Kiaran Kirk

Kiaran Kirk

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Kiaran Kirk

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Measuring Solute Transport in Toxoplasma gondii Parasites.

Methods Mol Biol 2020 ;2071:245-268

Research School of Biology, Australian National University, Acton, ACT, Australia.

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http://dx.doi.org/10.1007/978-1-4939-9857-9_14DOI Listing
January 2020

Characterization of the ATP4 ion pump in .

J Biol Chem 2019 04 5;294(14):5720-5734. Epub 2019 Feb 5.

From the Research School of Biology, Australian National University, Canberra, ACT 2601, Australia,

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http://dx.doi.org/10.1074/jbc.RA118.006706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462519PMC
April 2019

Biochemical characterization and chemical inhibition of PfATP4-associated Na-ATPase activity in membranes.

J Biol Chem 2018 08 9;293(34):13327-13337. Epub 2018 Jul 9.

From the Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia

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http://dx.doi.org/10.1074/jbc.RA118.003640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109929PMC
August 2018

Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials.

Antimicrob Agents Chemother 2018 06 25;62(6). Epub 2018 May 25.

Research School of Biology, Australian National University, Canberra, Australia

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http://dx.doi.org/10.1128/AAC.00087-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971608PMC
June 2018

Diverse antimalarials from whole-cell phenotypic screens disrupt malaria parasite ion and volume homeostasis.

Sci Rep 2018 06 11;8(1):8795. Epub 2018 Jun 11.

Research School of Biology, Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1038/s41598-018-26819-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995868PMC
June 2018

The NMR 'split peak effect' in cell suspensions: Historical perspective, explanation and applications.

Prog Nucl Magn Reson Spectrosc 2018 02 7;104:1-11. Epub 2017 Nov 7.

The University of Sydney, School of Life and Environmental Sciences, Faculty of Science, Sydney, NSW 2006, Australia; Australian National University, John Curtin School of Medical Research, College of Health and Medicine, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1016/j.pnmrs.2017.11.002DOI Listing
February 2018

Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites.

Nat Commun 2017 02 16;8:14455. Epub 2017 Feb 16.

Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia.

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http://dx.doi.org/10.1038/ncomms14455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316894PMC
February 2017

A high-sensitivity HPLC assay for measuring intracellular Na(+) and K(+) and its application to Plasmodium falciparum infected erythrocytes.

Sci Rep 2016 07 7;6:29241. Epub 2016 Jul 7.

Research School of Biology, Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1038/srep29241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935891PMC
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Ion Regulation in the Malaria Parasite.

Authors:
Kiaran Kirk

Annu Rev Microbiol 2015 ;69:341-59

Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia; email:

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http://dx.doi.org/10.1146/annurev-micro-091014-104506DOI Listing
June 2016

Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum.

Cell Microbiol 2016 06 6;18(6):820-30. Epub 2016 Jan 6.

Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia.

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http://dx.doi.org/10.1111/cmi.12552DOI Listing
June 2016

The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs.

Int J Parasitol Drugs Drug Resist 2015 Dec 27;5(3):149-62. Epub 2015 Aug 27.

Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S22113207153000
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http://dx.doi.org/10.1016/j.ijpddr.2015.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559606PMC
December 2015

A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum.

Nat Commun 2015 Mar 31;6:6721. Epub 2015 Mar 31.

Research School of Biology, Australian National University, Canberra, Australian Capital Territory 2601, Australia.

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http://dx.doi.org/10.1038/ncomms7721DOI Listing
March 2015

1H-NMR metabolite profiles of different strains of Plasmodium falciparum.

Biosci Rep 2014 Nov 21;34(6):e00150. Epub 2014 Nov 21.

*Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1042/BSR20140134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240024PMC
November 2014

Diverse chemotypes disrupt ion homeostasis in the Malaria parasite.

Mol Microbiol 2014 Oct 15;94(2):327-39. Epub 2014 Sep 15.

Research School of Biology, Australian National University, Canberra, ACT, 0200, Australia.

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http://doi.wiley.com/10.1111/mmi.12765
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http://dx.doi.org/10.1111/mmi.12765DOI Listing
October 2014

A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite.

Nat Commun 2014 Sep 8;5:4773. Epub 2014 Sep 8.

Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://dx.doi.org/10.1038/ncomms5773DOI Listing
September 2014

Membrane transport in the malaria parasite and its host erythrocyte.

