

Oral Coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to everest base cAMP.

Authors:
Cameron J Holloway Andrew J Murray Kay Mitchell Daniel S Martin Andrew W Johnson Lowri E Cochlin Ion Codreanu Sundeep Dhillon George W Rodway Tom Ashmore Denny Z H Levett Stefan Neubauer Hugh E Montgomery Michael P W Grocott Kieran Clarke

High Alt Med Biol 2014 Dec;15(4):459-67

1 Department of Physiology, Anatomy and Genetics, University of Oxford , United Kingdom .

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http://www.liebertpub.com/doi/10.1089/ham.2013.1053
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273181PMC
December 2014

Varying degrees of ventricular unloading in the heterotopic rat heart transplant model demonstrated by magnetic resonance imaging.

Authors:
Carolyn A Carr Daniel Ball Damian J Tyler Andrew Bushell Amelia Sykes Kieran Clarke Rhys D Evans

Int J Biomed Sci 2014 Dec;10(4):223-8

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, South Parks Road, Oxford OX1 3PT, U.K.;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289694PMC
December 2014

Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulation.

Authors:
Lucy J A Ambrose Amira H Abd-Jamil Renata S M Gomes Emma E Carter Carolyn A Carr Kieran Clarke Lisa C Heather

J Cardiovasc Pharmacol Ther 2014 Nov 7;19(6):574-85. Epub 2014 Mar 7.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, England, United Kingdom

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http://dx.doi.org/10.1177/1074248414524480DOI Listing
November 2014

Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.

Authors:
Michael S Dodd Helen J Atherton Carolyn A Carr Daniel J Stuckey James A West Julian L Griffin George K Radda Kieran Clarke Lisa C Heather Damian J Tyler

Circ Cardiovasc Imaging 2014 Nov 8;7(6):895-904. Epub 2014 Sep 8.

Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom (M.S.D., H.J.A., C.A.C., G.K.R., K.C., L.C.H., D.J.T.); Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom (D.J.S.); and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom (J.A.W., J.L.G.).

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http://circimaging.ahajournals.org/cgi/doi/10.1161/CIRCIMAGI
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http://dx.doi.org/10.1161/CIRCIMAGING.114.001857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450075PMC
November 2014

Acute nutritional ketosis: implications for exercise performance and metabolism.

Authors:
Pete J Cox Kieran Clarke

Extrem Physiol Med 2014 29;3:17. Epub 2014 Oct 29.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1186/2046-7648-3-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212585PMC
November 2014

HIV is an independent predictor of aortic stiffness.

Authors:
Oliver J Rider Mina Asaad Ntobeko Ntusi Emma Wainwright Genevieve Clutton Gemma Hancock Rajarshi Banerjee Alex Pitcher Katherine Samaras Kieran Clarke Stefan Neubauer Lucy Dorrell Cameron J Holloway

J Cardiovasc Magn Reson 2014 Aug 16;16:57. Epub 2014 Aug 16.

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/s12968-014-0057-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422254PMC
August 2014

Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart.

Authors:
Daniel R Ball Ben Rowlands Michael S Dodd Lydia Le Page Vicky Ball Carolyn A Carr Kieran Clarke Damian J Tyler

Magn Reson Med 2014 May 24;71(5):1663-9. Epub 2013 Jun 24.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/mrm.24849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238803PMC
May 2014

Murine cardiosphere-derived cells are impaired by age but not by cardiac dystrophic dysfunction.

Authors:
Lien-Cheng Hsiao Filippo Perbellini Renata S M Gomes Jun Jie Tan Silvia Vieira Giuseppe Faggian Kieran Clarke Carolyn A Carr

Stem Cells Dev 2014 May 31;23(9):1027-36. Epub 2014 Jan 31.

1 Cardiac Metabolism Research Group, Department of Physiology, Anatomy, and Genetics, University of Oxford , Oxford, United Kingdom .

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http://dx.doi.org/10.1089/scd.2013.0388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996995PMC
May 2014

Effect of isoproterenol on myocardial perfusion, function, energy metabolism and nitric oxide pathway in the rat heart - a longitudinal MR study.

