Khalid Hamid El Hachimi, PhD

Khalid Hamid El Hachimi

PhD

Paris | France

Main Specialties: Biology, Neuropathology

ORCID logohttps://orcid.org/0000-0002-8282-3443

Khalid Hamid El Hachimi, PhD

Khalid Hamid El Hachimi

PhD

Introduction

Specialties:

Education

Sep 1989 - Jun 1992
Université Paris VII Denis Diderot UFR Sciences du Vivant
PhD

Experience

Jan 1992
neurosciences neuropathologie
Jan 1994
Paris Sciences Lettres Research University/Ecole Pratique des Hautes Etudes
Senoir lecturer
Neurogénétique
Neurodegeneration

Publications

21Publications

634Reads

37Profile Views

283PubMed Central Citations

Evidence for altered dendritic spine compartmentalization in Alzheimer's disease and functional effects in a mouse model.

Acta Neuropathol 2018 06 25;135(6):839-854. Epub 2018 Apr 25.

Institut du Cerveau et de la Moelle épinière, INSERM U1127, CNRS UMR7225, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.

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http://dx.doi.org/10.1007/s00401-018-1847-6DOI Listing
June 2018
31 Reads
1 Citation
10.762 Impact Factor

Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration.

Cell Rep 2018 06;23(13):3813-3826

Sorbonne Université, F-75013 Paris, France; Inserm, U1127, F-75013 Paris, France; CNRS, UMR 7225, F-75013 Paris, France; Institut du Cerveau et de la Moelle Epinière (ICM), F-75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045775PMC
June 2018
58 Reads
7.210 Impact Factor

Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins.

Mol Neurodegener 2016 07 28;11(1):58. Epub 2016 Jul 28.

INSERM U 1127, CNRS UMR 7225, Sorbonne Universités UPMC, Univ Paris 06 UMR_S 1127, ICM (Brain and Spine Institute) Pitié-Salpêtrière Hospital, 75013, Paris, France.

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http://dx.doi.org/10.1186/s13024-016-0123-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964261PMC
July 2016
24 Reads
1 Citation
6.563 Impact Factor

Motor neuron degeneration in spastic paraplegia 11 mimics amyotrophic lateral sclerosis lesions.

Brain 2016 06 25;139(Pt 6):1723-34. Epub 2016 Mar 25.

1 Ecole Pratique des Hautes Etudes, EPHE, PSL université, laboratoire de neurogénétique, F-75013, Paris, France 2 Inserm, U1127, F-75013, Paris, France 3 CNRS, UMR7225, F-75013, Paris, France 4 Sorbonne Universités, UPMC Univ Paris 06, UMR_S1127, Institut du Cerveau et de la Moelle épinière - ICM, Pitié-Salpêtrière Hospital, F-75013, Paris, France.

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http://dx.doi.org/10.1093/brain/aww061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839621PMC
June 2016
43 Reads
4 Citations
9.200 Impact Factor

Juvenile frontotemporal dementia with parkinsonism associated with tau mutation G389R.

J Alzheimers Dis 2013 ;37(4):769-76

Department of Neurology, Maison Blanche Hospital, Reims University Hospital, Reims, France.

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http://dx.doi.org/10.3233/JAD-130413DOI Listing
July 2014
6 Reads
6 Citations
4.151 Impact Factor

Role of the phosphoinositide phosphatase FIG4 gene in familial epilepsy with polymicrogyria.

Neurology 2014 Mar 5;82(12):1068-75. Epub 2014 Mar 5.

