SimpleXMLElement Object ( [PubmedArticle] => Array ( [0] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631853 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1445-5994 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 51 [Issue] => 2 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb ) ) [Title] => Internal medicine journal [ISOAbbreviation] => Intern Med J ) [ArticleTitle] => Current issues in the prevalence, diagnosis and management of hepatocellular carcinoma in Australia. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 181-188 ) [ELocationID] => 10.1111/imj.15184 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Hepatocellular carcinoma (HCC) is the commonest primary liver cancer encountered in the community and a leading cause of cancer morbidity and mortality. In Australia, there are several current important issues that need to be addressed in HCC management. There is a dramatically rising incidence of HCC in Australia with comparatively poorer outcomes in remote regions and in socioeconomic disadvantaged groups. Aboriginal people have a greater incidence of HCC on a background of increased liver disease prevalence and face several barriers to delivery of better healthcare outcomes compared to other Australians. The previously adopted use of imaging alone to diagnose HCC is now being challenged with biopsy likely to become increasingly necessary with the increased uptake of personalised medicine management. Managing HCC is complex involving many disciplines with the multidisciplinary team approach being the current accepted standard of care for patients. New immunotherapy combinations promise to offer patients with advanced HCC promising novel management options. However, the Australian inequities in prevalence, diagnosis and service provision, especially in Aboriginal people, need to be redressed concurrently with the adoption of new HCC management options. [CopyrightInformation] => © 2021 Royal Australasian College of Physicians. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Lubel [ForeName] => John S [Initials] => JS [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Gastroenterology, Alfred Hospital, Melbourne, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Central Clinical School, Monash University, Melbourne, Victoria, Australia. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Roberts [ForeName] => Stuart K [Initials] => SK [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Gastroenterology, Alfred Hospital, Melbourne, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Central Clinical School, Monash University, Melbourne, Victoria, Australia. ) ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Howell [ForeName] => Jessica [Initials] => J [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Gastroenterology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. ) [2] => SimpleXMLElement Object ( [Affiliation] => Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia. ) [3] => SimpleXMLElement Object ( [Affiliation] => Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. ) ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ward [ForeName] => James [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Public Health, University of Queensland, Brisbane, Queensland, Australia. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Shackel [ForeName] => Nichols A [Initials] => NA [Identifier] => https://orcid.org/0000-0001-6441-7145 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => ANZAC Institute Concord Hospital, Sydney, New South Wales, Australia. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Australia [MedlineTA] => Intern Med J [NlmUniqueID] => 101092952 [ISSNLinking] => 1444-0903 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Aboriginal [1] => cirrhosis [2] => hepatocellular carcinoma [3] => liver [4] => liver cancer [5] => multidisciplinary meetiing ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 09 [Day] => 03 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 11 [Day] => 23 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 11 [Day] => 25 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 19 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631853 [1] => 10.1111/imj.15184 ) ) [ReferenceList] => SimpleXMLElement Object ( [Title] => References [Reference] => Array ( [0] => SimpleXMLElement Object ( [Citation] => The Lancet. 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Nivolumab (NIVO) + ipilimumab (IPI) + cabozantinib (CABO) combination therapy in patients (pts) with advanced hepatocellular carcinoma (aHCC): results from CheckMate 040. J Clin Oncol 2020; 38: 478. ) ) ) ) ) [1] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631698 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1879-2448 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 194 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 11 ) ) [Title] => Water research [ISOAbbreviation] => Water Res ) [ArticleTitle] => Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 116923 ) [ELocationID] => Array ( [0] => S0043-1354(21)00121-4 [1] => 10.1016/j.watres.2021.116923 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => The global increase in cyanobacterial blooms poses environmental and health threats. Selected cyanobacterial strains reveal toxicities despite a lack of synthesis of known toxic metabolites, and the mechanisms of these toxicities are not well understood. Here we investigated the toxicity of non-cylindrospermopsin and non-microcystin producing Aphanizomenon gracile and Raphidiopsis raciborskii of Central European origin to zebrafish exposed for 14 days to their extracts. Toxicological screening revealed the presence of anabaenopeptins and a lack of anatoxin-a, ß-methylamino-L-alanine or saxitoxins in examined extracts. The responses were compared to 20 μg L of common cyanobacterial toxins cylindrospermopsin (CYN) and microcystin-LR (MC-LR). The expression of the marker genes involved in apoptosis (caspase 3a and 3b, Bcl-2, BAX, p53, MAPK, Nrf2), DNA damage detection and repair (GADD45, RAD51, JUN, XPC), detoxification (CYP1A, CYP26, EPHX1), lipid metabolism (PPARa, FABP1, PLA2), phosphorylation/dephosphorylation (PPP6C, PPM1) and cytoskeleton (actin, tubulin) were examined using targeted transcriptomics. Cellular stress and toxicity biomarkers (oxidative injury, antioxidant enzymes, thiol pool status, and lactate dehydrogenase activity) were measured in the liver, and acetylcholinesterase activity was determined as an index of neurotoxicity in the brain. The extracts of three cyanobacterial strains that produce no known cyanotoxins caused marked toxicity in D. rerio, and the biomarker profiles indicate different toxic mechanisms between the bioactive compounds extracted from these strains and the purified cyanotoxins. All studied cyanobacterial extracts and purified cyanotoxins induced oxidative stress and neurotoxicity, downregulated Nrf2 and CYP26B1, disrupted phosphorylation/dephosphorylation processes and actin/tubulin cytoskeleton and upregulated apoptotic activity in the liver. The tested strains and purified toxins displayed distinctively different effects on lipid metabolism. Unlike CYN and MC-LR, the Central European strain of A. gracile and R. raciborskii did not reveal a genotoxic potential. These findings help to further understand the ecotoxicological consequences of toxic cyanobacterial blooms in freshwater ecosystems. [CopyrightInformation] => Copyright © 2021 Elsevier Ltd. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Falfushynska [ForeName] => Halina [Initials] => H [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Orthopedagogy and Physical Therapy, Ternopil V. Hnatiuk National Pedagogical University, Ternopil, Ukraine; Department of Marine Biology, Institute for Biological Sciences, University of Rostock, Rostock, Germany. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Horyn [ForeName] => Oksana [Initials] => O [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Orthopedagogy and Physical Therapy, Ternopil V. Hnatiuk National Pedagogical University, Ternopil, Ukraine. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Osypenko [ForeName] => Inna [Initials] => I [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Orthopedagogy and Physical Therapy, Ternopil V. Hnatiuk National Pedagogical University, Ternopil, Ukraine. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rzymski [ForeName] => Piotr [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Environmental Medicine, Poznan University of Medical Sciences, Poznan, Poland; Integrated Science Association (ISA), Universal Scientific Education and Research Network (USERN), Poznań, Poland. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wejnerowski [ForeName] => Łukasz [Initials] => Ł [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Hydrobiology, Institute of Environmental Biology, Faculty of Biology, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Dziuba [ForeName] => Marcin K [Initials] => MK [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Hydrobiology, Institute of Environmental Biology, Faculty of Biology, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sokolova [ForeName] => Inna M [Initials] => IM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Marine Biology, Institute for Biological Sciences, University of Rostock, Rostock, Germany; Department of Maritime Systems, Interdisciplinary Faculty, University of Rostock, Rostock, Germany. Electronic address: inna.sokolova@uni-rostock.de. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 11 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Water Res [NlmUniqueID] => 0105072 [ISSNLinking] => 0043-1354 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Apoptosis [1] => Cell signaling [2] => Cyanotoxin [3] => Genotoxicity [4] => Oxidative stress [5] => Protein phosphatase ) ) [CoiStatement] => Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 09 [Day] => 10 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2021 [Month] => 02 [Day] => 05 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2021 [Month] => 02 [Day] => 09 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 18 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631698 [1] => S0043-1354(21)00121-4 [2] => 10.1016/j.watres.2021.116923 ) ) ) ) [2] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631695 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1879-3363 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 166 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 22 ) ) [Title] => Marine pollution bulletin [ISOAbbreviation] => Mar Pollut Bull ) [ArticleTitle] => Distribution of mercury species in different tissues and trophic levels of commonly consumed fish species from the south Bay of Biscay (France). [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 112172 ) [ELocationID] => Array ( [0] => S0025-326X(21)00206-X [1] => 10.1016/j.marpolbul.2021.112172 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Mercury (Hg) is a contaminant of global concern in marine ecosystems, notably due to its ability to accumulate and concentrate in food webs. Concentrations of total mercury (THg), methylmercury (MeHg) and inorganic mercury (IHg) were assessed and compared in different tissues (liver, muscle, and gonads) of three common fish species (hake Merluccius merluccius, red mullet Mullus surmuletus, and sole Solea solea) from the continental shelf from the southern part of the Bay of Biscay. Several studies investigated Hg concentration in fish muscle, but few assessed concentrations in other organs, despite the importance of such data to understand contaminant organotropism and metabolization. Results showed that trophic position and feeding habitat are required to understand the variability of Hg concentration in muscle between fish species. In addition, high MeHg/THg ratio in muscle could be explained by the predatory behavior of the studied fish species and the biomagnification of this Hg species within the food web, MeHg. Despite differences between species, Hg concentration was always higher in muscle (from 118 ± 64 to 338 ± 101 ng g w.w.) and liver (from 122 ± 108 to 271 ± 95 ng g w.w.). These results can be related to physiological processes especially the MeHg detoxification strategies. [CopyrightInformation] => Copyright © 2021. Published by Elsevier Ltd. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mille [ForeName] => Tiphaine [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM-MIRA, UMR 5254, 64600 Anglet, France. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Bisch [ForeName] => Amaëlle [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM-MIRA, UMR 5254, 64600 Anglet, France. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Caill-Milly [ForeName] => Nathalie [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Ifremer, LITTORAL, Laboratoire Environnement Ressources d'Arcachon, 64600 Anglet, France. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Cresson [ForeName] => Pierre [Initials] => P [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Ifremer, Centre Manche Mer du Nord, Laboratoire Ressources Halieutiques Manche Mer du Nord, 150 quai Gambetta, 62200 Boulogne sur Mer, France. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Deborde [ForeName] => Jonathan [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Ifremer, LITTORAL, Laboratoire Environnement et Ressources des Pertuis Charentais (LER/PC), BP133, 17390 La Tremblade, France. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gueux [ForeName] => Aurore [Initials] => A [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Ifremer, LITTORAL, Laboratoire Environnement et Ressources des Pertuis Charentais (LER/PC), BP133, 17390 La Tremblade, France. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Morandeau [ForeName] => Gilles [Initials] => G [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Ifremer, LITTORAL, Laboratoire Environnement Ressources d'Arcachon, 64600 Anglet, France. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Monperrus [ForeName] => Mathilde [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Université de Pau et des Pays de l'Adour, E2S UPPA, CNRS, IPREM-MIRA, UMR 5254, 64600 Anglet, France. Electronic address: mathilde.monperrus@univ-pau.fr. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 22 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Mar Pollut Bull [NlmUniqueID] => 0260231 [ISSNLinking] => 0025-326X ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Bioaccumulation [1] => Contamination [2] => Methylmercury [3] => Organotropism [4] => Teleostei ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 04 [Day] => 27 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2021 [Month] => 02 [Day] => 09 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2021 [Month] => 02 [Day] => 10 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 17 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631695 [1] => S0025-326X(21)00206-X [2] => 10.1016/j.marpolbul.2021.112172 ) ) ) ) [3] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631572 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1879-1026 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 775 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 04 ) ) [Title] => The Science of the total environment [ISOAbbreviation] => Sci Total Environ ) [ArticleTitle] => Regional variations and relationships among cytokine profiles, white blood cell counts, and blood mercury concentrations in Steller sea lion (Eumetopias jubatus) pups. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 144894 ) [ELocationID] => Array ( [0] => S0048-9697(20)38427-8 [1] => 10.1016/j.scitotenv.2020.144894 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => The Steller sea lion (SSL) population west of 144°W longitude experienced a significant population decline. While there appears to be a stable or increasing population trend in rookeries in the Gulf of Alaska (GOA) and Southeast Alaska (SEA), some rookeries within the Aleutian Islands (AI) have failed to recover. Previous studies found regional differences in whole blood total mercury concentrations ([THg]) showing more than 20% of AI pups had [THg] above critical thresholds for increased risk of immunological effects and other adverse outcomes. Measurements of immune cell-signaling proteins can be used to evaluate the immune status of marine mammals in relation to [THg]. We compared serum cytokine and chemokine concentrations in pups among regions (AI, eastern GOA, SEA), and examined associations among cytokines, chemokines, white blood cell (WBC) counts, and [THg]. Considering liver is an important target organ for mercury and immune protein synthesis we additionally examined the relationship of [THg] with liver-related enzymes serum aspartate (AST) and alanine aminotransferase (ALT). We observed regional differences in cytokine and chemokine measurements and immune protein associations. There was a positive association between total WBC counts and [THg] in AI pups, whereas a negative association between lymphocytes and [THg] in SEA pups. These findings may indicate regional variation in proliferation and differentiation of hematopoietic cells, differences in immune system development, and/or a difference in antigenic stimuli. No associations between [THg] and cytokines, chemokines, AST or ALT were found. Observed regional differences in cytokine and chemokine milieu during gestational and early development in SSL pups could lead to an imbalance in cell differentiation that could impact immunological resiliency in juvenile and adult life stages. We report concentration ranges of a suite of cytokines and chemokines which may prove to be a useful metric for ecotoxicology and risk assessment studies in SSLs and other wildlife. [CopyrightInformation] => Copyright © 2021 Elsevier B.V. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kennedy [ForeName] => Stephanie N [Initials] => SN [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, AK, USA; Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA. Electronic address: Stephanie.Kennedy@childrens.harvard.edu. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Keogh [ForeName] => Mandy [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Alaska Department of Fish and Game, Division of Wildlife Conservation, Juneau, AK, USA. Electronic address: mandyjkeogh@gmail.com. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Levin [ForeName] => Milton [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Veterinary Medicine, University of Connecticut, Storrs, CT, USA. Electronic address: milton.levin@uconn.edu. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Castellini [ForeName] => J Margaret [Initials] => JM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Veterinary Medicine, University of Alaska Fairbanks, Fairbanks, AK, USA. Electronic address: jcastellini@alaska.edu. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Lian [ForeName] => Marianne [Initials] => M [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, AK, USA; Department of Veterinary Medicine, University of Alaska Fairbanks, Fairbanks, AK, USA. Electronic address: mlian@alaska.edu. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Fadely [ForeName] => Brian S [Initials] => BS [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Marine Mammal Laboratory, Alaska Fisheries Science Center, National Marine Fisheries Service, NOAA, Seattle, WA, USA. Electronic address: brian.fadely@noaa.gov. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Rea [ForeName] => Lorrie D [Initials] => LD [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Institute of Northern Engineering, University of Alaska Fairbanks, Fairbanks, AK, USA. Electronic address: LDREA@alaska.edu. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => O'Hara [ForeName] => Todd M [Initials] => TM [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Veterinary Medicine, University of Alaska Fairbanks, Fairbanks, AK, USA; Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA. Electronic address: tmohara@tamu.edu. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 04 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Netherlands [MedlineTA] => Sci Total Environ [NlmUniqueID] => 0330500 [ISSNLinking] => 0048-9697 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Alaska [1] => Cytokines [2] => Hematology [3] => Mercury [4] => Risk assessment [5] => Steller sea lions ) ) [CoiStatement] => Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 11 [Day] => 16 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 12 [Day] => 23 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 12 [Day] => 27 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 15 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631572 [1] => S0048-9697(20)38427-8 [2] => 10.1016/j.scitotenv.2020.144894 ) ) ) ) [4] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631495 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1879-0534 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 131 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 16 ) ) [Title] => Computers in biology and medicine [ISOAbbreviation] => Comput Biol Med ) [ArticleTitle] => Bipolar radiofrequency ablation treatment of liver cancer employing monopolar needles: A comprehensive investigation on the efficacy of time-based switching. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 104273 ) [ELocationID] => Array ( [0] => S0010-4825(21)00067-6 [1] => 10.1016/j.compbiomed.2021.104273 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Radiofrequency ablation (RFA) is a thermal ablative treatment method that is commonly used to treat liver cancer. However, the thermal coagulation zone generated using the conventional RFA system can only successfully treat tumours up to 3 cm in diameter. Switching bipolar RFA has been proposed as a way to increase the thermal coagulation zone. Presently, the understanding of the underlying thermal processes that takes place during switching bipolar RFA remains limited. Hence, the objective of this study is to provide a comprehensive understanding on the thermal ablative effects of time-based switching bipolar RFA on liver tissue. Five switch intervals, namely 50, 100, 150, 200 and 300 s were investigated using a two-compartment 3D finite element model. The study was performed using two pairs of RF electrodes in a four-probe configuration, where the electrodes were alternated based on their respective switch interval. The physics employed in the present study were verified against experimental data from the literature. Results obtained show that using a shorter switch interval can improve the homogeneity of temperature distribution within the tissue and increase the rate of temperature rise by delaying the occurrence of roll-off. The coagulation volume obtained was the largest using switch interval of 50 s, followed by 100, 150, 200 and 300 s. The present study demonstrated that the transient thermal response of switching bipolar RFA can be improved by using shorter switch intervals. [CopyrightInformation] => Copyright © 2021 Elsevier Ltd. All rights reserved. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Yap [ForeName] => Shelley [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ooi [ForeName] => Ean H [Initials] => EH [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia; Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia. Electronic address: ooi.ean.hin@monash.edu. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Foo [ForeName] => Ji J [Initials] => JJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ooi [ForeName] => Ean T [Initials] => ET [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => School of Engineering and Information Technology, Faculty of Science and Technology, Federation University, VIC, 3350, Australia. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 16 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Comput Biol Med [NlmUniqueID] => 1250250 [ISSNLinking] => 0010-4825 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Ablation efficacy [1] => Cancer treatment [2] => Multipolar [3] => RFA [4] => Thermal ablation ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 11 [Day] => 11 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2021 [Month] => 02 [Day] => 09 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2021 [Month] => 02 [Day] => 10 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 14 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631495 [1] => S0010-4825(21)00067-6 [2] => 10.1016/j.compbiomed.2021.104273 ) ) ) ) [5] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631343 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1532-0456 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 22 ) ) [Title] => Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [ISOAbbreviation] => Comp Biochem Physiol C Toxicol Pharmacol ) [ArticleTitle] => Transcriptomic analysis of lead-induced hepatoxicology in female Japanese quails (Coturnix japonica): Implications of triglyceride synthesis, degradation and transport disruption. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 109024 ) [ELocationID] => Array ( [0] => S1532-0456(21)00051-X [1] => 10.1016/j.cbpc.2021.109024 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Lead (Pb) pollution poses great threats to mammals including human and it is also hazardous to bird life. In this study, RNA sequencing analysis was employed to examine the molecular responses to lead exposure in the liver of a toxicological model species Japanese quails. Female birds were exposed to 0, 50, 500 and 1000 ppm waterborne Pb for 49 days. The results showed that hepatic microstructure was damaged under lead exposure featured by sinusoids dilation and irregularity as well as cell necrosis. Moreover, ultrastructural injury in the liver including mitochondrial swelling and vacuolization as well as nuclear deformation was induced by lead exposure. Lead exposure also caused the decrease of lipid droplets in the liver by oil red O staining. In addition, liver transcriptomic analysis revealed that molecular signaling and functional pathways were disrupted by lead exposure. Meanwhile, the expression of genes involved with hepatic glycerophospholipids metabolism of triglyceride synthesis and lipid transport of triglyceride transfer was significantly down-regulated by lead exposure. Moreover, the up-regulation of genes associated with fatty acid oxidation and the down-regulation of genes related with fatty acid synthesis were caused by lead exposure. The present study implied that lead induced liver malfunction and bird health risks through histopathological damages, molecular signaling disruption, genetic expression alteration and triglyceride metabolism disturbance. [CopyrightInformation] => Copyright © 2018. Published by Elsevier Inc. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wang [ForeName] => Ling [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => College of Life Sciences, Shaanxi Normal University, Xi'an 710119 No. 620, West Chang'an Avenue, Chang'an District, Xi'an, Shaanxi 710119, China. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Li [ForeName] => Xuan [Initials] => X [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => College of Life Sciences, Shaanxi Normal University, Xi'an 710119 No. 620, West Chang'an Avenue, Chang'an District, Xi'an, Shaanxi 710119, China. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zhang [ForeName] => Gaixia [Initials] => G [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => College of Life Sciences, Shaanxi Normal University, Xi'an 710119 No. 620, West Chang'an Avenue, Chang'an District, Xi'an, Shaanxi 710119, China. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zhao [ForeName] => Hongfeng [Initials] => H [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => College of Life Sciences, Shaanxi Normal University, Xi'an 710119 No. 620, West Chang'an Avenue, Chang'an District, Xi'an, Shaanxi 710119, China. Electronic address: zhaohf@snnu.edu.cn. ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 22 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => Comp Biochem Physiol C Toxicol Pharmacol [NlmUniqueID] => 100959500 [ISSNLinking] => 1532-0456 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Histopathology [1] => Japanese quail [2] => Lead [3] => Liver [4] => Transcriptome [5] => Triglyceride ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 11 [Day] => 11 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2021 [Month] => 02 [Day] => 13 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2021 [Month] => 02 [Day] => 16 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 11 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631343 [1] => S1532-0456(21)00051-X [2] => 10.1016/j.cbpc.2021.109024 ) ) ) ) ) ) SimpleXMLElement Object ( [PubmedArticle] => Array ( [0] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631867 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1447-0756 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 25 ) ) [Title] => The journal of obstetrics and gynaecology research [ISOAbbreviation] => J Obstet Gynaecol Res ) [ArticleTitle] => Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2017 and annual treatment report for 2012. [ELocationID] => 10.1111/jog.14724 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2017 and the Annual Treatment Report for 2012, on the outcomes of patients who started treatment in 2012. [1] => The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2017 were analyzed retrospectively. Survival of the patients who started treatment with cervical, endometrial and ovarian cancer in 2012 was analyzed by using the Kaplan-Meier, log-rank and Wilcoxon tests. [2] => Treatment was initiated in 2017 for 7710 patients with cervical cancer; 11 120 with endometrial cancer; 7029 with ovarian, tubal and peritoneal cancer; 2164 with ovarian borderline tumors; and with the others (213 vulvar cancer, 139 vaginal cancer, 366 uterine sarcoma, 41 uterine adenosarcoma and 131 trophoblastic diseases). This clinicopathological information was summarized as the patient annual report. The 5-year survival rates of the patients with cervical cancer were 92.9, 75.5, 58.2 and 26.7% for stages I, II, III and IV, respectively. The 5-year survival rates for the patients with endometrial cancer were 93.6, 85.6, 72.6 and 27.3% for stages I, II, III and IV, respectively. The 5-year survival rates for the patients with ovarian cancer (surface epithelial-stromal tumors) were 92.5, 83.5, 49.5 and 30.8% for stages I, II, III and IV, respectively. [3] => The annual tumor report is an important survey that provides knowledge on gynecological malignancy trends in Japan. ) [CopyrightInformation] => © 2021 Japan Society of Obstetrics and Gynecology. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Nagase [ForeName] => Satoru [Initials] => S [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Obstetrics and Gynecology, Yamagata University, Faculty of Medicine, Yamagata, Japan. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Ohta [ForeName] => Tsuyoshi [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Obstetrics and Gynecology, Yamagata University, Faculty of Medicine, Yamagata, Japan. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Takahashi [ForeName] => Fumiaki [Initials] => F [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Information Science, Iwate Medical University, Morioka, Japan. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Yaegashi [ForeName] => Nobuo [Initials] => N [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [CollectiveName] => Board members of the 2020 Committee on Gynecologic Oncology of the Japan Society of Obstetrics and Gynecology ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 25 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Australia [MedlineTA] => J Obstet Gynaecol Res [NlmUniqueID] => 9612761 [ISSNLinking] => 1341-8076 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => Japan [1] => annual report [2] => cervical cancer [3] => endometrial cancer [4] => gynecologic cancer [5] => ovarian [6] => tubal and peritoneal cancer ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 12 [Day] => 01 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2021 [Month] => 02 [Day] => 11 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 19 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631867 [1] => 10.1111/jog.14724 ) ) [ReferenceList] => SimpleXMLElement Object ( [Title] => References [Reference] => Array ( [0] => SimpleXMLElement Object ( [Citation] => Enomoto T. The patients annual report in 2017. Acta Obstet Gynecol Jpn. 2019;71:669-724. ) [1] => SimpleXMLElement Object ( [Citation] => Enomoto T. The treatment annual report in 2010. Acta Obstet Gynecol Jpn. 2019;71:725-803. ) [2] => SimpleXMLElement Object ( [Citation] => Nagase S, Ohta T, Takahashi F, Enomoto T, 2017 Committee on Gynecologic Oncology of the Japan Society of Obstetrics and Gynecology. Annual report of the committee on gynecologic oncology, the Japan Society of Obstetrics and Gynecology: Annual patients report for 2015 and annual treatment report for 2010. J Obstet Gynaecol Res. 2019;45:289-98. https://doi.org/10.1111/jog.13863. ) [3] => SimpleXMLElement Object ( [Citation] => Ramirez PT, Frumovitz M, Pareja R, Lopez A, Vieira M, Ribeiro R, et al. Minimally invasive versus abdominal radical hysterectomy for cervical cancer. N Engl J Med. 2018;379:1895-904. https://doi.org/10.1056/NEJMoa1806395. ) [4] => SimpleXMLElement Object ( [Citation] => Wollinga T, Ezendam NPM, Eggink FA, Smink M, van Hamont D, Pijlman B, et al. Implementation of laparoscopic hysterectomy for endometrial cancer over the past decade. Gynecol Surg. 2018;15(1):7. https://doi.org/10.1186/s10397-018-1040-x. ) [5] => SimpleXMLElement Object ( [Citation] => American Cancer Society. https://www.cancer.org/ ) ) ) ) ) [1] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631863 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1445-5994 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 51 [Issue] => 2 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb ) ) [Title] => Internal medicine journal [ISOAbbreviation] => Intern Med J ) [ArticleTitle] => Autologous stem cell transplantation in elderly multiple myeloma patients aged ≥65 years: a two-centre Australian experience. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 280-283 ) [ELocationID] => 10.1111/imj.15182 [Abstract] => SimpleXMLElement Object ( [AbstractText] => There are currently limited Australian data on the outcomes of autologous stem cell transplantation (ASCT) in elderly multiple myeloma (MM) patients. We present the largest cohort of elderly MM patients aged ≥65 years undergoing ASCT in Australia and report their outcomes based on our two-centre experience. Our study affirms that ASCT is well tolerated, safe and effective in elderly MM patients aged ≥65 years and should be considered an important component of treatment in patients who are fit enough for the procedure. [CopyrightInformation] => © 2021 Royal Australasian College of Physicians. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Er [ForeName] => Jeremy [Initials] => J [Identifier] => https://orcid.org/0000-0002-0512-2862 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => University Hospital Geelong, Barwon Health, Geelong, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Routledge [ForeName] => David [Initials] => D [Identifier] => https://orcid.org/0000-0002-9701-3216 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => University Hospital Geelong, Barwon Health, Geelong, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia. ) [2] => SimpleXMLElement Object ( [Affiliation] => Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. ) ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hempton [ForeName] => Jennifer [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => University Hospital Geelong, Barwon Health, Geelong, Victoria, Australia. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wood [ForeName] => Colin [Initials] => C [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia. ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Joyce [ForeName] => Trish [Initials] => T [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Harrison [ForeName] => Simon [Initials] => S [Identifier] => https://orcid.org/0000-0003-4555-6582 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. ) ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Campbell [ForeName] => Philip [Initials] => P [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => University Hospital Geelong, Barwon Health, Geelong, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Deakin University, Geelong, Victoria, Australia. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Australia [MedlineTA] => Intern Med J [NlmUniqueID] => 101092952 [ISSNLinking] => 1444-0903 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => myeloma, elderly, autologous stem cell transplant, outcomes ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 04 [Day] => 03 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 12 [Day] => 29 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2021 [Month] => 01 [Day] => 10 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 19 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631863 [1] => 10.1111/imj.15182 ) ) [ReferenceList] => SimpleXMLElement Object ( [Title] => References [Reference] => Array ( [0] => SimpleXMLElement Object ( [Citation] => Australian Institute of Health and Welfare (AIHW). 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Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an international myeloma working group report. Blood 2015; 125: 2068-74. ) [14] => SimpleXMLElement Object ( [Citation] => Gay F, Engelhardt M, Terpos E, Wasch R, Giaccone L, Auner HW et al. From transplant to novel cellular therapies in multiple myeloma: European myeloma network guidelines and future perspectives. Haematologica 2018; 103: 197-211. ) ) ) ) ) [2] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631849 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1445-5994 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 51 [Issue] => 2 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb ) ) [Title] => Internal medicine journal [ISOAbbreviation] => Intern Med J ) [ArticleTitle] => Blood-borne virus testing in patients diagnosed with non-Hodgkin lymphoma. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 301-302 ) [ELocationID] => 10.1111/imj.15178 [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Sullivan [ForeName] => Richard P [Initials] => RP [Identifier] => https://orcid.org/0000-0001-7176-1673 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Infectious Diseases, Prince of Wales Hospital, Sydney, New South Wales, Australia. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gaskell [ForeName] => Catriona [Initials] => C [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Infectious Diseases, Prince of Wales Hospital, Sydney, New South Wales, Australia. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Lewis [ForeName] => Craig R [Initials] => CR [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Medical Oncology, Prince of Wales Hospital, Sydney, New South Wales, Australia. ) ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Post [ForeName] => Jeffrey J [Initials] => JJ [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Infectious Diseases, Prince of Wales Hospital, Sydney, New South Wales, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Letter ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Australia [MedlineTA] => Intern Med J [NlmUniqueID] => 101092952 [ISSNLinking] => 1444-0903 ) [CitationSubset] => IM ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2019 [Month] => 12 [Day] => 01 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 01 [Day] => 27 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 01 [Day] => 27 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 19 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631849 [1] => 10.1111/imj.15178 ) ) ) ) [3] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631848 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1445-5994 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [Volume] => 51 [Issue] => 2 [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb ) ) [Title] => Internal medicine journal [ISOAbbreviation] => Intern Med J ) [ArticleTitle] => Mainstreaming genomics: training experience of hospital medical officers at the Royal Melbourne Hospital. [Pagination] => SimpleXMLElement Object ( [MedlinePgn] => 268-271 ) [ELocationID] => 10.1111/imj.15185 [Abstract] => SimpleXMLElement Object ( [AbstractText] => The rapid evolution and wide applicability of genomic testing means that medical practitioners outside the field are not appropriately skilled to understand the utility of genomics for their patients. Rotating junior doctors through genomic medicine provides them with the hands-on experience necessary to understand the complexities in this field. In this study, we analysed the training experience of 12 hospital medical officers who rotated through genomic medicine at the Royal Melbourne Hospital. Here, we demonstrate that immersion in clinical genomics aids in mainstreaming genomics knowledge. [CopyrightInformation] => © 2021 Royal Australasian College of Physicians. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Huq [ForeName] => Aamira J [Initials] => AJ [Identifier] => https://orcid.org/0000-0003-2341-2932 [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Genomic Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Healy [ForeName] => Lachlan [Initials] => L [Identifier] => https://orcid.org/0000-0002-0403-1766 [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Gorelik [ForeName] => Alexandra [Initials] => A [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. ) [2] => SimpleXMLElement Object ( [Affiliation] => Monash Department of Clinical Epidemiology, Cabrini Institute, Melbourne, Victoria, Australia. ) ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Forrest [ForeName] => Laura E [Initials] => LE [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Genomic Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. ) [2] => SimpleXMLElement Object ( [Affiliation] => Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. ) ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Winship [ForeName] => Ingrid M [Initials] => IM [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Department of Genomic Medicine, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => Australia [MedlineTA] => Intern Med J [NlmUniqueID] => 101092952 [ISSNLinking] => 1444-0903 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => HMO education [1] => clinical genetics [2] => genomic medicine [3] => genomics immersion [4] => mainstreaming genomic medicine ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 02 [Day] => 25 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => revised ) [Year] => 2020 [Month] => 10 [Day] => 20 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => accepted ) [Year] => 2020 [Month] => 10 [Day] => 27 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 19 ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => ppublish [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631848 [1] => 10.1111/imj.15185 ) ) [ReferenceList] => SimpleXMLElement Object ( [Title] => References [Reference] => Array ( [0] => SimpleXMLElement Object ( [Citation] => Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J et al. 