Authors:
Martine Desrois Frank Kober Carole Lan Christiane Dalmasso Mark Cole Kieran Clarke Patrick J Cozzone Monique Bernard

NMR Biomed 2014 May 20;27(5):529-38. Epub 2014 Feb 20.

Aix-Marseille Université UMR CNRS n°7339, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), Faculté de Médecine, Marseille, France.

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http://doi.wiley.com/10.1002/nbm.3088
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May 2014

Normal values of regional and global myocardial wall motion in young and elderly individuals using navigator gated tissue phase mapping.

Authors:
Ion Codreanu Tammy J Pegg Joseph B Selvanayagam Matthew D Robson Oliver J Rider Constantin A Dasanu Bernd A Jung David P Taggart Stephen J Golding Kieran Clarke Cameron J Holloway

Age (Dordr) 2014 Feb 21;36(1):231-41. Epub 2013 Apr 21.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK,

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http://dx.doi.org/10.1007/s11357-013-9535-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889897PMC
February 2014

Stem cell-based therapy for ischemic heart disease.

Authors:
Lien-Cheng Hsiao Carolyn Carr Kuan-Cheng Chang Shinn-Zong Lin Kieran Clarke

Cell Transplant 2013 4;22(4):663-75. Epub 2012 Oct 4.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.3727/096368912X655109DOI Listing
January 2014

Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate.

Authors:
Daniel R Ball Rachel Cruickshank Carolyn A Carr Daniel J Stuckey Philip Lee Kieran Clarke Damian J Tyler

NMR Biomed 2013 Nov 14;26(11):1441-50. Epub 2013 Jun 14.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/nbm.2972DOI Listing
November 2013

Concentric left ventricular remodeling and aortic stiffness: a comparison of obesity and hypertension.

Authors:
Oliver J Rider Richard Nethononda Steffen E Petersen Jane M Francis James P Byrne Paul Leeson Kieran Clarke Stefan Neubauer

Int J Cardiol 2013 Sep 2;167(6):2989-94. Epub 2012 Oct 2.

Department of Cardiovascular Medicine, University of Oxford, UK.

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http://dx.doi.org/10.1016/j.ijcard.2012.08.049DOI Listing
September 2013

Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion.

Authors:
Lisa C Heather Katharine M Pates Helen J Atherton Mark A Cole Daniel R Ball Rhys D Evans Jan F Glatz Joost J Luiken Julian L Griffin Kieran Clarke

Circ Heart Fail 2013 Sep 12;6(5):1058-66. Epub 2013 Aug 12.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy, and Genetics, University of Oxford, UK.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.000342DOI Listing
September 2013

Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin.

Authors:
Latt S Mansor Eileen R Gonzalez Mark A Cole Damian J Tyler Jessica H Beeson Kieran Clarke Carolyn A Carr Lisa C Heather

Cardiovasc Diabetol 2013 Sep 24;12:136. Epub 2013 Sep 24.

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, Oxford, UK.

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http://dx.doi.org/10.1186/1475-2840-12-136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849358PMC
September 2013

Comprehensive cardiac magnetic resonance imaging and spectroscopy reveal a high burden of myocardial disease in HIV patients.

Authors:
Cameron J Holloway Ntobeko Ntusi Joseph Suttie Masliza Mahmod Emma Wainwright Genevieve Clutton Gemma Hancock Philip Beak Abdelouahid Tajar Stefan K Piechnik Jurgen E Schneider Brian Angus Kieran Clarke Lucy Dorrell Stefan Neubauer

Circulation 2013 Aug 1;128(8):814-22. Epub 2013 Jul 1.

Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.001719DOI Listing
August 2013

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.

Authors:
Yoshihiro Kashiwaya Christian Bergman Jong-Hwan Lee Ruiqian Wan M Todd King Mohamed R Mughal Eitan Okun Kieran Clarke Mark P Mattson Richard L Veech

Neurobiol Aging 2013 Jun 29;34(6):1530-9. Epub 2012 Dec 29.

Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619192PMC
June 2013

Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial.

Authors:
Renata S M Gomes Ricardo Pires das Neves Lowri Cochlin Ana Lima Rui Carvalho Petra Korpisalo Galina Dragneva Mikko Turunen Timmo Liimatainen Kieran Clarke Seppo Ylä-Herttuala Carolyn Carr Lino Ferreira

ACS Nano 2013 Apr 8;7(4):3362-72. Epub 2013 Mar 8.

CNC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.

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http://dx.doi.org/10.1021/nn400171wDOI Listing
April 2013

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.

Authors:
Craig A Lygate Dunja Aksentijevic Dana Dawson Michiel ten Hove Darci Phillips Joseph P de Bono Debra J Medway Liam Sebag-Montefiore Imre Hunyor Keith M Channon Kieran Clarke Sevasti Zervou Hugh Watkins Robert S Balaban Stefan Neubauer

Circ Res 2013 Mar 16;112(6):945-55. Epub 2013 Jan 16.

Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.300725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182017PMC
March 2013

Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics.

Authors:
Marie A Schroeder Mohammad A Ali Alzbeta Hulikova Claudiu T Supuran Kieran Clarke Richard D Vaughan-Jones Damian J Tyler Pawel Swietach

Proc Natl Acad Sci U S A 2013 Mar 19;110(10):E958-67. Epub 2013 Feb 19.

Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1213471110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593844PMC
March 2013

Cerebral venous system and anatomical predisposition to high-altitude headache.

Authors:
Mark H Wilson Indran Davagnanam Graeme Holland Raj S Dattani Alexander Tamm Shashivadan P Hirani Nicky Kolfschoten Lisa Strycharczuk Cathy Green John S Thornton Alex Wright Mark Edsell Neil D Kitchen David J Sharp Timothy E Ham Andrew Murray Cameron J Holloway Kieran Clarke Mike P W Grocott Hugh Montgomery Chris Imray

Ann Neurol 2013 Mar 26;73(3):381-9. Epub 2013 Feb 26.

The Traumatic Brain Injury Centre, St Mary's Hospital, Imperial College, London, W1 2NY United Kingdom.

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http://dx.doi.org/10.1002/ana.23796DOI Listing
March 2013

Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance.

Authors:
Yaso Emmanuel Lowri E Cochlin Damian J Tyler Celeste A de Jager A David Smith Kieran Clarke

Brain Behav 2013 Mar 15;3(2):134-44. Epub 2013 Feb 15.

Cardiac Metabolism Research Group Department of Physiology, Anatomy and Genetics, University of Oxford Oxford, United Kingdom ; Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford Oxford, United Kingdom ; Oxford Project to Investigate Memory and Ageing (OPTIMA) Nuffield Department of Medicine, University of Oxford Oxford, United Kingdom.

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http://dx.doi.org/10.1002/brb3.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607154PMC
March 2013

Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths.

Authors:
Eamon P Breen Wayne Pilgrim Kieran J Clarke Cristy Yssel Mark Farrell Jian Zhou Paul V Murphy Richard K Porter

J Chem Biol 2013 Mar 27;6(3):121-33. Epub 2013 Mar 27.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.

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http://dx.doi.org/10.1007/s12154-013-0093-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691397PMC
March 2013

Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.

Authors:
Marie A Schroeder Angus Z Lau Albert P Chen Yiping Gu Jeevan Nagendran Jennifer Barry Xudong Hu Jason R B Dyck Damian J Tyler Kieran Clarke Kim A Connelly Graham A Wright Charles H Cunningham

Eur J Heart Fail 2013 Feb 19;15(2):130-40. Epub 2012 Dec 19.

Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room M326A, Toronto, Ontario M4N 3M5, Canada.

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http://dx.doi.org/10.1093/eurjhf/hfs192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547367PMC
February 2013

In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.

Authors:
Michael S Dodd Vicky Ball Rosalind Bray Houman Ashrafian Hugh Watkins Kieran Clarke Damian J Tyler

J Cardiovasc Magn Reson 2013 Feb 18;15:19. Epub 2013 Feb 18.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/1532-429X-15-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599631PMC
February 2013

Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria.

