Khedoudja Nafa

Rapid EGFR Mutation Detection Using the Idylla Platform: Single-Institution Experience of 1200 Cases Analyzed by an In-House Developed Pipeline and Comparison with Concurrent Next-Generation Sequencing Results.

Authors:

Amir Momeni-Boroujeni Paulo Salazar Tao Zheng Nana Mensah Ivelise Rijo Snjezana Dogan JinYuan Yao Christine Moung Chad Vanderbilt Jamal Benhamida Jason Chang William Travis Natasha Rekhtman Marc Ladanyi Khedoudja Nafa Maria E Arcila

J Mol Diagn 2020 Dec 18. Epub 2020 Dec 18.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

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December 2020

Routine Evaluation of Minimal Residual Disease in Myeloma Using Next-Generation Sequencing Clonality Testing: Feasibility, Challenges, and Direct Comparison with High-Sensitivity Flow Cytometry.

J Mol Diagn 2020 Nov 17. Epub 2020 Nov 17.

Hematopathology Service, Memorial Sloan-Kettering Cancer Center, New York, New York; Diagnostic Molecular Pathology Service, Memorial Sloan-Kettering Cancer Center, New York, New York. Electronic address:

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November 2020

Chromosome 3p loss of heterozygosity and reduced expression of H3K36me3 correlate with longer relapse-free survival in sacral conventional chordoma.

Authors:

Guo Gord Zhu Daniel Ramirez Wen Chen Chao Lu Lu Wang Denise Frosina Achim Jungbluth Peter Ntiamoah Khedoudja Nafa Patrick J Boland Meera R Hameed

Hum Pathol 2020 Oct 12;104:73-83. Epub 2020 Aug 12.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. Electronic address:

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October 2020

Reliable Clinical MLH1 Promoter Hypermethylation Assessment Using a High-Throughput Genome-Wide Methylation Array Platform.

Authors:

Jamal K Benhamida Jaclyn F Hechtman Khedoudja Nafa Liliana Villafania Justyna Sadowska Jiajing Wang Donna Wong Ahmet Zehir Liying Zhang Tejus Bale Maria E Arcila Marc Ladanyi

J Mol Diagn 2020 03 24;22(3):368-375. Epub 2019 Dec 24.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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March 2020

RUNX2 (6p21.1) amplification in osteosarcoma.

Authors:

Sounak Gupta Tatsuo Ito Deepu Alex Chad M Vanderbilt Jason C Chang Nasrin Islamdoust Yanming Zhang Khedoudja Nafa John Healey Marc Ladanyi Meera R Hameed

Hum Pathol 2019 12 25;94:23-28. Epub 2019 Oct 25.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA, 10065. Electronic address:

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December 2019

Genomic Profiling Identifies Association of Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma.

Authors:

Guo Gord Zhu Khedoudja Nafa Narasimhan Agaram Ahmet Zehir Ryma Benayed Justyna Sadowska Laetitia Borsu Ciara Kelly William D Tap Nicola Fabbri Edward Athanasian Patrick J Boland John H Healey Michael F Berger Marc Ladanyi Meera Hameed

Clin Cancer Res 2020 01 15;26(2):419-427. Epub 2019 Oct 15.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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January 2020

Clonally-Related CD5+ CLL/SLL and CD10+ high grade B-cell lymphoma suggests common neoplastic progenitor with branched disease evolution, with therapeutic implications.

Authors:

Priyadarshini Kumar Manik Uppal Wenbin Xiao Ahmet Dogan Mikhail Roshal Qi Gao Umut Aypar Yanming Zhang Maria E Arcila Christine Moung Jinjuan Yao Khedoudja Nafa Wayne Yu Mustafa H Syed Jae Park Anita Kumar Caleb Ho

Leuk Lymphoma 2020 02 15;61(2):460-464. Epub 2019 Oct 15.

Hematopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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February 2020

Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations.

Authors:

Yoshiyuki Suehara Deepu Alex Anita Bowman Sumit Middha Ahmet Zehir Debyani Chakravarty Lu Wang George Jour Khedoudja Nafa Takuo Hayashi Achim A Jungbluth Denise Frosina Emily Slotkin Neerav Shukla Paul Meyers John H Healey Meera Hameed Marc Ladanyi

Clin Cancer Res 2019 11 7;25(21):6346-6356. Epub 2019 Jun 7.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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November 2019

The t(11;14)(q13;q32)/CCND1-IGH translocation in chronic lymphocytic leukaemia/small lymphocytic lymphoma: an unusual genetic aberration during the natural clinical course.

