Dr. Khalid Z. Masoodi, PhD - Transcriptomics Lab, Division of Biotechnology, SKUAST-K, Shalimar - Assistant Professor

Dr. Khalid Z. Masoodi

PhD

Transcriptomics Lab, Division of Biotechnology, SKUAST-K, Shalimar

Assistant Professor

Srinagar, J&K | India

Main Specialties: Biology

Additional Specialties: Biotechnology, Transcriptomics, Molecular Biology, Bioinformatics,Prostate cancer, Transgenics, Drug Discovery

ORCID logohttps://orcid.org/0000-0002-4889-5558

Dr. Khalid Z. Masoodi, PhD - Transcriptomics Lab, Division of Biotechnology, SKUAST-K, Shalimar - Assistant Professor

Dr. Khalid Z. Masoodi

PhD

Introduction

Primary Affiliation: Transcriptomics Lab, Division of Biotechnology, SKUAST-K, Shalimar - Srinagar, J&K , India

Specialties:

Additional Specialties:

Education

Jun 2014
University of Pittsburgh,PA, USA
Postdoc
Biotechnology
Apr 2010
University of Jammu, Jammu
Ph.D.
Biotechnology
Dec 2014
SKUAST-K
Assistant Professor
Division of Plant Biotechnology

Publications

22Publications

282Reads

688Profile Views

51PubMed Central Citations

DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor.

Oncogene 2018 02 9;37(5):638-650. Epub 2017 Oct 9.

Department of Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://www.nature.com/doifinder/10.1038/onc.2017.371
Publisher Site
http://dx.doi.org/10.1038/onc.2017.371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794523PMC
February 2018
8 Reads
3 Citations
8.460 Impact Factor

Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.

J Endocrinol 2017 Nov;235(2):123-136

Department of UrologyUniversity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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http://dx.doi.org/10.1530/JOE-17-0112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679084PMC
November 2017
8 Reads
1 Citation
3.720 Impact Factor

Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules.

Mol Cancer Ther 2017 10 27;16(10):2120-2129. Epub 2017 Jun 27.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628124PMC
October 2017
42 Reads
2 Citations
5.683 Impact Factor

Aquaporins as potential drought tolerance inducing proteins: Towards instigating stress tolerance.

J Proteomics 2017 10 13;169:233-238. Epub 2017 Apr 13.

Research Laboratory for Biotechnology and Biochemistry (RLABB), GPO 13265, Kathmandu, Nepal; GRADE (Global Research Arch for Developing Education) Academy Pvt. Ltd., Adarsh Nagar-13, Birgunj, Nepal; Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8574, Ibaraki, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S18743919173013
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http://dx.doi.org/10.1016/j.jprot.2017.04.010DOI Listing
October 2017
26 Reads
1 Citation
3.890 Impact Factor

Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor.

PLoS One 2015 15;10(7):e0128495. Epub 2015 Jul 15.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128495PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503479PMC
April 2016
6 Reads
3 Citations
3.234 Impact Factor

Significant impact of IL-6 -174G/C but inverse relation with -634 C/G polymorphism in patients with non-small cell lung cancer in Kashmiri population.

Immunol Invest 2015 ;44(4):349-60

Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences , Srinagar , India .

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http://dx.doi.org/10.3109/08820139.2015.1004336DOI Listing
February 2016
18 Reads
2 Citations
1.903 Impact Factor

Splicing Factor Prp8 Interacts With NES(AR) and Regulates Androgen Receptor in Prostate Cancer Cells.

Mol Endocrinol 2015 Dec 15;29(12):1731-42. Epub 2015 Sep 15.

Departments of Urology (D.W., M.M.N., K.Z.M., P.S., Y.J., K.O., J.A.D., Z.W.), Pharmacology and Chemical Biology (Z.W.), and Pathology (R.D., Z.W.) and University of Pittsburgh Cancer Institute (R.D., Z.W.), University of Pittsburgh, Pittsburgh, Pennsylvania 15232; and Department of Urology (Y.J.), The First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China.

