Publications Authored by Khurum Khan

Targeting EGFR pathway in metastatic colorectal cancer- tumour heterogeniety and convergent evolution.

Authors:

Khurum Khan Nicola Valeri Charles Dearman Sheela Rao David Watkins Naureen Starling Ian Chau David Cunningham

Crit Rev Oncol Hematol 2019 Nov 7;143:153-163. Epub 2019 Sep 7.

Gastrointestinal Unit, The Royal Marsden NHS Foundation Trust, Sutton SM2 5PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2019.09.001	DOI Listing

November 2019

miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial.

Clin Cancer Res 2019 Jul 5;25(13):3830-3838. Epub 2019 Apr 5.

Department of Medicine, The Royal Marsden NHS Trust, London and Sutton, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3769	DOI Listing

July 2019

Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.

Oncogene 2019 Jul;38(28):5746

Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41388-019-0835-1	DOI Listing

July 2019

Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.

Cancer Cell 2019 Jul;36(1):35-50.e9

Translational Oncogenomics Lab, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; GI Cancer Unit, The Royal Marsden Hospital, London SW3 6JJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.05.013	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617392	PMC

July 2019

Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer: a systematic review and patient-level meta-analysis.

J Natl Cancer Inst 2019 May 14. Epub 2019 May 14.

Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1093/jnci/djz073	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695305	PMC

May 2019

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids.

J Immunother Cancer 2019 Apr 15;7(1):101. Epub 2019 Apr 15.

Translational Oncogenomics Laboratory, Centre for Evolution and Cancer, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.

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http://dx.doi.org/10.1186/s40425-019-0575-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463631	PMC

April 2019

Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.

Oncogene 2019 03 23;38(10):1717-1733. Epub 2018 Oct 23.

Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41388-018-0554-z	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462854	PMC

March 2019

Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience.

Authors:

Khurum Khan Jayant K Rane David Cunningham Sheela Rao David Watkins Naureen Starling Eleftheria Kalaitzaki Martin Forster Chiara Braconi Nicola Valeri Marco Gerlinger Ian Chau

Clin Colorectal Cancer 2019 03 29;18(1):64-71.e1. Epub 2018 Sep 29.

Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183021	Publisher Site
http://dx.doi.org/10.1016/j.clcc.2018.09.010	DOI Listing

March 2019

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.

Cancer Discov 2018 10 30;8(10):1270-1285. Epub 2018 Aug 30.

Department of Medicine, The Royal Marsden NHS Trust, London and Sutton, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0891	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380469	PMC

October 2018

Clinical outcomes of adolescents and young adults with advanced solid tumours participating in phase I trials.

Authors:

Raghav Sundar Terri McVeigh David Dolling Ann Petruckevitch Nikolaos Diamantis Joo Ern Ang Maxime Chenard-Poiriér Dearbhaile Collins Joline Lim Malaka Ameratunga Khurum Khan Stan B Kaye Udai Banerji Juanita Lopez Angela J George Johann S de Bono Winette T van der Graaf

Eur J Cancer 2018 09 17;101:55-61. Epub 2018 Jul 17.

Sarcoma Unit, The Royal Marsden NHS Foundation Trust, The Institute of Cancer Research, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183089	Publisher Site
http://dx.doi.org/10.1016/j.ejca.2018.06.003	DOI Listing

September 2018

Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study.

Gut 2018 08 8;67(8):1484-1492. Epub 2017 Aug 8.

Department of Medicine, The Royal Marsden NHS Trust, London and Sutton, UK.

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http://dx.doi.org/10.1136/gutjnl-2017-314178	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204951	PMC

August 2018

Translational research and application of basic biology to clinical trial development in GI cancers.

Authors:

Elizabeth Smyth Khurum Khan Nicola Valeri

Ann Transl Med 2018 May;6(9):164

Department of Gastrointestinal Cancer and Lymphoma, Royal Marsden, UK.

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http://dx.doi.org/10.21037/atm.2018.05.05	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985276	PMC

May 2018

MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.

Gastroenterology 2018 03 4;154(4):1066-1079.e5. Epub 2017 Nov 4.

The Institute of Cancer Research, London, UK; The Royal Marsden NHS Trust, London and Surrey, UK. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.10.043	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863695	PMC

March 2018

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

Science 2018 02;359(6378):920-926

Division of Molecular Pathology, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1126/science.aao2774	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112415	PMC

February 2018

In Reply.

Authors:

Khurum Khan David Cunningham Katharine Aitken Sheela Rao

Oncologist 2017 11 10;22(11):1411-1412. Epub 2017 Aug 10.

GI and Lymphoma Unit, Department of Medicine, The Royal Marsden National Health Service Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1634/theoncologist.2017-0258	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679830	PMC

November 2017

Targeting Angiogenic Pathways in Colorectal Cancer: Complexities, Challenges and Future Directions.

Authors:

Khurum Khan David Cunningham Ian Chau

Curr Drug Targets 2017 ;18(1):56-71

Consultant in Medical Oncology, Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, Sutton SM2 5PT, UK.

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http://dx.doi.org/10.2174/1389450116666150325231555	DOI Listing

September 2017

Survival Outcomes in Asymptomatic Patients With Normal Conventional Imaging but Raised Carcinoembryonic Antigen Levels in Colorectal Cancer Following Positron Emission Tomography-Computed Tomography Imaging.