Authors:
Kieran J Clarke Richard K Porter

Int J Biochem Cell Biol 2013 Jan 2;45(1):81-9. Epub 2012 Oct 2.

School of Biochemistry and Immunology, Trinity Institute of Biomedical Science, Trinity College Dublin, Ireland.

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http://dx.doi.org/10.1016/j.biocel.2012.09.023DOI Listing
January 2013

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.

Authors:
Craig A Lygate Steffen Bohl Michiel ten Hove Kiterie M E Faller Philip J Ostrowski Sevasti Zervou Debra J Medway Dunja Aksentijevic Liam Sebag-Montefiore Julie Wallis Kieran Clarke Hugh Watkins Jürgen E Schneider Stefan Neubauer

Cardiovasc Res 2012 Dec 21;96(3):466-75. Epub 2012 Aug 21.

Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/cvr/cvs272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500046PMC
December 2012

The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men.

Authors:
Lindsay M Edwards Damian J Tyler Graham J Kemp Renee M Dwyer Andrew Johnson Cameron J Holloway Alan M Nevill Kieran Clarke

PLoS One 2012 11;7(6):e37237. Epub 2012 Jun 11.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037237PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372482PMC
November 2012

A role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial uncoupling protein 1 (UCP1).

Authors:
Kieran J Clarke Alison E Adams Lars H Manzke Terry W Pearson Christoph H Borchers Richard K Porter

Biochim Biophys Acta 2012 Oct 16;1817(10):1759-67. Epub 2012 Apr 16.

School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.

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https://linkinghub.elsevier.com/retrieve/pii/S00052728120011
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http://dx.doi.org/10.1016/j.bbabio.2012.03.035DOI Listing
October 2012

Human cardiosphere-derived cells from patients with chronic ischaemic heart disease can be routinely expanded from atrial but not epicardial ventricular biopsies.

Authors:
Helen H L Chan Zaal Meher Homji Renata S M Gomes Dominic Sweeney George N Thomas Jun Jie Tan Huajun Zhang Filippo Perbellini Daniel J Stuckey Suzanne M Watt David Taggart Kieran Clarke Enca Martin-Rendon Carolyn A Carr

J Cardiovasc Transl Res 2012 Oct 3;5(5):678-87. Epub 2012 Jul 3.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, UK.

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http://dx.doi.org/10.1007/s12265-012-9389-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447135PMC
October 2012

MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas.

Authors:
Gerard V Walls Manuel C Lemos Mahsa Javid Miriam Bazan-Peregrino Jeshmi Jeyabalan Anita A C Reed Brian Harding Damian J Tyler Daniel J Stuckey Sian Piret Paul T Christie Olaf Ansorge Kieran Clarke Len Seymour Rajesh V Thakker

Cancer Res 2012 Oct 21;72(19):5060-8. Epub 2012 Aug 21.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463502PMC
October 2012

Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects.

Authors:
Kieran Clarke Kirill Tchabanenko Robert Pawlosky Emma Carter M Todd King Kathy Musa-Veloso Manki Ho Ashley Roberts Jeremy Robertson Theodore B Vanitallie Richard L Veech

Regul Toxicol Pharmacol 2012 Aug 3;63(3):401-8. Epub 2012 May 3.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S027323001200080
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http://dx.doi.org/10.1016/j.yrtph.2012.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810007PMC
August 2012

Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate.

Authors:
Kieran Clarke Kirill Tchabanenko Robert Pawlosky Emma Carter Nicholas S Knight Andrew J Murray Lowri E Cochlin M Todd King Andrea W Wong Ashley Roberts Jeremy Robertson Richard L Veech

Regul Toxicol Pharmacol 2012 Jul 11;63(2):196-208. Epub 2012 Apr 11.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.yrtph.2012.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809901PMC
July 2012

In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.