Biochem J 2014 Jan;457(1):1-18

*Research School of Biology, Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1042/BJ20131007DOI Listing
January 2014

Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress.

PLoS One 2013 11;8(3):e58933. Epub 2013 Mar 11.

Research School of Biology, The Australian National University, Canberra, Australian Capital Territory, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058933PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594203PMC
December 2013

Na+ extrusion imposes an acid load on the intraerythrocytic malaria parasite.

Mol Biochem Parasitol 2013 May 23;189(1-2):1-4. Epub 2013 Apr 23.

Research School of Biology, Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2013.04.004DOI Listing
May 2013

Degrees of chloroquine resistance in Plasmodium - is the redox system involved?

Int J Parasitol Drugs Drug Resist 2012 Dec;2:47-57

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.ijpddr.2011.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388501PMC
December 2012

Glutathione export from human erythrocytes and Plasmodium falciparum malaria parasites.

Biochem J 2012 Dec;448(3):389-400

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.

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http://dx.doi.org/10.1042/BJ20121050DOI Listing
December 2012

Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.

Antimicrob Agents Chemother 2012 May 21;56(5):2283-9. Epub 2012 Feb 21.

Research School of Biology, The Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1128/AAC.00166-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346596PMC
May 2012

Chemical activation of a high-affinity glutamate transporter in human erythrocytes and its implications for malaria-parasite-induced glutamate uptake.

Blood 2012 Apr 2;119(15):3604-12. Epub 2012 Mar 2.

Faculty of Biology, Department of Parasitology, Philipps-Universität Marburg, Marburg, Germany.

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http://dx.doi.org/10.1182/blood-2011-10-386003DOI Listing
April 2012

The Plasmodium falciparum-infected red blood cell.

Int J Biochem Cell Biol 2011 Jun 31;43(6):839-42. Epub 2011 Mar 31.

Department of Biochemistry, La Trobe University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/j.biocel.2011.03.012DOI Listing
June 2011

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.

Eur J Med Chem 2011 May 22;46(5):1729-42. Epub 2011 Feb 22.

Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa.

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http://linkinghub.elsevier.com/retrieve/pii/S022352341100137
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http://dx.doi.org/10.1016/j.ejmech.2011.02.026DOI Listing
May 2011

Methionine transport in the malaria parasite Plasmodium falciparum.

Int J Parasitol 2011 Jan 17;41(1):125-35. Epub 2010 Sep 17.

Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00207519100029
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http://dx.doi.org/10.1016/j.ijpara.2010.09.001DOI Listing
January 2011

Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT.

Mol Microbiol 2010 Aug 28;77(4):1039-51. Epub 2010 Jun 28.

Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1111/j.1365-2958.2010.07272.xDOI Listing
August 2010

An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum.

J Biol Chem 2010 Jun 23;285(24):18615-26. Epub 2010 Mar 23.

Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://dx.doi.org/10.1074/jbc.M110.120980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881787PMC
June 2010

Plasmodium falciparum culture: the benefits of shaking.

Mol Biochem Parasitol 2010 Jan 17;169(1):63-5. Epub 2009 Sep 17.

The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2009.09.005DOI Listing
January 2010

Membrane transport proteins of the malaria parasite.

Mol Microbiol 2009 Nov 1;74(3):519-28. Epub 2009 Oct 1.

Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06863.xDOI Listing
November 2009

Chloroquine transport via the malaria parasite's chloroquine resistance transporter.

Science 2009 Sep;325(5948):1680-2

Research School of Biology, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://dx.doi.org/10.1126/science.1175667DOI Listing
September 2009

Purine uptake in Plasmodium: transport versus metabolism.

Trends Parasitol 2009 Jun 5;25(6):246-9. Epub 2009 May 5.

Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.pt.2009.03.006DOI Listing
June 2009

A surface transporter family conveys the trypanosome differentiation signal.

Nature 2009 May;459(7244):213-7

Centre for Immunity, Infection and Evolution, Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK.

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http://dx.doi.org/10.1038/nature07997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685892PMC
May 2009

Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by (1)H NMR spectroscopy.

NMR Biomed 2009 Apr;22(3):292-302

Biochemistry and Molecular Biology, The Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1002/nbm.1323DOI Listing
April 2009

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.