Authors:

Ying Liu Mikhail Roshal Wenbin Xiao Yanming Zhang Umut Aypar Wayne Yu Khedoudja Nafa Maria Arcila Christine Moung Ahmet Dogan Jae Park Caleb Ho

Histopathology 2019 08;75(2):291-294

Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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August 2019

Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions.

Cancer Res 2019 03 14;79(6):1047-1053. Epub 2019 Jan 14.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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March 2019

Establishment of Immunoglobulin Heavy (IGH) Chain Clonality Testing by Next-Generation Sequencing for Routine Characterization of B-Cell and Plasma Cell Neoplasms.

Authors:

Maria E Arcila Wayne Yu Mustafa Syed Hannah Kim Lidia Maciag JinJuan Yao Caleb Ho Kseniya Petrova Christine Moung Paulo Salazar Ivelise Rijo Tessara Baldi Ahmet Zehir Ola Landgren Jae Park Mikhail Roshal Ahmet Dogan Khedoudja Nafa

J Mol Diagn 2019 03 25;21(2):330-342. Epub 2018 Dec 25.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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March 2019

Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma.

Authors:

Guo Zhu Ryma Benayed Caleb Ho Kerry Mullaney Purvil Sukhadia Kelly Rios Ryan Berry Brian P Rubin Khedoudja Nafa Lu Wang David S Klimstra Marc Ladanyi Meera R Hameed

Mod Pathol 2019 05 21;32(5):609-620. Epub 2018 Nov 21.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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May 2019

Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.

JAMA 2017 09;318(9):825-835

Memorial Sloan Kettering Cancer Center, New York, New York.

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September 2017

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Authors:

Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Deborah F DeLair JinJuan Yao Diana L Mandelker Donavan T Cheng Raghu Chandramohan Abhinita S Mohanty Ryan N Ptashkin Gowtham Jayakumaran Meera Prasad Mustafa H Syed Anoop Balakrishnan Rema Zhen Y Liu Khedoudja Nafa Laetitia Borsu Justyna Sadowska Jacklyn Casanova Ruben Bacares Iwona J Kiecka Anna Razumova Julie B Son Lisa Stewart Tessara Baldi Kerry A Mullaney Hikmat Al-Ahmadie Efsevia Vakiani Adam A Abeshouse Alexander V Penson Philip Jonsson Niedzica Camacho Matthew T Chang Helen H Won Benjamin E Gross Ritika Kundra Zachary J Heins Hsiao-Wei Chen Sarah Phillips Hongxin Zhang Jiaojiao Wang Angelica Ochoa Jonathan Wills Michael Eubank Stacy B Thomas Stuart M Gardos Dalicia N Reales Jesse Galle Robert Durany Roy Cambria Wassim Abida Andrea Cercek Darren R Feldman Mrinal M Gounder A Ari Hakimi James J Harding Gopa Iyer Yelena Y Janjigian Emmet J Jordan Ciara M Kelly Maeve A Lowery Luc G T Morris Antonio M Omuro Nitya Raj Pedram Razavi Alexander N Shoushtari Neerav Shukla Tara E Soumerai Anna M Varghese Rona Yaeger Jonathan Coleman Bernard Bochner Gregory J Riely Leonard B Saltz Howard I Scher Paul J Sabbatini Mark E Robson David S Klimstra Barry S Taylor Jose Baselga Nikolaus Schultz David M Hyman Maria E Arcila David B Solit Marc Ladanyi Michael F Berger

Nat Med 2017 08;23(8):1004

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August 2017

Comprehensive detection of germline variants by MSK-IMPACT, a clinical diagnostic platform for solid tumor molecular oncology and concurrent cancer predisposition testing.

Authors:

Donavan T Cheng Meera Prasad Yvonne Chekaluk Ryma Benayed Justyna Sadowska Ahmet Zehir Aijazuddin Syed Yan Elsa Wang Joshua Somar Yirong Li Zarina Yelskaya Donna Wong Mark E Robson Kenneth Offit Michael F Berger Khedoudja Nafa Marc Ladanyi Liying Zhang

BMC Med Genomics 2017 05 19;10(1):33. Epub 2017 May 19.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 36, New York, NY, 10065, USA.

