Publications by authors named "Kiandokht Ghanati"

9 Publications

  • Page 1 of 1

The aflatoxin B1 content of peanut-based foods in Iran: a systematic review.

Rev Environ Health 2021 Jul 29. Epub 2021 Jul 29.

Tehran, Iran.

Backgrounds: One of the common consumed snacks among Iranian is nuts. The aim of this systematic review was to determine the rate of peanut contamination with aflatoxin B1 (AfB1) in different provinces of the Iran.

Materials And Methods: The research studies with keywords "aflatoxin B1", "peanut", "peanut butter", "peanut oil", "coated peanut", "roasted peanut", "snack peanut" were searched in PubMed, Scopus, Science Direct, Google Scholar and scientific information databases (SID), regardless of publication time. A total of 43 studies were obtained and only six articles were finally selected according to exclusion and inclusion criteria. Margin of Exposure (MOE) and Hazard Quotient (HQ) were also calculated to evaluate the oral exposure of AfB1 through peanuts and peanut-based products.

Results: The contamination of AFB1 in peanut was high in Mashhad and Tehran compared with the other cities. The value of MOE was calculated less than 10,000. The results of MOE indicate that there are chances of the risk of developing cancer and these products may not be safe. Therefore, AFB1 levels should be measured regularly in peanut products in large cities.
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http://dx.doi.org/10.1515/reveh-2021-0065DOI Listing
July 2021

Response Surface Methodology of Quantitative of Heterocyclic Aromatic Amines in Fried Fish Using Efficient Microextraction Method Coupled with High-Performance Liquid Chromatography: Central Composite Design.

J Chromatogr Sci 2021 Apr;59(5):473-481

Department of Food Science and Technology, National Nutrition and Food Technology Research Institute/Faculty of Nutrition Science, Food Science and Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Meat and meat products are indispensable part of our diet. Heat processing of these tasty foods such as fried fish causes to form heterocyclic aromatic amines (HAAs). The sources of heating have directly affected on the level and type of HAAs. In this research, 2-amino-1-methyl-6-phenylimidazo [4'5-b] pyridine (PhIP), 2-amino-3-methylimidazo [4,5-f]quinolone (IQ), 2-amino-3,4-dimethylimidazo [4,5-f] quinoline (MeIQ) and 2-amino-3,4-dimethylimidazo [4,5-f] quinoxaline (MeIQx) were determined using an efficient analytical methodology coupled with high-performance liquid chromatography. The effective parameters were optimized by central composite design. The results of this survey demonstrated that rang of relative standard deviation were between 4.5 and 8.2, extraction recoveries were obtained 86-97% and limits of detection were between 0.40 and 0.63 for 4 HAAs. The amounts of HAAs found in 20 different fried fish samples were between 0 and 4.8 ng g-1. PhIP with 1.57 ng g-1 and MeIQ with 2.08 ng g-1 have the lowest and highest average level of HAAs, respectively.
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http://dx.doi.org/10.1093/chromsci/bmaa137DOI Listing
April 2021

Genetic relatedness of the isolates in stool and urine samples of patients with community-acquired urinary tract infection.

Gut Pathog 2020 9;12:42. Epub 2020 Sep 9.

School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

Background: Community-acquired urinary tract infection (CA-UTI) could be caused by endogenous or exogenous routes. To show this relationship, we investigated molecular fingerprints and genotypes of paired isolated from the urine of symptomatic patients and their fecal samples.

Results: Out of the studied patients, 63 pairs of isolates were obtained simultaneously from their urine and feces samples. All the strains were sensitive to vancomycin, linezolid, nitrofurantoin, and daptomycin (MIC value: ≤ 4 µg/ml), while resistance to tetracycline (urine: 88.9%; stool: 76.2%) and minocycline (urine: 87.3%, stool: 71.4%) was detected in most of them. The most common detected virulence genes were included , , and . RAPD-PCR and PFGE analyses showed the same patterns of molecular fingerprints between paired of the isolates in 26.9% and 15.8% of the patients, respectively.

