Publications by authors named "Kian Fan Chung"

100Publications

Mitochondrial dysfunction in airways and quadriceps muscle of patients with chronic obstructive pulmonary disease.

Respir Res 2020 Oct 12;21(1):262. Epub 2020 Oct 12.

Airways Disease, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK.

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http://dx.doi.org/10.1186/s12931-020-01527-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552476PMC
October 2020

Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease.

Front Immunol 2020 2;11:1957. Epub 2020 Sep 2.

Section of Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2020.01957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492639PMC
September 2020

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4.

Sci Transl Med 2020 Aug;12(557)

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow Glasgow, G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1126/scitranslmed.aaw9009DOI Listing
August 2020

Impaired lnc-IL7R modulatory mechanism of Toll-like receptors is associated with an exacerbator phenotype of chronic obstructive pulmonary disease.

FASEB J 2020 Aug 11. Epub 2020 Aug 11.

Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

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http://dx.doi.org/10.1096/fj.202000632RDOI Listing
August 2020

Sputum macrophage diversity and activation in asthma: Role of severity and inflammatory phenotype.

Allergy 2020 Aug 1. Epub 2020 Aug 1.

National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/all.14535DOI Listing
August 2020

Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study.

Lancet Respir Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; Beijing Chao-Yang Hospital, Department of Respiratory Medicine, Capital Medical University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(20)30155-7DOI Listing
June 2020

eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy.

J Allergy Clin Immunol 2020 Jun 10. Epub 2020 Jun 10.

Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands; Department of Paediatric Respiratory Medicine, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.05.038DOI Listing
June 2020

Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months.

J Allergy Clin Immunol 2020 Apr 28. Epub 2020 Apr 28.

Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Pediatric Respiratory Medicine, Emma Children's Hospital, Amsterdam UMC, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.04.018DOI Listing
April 2020

Pharmacotherapeutic Options for Chronic Refractory Cough.

Expert Opin Pharmacother 2020 Aug 17;21(11):1345-1358. Epub 2020 Apr 17.

National Heart & Lung Institute, Imperial College London & Royal Brompton and Harefield NHS Trust , London, UK.

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http://dx.doi.org/10.1080/14656566.2020.1751816DOI Listing
August 2020

Cough in hypereosinophilic syndrome: case report and literature review.

BMC Pulm Med 2020 Apr 15;20(1):90. Epub 2020 Apr 15.

National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.

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http://dx.doi.org/10.1186/s12890-020-1134-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158094PMC
April 2020

Personal strategies to minimise effects of air pollution on respiratory health: advice for providers, patients and the public.

Eur Respir J 2020 Jun 4;55(6). Epub 2020 Jun 4.

Faculty of Medicine, National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1183/13993003.02056-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270362PMC
June 2020

Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease.

Am J Respir Crit Care Med 2020 Aug;202(3):371-382

Asthma UK Centre for Applied Research, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201909-1867OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397796PMC
August 2020

Effectiveness of myAirCoach: A mHealth Self-Management System in Asthma.

J Allergy Clin Immunol Pract 2020 Jun 3;8(6):1972-1979.e8. Epub 2020 Mar 3.

Department of Biomedical Data Sciences, Section Medical Decision Making, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.jaip.2020.02.018DOI Listing
June 2020

Toward personalization of asthma treatment according to trigger factors.

J Allergy Clin Immunol 2020 Jun 18;145(6):1529-1534. Epub 2020 Feb 18.

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia; NRC Institute of Immunology FMBA of Russia, Moscow, Russia; Division of Immunology and Allergy, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner University, Krems, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.02.001DOI Listing
June 2020

Exploring the clinical relevance of cough hypersensitivity syndrome.

Expert Rev Respir Med 2020 Mar 15;14(3):275-284. Epub 2020 Jan 15.

National Heart & Lung Institute, Imperial College London & Royal Brompton and Harefield NHS Trust, London, UK.

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http://dx.doi.org/10.1080/17476348.2020.1713102DOI Listing
March 2020

Accounting for measurement error to assess the effect of air pollution on omic signals.

PLoS One 2020 2;15(1):e0226102. Epub 2020 Jan 2.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226102PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940143PMC
April 2020

Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases.

J Innate Immun 2020 29;12(1):31-46. Epub 2019 Nov 29.

Experimental Studies and Cell and Molecular Biology, Airway Disease Section, National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom.

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http://dx.doi.org/10.1159/000504344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959099PMC
November 2019

Acute Respiratory Barrier Disruption by Ozone Exposure in Mice.

Front Immunol 2019 13;10:2169. Epub 2019 Sep 13.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orléans, France.