Authors:

Khurum Khan Avani Athauda Katharine Aitken David Cunningham David Watkins Naureen Starling Gary J Cook Eleftheria Kalaitzaki Ian Chau Sheela Rao

Oncologist 2016 12 14;21(12):1502-1508. Epub 2016 Oct 14.

GI and Lymphoma Unit, Department of Medicine, The Royal Marsden National Health Service Foundation Trust, London, United Kingdom

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http://dx.doi.org/10.1634/theoncologist.2016-0222	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153343	PMC

December 2016

Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management.

Authors:

Khurum H Khan Mabel Wong Karim Rihawi Shankar Bodla Daniel Morganstein Udai Banerji Lulama R Molife

Oncologist 2016 07 5;21(7):855-60. Epub 2016 May 5.

Drug Development Unit, Royal Marsden National Health Service Trust, London, United Kingdom

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http://dx.doi.org/10.1634/theoncologist.2015-0248	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943382	PMC

July 2016

AREG and EREG as Predictive Biomarkers for RAS Wild-Type Colorectal Cancer Treated With Panitumumab: A Fresh Approach to an Old Puzzle.

Authors:

Elizabeth C Smyth Khurum Khan David Cunningham

JAMA Oncol 2016 May;2(5):578-579

Royal Marsden Hospital, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaoncol.2015.6274	DOI Listing

May 2016

miR-21 expression and clinical outcome in locally advanced pancreatic cancer: exploratory analysis of the pancreatic cancer Erbitux, radiotherapy and UFT (PERU) trial.

Authors:

Khurum Khan David Cunningham Clare Peckitt Sarah Barton Diana Tait Maria Hawkins David Watkins Naureen Starling Sheela Rao Ruwaida Begum Janet Thomas Jacqui Oates Vincenza Guzzardo Matteo Fassan Chiara Braconi Ian Chau

Oncotarget 2016 Mar;7(11):12672-81

Gastrointestinal Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK.

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http://dx.doi.org/10.18632/oncotarget.7208	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914313	PMC

March 2016

Phase I trial of cyclophosphamide as an immune modulator for optimizing oncolytic reovirus delivery to solid tumors.

Authors:

Victoria Roulstone Khurum Khan Hardev S Pandha Sarah Rudman Matt Coffey George M Gill Alan A Melcher Richard Vile Kevin J Harrington Johann de Bono James Spicer

Clin Cancer Res 2015 Mar 25;21(6):1305-12. Epub 2014 Nov 25.

King's College London, Guy's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1770	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821068	PMC

March 2015

Antitumor activity in RAS-driven tumors by blocking AKT and MEK.

Clin Cancer Res 2015 Feb 16;21(4):739-48. Epub 2014 Dec 16.

Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1901	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335074	PMC

February 2015

Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): the Royal Marsden Hospital (RMH) experience.

Authors:

Khurum Khan Clare Peckitt Francesco Sclafani David Watkins Sheela Rao Naureen Starling Vikram Jain Sachin Trivedi Susannah Stanway David Cunningham Ian Chau

BMC Cancer 2015 Jan 21;15:15. Epub 2015 Jan 21.

Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK.

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http://dx.doi.org/10.1186/s12885-015-1014-6	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305243	PMC

January 2015

FOLFIRINOX for locally advanced or metastatic pancreatic ductal adenocarcinoma: the Royal Marsden experience.

Authors:

Sing Yu Moorcraft Khurum Khan Clare Peckitt David Watkins Sheela Rao David Cunningham Ian Chau

Clin Colorectal Cancer 2014 Dec 21;13(4):232-8. Epub 2014 Sep 21.

Gastrointestinal Unit, The Royal Marsden NHS Foundation Trust, Surrey, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2014.09.005	DOI Listing

December 2014

Phase I trials in patients with relapsed, advanced upper gastrointestinal carcinomas: experience in a specialist unit.

Authors:

Khurum Khan Joo Ern Ang Naureen Starling Francesco Sclafani Krunal Shah Ian Judson L Rhoda Molife Udai Banerji Johann S de Bono David Cunningham Stan B Kaye

Gastric Cancer 2014 Oct 21;17(4):621-629. Epub 2014 Jan 21.

Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton SM2 5PT, UK.

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http://dx.doi.org/10.1007/s10120-013-0328-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881817	PMC

October 2014

Colorectal cancer with liver metastases: neoadjuvant chemotherapy, surgical resection first or palliation alone?

Authors:

Khurum Khan Anita Wale Gina Brown Ian Chau

World J Gastroenterol 2014 Sep;20(35):12391-406

Khurum Khan, Ian Chau, Gastrointestinal Unit, the Royal Marsden NHS Foundation Trust, Sutton SM2 5PT, United Kingdom.

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http://dx.doi.org/10.3748/wjg.v20.i35.12391	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168073	PMC

September 2014

Cancer therapeutics: Targeting the apoptotic pathway.

Authors:

Khurum H Khan Montserrat Blanco-Codesido L Rhoda Molife

Crit Rev Oncol Hematol 2014 Jun 18;90(3):200-19. Epub 2013 Dec 18.

Drug Development Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Downs Road, Surrey, Sutton, UK. Electronic address:

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