Antimicrob Agents Chemother 2008 Dec 13;52(12):4374-80. Epub 2008 Oct 13.

Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1128/AAC.00666-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592892PMC
December 2008

Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger.

Mol Biochem Parasitol 2008 Nov 15;162(1):96-9. Epub 2008 Jul 15.

Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2008.07.001DOI Listing
November 2008

A polymorphic drug pump in the malaria parasite.

Mol Microbiol 2008 Nov;70(4):775-9

Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra, ACT 0200, Australia.

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http://doi.wiley.com/10.1111/j.1365-2958.2008.06451.x
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http://dx.doi.org/10.1111/j.1365-2958.2008.06451.xDOI Listing
November 2008

Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum.

Eukaryot Cell 2008 Aug 20;7(8):1231-7. Epub 2008 Jun 20.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1128/EC.00159-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519781PMC
August 2008

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites.

J Cell Sci 2008 May 29;121(Pt 10):1624-32. Epub 2008 Apr 29.

School of Biochemistry and Molecular Biology, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1242/jcs.016758DOI Listing
May 2008

Purine nucleobase transport in the intraerythrocytic malaria parasite.

Int J Parasitol 2008 Feb 25;38(2):203-9. Epub 2007 Jul 25.

School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.ijpara.2007.07.005DOI Listing
February 2008

Coenzyme A biosynthesis: an antimicrobial drug target.

FEMS Microbiol Rev 2008 Jan;32(1):56-106

School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1111/j.1574-6976.2007.00093.xDOI Listing
January 2008

Localisation of a candidate anion transporter to the surface of the malaria parasite.

Biochem Biophys Res Commun 2007 Nov 29;363(2):288-91. Epub 2007 Aug 29.

School of Biochemistry and Molecular Biology, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2007.08.116DOI Listing
November 2007

Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.

J Biol Chem 2007 Aug 20;282(35):25395-405. Epub 2007 Jun 20.

School of Biochemistry and Molecular Biology, Medical School, The Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1074/jbc.M704610200DOI Listing
August 2007

Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum.

Blood 2007 Mar 17;109(5):2217-24. Epub 2006 Oct 17.

School of Biochemistry and Molecular Biology, The Australian National University, Canberra, Australia.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-11-02
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http://dx.doi.org/10.1182/blood-2005-11-026963DOI Listing
March 2007

Targeting nutrient uptake mechanisms in Plasmodium.

Curr Drug Targets 2007 Jan;8(1):75-88

School of Biochemistry and Molecular Biology, The Australian National University, Canberra A.C.T. 0200, Australia.

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http://dx.doi.org/10.2174/138945007779315560DOI Listing
January 2007

Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite.

Nature 2006 Oct 27;443(7111):582-5. Epub 2006 Sep 27.

School of Biochemistry and Molecular Biology, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1038/nature05149DOI Listing
October 2006

Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1.

Mol Microbiol 2006 May;60(3):738-48

School of Biochemistry and Molecular Biology, The Australian National University, Canberra ACT 0200, Australia.

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http://doi.wiley.com/10.1111/j.1365-2958.2006.05125.x
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http://dx.doi.org/10.1111/j.1365-2958.2006.05125.xDOI Listing
May 2006

The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum.

Genome Biol 2005 2;6(3):R26. Epub 2005 Mar 2.

School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1186/gb-2005-6-3-r26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088945PMC
March 2006

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance.

J Cell Sci 2006 Mar 21;119(Pt 6):1016-25. Epub 2006 Feb 21.

School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1242/jcs.02795DOI Listing
March 2006

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites.

Antimicrob Agents Chemother 2005 Nov;49(11):4649-57

School of Biochemistry and Molecular Biology, The Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1128/AAC.49.11.4649-4657.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280137PMC
November 2005

CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation.

Mol Biochem Parasitol 2005 May;141(1):129-31

School of Biochemistry and Molecular Biology, The Australian National University, Canberra, ACT 0200, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S016668510500062
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http://dx.doi.org/10.1016/j.molbiopara.2005.02.003DOI Listing
May 2005

Osmotic swelling activates two pathways for K+ efflux in a rat hepatoma cell line.

Cell Physiol Biochem 2004 ;14(3):143-54

School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT, Australia.

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https://www.karger.com/Article/FullText/78106
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http://dx.doi.org/10.1159/000078106DOI Listing
April 2005

Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance.