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May 2017

Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.

Authors:

Snjezana Dogan Deborah J Chute Bin Xu Ryan N Ptashkin Raghu Chandramohan Jacklyn Casanova-Murphy Khedoudja Nafa Justin A Bishop Simion I Chiosea Edward B Stelow Ian Ganly David G Pfister Nora Katabi Ronald A Ghossein Michael F Berger

J Pathol 2017 08 9;242(4):400-408. Epub 2017 Jun 9.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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August 2017

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Authors:

Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Deborah F DeLair JinJuan Yao Diana L Mandelker Donavan T Cheng Raghu Chandramohan Abhinita S Mohanty Ryan N Ptashkin Gowtham Jayakumaran Meera Prasad Mustafa H Syed Anoop Balakrishnan Rema Zhen Y Liu Khedoudja Nafa Laetitia Borsu Justyna Sadowska Jacklyn Casanova Ruben Bacares Iwona J Kiecka Anna Razumova Julie B Son Lisa Stewart Tessara Baldi Kerry A Mullaney Hikmat Al-Ahmadie Efsevia Vakiani Adam A Abeshouse Alexander V Penson Philip Jonsson Niedzica Camacho Matthew T Chang Helen H Won Benjamin E Gross Ritika Kundra Zachary J Heins Hsiao-Wei Chen Sarah Phillips Hongxin Zhang Jiaojiao Wang Angelica Ochoa Jonathan Wills Michael Eubank Stacy B Thomas Stuart M Gardos Dalicia N Reales Jesse Galle Robert Durany Roy Cambria Wassim Abida Andrea Cercek Darren R Feldman Mrinal M Gounder A Ari Hakimi James J Harding Gopa Iyer Yelena Y Janjigian Emmet J Jordan Ciara M Kelly Maeve A Lowery Luc G T Morris Antonio M Omuro Nitya Raj Pedram Razavi Alexander N Shoushtari Neerav Shukla Tara E Soumerai Anna M Varghese Rona Yaeger Jonathan Coleman Bernard Bochner Gregory J Riely Leonard B Saltz Howard I Scher Paul J Sabbatini Mark E Robson David S Klimstra Barry S Taylor Jose Baselga Nikolaus Schultz David M Hyman Maria E Arcila David B Solit Marc Ladanyi Michael F Berger

Nat Med 2017 Jun 8;23(6):703-713. Epub 2017 May 8.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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June 2017

A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia.

Authors:

Jinjuan Yao Dan Douer Lu Wang Maria E Arcila Khedoudja Nafa April Chiu

Leuk Res Rep 2017 31;7:17-19. Epub 2017 Jan 31.

Department of Laboratory Medicine and Pathology Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

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January 2017

Reliable Pan-Cancer Microsatellite Instability Assessment by Using Targeted Next-Generation Sequencing Data.

Authors:

Sumit Middha Liying Zhang Khedoudja Nafa Gowtham Jayakumaran Donna Wong Hyunjae R Kim Justyna Sadowska Michael F Berger Deborah F Delair Jinru Shia Zsofia Stadler David S Klimstra Marc Ladanyi Ahmet Zehir Jaclyn F Hechtman

JCO Precis Oncol 2017 3;2017. Epub 2017 Oct 3.

Memorial Sloan Kettering Cancer Center, New York, NY.

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October 2017

Next-Generation Assessment of Human Epidermal Growth Factor Receptor 2 (ERBB2) Amplification Status: Clinical Validation in the Context of a Hybrid Capture-Based, Comprehensive Solid Tumor Genomic Profiling Assay.

Authors:

Dara S Ross Ahmet Zehir Donavan T Cheng Ryma Benayed Khedoudja Nafa Jaclyn F Hechtman Yelena Y Janjigian Britta Weigelt Pedram Razavi David M Hyman José Baselga Michael F Berger Marc Ladanyi Maria E Arcila

J Mol Diagn 2017 03 25;19(2):244-254. Epub 2016 Dec 25.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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March 2017

Clinical Application of Picodroplet Digital PCR Technology for Rapid Detection of EGFR T790M in Next-Generation Sequencing Libraries and DNA from Limited Tumor Samples.