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http://dx.doi.org/10.3389/fimmu.2019.02169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758598PMC
October 2020

Progress in cough hypersensitivity at the Tenth London International Cough Symposium 2018 (10th LICS 2018).

Pulm Pharmacol Ther 2019 12 26;59:101850. Epub 2019 Sep 26.

Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1016/j.pupt.2019.101850DOI Listing
December 2019

Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity.

Allergy Asthma Immunol Res 2019 Nov;11(6):871-884

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.4168/aair.2019.11.6.871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761072PMC
November 2019

Future Risks in Patients With Severe Asthma.

Allergy Asthma Immunol Res 2019 Nov;11(6):763-778

National Heart & Lung Institute, Imperial College London & Royal Brompton and Harefield NHS Trust, London, United Kingdom.

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http://dx.doi.org/10.4168/aair.2019.11.6.763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761069PMC
November 2019

Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study.

Chemosphere 2020 Jan 24;239:124667. Epub 2019 Aug 24.

MRC-PHE Centre for Environment & Health, Department of Analytical, Environmental & Forensic Sciences, School of Population Health & Environmental Sciences, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2019.124667DOI Listing
January 2020

Asthma phenotypes in a multi-ethnic Asian cohort.

Respir Med 2019 10 31;157:42-48. Epub 2019 Aug 31.

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore.

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http://dx.doi.org/10.1016/j.rmed.2019.08.016DOI Listing
October 2019

Transcriptional Effects of Ozone and Impact on Airway Inflammation.

Front Immunol 2019 10;10:1610. Epub 2019 Jul 10.

Respiratory Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2019.01610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635463PMC
October 2020

Blood eosinophil count correlates with severity of respiratory failure in life-threatening asthma and predicts risk of subsequent exacerbations.

Clin Exp Allergy 2019 12 6;49(12):1578-1586. Epub 2019 Aug 6.

Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.

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http://dx.doi.org/10.1111/cea.13465DOI Listing
December 2019

TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM).

Oxid Med Cell Longev 2019 2;2019:7450151. Epub 2019 Jun 2.

Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.

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http://dx.doi.org/10.1155/2019/7450151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589236PMC
February 2020

Prevalence, risk factors, and management of asthma in China: a national cross-sectional study.

Lancet 2019 08 20;394(10196):407-418. Epub 2019 Jun 20.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(19)31147-XDOI Listing
August 2019

Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness.

Free Radic Res 2019 Jul 27;53(7):780-790. Epub 2019 Jun 27.

a Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai , PR China.

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http://dx.doi.org/10.1080/10715762.2019.1630735DOI Listing
July 2019

Health effects of air pollution: what we need to know and to do in the next decade.

J Thorac Dis 2019 Apr;11(4):1727-1730

Beijing Innovation Center for Engineering Science and Advanced Technology, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100000, China.

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http://dx.doi.org/10.21037/jtd.2019.03.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531724PMC
April 2019

Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough.

Respir Res 2019 Jun 6;20(1):112. Epub 2019 Jun 6.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, 510120, People's Republic of China.

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http://dx.doi.org/10.1186/s12931-019-1077-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554907PMC
June 2019

Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation.

Biomed Res Int 2019 18;2019:1484736. Epub 2019 Apr 18.

Interstitial Lung Disease Unit, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, Sydney Street, London SW3 6NP, UK.

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https://www.hindawi.com/journals/bmri/2019/1484736/
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http://dx.doi.org/10.1155/2019/1484736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500679PMC
November 2019

Functional effects of the microbiota in chronic respiratory disease.

Lancet Respir Med 2019 10 8;7(10):907-920. Epub 2019 Apr 8.

Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW, Australia; Centre for Inflammation, Centenary Institute, and University of Technology Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30510-1DOI Listing
October 2019

Precision medicine for the discovery of treatable mechanisms in severe asthma.

Allergy 2019 09 15;74(9):1649-1659. Epub 2019 Apr 15.

National Heart & Lung Institute, Imperial College London and Royal Brompton & Harefield NHS Trust, London, UK.

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http://doi.wiley.com/10.1111/all.13771
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http://dx.doi.org/10.1111/all.13771DOI Listing
September 2019

Predicting Response to Triamcinolone in Severe Asthma by Machine Learning. Solving the Enigma.

Authors:
Kian Fan Chung

Am J Respir Crit Care Med 2019 Jun;199(11):1299-1300

1 National Heart & Lung Institute Imperial College London London, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201902-0320EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543711PMC
June 2019

Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model.

Free Radic Biol Med 2019 04 9;134:229-238. Epub 2019 Jan 9.

Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, NO.241, West HuaiHai Road, Shanghai 200030, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.01.004DOI Listing
April 2019

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema.

Respir Res 2018 Nov 22;19(1):230. Epub 2018 Nov 22.

Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, No.100, Haining Road, Shanghai, 200080, China.

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http://dx.doi.org/10.1186/s12931-018-0931-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249848PMC
November 2018

Shedding light on corticosteroid-resistant type 2-high severe asthma.

Authors:
Kian Fan Chung

J Allergy Clin Immunol 2019 01 14;143(1):89-90. Epub 2018 Nov 14.

National Heart & Lung Institute, Imperial College London & Royal Brompton and Harefield NHS Trust, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.11.002DOI Listing
January 2019

Protective effects of VGX-1027 in PM-induced airway inflammation and bronchial hyperresponsiveness.

Eur J Pharmacol 2019 Jan 9;842:373-383. Epub 2018 Nov 9.

Department of Respiratory and Critical Care Medicine, The Geriatric Institute of Anhui, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183065
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http://dx.doi.org/10.1016/j.ejphar.2018.11.010DOI Listing
January 2019

2-year safety and efficacy results for benralizumab.

Authors:
Kian Fan Chung

Lancet Respir Med 2019 01 8;7(1):5-6. Epub 2018 Nov 8.

National Heart & Lung Institute, Faculty of Medicine, Imperial College London, London SW3 6LY, UK; Respiratory Unit, Royal Brompton & Harefield NHS Foundation Trust, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132600183046
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http://dx.doi.org/10.1016/S2213-2600(18)30468-5DOI Listing
January 2019

CSF3R/CD114 mediates infection-dependent transition to severe asthma.

J Allergy Clin Immunol 2019 02 9;143(2):785-788.e6. Epub 2018 Oct 9.

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia; Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183143
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http://dx.doi.org/10.1016/j.jaci.2018.10.001DOI Listing
February 2019

AsthmaMap: An expert-driven computational representation of disease mechanisms.

Clin Exp Allergy 2018 08;48(8):916-918

European Institute for Systems Biology and Medicine, CIRI UMR5308, CNRS-ENS-UCBL-INSERM, Université de Lyon, Lyon, France.

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http://dx.doi.org/10.1111/cea.13211DOI Listing
August 2018

The heterogeneity of chronic cough: a case for endotypes of cough hypersensitivity.

Lancet Respir Med 2018 08 18;6(8):636-646. Epub 2018 Jun 18.

Centre for Experimental Medicine, The Queen's University of Belfast, Belfast, UK.

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http://dx.doi.org/10.1016/S2213-2600(18)30150-4DOI Listing
August 2018

Interleukin-1α Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation.

Front Immunol 2018 7;9:916. Epub 2018 May 7.

Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS-University of Orleans, Orleans, France.

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http://dx.doi.org/10.3389/fimmu.2018.00916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950844PMC
June 2019

Tralokinumab unsuccessful for management of severe, uncontrolled asthma.

Authors:
Kian Fan Chung

Lancet Respir Med 2018 07 21;6(7):480-481. Epub 2018 May 21.

National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK; Royal Brompton and Harefield NHS Trust, London SW3 6LY, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30194-2DOI Listing
July 2018

IFN-γ: A Driver of Cough Hypersensitivity Pathways in Chronic Cough?

Authors:
Kian Fan Chung

Am J Respir Crit Care Med 2018 10;198(7):827-828

1 National Heart and Lung Institute Imperial College London London, United Kingdom and.

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http://dx.doi.org/10.1164/rccm.201804-0740EDDOI Listing
October 2018

The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide.

Respir Res 2018 05 9;19(1):85. Epub 2018 May 9.

Airways Disease, National Heart and Lung Institute, Imperial College, London & Royal Brompton NIHR Biomedical Research Unit, London, SW3 6LY, UK.

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http://dx.doi.org/10.1186/s12931-018-0788-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944010PMC
May 2018

Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline.

Int J Chron Obstruct Pulmon Dis 2018;13:1135-1144. Epub 2018 Apr 11.

Department of Thoracic Medicine, Chang Gung Medical Foundation, College of Medicine, Chang Gung University, Taipei, Taiwan.

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http://dx.doi.org/10.2147/COPD.S161257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903494PMC
October 2018

Green respiratory health care: Time for us all to act.

Respirology 2018 05 6;23(5):452-454. Epub 2018 Mar 6.

The National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/resp.13281DOI Listing
May 2018

Asthma Phenotypes Defined From Parameters Obtained During Recovery From a Hospital-Treated Exacerbation.