Authors:
Michael S Dodd Daniel R Ball Marie A Schroeder Lydia M Le Page Helen J Atherton Lisa C Heather Anne-Marie Seymour Houman Ashrafian Hugh Watkins Kieran Clarke Damian J Tyler

Cardiovasc Res 2012 Jul 16;95(1):69-76. Epub 2012 May 16.

Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK.

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http://dx.doi.org/10.1093/cvr/cvs164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617603PMC
July 2012

Exercise training in dilated cardiomyopathy improves rest and stress cardiac function without changes in cardiac high energy phosphate metabolism.

Authors:
Cameron J Holloway Sairia Dass Joseph J Suttie Oliver J Rider Pete Cox Lowri E Cochlin Hamish Jackson Angela M Fast Andrew W Johnson Theodoros D Karamitsos Stefan Neubauer Kieran Clarke

Heart 2012 Jul;98(14):1083-90

Department of Physiology, Anatomy and Genetics, The University of Oxford, Parks Road, Sherrington Building, Oxford OX1 3PT, UK.

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July 2012

Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet.

Authors:
Shireesh Srivastava Yoshihiro Kashiwaya M Todd King Ulrich Baxa Joseph Tam Gang Niu Xiaoyuan Chen Kieran Clarke Richard L Veech

FASEB J 2012 Jun 23;26(6):2351-62. Epub 2012 Feb 23.

Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA.

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http://dx.doi.org/10.1096/fj.11-200410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360149PMC
June 2012

In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy.

Authors:
Daniel J Stuckey Carolyn A Carr Patrizia Camelliti Damian J Tyler Kay E Davies Kieran Clarke

PLoS One 2012 3;7(1):e28569. Epub 2012 Jan 3.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250389PMC
May 2012

Increasing plasma free fatty acids in healthy subjects induces aortic distensibility changes seen in obesity.

Authors:
Oliver J Rider Cameron J Holloway Yaso Emmanuel Edward Bloch Kieran Clarke Stefan Neubauer

Circ Cardiovasc Imaging 2012 May 5;5(3):367-75. Epub 2012 Apr 5.

University of Oxford Centre for Clinical Magnetic Resonance Research and the Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.111.9718
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May 2012

Metabolic adaptation to chronic hypoxia in cardiac mitochondria.

Authors:
Lisa C Heather Mark A Cole Jun-Jie Tan Lucy J A Ambrose Simon Pope Amira H Abd-Jamil Emma E Carter Michael S Dodd Kar Kheng Yeoh Christopher J Schofield Kieran Clarke

Basic Res Cardiol 2012 May 27;107(3):268. Epub 2012 Apr 27.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1007/s00395-012-0268-2DOI Listing
May 2012

Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study.

Authors:
Carolyn A Carr Daniel J Stuckey Jun Jie Tan Suat Cheng Tan Renata S M Gomes Patrizia Camelliti Elisa Messina Alessandro Giacomello Georgina M Ellison Kieran Clarke

PLoS One 2011 17;6(10):e25669. Epub 2011 Oct 17.

Department of Physiology, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025669PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197153PMC
April 2012

Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors.

Authors:
Suat Cheng Tan Carolyn A Carr Kar Kheng Yeoh Christopher J Schofield Kay E Davies Kieran Clarke

Mol Biol Rep 2012 Apr 9;39(4):4857-67. Epub 2011 Nov 9.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy & Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1007/s11033-011-1281-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294216PMC
April 2012

Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat.

Authors:
Lee Carpenter Carolyn Carr Cheng Tao Yang Daniel J Stuckey Kieran Clarke Suzanne M Watt

Stem Cells Dev 2012 Apr 15;21(6):977-86. Epub 2012 Feb 15.

Stem Cell Research Laboratory, NHS Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

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https://www.liebertpub.com/doi/10.1089/scd.2011.0075
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http://dx.doi.org/10.1089/scd.2011.0075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315757PMC
April 2012

Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest.

Authors:
Denny Z Levett Elizabeth J Radford David A Menassa E Franziska Graber Andrea J Morash Hans Hoppeler Kieran Clarke Daniel S Martin Anne C Ferguson-Smith Hugh E Montgomery Michael P W Grocott Andrew J Murray

FASEB J 2012 Apr 20;26(4):1431-41. Epub 2011 Dec 20.