Conclusions: Similarity of strains between the urine and feces samples confirmed the occurrence of endogenous infection via contamination with colonized bacteria in the intestinal tract. Carriage of a complete virulence genotype in the responsible strains was statistically in correlation with endogenous UTI, which shows their possible involvement in pathogenicity of uropathogenic strains.
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http://dx.doi.org/10.1186/s13099-020-00380-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488108PMC
September 2020

Potential Health Risk Assessment of Different Heavy Metals in Wheat Products.

Iran J Pharm Res 2019 ;18(4):2093-2100

Food Safety Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

In the present work, health risk of heavy metals such as As, Cd, Co, Cr, Cu, Hg, Ni, Pb, and Zn in Iranian urban and rural samples including wheat, wheat flour, bread, pasta and sweets were assessed. The real amount of heavy metals in target samples were determined by inductively coupled plasma-atomic emission spectrometry (ICP-AES) and atomic absorption spectroscopy (AAS). Wet ashing and hydride generation techniques were used in sample preparation step. Results demonstrated that heavy metal contaminations in cereal samples were significant. The average concentrations of heavy metals in wheat products were between 0.01 mg kg to 46 mg kg. Finally, the health risk assessment results showed that heavy metal contents in rural samples were higher than those in urban samples. The risk of Cu and Zn was significant in two areas and risk of Cr and Cd was not significant.
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http://dx.doi.org/10.22037/ijpr.2019.1100865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059047PMC
January 2019

Characterization of Microcapsule Containing Walnut ( L.) Green Husk Extract as Preventive Antioxidant and Antimicrobial Agent.

Int J Prev Med 2018 15;9:101. Epub 2018 Nov 15.

Food and Drug Control Reference Laboratories Center, Food and Drug Organization, Ministry of Health and Medical Education, Tehran, Iran.

Background: Walnut green husk (WGH) extract has been known as potential preventive and therapeutic antioxidants and antimicrobials due to its high polyphenol content. In this study, preparation of spray dried WGH extract-loaded microcapsules by maltodextrin and its blending with two other natural biodegradable polymers, pectin, or alginate were investigated.

Methods: In this study, encapsulation efficiency (EE), total phenol content (Folin-Ciocalteu reagent method), antioxidant (DPPH scavenging assay) and antimicrobial activities (agar well diffusion method) structural (SEM and FTIR studies), and release properties of WGH extract-loaded microcapsules were investigated.

Results: High retention of phenolic content in microcapsules indicated the successful encapsulation of WGH extract. Addition of biopolymers to maltodextrin matrix has a positive effect on EE and other properties of microcapsules. The microcapsules prepared with mixture of maltodextrin and pectin had higher EE (79.35 ± 0.87%) and total phenolic (TP) content (56.83 ± 1.04 mg gallic acid equivalents [GAE]/100 g) in comparison to maltodextrin and alginate mixture (EE: 75.21 ± 0.24%, TP content: 54.33 ± 1.53 mg GAE/100 g) and maltodextrin only matrix (EE: 72.50 ± 1.00%, TP content: 50.67 ± 1.35 mg GAE/100 g). Extract-loaded microcapsules also showed nearly spherical structure, good antioxidant (with the percentage DPPH inhibition ranged from 75.17 ± 1.42% to 80.87 ± 2.29%), and antimicrobial properties (with mean inhibition diameter zone ranged from 7.76 ± 0.86 mm to 11.53 ± 0.45 mm). Fourier transform infrared analyses suggested the presence of extract on microcapsules. The extract release from microcapsules followed an anomalous non-Fickian diffusion mechanism with almost complete release.

Conclusions: WGH extract microcapsules can be used as novel and economic bioactive phytochemical and therapeutic agents to prevent oxidation and microbial activity.
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http://dx.doi.org/10.4103/ijpvm.IJPVM_308_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259432PMC
November 2018

Evaluating Total Mercury and Methyl Mercury Contents in Canned Tuna Fish of the Persian Gulf.