Authors:

Laetitia Borsu Julie Intrieri Linta Thampi Helena Yu Gregory Riely Khedoudja Nafa Raghu Chandramohan Marc Ladanyi Maria E Arcila

J Mol Diagn 2016 11 12;18(6):903-911. Epub 2016 Sep 12.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.

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November 2016

GNAS Mutations in Fibrous Dysplasia: A Comparative Study of Standard Sequencing and Locked Nucleic Acid PCR Sequencing on Decalcified and Nondecalcified Formalin-fixed Paraffin-embedded Tissues.

Authors:

George Jour Alifya Oultache Justyna Sadowska Talia Mitchell John Healey Khedoudja Nafa Meera Hameed

Appl Immunohistochem Mol Morphol 2016 10;24(9):660-667

Departments of *Pathology †Orthopedic Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

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October 2016

The molecular landscape of extraskeletal osteosarcoma: A clinicopathological and molecular biomarker study.

Authors:

George Jour Lu Wang Sumit Middha Ahmet Zehir Wen Chen Justyna Sadowska John Healey Narasimhan P Agaram Lisa Choi Khedoudja Nafa Meera Hameed

J Pathol Clin Res 2016 Jan 29;2(1):9-20. Epub 2015 Oct 29.

Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA.

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January 2016

Genomic aberrations frequently alter chromatin regulatory genes in chordoma.

Authors:

Lu Wang Ahmet Zehir Khedoudja Nafa Nengyi Zhou Michael F Berger Jacklyn Casanova Justyna Sadowska Chao Lu C David Allis Mrinal Gounder Chandhanarat Chandhanayingyong Marc Ladanyi Patrick J Boland Meera Hameed

Genes Chromosomes Cancer 2016 07 9;55(7):591-600. Epub 2016 May 9.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

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July 2016

Locked Nucleic Acid Probes (LNA) for Enhanced Detection of Low-Level, Clinically Significant Mutations.

Authors:

Khedoudja Nafa Meera Hameed Marie E Arcila

Methods Mol Biol 2016 ;1392:71-82

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

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November 2016

Consistent copy number changes and recurrent PRKAR1A mutations distinguish Melanotic Schwannomas from Melanomas: SNP-array and next generation sequencing analysis.

Authors:

Lu Wang Ahmet Zehir Justyna Sadowska Nengyi Zhou Marc Rosenblum Klaus Busam Narasimhan Agaram William Travis Maria Arcila Snjezana Dogan Michael F Berger Donavan T Cheng Marc Ladanyi Khedoudja Nafa Meera Hameed

Genes Chromosomes Cancer 2015 Aug 29;54(8):463-471. Epub 2015 May 29.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

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August 2015

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology.

J Mol Diagn 2015 May 20;17(3):251-64. Epub 2015 Mar 20.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address:

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May 2015

Additional Primary Malignancies in Patients with Gastrointestinal Stromal Tumor (GIST): A Clinicopathologic Study of 260 Patients with Molecular Analysis and Review of the Literature.

Authors:

Jaclyn Frances Hechtman Ronald DeMatteo Khedoudja Nafa Ping Chi Maria E Arcila Snjezana Dogan Alifya Oultache Wen Chen Meera Hameed

Ann Surg Oncol 2015 Aug 7;22(8):2633-9. Epub 2015 Jan 7.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA,

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August 2015

Novel oncogene and tumor suppressor mutations in KIT and PDGFRA wild type gastrointestinal stromal tumors revealed by next generation sequencing.

Authors:

Jaclyn Frances Hechtman Ahmet Zehir Talia Mitchell Laetitia Borsu Samuel Singer William Tap Alifya Oultache Marc Ladanyi Khedoudja Nafa

Genes Chromosomes Cancer 2015 Mar 27;54(3):177-84. Epub 2014 Nov 27.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

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March 2015

Detection of mutations in myeloid malignancies through paired-sample analysis of microdroplet-PCR deep sequencing data.

Authors:

Donavan T Cheng Janice Cheng Talia N Mitchell Aijazuddin Syed Ahmet Zehir Nana Yaa T Mensah Alifya Oultache Khedoudja Nafa Ross L Levine Maria E Arcila Michael F Berger Cyrus V Hedvat

J Mol Diagn 2014 Sep 10;16(5):504-518. Epub 2014 Jul 10.

Molecular Diagnostics Service, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York.

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September 2014

Induction of sarcomas by mutant IDH2.