Centre for Altitude, Space, and Extreme Environment Medicine, University College London (UCL) Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1096/fj.11-197772DOI Listing
April 2012

The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.

Authors:
Marie A Schroeder Helen J Atherton Michael S Dodd Phillip Lee Lowri E Cochlin George K Radda Kieran Clarke Damian J Tyler

Circ Cardiovasc Imaging 2012 Mar 11;5(2):201-9. Epub 2012 Jan 11.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.111.9694
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http://dx.doi.org/10.1161/CIRCIMAGING.111.969451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378498PMC
March 2012

Effects of catecholamine stress on diastolic function and myocardial energetics in obesity.

Authors:
Oliver J Rider Jane M Francis Mohammed K Ali Cameron Holloway Tammy Pegg Matthew D Robson Damian Tyler James Byrne Kieran Clarke Stefan Neubauer

Circulation 2012 Mar 24;125(12):1511-9. Epub 2012 Feb 24.

Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.069518DOI Listing
March 2012

Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis.

Authors:
Lisa C Heather Neil J Howell Yaso Emmanuel Mark A Cole Michael P Frenneaux Domenico Pagano Kieran Clarke

PLoS One 2011 18;6(10):e26326. Epub 2011 Oct 18.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026326PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196577PMC
February 2012

Myocardial substrate metabolism in heart disease.

Authors:
Rhys D Evans Kieran Clarke

Front Biosci (Schol Ed) 2012 Jan 1;4:556-80. Epub 2012 Jan 1.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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January 2012

Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Authors:
Marie A Schroeder Helen J Atherton Lisa C Heather Julian L Griffin Kieran Clarke George K Radda Damian J Tyler

NMR Biomed 2011 Oct 8;24(8):980-987. Epub 2011 Mar 8.

Cardiac Metabolism Research Group, Department of Physiology, Anatomy & Genetics, University of Oxford.

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http://doi.wiley.com/10.1002/nbm.1668
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http://dx.doi.org/10.1002/nbm.1668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604660PMC
October 2011

Chasing the reflected wave back into the heart: a new hypothesis while the jury is still out.

Authors:
Ion Codreanu Matthew D Robson Oliver J Rider Tammy J Pegg Bernd A Jung Constantin A Dasanu Kieran Clarke Cameron J Holloway

Vasc Health Risk Manag 2011 8;7:365-73. Epub 2011 Jun 8.

Department of Physiology, Anatomy, and Genetics, University of Oxford, UK.

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http://dx.doi.org/10.2147/VHRM.S20845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119594PMC
October 2011

Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease.

Authors:
Marie A Schroeder Kieran Clarke Stefan Neubauer Damian J Tyler

Circulation 2011 Oct;124(14):1580-94

Department of Physiology, Anatomy, and Genetics, Sherrington Bldg, University of Oxford, Parks Rd, Oxford, UK OX1 3PT.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.111.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.024919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189851PMC
October 2011

Normobaric hypoxia impairs human cardiac energetics.

Authors:
Cameron Holloway Lowri Cochlin Ion Codreanu Edward Bloch Marzieh Fatemian Cezary Szmigielski Helen Atherton Lisa Heather Jane Francis Stefan Neubauer Peter Robbins Hugh Montgomery Kieran Clarke

FASEB J 2011 Sep 6;25(9):3130-5. Epub 2011 Jun 6.

Department of Physiology, Anatomy and Genetics, The University of Oxford, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1096/fj.11-183426DOI Listing
September 2011

Response to "Weight loss, blood pressure reduction, and aortic stiffness: an old dilemma revisited".

Authors:
Oliver J Rider Upasana Tayal Jane M Francis Mohammed K Ali Monique Robinson James P Byrne Kieran Clarke Stefan Neubauer

Obesity (Silver Spring) 2011 Sep;19(9):1730

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http://dx.doi.org/10.1038/oby.2011.75DOI Listing
September 2011

Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.