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http://dx.doi.org/10.1210/me.2015-1112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664230PMC
December 2015
8 Reads
3 Citations
4.022 Impact Factor

Role of +405C>G and +936C>T polymorphisms of the vascular endothelial growth factor gene and risk of esophageal cancer in the Kashmiri population.

Asian Pac J Cancer Prev 2015 ;16(1):97-101

Department of Immunology and Molecular Medicine Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India E-mail : zaff

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October 2015
6 Reads
1.500 Impact Factor

Chronic urticaria merits serum vitamin D evaluation and supplementation; a randomized case control study.

World Allergy Organ J 2015 4;8(1):15. Epub 2015 Jun 4.

Department of Immunology and Molecular Medicine, Sher-i- Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K 190011 India.

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http://waojournal.biomedcentral.com/articles/10.1186/s40413-
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http://dx.doi.org/10.1186/s40413-015-0066-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455331PMC
June 2015
10 Reads

5α-Reductase inhibition coupled with short off cycles increases survival in the LNCaP xenograft prostate tumor model on intermittent androgen deprivation therapy.

J Urol 2015 Apr 31;193(4):1388-93. Epub 2014 Oct 31.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2014.10.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404193PMC
April 2015
9 Reads
1 Citation
4.471 Impact Factor

Relationship between Serum Soluble Interleukin-2 Receptor and Renal Allograft Rejection: A Hospital-Based Study in KashmirValley.

Int J Organ Transplant Med 2015 ;6(1):8-13

Department of Urology, Sher-I-Kashmir Institute of Medical Sciences.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346457PMC
March 2015
4 Reads
1 Citation

COX-2 overexpression and -8473 T/C polymorphism in 3' UTR in non-small cell lung cancer.

Tumour Biol 2014 Nov 12;35(11):11209-18. Epub 2014 Aug 12.

Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India,

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http://dx.doi.org/10.1007/s13277-014-2420-0DOI Listing
November 2014
16 Reads
5 Citations
2.840 Impact Factor

Growth of LAPC4 prostate cancer xenograft tumor is insensitive to 5α-reductase inhibitor dutasteride.

Am J Clin Exp Urol 2014 5;2(1):82-91. Epub 2014 Apr 5.

Department of Urology, University of Pittsburgh School of Medicine Pittsburgh PA 15232, USA ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine Pittsburgh, PA 15232, USA ; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219295PMC
November 2014
9 Reads

Stroke-induced immune depression-a randomized case control study in Kashmiri population of North India.

J Stroke Cerebrovasc Dis 2014 Sep 10;23(8):2041-2046. Epub 2014 Aug 10.

Department of Neurology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, India.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.03.002DOI Listing
September 2014
7 Reads
1.993 Impact Factor

The N-terminal domain of the androgen receptor drives its nuclear localization in castration-resistant prostate cancer cells.

J Steroid Biochem Mol Biol 2014 Sep 22;143:473-80. Epub 2014 Mar 22.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, United States; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2014.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127361PMC
September 2014
16 Reads
4 Citations
3.630 Impact Factor

A. Paul, Bashir A. Bhat, Farooq A. Ganaie, Sheikh A. Aziz, Zafar A. Shah. COX-2 overexpression and -8473 T/C polymorphism in 3′ UTR in non-small cell lung cancer

Tumor Biology

Abstract A new class of compounds targeting cyclooxygenase 2 (COX-2) together with other different clinically used therapeutic strategies has recently shown a promise for the chemoprevention of several solid tumors including lung cancer. The aim was to study the possible role of COX-2 -8473 T/C NP and its expression in the pathogenesis of non-small cell lung cancer. One hundred ninety non-small cell lung cancer (NSCLC) patients and 200 healthy age-, sex-, and smoking-matched controls were used for polymorphic analysis, and 48 histopathologically confirmed NSCLC patients were analyzed for COX-2 messenger RNA (mRNA) and protein expression. Our results showed that the frequencies of variant genotypes 8473 CT/CC were significantly less common in the cases (30.0 %) than in the controls (36 %), suggesting that the 8473C variant allele is related with lower susceptibility in NSCLC (OR=0.79, 95 % CI 0.54–1.4). However, the frequency of COX-2 -8473 TC and CC genotypes were significantly associated with age in NSCLC (P= 0.02). Quantitative real-time expression analysis showed a significant increase in the COX-2 mRNA in tumor tissues as compared to their adjacent normal tissues [delta cycle threshold (ΔCT) = 9.25 ± 4.67 vs 5.63 ± 3.85, P= 0.0001]. Multivariate logistic regression analyses revealed that the COX-2 expression was associated significantly with age (P=0.044). Also, an increasing trend was observed in stages I and II and in female patients compared to stages III and IV and male patients, respectively, but no statistical significance was observed. However, COX-2 mRNA expression shown no association with the -8473C variant allele. Our findings indicate that the COX-2 T8473C polymorphism may contribute to NSCLC cancer susceptibility in the Kashmiri population, while our expression analysis revealed a significant increase of COX-2 in tumor tissues as compared to their adjacent normal tissues, suggesting that it could become an important therapeutic marker in NSCLC in the future.