Genes Dev 2013 Sep;27(18):1986-98

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA;

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September 2013

Use of touch imprint cytology as a simple method to enrich tumor cells for molecular analysis.

Authors:

Snjezana Dogan Jillian C Becker Natasha Rekhtman Laura H Tang Khedoudja Nafa Marc Ladanyi David S Klimstra

Cancer Cytopathol 2013 Jul 10;121(7):354-60. Epub 2013 Apr 10.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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July 2013

EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics.

Authors:

Maria E Arcila Khedoudja Nafa Jamie E Chaft Natasha Rekhtman Christopher Lau Boris A Reva Maureen F Zakowski Mark G Kris Marc Ladanyi

Mol Cancer Ther 2013 Feb 31;12(2):220-9. Epub 2013 Jan 31.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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February 2013

Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy.

Authors:

Cristina R Antonescu Salvatore Romeo Lei Zhang Khedoudja Nafa Jason L Hornick Gunnlaugur Petur Nielsen Mari Mino-Kenudson Hsuan-Ying Huang Juan-Miguel Mosquera Paolo A Dei Tos Christopher D M Fletcher

Am J Surg Pathol 2013 Mar;37(3):385-92

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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March 2013

Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas.

Authors:

Maria E Arcila Jamie E Chaft Khedoudja Nafa Sinchita Roy-Chowdhuri Christopher Lau Michael Zaidinski Paul K Paik Maureen F Zakowski Mark G Kris Marc Ladanyi

Clin Cancer Res 2012 Sep 3;18(18):4910-8. Epub 2012 Jul 3.

Department of Pathology, and Thoracic Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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September 2012

Melanocytic tumor with GNA11 p.Q209L mutation mimicking a foramen magnum meningioma.

Authors:

Russell G Strom Marianna Shvartsbeyn Marc K Rosenblum Meera R Hameed Khedoudja Nafa Irina Mikolaenko Ramesh P Babu

Clin Neurol Neurosurg 2012 Oct 13;114(8):1197-200. Epub 2012 Mar 13.

Department of Neurosurgery, NYU Langone Medical Center, New York, NY, United States.

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October 2012

EGFR exon 19 insertions: a new family of sensitizing EGFR mutations in lung adenocarcinoma.

Authors:

Mai He Marzia Capelletti Khedoudja Nafa Cai-Hong Yun Maria E Arcila Vincent A Miller Michelle S Ginsberg Binsheng Zhao Mark G Kris Michael J Eck Pasi A Jänne Marc Ladanyi Geoffrey R Oxnard

Clin Cancer Res 2012 Mar 21;18(6):1790-7. Epub 2011 Dec 21.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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March 2012

BRAF mutation analysis of fine-needle aspiration biopsies of papillary thyroid carcinoma: impact on diagnosis and prognosis.

Authors:

Agnes Colanta Oscar Lin Laura Tafe Ronald Ghossein Khedoudja Nafa Talia Mitchell Marc Ladanyi Maria Arcila

Acta Cytol 2011 9;55(6):563-9. Epub 2011 Dec 9.

Memorial Sloan-Kettering Cancer Center, New York, N.Y., USA.

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August 2013

Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.

Authors:

Neerav Shukla Nabahet Ameur Ismail Yilmaz Khedoudja Nafa Chyau-Yueh Lau Angela Marchetti Laetitia Borsu Frederic G Barr Marc Ladanyi

Clin Cancer Res 2012 Feb 5;18(3):748-57. Epub 2011 Dec 5.

Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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February 2012

High frequency of IDH-1 mutation links glioneuronal tumors with neuropil-like islands to diffuse astrocytomas.

Authors:

Jason T Huse Khedoudja Nafa Neerav Shukla Edward R Kastenhuber Ehud Lavi Cyrus V Hedvat Marc Ladanyi Marc K Rosenblum

Acta Neuropathol 2011 Sep 14;122(3):367-9. Epub 2011 Jul 14.

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September 2011

Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay.

Authors:

Maria E Arcila Geoffrey R Oxnard Khedoudja Nafa Gregory J Riely Stephen B Solomon Maureen F Zakowski Mark G Kris William Pao Vincent A Miller Marc Ladanyi

Clin Cancer Res 2011 Mar 19;17(5):1169-80. Epub 2011 Jan 19.