Authors:
Weihua Song Emma Dyer Daniel J Stuckey O'Neal Copeland Man-Ching Leung Christopher Bayliss Andrew Messer Ross Wilkinson Jordi Lopez Tremoleda Michael D Schneider Sian E Harding Charles S Redwood Kieran Clarke Kristen Nowak Lorenzo Monserrat Dominic Wells Steven B Marston

J Biol Chem 2011 Aug 26;286(31):27582-93. Epub 2011 May 26.

National Heart and Lung Institute, Imperial College London, London SW32 6LY, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.252320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149350PMC
August 2011

Endurance exercise training blunts the deleterious effect of high-fat feeding on whole body efficiency.

Authors:
Lindsay M Edwards Cameron J Holloway Andrew J Murray Nicholas S Knight Emma E Carter Graham J Kemp Campbell H Thompson Damian J Tyler Stefan Neubauer Peter A Robbins Kieran Clarke

Am J Physiol Regul Integr Comp Physiol 2011 Aug 1;301(2):R320-6. Epub 2011 Jun 1.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://ajpregu.physiology.org/cgi/doi/10.1152/ajpregu.00850.
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http://dx.doi.org/10.1152/ajpregu.00850.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154712PMC
August 2011

Dietary long-chain, but not medium-chain, triglycerides impair exercise performance and uncouple cardiac mitochondria in rats.

Authors:
Andrew J Murray Nicholas S Knight Sarah E Little Lowri E Cochlin Mary Clements Kieran Clarke

Nutr Metab (Lond) 2011 Aug 1;8:55. Epub 2011 Aug 1.

Department of Physiology, Anatomy & Genetics, University of Oxford, Parks Rd, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/1743-7075-8-55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168416PMC
August 2011

First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart.

Authors:
Daniel J Stuckey Carolyn A Carr Stephanie J Meader Damian J Tyler Mark A Cole Kieran Clarke

J Cardiovasc Magn Reson 2011 Aug 3;13:38. Epub 2011 Aug 3.

Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

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http://jcmr-online.biomedcentral.com/articles/10.1186/1532-4
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http://dx.doi.org/10.1186/1532-429X-13-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162911PMC
August 2011

Details of left ventricular remodeling and the mechanism of paradoxical ventricular septal motion after coronary artery bypass graft surgery.

Authors:
Ion Codreanu Tammy J Pegg Joseph B Selvanayagam Matthew D Robson Oliver J Rider Constantin A Dasanu Bernd A Jung David P Taggart Kieran Clarke Cameron J Holloway

J Invasive Cardiol 2011 Jul;23(7):276-82

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, United Kingdom.

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July 2011

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.

Authors:
Helen J Atherton Michael S Dodd Lisa C Heather Marie A Schroeder Julian L Griffin George K Radda Kieran Clarke Damian J Tyler

Circulation 2011 Jun 23;123(22):2552-61. Epub 2011 May 23.

Department of Biochemistry, Sanger Bldg, University of Cambridge, Tennis Court Rd, Cambridge CB2 1GA, UK.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.110.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.011387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608046PMC
June 2011

A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart.

Authors:
Mark A Cole Andrew J Murray Lowri E Cochlin Lisa C Heather Sara McAleese Nicholas S Knight Elizabeth Sutton Amira Abd Jamil Nadege Parassol Kieran Clarke

Basic Res Cardiol 2011 May 12;106(3):447-57. Epub 2011 Feb 12.

Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

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http://dx.doi.org/10.1007/s00395-011-0156-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071466PMC
May 2011

A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects.

Authors:
Cameron J Holloway Lowri E Cochlin Yaso Emmanuel Andrew Murray Ion Codreanu Lindsay M Edwards Cezary Szmigielski Damian J Tyler Nicholas S Knight Brian K Saxby Bridget Lambert Campbell Thompson Stefan Neubauer Kieran Clarke

Am J Clin Nutr 2011 Apr 26;93(4):748-55. Epub 2011 Jan 26.

Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom.

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http://dx.doi.org/10.3945/ajcn.110.002758DOI Listing
April 2011