Publications by authors named "Khoa M Le"

16Publications

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.

Cell Rep 2016 11;17(9):2195-2209

Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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November 2016

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.

Cell 2016 Sep;166(6):1459-1470.e11

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02129, USA. Electronic address:

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September 2016

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice.

Science 2016 09 8;353(6307):1557-1560. Epub 2016 Sep 8.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital (MGH), MIT, and Harvard, Cambridge, MA 02129, USA.

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September 2016

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

Immunity 2016 07;45(1):31-45

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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July 2016

Protection of Humanized Mice From Repeated Intravaginal HIV Challenge by Passive Immunization: A Model for Studying the Efficacy of Neutralizing Antibodies In Vivo.

J Infect Dis 2016 08 29;214(4):612-6. Epub 2016 Jun 29.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston.

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August 2016

Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques.

AIDS 2016 06;30(10):1543-51

aDepartment of Immunology and Microbial Science, IAVI Neutralizing Antibody Center and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California bEmory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia cCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts dBioqual, Inc., Rockville, Maryland eBioinformatics and Systems Biology Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA fGenmab, Utrecht, The Netherlands gRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA. *Present address: MedImmune, LLC, Gaithersburg, Maryland, USA.

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June 2016

Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies.

Retrovirology 2016 Feb 2;13. Epub 2016 Feb 2.

Department of Infectious Diseases, King's College London School of Medicine, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.

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February 2016

Correction for Doores et al., Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope.

J Virol 2015 Jun;89(12):6525

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, USA Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, USA.

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June 2015

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.

Proc Natl Acad Sci U S A 2014 Dec 24;111(49):17624-9. Epub 2014 Nov 24.

Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, MA 02142

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December 2014

Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope.

J Virol 2015 Jan 5;89(2):1105-18. Epub 2014 Nov 5.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, USA Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, USA

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January 2015

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

Sci Transl Med 2014 May;6(236):236ra63

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, MA 02142, USA.

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May 2014

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.

Immunity 2014 May 24;40(5):657-68. Epub 2014 Apr 24.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, MA 02114, USA. Electronic address:

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May 2014

2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies.

J Virol 2013 Feb 5;87(4):2234-41. Epub 2012 Dec 5.

Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, California, USA.

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February 2013

Very few substitutions in a germ line antibody are required to initiate significant domain exchange.

J Virol 2010 Oct 11;84(20):10700-7. Epub 2010 Aug 11.

Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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October 2010