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J Clin Oncol 2017; 35: 2232-9. ) [9] => SimpleXMLElement Object ( [Citation] => Whitley KV, Tueller JA, Weber KS. Genomics education in the era of personal genomics: academic, professional, and public considerations. Int J Mol Sci 2020; 21: 768. ) [10] => SimpleXMLElement Object ( [Citation] => Iblher P, Hofmann M, Zupanic M, Breuer G. What motivates young physicians? - a qualitative analysis of the learning climate in specialist medical training. BMC Med Educ 2015; 15: 176. ) [11] => SimpleXMLElement Object ( [Citation] => Boor K, Scheele F, van der Vleuten CP, Scherpbier AJJA, Teunissen PW, Sijtsma K. Psychometric properties of an instrument to measure the clinical learning environment. Med Educ 2007; 41: 92-9. ) [12] => SimpleXMLElement Object ( [Citation] => Pales J, Gual A, Escanero J, Tomás I, Castro F R-d, Elorduy M et al. Educational climate perception by preclinical and clinical medical students in five Spanish medical schools. Int J Med Educ 2015; 6: 65-75. ) [13] => SimpleXMLElement Object ( [Citation] => Bosner S, Roth LM, Duncan GF, Donner-Banzhoff N. Verification and feedback for medical students: an observational study during general practice rotations. Postgrad Med J 2016; 93: 3-7. ) [14] => SimpleXMLElement Object ( [Citation] => Nikendei C, Huhn D, Pittius G, Trost Y, Bugaj TJ, Koechel A et al. Students' perceptions on an Interprofessional Ward round training - a qualitative pilot study. GMS J Med Educ 2016; 33: Doc14. ) [15] => SimpleXMLElement Object ( [Citation] => Hendaus MA, Khan S, Osman S, Alsamman Y, Khanna T, Alhammadi A. Physician and medical student perceptions and expectations of the pediatric clerkship: a Qatar experience. Adv Med Educ Pract 2016; 7: 287-92. ) ) ) ) ) [4] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631792 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1523-5866 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 25 ) ) [Title] => Neuro-oncology [ISOAbbreviation] => Neuro Oncol ) [ArticleTitle] => The combined use of steroids and immune checkpoint inhibitors in brain metastasis patients: a systematic review and meta-analysis. [ELocationID] => Array ( [0] => noab046 [1] => 10.1093/neuonc/noab046 ) [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => Immune checkpoint inhibitors (ICI) have been a breakthrough for selected cancer patients, including those with brain metastases (BMs). Likewise, steroids have been an integral component of symptomatic management of BM patients. However, clinical evidence on the interaction between ICI and steroids in BM patients is conflicting and has not adequately been summarized thus far. Hence, the aim of this study was to perform a systematic literature review and meta-analysis on the association between steroid use and overall survival (OS) in BM patients receiving ICI. [1] => A systematic literature search was performed. Pooled effect estimates were calculated using random-effects models across included studies. [2] => After screening 1145 abstracts, fifteen observational studies were included. Fourteen studies reported sufficient data for meta-analysis, comprising 1102 BM patients of which 32.1% received steroids. In the steroid group, median OS ranged from 2.9-10.2 months. In the non-steroid group, median OS ranged from 4.9-25.1 months. Pooled results demonstrated significantly worse OS (HR 1.84, 95% CI 1.22-2.77) and systemic progression free survival (PFS; HR 2.00, 95% CI 1.37-2.91) in the steroid group. Stratified analysis showed a consistent effect across the melanoma subgroup; not in the lung cancer subgroup. No significant association was shown between steroid use and intracranial PFS (HR 1.31, 95% CI 0.42-4.07). [3] => Administration of steroids was associated with significantly worse OS and PFS in BM patients receiving ICI. Further research on dose, timing, and duration of steroids is needed to elucidate the cause of this association and optimize outcomes in BM patients receiving ICI. ) [CopyrightInformation] => © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Jessurun [ForeName] => Charissa A C [Initials] => CAC [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Computational Neuroscience Outcomes Center (CNOC), Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, Zuid-Holland, The Netherlands. Department of Neurosurgery, Haaglanden Medical Center, Lijnbaan, Hague, Zuid-Holland, The Netherlands. ) ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hulsbergen [ForeName] => Alexander F C [Initials] => AFC [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Computational Neuroscience Outcomes Center (CNOC), Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, Zuid-Holland, The Netherlands. Department of Neurosurgery, Haaglanden Medical Center, Lijnbaan, Hague, Zuid-Holland, The Netherlands. ) ) ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => de Wit [ForeName] => Anouk E [Initials] => AE [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. ) ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Tewarie [ForeName] => Ishaan A [Initials] => IA [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Computational Neuroscience Outcomes Center (CNOC), Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, Zuid-Holland, The Netherlands. Department of Neurosurgery, Haaglanden Medical Center, Lijnbaan, Hague, Zuid-Holland, The Netherlands. ) ) ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Snijders [ForeName] => Tom J [Initials] => TJ [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, The Netherlands. ) ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Verhoeff [ForeName] => Joost [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. ) ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Phillips [ForeName] => John [Initials] => J [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Department of Radiation Oncology, Dana Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ) ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Reardon [ForeName] => David A [Initials] => DA [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Harvard Medical School, Boston, MA, USA. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ) ) ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Mekary [ForeName] => Rania A [Initials] => RA [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Computational Neuroscience Outcomes Center (CNOC), Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Pharmaceutical Business and Administrative Sciences, School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, United States. ) ) ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Broekman [ForeName] => Marike L D [Initials] => MLD [AffiliationInfo] => Array ( [0] => SimpleXMLElement Object ( [Affiliation] => Computational Neuroscience Outcomes Center (CNOC), Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States. ) [1] => SimpleXMLElement Object ( [Affiliation] => Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, Zuid-Holland, The Netherlands. Department of Neurosurgery, Haaglanden Medical Center, Lijnbaan, Hague, Zuid-Holland, The Netherlands. ) [2] => SimpleXMLElement Object ( [Affiliation] => Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States. ) ) ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 25 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => England [MedlineTA] => Neuro Oncol [NlmUniqueID] => 100887420 [ISSNLinking] => 1522-8517 ) [CitationSubset] => IM [KeywordList] => SimpleXMLElement Object ( [@attributes] => Array ( [Owner] => NOTNLM ) [Keyword] => Array ( [0] => brain metastases [1] => immune checkpoint inhibitors [2] => meta-analysis [3] => steroids [4] => survival ) ) ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => received ) [Year] => 2020 [Month] => 10 [Day] => 31 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 18 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631792 [1] => 6150018 [2] => 10.1093/neuonc/noab046 ) ) ) ) [5] => SimpleXMLElement Object ( [MedlineCitation] => SimpleXMLElement Object ( [@attributes] => Array ( [Status] => Publisher [Owner] => NLM ) [PMID] => 33631781 [DateRevised] => SimpleXMLElement Object ( [Year] => 2021 [Month] => 02 [Day] => 25 ) [Article] => SimpleXMLElement Object ( [@attributes] => Array ( [PubModel] => Print-Electronic ) [Journal] => SimpleXMLElement Object ( [ISSN] => 1526-0976 [JournalIssue] => SimpleXMLElement Object ( [@attributes] => Array ( [CitedMedium] => Internet ) [PubDate] => SimpleXMLElement Object ( [Year] => 2021 [Month] => Feb [Day] => 25 ) ) [Title] => Journal of lower genital tract disease [ISOAbbreviation] => J Low Genit Tract Dis ) [ArticleTitle] => Addressing Unmet Basic Needs to Improve Colposcopy Adherence Among Women With Abnormal Cervical Cancer Screening. [ELocationID] => 10.1097/LGT.0000000000000593 [Abstract] => SimpleXMLElement Object ( [AbstractText] => Array ( [0] => The aims of the study were to identify unmet basic needs (BNs) among women referred to colposcopy, to assess patient acceptability/satisfaction with assistance from a navigator to address unmet BNs, and to estimate adherence to colposcopy. [1] => Women were recruited between September 2017 and January 2019 from 2 academic colposcopy centers, one serving a rural and one an urban area. Basic needs were assessed by phone before colposcopy appointments and considered unmet if unlikely to resolve in 1 month. Colposcopy adherence prestudy and poststudy implementation was abstracted over 4-6 months from administrative records. After a lead-in phase of 25 patients at each site, a BN navigator was offered to new participants with 1 or more unmet BNs. Primary outcome was adherence to initial appointment. [2] => Among 100 women, 59% had 1 or more unmet BNs, with similar prevalence between urban and rural sites. Adherence to initial colposcopy was 83% overall, 72% at the rural clinic, and 94% at the urban clinic (p = .006). These adherence rates were improved from 4 months before study launch (30/59 [51%] rural clinic and 68/137 [50%] urban clinic). Although acceptability of BN navigation was greater than 96% and women felt that it helped them get to their colposcopy visit, having a navigator was not associated with adherence. Women reporting no unmet BNs had the lowest adherence compared with women with 1 or more unmet BNs, regardless of navigator assistance (p = .03). [3] => Disadvantaged women who need colposcopy have unmet BNs and value navigator assistance for initial appointments. However, when appointment scheduling includes telephone reminders and inquiring about BNs, a navigator may not add value. ) [CopyrightInformation] => Copyright © 2021 by the American Society for Colposcopy and Cervical Pathology. ) [AuthorList] => SimpleXMLElement Object ( [@attributes] => Array ( [CompleteYN] => Y ) [Author] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kuroki [ForeName] => Lindsay [Initials] => L [AffiliationInfo] => SimpleXMLElement Object ( [Affiliation] => Division of Gynecologic Oncology, Washington University School of Medicine, Alvin J. Siteman Cancer Center, St Louis, MO Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine (SIUM), Springfield, IL Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO Health Communication Research Laboratory, The Brown School, Washington University in St Louis, St Louis, MO Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO Center for Clinical Research, SIUM, Springfield, IL. ) ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Massad [ForeName] => L Stewart [Initials] => LS ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Martin [ForeName] => Anne [Initials] => A ) [3] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Liu [ForeName] => Jingxia [Initials] => J ) [4] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Brown [ForeName] => Dominique [Initials] => D ) [5] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Leon [ForeName] => Andrea [Initials] => A ) [6] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Groesch [ForeName] => Kathleen [Initials] => K ) [7] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Wilson [ForeName] => Teresa [Initials] => T ) [8] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Zeino [ForeName] => Yahia [Initials] => Y ) [9] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Diaz-Sylvester [ForeName] => Paula [Initials] => P ) [10] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Delfino [ForeName] => Kristin [Initials] => K ) [11] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Hyon [ForeName] => Katherine [Initials] => K ) [12] => SimpleXMLElement Object ( [@attributes] => Array ( [ValidYN] => Y ) [LastName] => Kreuter [ForeName] => Matthew [Initials] => M ) ) ) [Language] => eng [PublicationTypeList] => SimpleXMLElement Object ( [PublicationType] => Journal Article ) [ArticleDate] => SimpleXMLElement Object ( [@attributes] => Array ( [DateType] => Electronic ) [Year] => 2021 [Month] => 02 [Day] => 25 ) ) [MedlineJournalInfo] => SimpleXMLElement Object ( [Country] => United States [MedlineTA] => J Low Genit Tract Dis [NlmUniqueID] => 9704963 [ISSNLinking] => 1089-2591 ) [CitationSubset] => IM [CoiStatement] => The authors have declared they have no conflicts of interest. ) [PubmedData] => SimpleXMLElement Object ( [History] => SimpleXMLElement Object ( [PubMedPubDate] => Array ( [0] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => entrez ) [Year] => 2021 [Month] => 2 [Day] => 25 [Hour] => 20 [Minute] => 18 ) [1] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => pubmed ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) [2] => SimpleXMLElement Object ( [@attributes] => Array ( [PubStatus] => medline ) [Year] => 2021 [Month] => 2 [Day] => 26 [Hour] => 6 [Minute] => 0 ) ) ) [PublicationStatus] => aheadofprint [ArticleIdList] => SimpleXMLElement Object ( [ArticleId] => Array ( [0] => 33631781 [1] => 10.1097/LGT.0000000000000593 [2] => 00128360-900000000-99356 ) ) ) ) ) ) 10 Ki-Jo Lim | PubFacts

Publications by authors named "Ki-Jo Lim"