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):1960-1967. Epub 2018 Mar 1.

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132198183010
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http://dx.doi.org/10.1016/j.jaip.2018.02.012DOI Listing
November 2019

DNA methylation modules in airway smooth muscle are associated with asthma severity.

Eur Respir J 2018 04 12;51(4). Epub 2018 Apr 12.

Airways Disease, National Heart and Lung Institute, Imperial College, London and Royal Brompton NIHR Biomedical Research Unit, London, UK.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01068
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http://dx.doi.org/10.1183/13993003.01068-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902304PMC
April 2018

Diagnosis and Management of Severe Asthma.

Authors:
Kian Fan Chung

Semin Respir Crit Care Med 2018 Feb 10;39(1):91-99. Epub 2018 Feb 10.

Department of Respiratory Medicine, Airways Disease, National Heart & Lung Institute, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1055/s-0037-1607391DOI Listing
February 2018

Cys34 Adductomes Differ between Patients with Chronic Lung or Heart Disease and Healthy Controls in Central London.

Environ Sci Technol 2018 02 2;52(4):2307-2313. Epub 2018 Feb 2.

Division of Environmental Health Sciences, School of Public Health, University of California , Berkeley, California 94720, United States.

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http://dx.doi.org/10.1021/acs.est.7b05554DOI Listing
February 2018

TGF-β Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD.

Chest 2018 04 28;153(4):851-862. Epub 2017 Dec 28.

Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle Vie Aeree e Patologie Fumo-Correlate (CEMICEF), Sezione di Medicina Interna e Cardiorespiratoria, Università di Ferrara, Ferrara, Italy; Unità Operativa Complessa di Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy.

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http://dx.doi.org/10.1016/j.chest.2017.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883327PMC
April 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Metabolic re-patterning in COPD airway smooth muscle cells.

Eur Respir J 2017 11 30;50(5). Epub 2017 Nov 30.

Airways Disease, National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1183/13993003.00202-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725208PMC
November 2017

The Ninth 2016 International London Cough Symposium.

Authors:
Kian Fan Chung

Pulm Pharmacol Ther 2017 12;47

National Heart & Lung Institute, Imperial College & Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, UK.

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http://dx.doi.org/10.1016/j.pupt.2017.11.005DOI Listing
December 2017

Reduced suppressive effect of β-adrenoceptor agonist on fibrocyte function in severe asthma.

Respir Res 2017 Nov 21;18(1):194. Epub 2017 Nov 21.

Airway Disease Section, National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, London, UK.

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http://dx.doi.org/10.1186/s12931-017-0678-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697384PMC
November 2017

Dealing with Stress: Defective Metabolic Adaptation in Chronic Obstructive Pulmonary Disease Pathogenesis.

Ann Am Thorac Soc 2017 Nov;14(Supplement_5):S374-S382

Experimental Studies and Cell and Molecular Biology, Airway Disease Section, National Heart and Lung Institute, Imperial College London and Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom.

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http://dx.doi.org/10.1513/AnnalsATS.201702-153AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711272PMC
November 2017

Potential Role of the Lung Microbiome in Shaping Asthma Phenotypes.

Authors:
Kian Fan Chung

Ann Am Thorac Soc 2017 Nov;14(Supplement_5):S326-S331

1 National Heart and Lung Institute, Imperial College London, London, United Kingdom; and.

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http://dx.doi.org/10.1513/AnnalsATS.201702-138AWDOI Listing
November 2017

Mitochondrial Dysfunction as a Therapeutic Target in COPD.

Authors:
Kian Fan Chung

Tanaffos 2017 ;16(Suppl 1):S19

National Heart & Lung Institute, Imperial College, London UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684722PMC
January 2017

Asthma, COPD & ACOS: -Omics Approach to Refine Treatable Traits in These Conditions.

Authors:
Kian Fan Chung

Tanaffos 2017 ;16(Suppl 1):S18

National Heart & Lung Institute, Imperial College, London UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684721PMC
January 2017

Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma?

Eur Respir Rev 2017 Dec 25;26(146). Epub 2017 Oct 25.

Experimental Studies, National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1183/16000617.0040-2017DOI Listing
December 2017

Fluticasone furoate and vilanterol for the treatment of chronic obstructive pulmonary disease.

Expert Rev Respir Med 2017 12 6;11(12):955-967. Epub 2017 Oct 6.

c Airways Disease Section, National Heart and Lung Institute, Royal Brompton Hospital Biomedical Research Unit , Imperial College London , London , UK.

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http://dx.doi.org/10.1080/17476348.2017.1386564DOI Listing
December 2017