From INSERM (S.B., B.D., B.O.A.B., P.C., J.R., E.N., K.H.E.H., E.L.), U1127; Sorbonne Universités, UPMC Univ Paris 06 (S.B., B.D., B.O.A.B., P.C., J.R., E.N., K.H.E.H., E.L.), UM 75; CNRS (S.B., B.D., B.O.A.B., P.C., J.R., E.N., K.H.E.H., E.L.), UMR 7225, ICM, Paris, ICM, (S.B., B.D., B.O.A.B., P.C., J.R., E.N., K.H.E.H., E.L.) Paris, F-75013 Paris, France; Department of Human Genetics (G.M.L., P.A.L., C.J.F., M.H.M.), University of Michigan, Ann Arbor; Service de Neurophysiologie Clinique (B.O.A.B.), Hôpital des Spécialités, Centre Hospitalier Ibn Sina Rabat, Morocco; Genetics and Pathophysiology of Neurodevelopmental and Neuromuscular Diseases (K.P.), Cochin Institute, Paris; GenoScreen (C.H., S.F.), Lille, France; Neuroscience Department (R.G.), Children's Hospital A. Meyer, University of Florence and IRCCS Stella Maris, Pisa, Italy; Laboratoire de Neurogénétique (K.H.E.H.), Ecole Pratique des Hautes Etudes, Paris; and Département de Génétique et de Cytogénétique (E.L.), AP-HP Groupe hospitalier Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1212/WNL.0000000000000241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962989PMC
March 2014
18 Reads
14 Citations
8.290 Impact Factor

Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia.

Am J Hum Genet 2014 Feb 2;94(2):268-77. Epub 2014 Jan 2.

Université Pierre and Marie Curie - Paris VI, Unité Mixte de Recherche S975, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France; Institut National de la Santé et de la Recherche Médicale, Unité 975, 75013 Paris, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, 75013 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928657PMC
February 2014
37 Reads
15 Citations
10.931 Impact Factor

Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia.

Mol Cell Neurosci 2011 Jul 27;47(3):191-202. Epub 2011 Apr 27.

INSERM, U975, Université Pierre et Marie Curie-Paris 6, UMR_S975, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CR-icm), GHU Pitié-Salpêtrière, CNRS, Paris, France.

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http://dx.doi.org/10.1016/j.mcn.2011.04.004DOI Listing
July 2011
27 Reads
22 Citations
3.840 Impact Factor

Prokineticin 2 expression is associated with neural repair of injured adult zebrafish telencephalon.

J Neurotrauma 2010 May;27(5):959-72

Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), 75651 Paris Cedex, France.

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http://dx.doi.org/10.1089/neu.2009.0972DOI Listing
May 2010
3 Reads
13 Citations
3.714 Impact Factor

Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter.

J Neurosci 2007 Feb;27(6):1315-24

Institut National de la Santé et de la Recherche Médicale, Unité 616, Institut Fédératif de Recherche Neurosciences, Hôpital de la Pitié-Salpêtrière, 75651 Paris, France.

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http://dx.doi.org/10.1523/JNEUROSCI.4395-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673577PMC
February 2007
24 Reads
11 Citations
6.344 Impact Factor

Polyglutamine and polyalanine expansions in ataxin7 result in different types of aggregation and levels of toxicity.

Mol Cell Neurosci 2006 Mar 1;31(3):438-45. Epub 2005 Dec 1.

INSERM U679 (former U289), Neurologie et Thérapeutique Expérimentale, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/j.mcn.2005.10.013DOI Listing
March 2006
13 Reads
6 Citations
3.840 Impact Factor

Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.

Am J Pathol 2004 Nov;165(5):1465-77

Laboratoire de Neuropathologie Raymond Escourolle, Groupe hospitalier Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618656PMC
http://dx.doi.org/10.1016/s0002-9440(10)63405-0DOI Listing
November 2004
2 Reads
44 Citations
4.591 Impact Factor

Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions.

Acta Neuropathol 2004 Jul 27;108(1):81-7. Epub 2004 Apr 27.

Laboratoire de Neuropathologie Raymond Escourolle, INSERM U360, Association Claude Bernard, Hôpital de La Salpêtrière, 47 boulevard de l'Hôpital, 75651, Paris cedex 13, France.

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http://dx.doi.org/10.1007/s00401-004-0855-xDOI Listing
July 2004
7 Reads
11 Citations
10.762 Impact Factor

PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases.

Neurobiol Dis 2003 Aug;13(3):230-7

Laboratoire de Neuropathologie Raymond Escourolle, Hôpital de la Salpêtrière, AP-HP, Paris, France.

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http://dx.doi.org/10.1016/s0969-9961(03)00080-9DOI Listing
August 2003
40 Reads
11 Citations
5.080 Impact Factor