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July 2014
9 Reads

Growth of LAPC4 prostate cancer xenograft tumor is insensitive to 5α-reductase inhibitor dutasteride

Journal of Clinical and Experimental Urology

Intermittent androgen deprivation therapy (IADT) allows prostate cancer patients a break from the side-effects of continuous androgen deprivation therapy (ADT). Although clinical studies suggest that IADT can significantly improve patient quality of life over ADT, it has not been demonstrated to improve patient survival. Recently, increased survival has been demonstrated when 5 alpha-reductase inhibitors have been used during the off-cycle of IADT in animal xenograft tumor models LNCaP and LuCaP35. In the current study, the sensitivity of LAPC4 xenograft tumor regrowth to the 5ARI dutasteride was determined. Tumor regrowth and gene expression changes in LAPC4 tumors were compared to the previously determined response of LNCaP and LuCaP35 xenograft tumors to 5ARI treatment during the off-cycle of IADT. LAPC4, LNCaP and LuCaP35 tumors were sensitive to androgen manipulation. However, in contrast to LNCaP and LuCaP35, dutasteride treatment during testosterone-stimulated prostate regrowth did not affect tumor regrowth or the expression of androgen responsive genes. Tumor response to dutasteride during the off-cycle of IADT is variable in xenograft prostate tumor models. Future studies will be required to elucidate the mechanisms contributing to the dutasteride resistance observed in the LAPC4 model during the off-cycle.

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April 2014
3 Reads

N-terminal domain of the androgen receptor contains a region that can promote cytoplasmic localization.

J Steroid Biochem Mol Biol 2014 Jan 4;139:16-24. Epub 2013 Oct 4.

Department of Urology, University of Pittsburgh, Pittsburgh, PA, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S09600760130018
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http://dx.doi.org/10.1016/j.jsbmb.2013.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858452PMC
January 2014
6 Reads
6 Citations
3.630 Impact Factor

5α-reductase inhibition suppresses testosterone-induced initial regrowth of regressed xenograft prostate tumors in animal models.

Endocrinology 2013 Jul 13;154(7):2296-307. Epub 2013 May 13.

Department of Urology, Hillman Cancer Centre, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.

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http://dx.doi.org/10.1210/en.2012-2077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689274PMC
July 2013
24 Reads
6 Citations
4.503 Impact Factor

Top co-authors

Zhou Wang
Zhou Wang

Shandong Provincial Hospital Affiliated to Shandong University

12
Javid A Dar
Javid A Dar

University of Pittsburgh School of Medicine

8
Laura E Pascal
Laura E Pascal

University of Washington

8
Kurtis Eisermann
Kurtis Eisermann

University of Pittsburgh School of Medicine

7
Joel B Nelson
Joel B Nelson

University of Pittsburgh School of Medicine

6
Junkui Ai
Junkui Ai

Peking University

5
Yujuan Wang
Yujuan Wang

Sun Yat-sen University

4
Dan Wang
Dan Wang

College of Life Sciences

4
Roohi Rasool
Roohi Rasool

Sher-I-Kashmir Institute of Medical Sciences

4
Imtiyaz A Bhat
Imtiyaz A Bhat

Sher-i-Kashmir Institute of Medical Sciences

4