Molecular Diagnostics Service, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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March 2011

Detection of KRAS and BRAF mutations in colorectal carcinoma roles for high-sensitivity locked nucleic acid-PCR sequencing and broad-spectrum mass spectrometry genotyping.

Authors:

Maria Arcila Christopher Lau Khedoudja Nafa Marc Ladanyi

J Mol Diagn 2011 Jan 23;13(1):64-73. Epub 2010 Dec 23.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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January 2011

Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report.

Authors:

Nicolas Girard Emil Lou Christopher G Azzoli Rekha Reddy Mark Robson Megan Harlan Irene Orlow Yasushi Yatabe Khedoudja Nafa Marc Ladanyi Agnes Viale Mark G Kris Gregory Riely Vincent Miller Robert J Klein Keitaro Matsuo William Pao

Clin Cancer Res 2010 Jan 12;16(2):755-63. Epub 2010 Jan 12.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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January 2010

CpG methylation analysis--current status of clinical assays and potential applications in molecular diagnostics: a report of the Association for Molecular Pathology.

Authors:

Antonia R Sepulveda Dan Jones Shuji Ogino Wade Samowitz Margaret L Gulley Robin Edwards Victor Levenson Victoria M Pratt Bin Yang Khedoudja Nafa Liying Yan Patrick Vitazka

J Mol Diagn 2009 Jul 18;11(4):266-78. Epub 2009 Jun 18.

Methylation Working Group of the Association for Molecular Pathology Clinical Practice Committee, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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July 2009

cDNA analysis demonstrates that the BRCA2 intronic variant IVS4-12del5 is a deleterious mutation.

Authors:

Liying Zhang Ruben Bacares Sherry Boyar Clifford Hudis Khedoudja Nafa Kenneth Offit

Mutat Res 2009 Apr 25;663(1-2):84-9. Epub 2008 Nov 25.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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April 2009

KRAS mutational testing in the selection of patients for EGFR-targeted therapies.

Authors:

Joaquin Garcia Gregory J Riely Khedoudja Nafa Marc Ladanyi

Semin Diagn Pathol 2008 Nov;25(4):288-94

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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November 2008

Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma.

Authors:

Gregory J Riely Mark G Kris Daniel Rosenbaum Jenifer Marks Allan Li Dhananjay A Chitale Khedoudja Nafa Elyn R Riedel Meier Hsu William Pao Vincent A Miller Marc Ladanyi

Clin Cancer Res 2008 Sep;14(18):5731-4

Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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September 2008

EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.

Authors:

Cristina R Antonescu Paola Dal Cin Khedoudja Nafa Lisa A Teot Urvashi Surti Christopher D Fletcher Marc Ladanyi

Genes Chromosomes Cancer 2007 Dec;46(12):1051-60

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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December 2007

Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management.

Authors:

Jose G Guillem Emily Glogowski Harvey G Moore Khedoudja Nafa Arnold J Markowitz Jinru Shia Kenneth Offit Nathan A Ellis

Ann Surg 2007 Apr;245(4):560-5

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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April 2007

Prediction of germline mutations and cancer risk in the Lynch syndrome.

Authors:

Sining Chen Wenyi Wang Shing Lee Khedoudja Nafa Johanna Lee Kathy Romans Patrice Watson Stephen B Gruber David Euhus Kenneth W Kinzler Jeremy Jass Steven Gallinger Noralane M Lindor Graham Casey Nathan Ellis Francis M Giardiello Kenneth Offit Giovanni Parmigiani

JAMA 2006 Sep;296(12):1479-87

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md 21205, USA.

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September 2006

EWS-CREB1: a recurrent variant fusion in clear cell sarcoma--association with gastrointestinal location and absence of melanocytic differentiation.

Authors:

Cristina R Antonescu Khedoudja Nafa Neil H Segal Paola Dal Cin Marc Ladanyi

Clin Cancer Res 2006 Sep;12(18):5356-62

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, and Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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September 2006

Increased frequency of disease-causing MYH mutations in colon cancer families.

Authors:

Paolo Peterlongo Nandita Mitra Ana Sanchez de Abajo Miguel de la Hoya Chiara Bassi Lucio Bertario Paolo Radice Emily Glogowski Khedoudja Nafa Trinidad Caldes Kenneth Offit Nathan A Ellis

Carcinogenesis 2006 Nov 14;27(11):2243-9. Epub 2006 Jun 14.