Mol Microbiol 2005 Apr;56(2):323-33

Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2005.04556.xDOI Listing
April 2005

Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.

Antimicrob Agents Chemother 2005 Feb;49(2):632-7

School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra ACT 0200, Australia.

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https://repository.ubn.ru.nl/bitstream/handle/2066/153528/15
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http://aac.asm.org/cgi/doi/10.1128/AAC.49.2.632-637.2005
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http://dx.doi.org/10.1128/AAC.49.2.632-637.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC547364PMC
February 2005

Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil.

Antimicrob Agents Chemother 2005 Feb;49(2):840-2

School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra A.C.T. 0200, Australia.

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http://aac.asm.org/cgi/doi/10.1128/AAC.49.2.840-842.2005
Publisher Site
http://dx.doi.org/10.1128/AAC.49.2.840-842.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC547358PMC
February 2005

pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum.

Mol Microbiol 2005 Feb;55(4):1285-95

School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra ACT 0200, Australia.

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http://doi.wiley.com/10.1111/j.1365-2958.2004.04470.x
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http://dx.doi.org/10.1111/j.1365-2958.2004.04470.xDOI Listing
February 2005

Of malaria, metabolism and membrane transport.

Trends Parasitol 2004 Dec;20(12):590-6

Department of Biochemistry, Interdisciplinary Research Center, Justus-Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.

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http://dx.doi.org/10.1016/j.pt.2004.09.004DOI Listing
December 2004

Molecular approaches to malaria.

Mol Microbiol 2004 Nov;54(3):575-87

FB Biology, Philipps-University, Marburg, Germany.

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http://dx.doi.org/10.1111/j.1365-2958.2004.04362.xDOI Listing
November 2004

The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily.

Mol Biol Evol 2004 Oct 7;21(10):1938-49. Epub 2004 Jul 7.

School of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1093/molbev/msh205DOI Listing
October 2004

Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes.

Antimicrob Agents Chemother 2004 Sep;48(9):3241-5

Department of Pharmacy, National University of Singapore, Science Dr. 4, Republic of Singapore.

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http://dx.doi.org/10.1128/AAC.48.9.3241-3245.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514760PMC
September 2004

Choline uptake into the malaria parasite is energized by the membrane potential.

Biochem Biophys Res Commun 2004 Jul;320(2):311-7

School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2004.05.164DOI Listing
July 2004

Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative.

FEBS Lett 2004 Jul;570(1-3):93-6

School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1016/j.febslet.2004.06.032DOI Listing
July 2004

The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum.

J Biol Chem 2004 Mar 20;279(12):11264-72. Epub 2003 Nov 20.

School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://dx.doi.org/10.1074/jbc.M311110200DOI Listing
March 2004

Channels and transporters as drug targets in the Plasmodium-infected erythrocyte.

Authors:
Kiaran Kirk

Acta Trop 2004 Feb;89(3):285-98

School of Biochemistry and Molecular Biology, Australian National University, Faculty of Science, 0200 ACT, Canberra, Australia.

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http://dx.doi.org/10.1016/j.actatropica.2003.10.002DOI Listing
February 2004

Cell volume control in the Plasmodium-infected erythrocyte.

Trends Parasitol 2004 Jan;20(1):7-10; discussion 10-1

School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://dx.doi.org/10.1016/j.pt.2003.10.015DOI Listing
January 2004

Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.

J Biol Chem 2003 Feb 8;278(8):5605-12. Epub 2002 Nov 8.

School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://dx.doi.org/10.1074/jbc.M208648200DOI Listing
February 2003

The role of P2Y1 purinergic receptors and cytosolic Ca2+ in hypotonically activated osmolyte efflux from a rat hepatoma cell line.

J Biol Chem 2002 Oct 22;277(43):40324-34. Epub 2002 Jul 22.

School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra ACT 0200, Australia.

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http://dx.doi.org/10.1074/jbc.M204712200DOI Listing
October 2002

Role of K+ and amino acids in osmoregulation by the free-living microaerophilic protozoon Hexamita inflata.

Microbiology 2000 Feb;146 ( Pt 2):427-433

School of Biochemistry and Molecular Biology, University of New South Wales, Sydney, NSW 2052, Australia1.

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http://dx.doi.org/10.1099/00221287-146-2-427DOI Listing
February 2000