Iran J Pharm Res 2018 ;17(2):585-592

National Nutrition Food Technology Research Institute (NNFTRI), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Due to hygienic risks of mercury residues in food and marine originated supplements, measuring total mercury and methyl mercury contents of canned tuna as a highly consumable marine food product is essential. In this study, 40 canned Tuna fish (from Persian Gulf) were collected in 2015 and then flame atomic absorption spectrometer (FAAS) and thermo gas chromatography mass spectrophotometry were used to measure total mercury and methyl mercury, respectively. The results indicated that the average contents of total mercury and methyl mercury of the canned tunas, with 34.2 and 29.5 ppb decrements compared with 2009's measurement, were 177.4 and 143.7 ppb respectively. The highest concentration of the total mercury was 315.2 while it was 267.9 ppb for methyl mercury. This study showed that the content of the mercury in canned tunas of the Persian Gulf was less than the Maximum Residue Limit (MRL).
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985176PMC
January 2018

The Effect of Prangos Ferulacea Vaginal Cream on Accelerating the Recovery of Bacterial Vaginosis: A Randomized Controlled Clinical Trial.

Int J Community Based Nurs Midwifery 2018 Apr;6(2):100-110

National Nutrition and Food Technology Research Institute, Department of the International Affairs of Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The present study was conducted on the effect of prangos ferulacea vaginal cream on accelerating the recovery of bacterial vaginosis.

Methods: This randomized controlled clinical trial was conducted on 100 non-pregnant women referring to health centers affiliated to Lorestan University of Medical Sciences in 2016 with the diagnosis of bacterial vaginosis based on the patient's complaints, Amsel's clinical criteria, and the Nugent microscopic criteria. The women were randomly divided into two groups of 50. One group was treated with oral metronidazole plus Prangos ferulacea vaginal cream and the other with oral metronidazole plus a placebo vaginal cream for seven days. The patient's complaints, Amsel's clinical criteria and the Nugent microscopic criteria were assessed seven days after treatment. The data were analyzed using SPSS, version 20, with a significance level of 0.05.

Results: The response to oral metronidazole plus Prangos ferulacea vaginal cream treatment was 94% according to Amsel's clinical criteria and 88% according to the Nugent microscopic criteria. The response to oral metronidazole plus placebo vaginal cream treatment was 94% according to Amsel's criteria and 86% according to the Nugent criteria. The analysis of the patients' complaints, Amsel's clinical criteria and the Nugent microscopic criteria showed significant differences in each group before and after the treatment.

Conclusion: This trial showed that Prangos ferulacea vaginal cream accelerated the recovery of bacterial vaginosis of patients with bacterial vaginosis. It can be used effectively as a complementary treatment with oral metronidazole in cases of medication resistance and also in people wishing to use herbal remedies IRCT2016042327534N1.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845114PMC
April 2018

Antioxidant and antimicrobial carboxymethyl cellulose films containing Zataria multiflora essential oil.

Int J Biol Macromol 2015 Jan 16;72:606-13. Epub 2014 Sep 16.

Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

The present study describes the physical, antioxidant, and antimicrobial properties of biodegradable films prepared by incorporating different concentrations (1, 2, and 3% v/v) of Zataria multiflora Boiss (avishan-e shirazi) essential oil (ZEO) into carboxymethyl cellulose (CMC) film. The films' tensile strength, elongation at break, water-vapor permeability, optical characteristics, microstructure, and antimicrobial and antioxidant properties were investigated. The results indicated that the film containing 1% ZEO had the highest tensile strength and elongation at break. The control film showed the lowest water-vapor permeability. The resulting optical data showed that the control films were transparent in appearance; transparency was significantly reduced by an increase in ZEO concentration. Solubility in water decreased with increased ZEO. Films with ZEO, especially at higher concentrations, were more effective against all tested bacteria than the control film. Those films incorporating essential oil revealed antioxidant properties as well; this effect was greatly improved when the proportion of ZEO was increased. The results indicated that the antioxidant and antibacterial activity of ZEO is retained when it is used in CMC film. These properties with some good physical characteristics suggest applications for ZEO-incorporated film in a wide range of food products.
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http://dx.doi.org/10.1016/j.ijbiomac.2014.09.006DOI Listing
January 2015

Identification of homogeneously staining regions in leukemia patients.

J Res Med Sci 2013 Apr;18(4):363-5

School of Medical Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplification in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. This study report two cases, one with Acute Myeloblastic Leukemia without maturation (AML-M1), aged 23-year-old female, and the other with chronic myelogenous leukemia (CML)-blast crisis, a 28-year-old female associated with double minute chromosomes. Most cases of acute myeloid leukemia with dmin in the literature (including our cases) have been diagnosed as having acute myeloid leukemia.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793386PMC
April 2013
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