Cell Biology Program, Memorial Sloan-Kettering Cancer Center New York, NY, USA.

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November 2006

Localization of breast cancer susceptibility loci by genome-wide SNP linkage disequilibrium mapping.

Authors:

Nathan A Ellis Tomas Kirchhoff Nandita Mitra Tian-Zhang Ye Shaokun Chuai Helen Huang Khedoudja Nafa Larry Norton Susan Neuhausen Derek Gordon Jeffery P Struewing Steven Narod Kenneth Offit

Genet Epidemiol 2006 Jan;30(1):48-61

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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January 2006

TGFBR1*6A may contribute to hereditary colorectal cancer.

J Clin Oncol 2005 May;23(13):3074-8

Cancer Genetics Program, Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 880, Chicago, IL 60611, USA.

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May 2005

Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.

Authors:

Avraham Shaag Tom Walsh Paul Renbaum Tomas Kirchhoff Khedoudja Nafa Stacey Shiovitz Jessica B Mandell Piri Welcsh Ming K Lee Nathan Ellis Kenneth Offit Ephrat Levy-Lahad Mary-Claire King

Hum Mol Genet 2005 Feb 13;14(4):555-63. Epub 2005 Jan 13.

Department of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195-7720, USA.

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February 2005

Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms.

Authors:

Jinru Shia David S Klimstra Khedoudja Nafa Kenneth Offit Jose G Guillem Arnold J Markowitz William L Gerald Nathan A Ellis

Am J Surg Pathol 2005 Jan;29(1):96-104

Department of Pathology, Memorial Sloan-Kettering, Cancer Center, New York, NY 10021, USA.

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January 2005

Colorectal cancer risk in individuals with biallelic or monoallelic mutations of MYH.

Authors:

Paolo Peterlongo Nandita Mitra Shaokun Chuai Tomas Kirchhoff Crystal Palmer Helen Huang Khedoudja Nafa Kenneth Offit Nathan A Ellis

Int J Cancer 2005 Apr;114(3):505-7

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April 2005

Localization of cancer susceptibility genes by genome-wide single-nucleotide polymorphism linkage-disequilibrium mapping.

Authors:

Nandita Mitra Tian-Zhang Ye Alex Smith Shaokun Chuai Tomas Kirchhoff Paolo Peterlongo Khedoudja Nafa Michael S Phillips Kenneth Offit Nathan A Ellis

Cancer Res 2004 Nov;64(21):8116-25

Department of Epidemiology and Biostatistics, and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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November 2004

A636P testing in Ashkenazi Jews.

Authors:

Jose G Guillem Harvey G Moore Crystal Palmer Emily Glogowski Rob Finch Khedoudja Nafa Arnold J Markowitz Kenneth Offit Nathan A Ellis

Fam Cancer 2004 ;3(3-4):223-7

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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February 2005

Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia.

Authors:

Mark E Robson Emily Glogowski Gunhild Sommer Cristina R Antonescu Khedoudja Nafa Robert G Maki Nathan Ellis Peter Besmer Murray Brennan Kenneth Offit

Clin Cancer Res 2004 Feb;10(4):1250-4

Clinical Genetics and Gastrointestinal Oncology Services, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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February 2004

Loss of the tumor suppressor PML in human cancers of multiple histologic origins.

Authors:

Carmela Gurrieri Paola Capodieci Rosa Bernardi Pier Paolo Scaglioni Khedoudja Nafa Laura J Rush David A Verbel Carlos Cordon-Cardo Pier Paolo Pandolfi

J Natl Cancer Inst 2004 Feb;96(4):269-79

Molecular Biology Program and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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February 2004

Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancer.

Authors:

Tomas Kirchhoff Jaya M Satagopan Noah D Kauff Helen Huang Prema Kolachana Crystal Palmer Hannah Rapaport Khedoudja Nafa Nathan A Ellis Kenneth Offit

J Natl Cancer Inst 2004 Jan;96(1):68-70

Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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January 2004

Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia.

Authors:

Carmela Gurrieri Khedoudja Nafa Taha Merghoub Rosa Bernardi Paola Capodieci Andrea Biondi Stephen Nimer Dan Douer Carlos Cordon-Cardo Robert Gallagher Pier Paolo Pandolfi

Blood 2004 Mar 20;103(6):2358-62. Epub 2003 Nov 20.

Molecular Biology Program and Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA.

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March 2004