Khaled R A Abdellatif

Khaled R A Abdellatif

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Khaled R A Abdellatif

Khaled R A Abdellatif

Publications by authors named "Khaled R A Abdellatif"

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New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.

Bioorg Chem 2020 Mar 12;98:103752. Epub 2020 Mar 12.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt; Pharmaceutical Sciences Department, Ibn Sina National College for Medical Studies, Jeddah 21418, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2020.103752DOI Listing
March 2020

Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities.

Bioorg Chem 2019 Oct 19;91:103132. Epub 2019 Jul 19.

Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

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http://dx.doi.org/10.1016/j.bioorg.2019.103132DOI Listing
October 2019

Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.

Bioorg Chem 2019 Sep 3;90:103029. Epub 2019 Jun 3.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183151
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http://dx.doi.org/10.1016/j.bioorg.2019.103029DOI Listing
September 2019

Design, Synthesis and Cytotoxicity Evaluation of New 3, 5-Disubstituted-2-Thioxoimidazolidinones.

Anticancer Agents Med Chem 2018 ;18(4):573-582

Department of Organic Chemistry, Faculty of Science, Kafrelsheikh University, Kafrelsheikh, Egypt.

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http://www.eurekaselect.com/157874/article
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http://dx.doi.org/10.2174/1871520618666171129213838DOI Listing
July 2019

Treatment of breast cancer with engineered novel pH-sensitive triaryl-(Z)-olefin niosomes containing hydrogel: an in vitro and in vivo study.

J Liposome Res 2019 Apr 1:1-10. Epub 2019 Apr 1.

c Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy , Beni Suef University , Beni Suef , Egypt.

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http://dx.doi.org/10.1080/08982104.2019.1601213DOI Listing
April 2019

New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds.

Bioorg Chem 2018 08 3;78:341-357. Epub 2018 Apr 3.

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Al Jouf 2014, Saudi Arabia.

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http://dx.doi.org/10.1016/j.bioorg.2018.03.032DOI Listing
August 2018

Evaluation and optimization of pH-responsive niosomes as a carrier for efficient treatment of breast cancer.

Drug Deliv Transl Res 2018 06;8(3):633-644

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

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http://dx.doi.org/10.1007/s13346-018-0499-3DOI Listing
June 2018

Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities.

Eur J Med Chem 2018 Apr 5;150:567-578. Epub 2018 Mar 5.

Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef, 62514, Egypt; Pharmaceutical Sciences Department, Ibn Sina National College for Medical Studies, Jeddah 21418, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.03.001DOI Listing
April 2018

3-methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents.

J Enzyme Inhib Med Chem 2016 23;31(2):318-24. Epub 2015 Mar 23.

b Department of Pharmacology , Faculty of Pharmacy, Beni-Suef University , Beni-Suef , Egypt , and.

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http://dx.doi.org/10.3109/14756366.2015.1022174DOI Listing
November 2017

Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives.

Anticancer Agents Med Chem 2017 ;17(10):1389-1400

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514. Egypt.

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http://dx.doi.org/10.2174/1872211311666170213105004DOI Listing
October 2017

Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX-2 Inhibitors.

Arch Pharm (Weinheim) 2017 Aug 12;350(8). Epub 2017 Jun 12.

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

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http://dx.doi.org/10.1002/ardp.201600386DOI Listing
August 2017

New 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents.

Bioorg Chem 2017 06 9;72:123-129. Epub 2017 Apr 9.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

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http://dx.doi.org/10.1016/j.bioorg.2017.04.002DOI Listing
June 2017

Nitric Oxide-NASIDS Donor Prodrugs as Hybrid Safe Anti-inflammatory Agents.

Curr Top Med Chem 2017 ;17(8):941-955

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni- Suef 62514, Egypt.

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http://dx.doi.org/10.2174/1568026616666160927153435DOI Listing
May 2017

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1-phenylpyrazolo[3,4-d]pyrimidine derivatives.

J Enzyme Inhib Med Chem 2016 22;31(sup2):6-12. Epub 2016 May 22.

a Department of Pharmaceutical Organic Chemistry , Beni-Suef University , Beni-Suef , Egypt , and.

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http://dx.doi.org/10.1080/14756366.2016.1186018DOI Listing
February 2017

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,5-diarylpyrazole derivatives.

J Enzyme Inhib Med Chem 2016 10;31(sup3):54-60. Epub 2016 Aug 10.

c Pharmacology Department, Faculty of Veterinary, Cairo University , Cairo , Egypt.

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http://dx.doi.org/10.1080/14756366.2016.1201815DOI Listing
February 2017

Design, synthesis, cyclooxygenase inhibition and biological evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing amino/methanesulfonyl pharmacophore.

Bioorg Chem 2017 02 21;70:57-66. Epub 2016 Nov 21.

Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.

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http://dx.doi.org/10.1016/j.bioorg.2016.11.008DOI Listing
February 2017

Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.

Bioorg Chem 2017 02 26;70:173-183. Epub 2016 Dec 26.

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni Suef University, Beni Suef 62514, Egypt; Pharmaceutical Sciences Department, Ibn Sina National College for Medical Studies, Jeddah 21418, Kingdom of Saudi Arabia.

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https://linkinghub.elsevier.com/retrieve/pii/S00452068163023
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http://dx.doi.org/10.1016/j.bioorg.2016.12.008DOI Listing
February 2017

Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore.

J Enzyme Inhib Med Chem 2016 Dec 12;31(6):1545-55. Epub 2016 Apr 12.

c Department of Pharmaceutical Medicinal Chemistry , Al-Azhar University , Assuit , Egypt.

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http://dx.doi.org/10.3109/14756366.2016.1158168DOI Listing
December 2016

Synthesis, Cyclooxygenase Inhibition, Anti-Inflammatory Evaluation, and Ulcerogenic Liability of New 1,3,5-Triarylpyrazoline Derivatives Possessing a Methanesulfonyl Pharmacophore.

Arch Pharm (Weinheim) 2016 Oct 7;349(10):801-807. Epub 2016 Sep 7.

Faculty of Pharmacy, Department of Pharmacology and Toxicology, Beni-Suef University, Beni-Suef, Egypt.

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http://dx.doi.org/10.1002/ardp.201600145DOI Listing
October 2016

Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.

Bioorg Chem 2016 Feb 6;64:1-12. Epub 2015 Nov 6.

Department of Pharmaceutical Organic Chemistry, Beni Suef University, Beni Suef 62514, Egypt.

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http://dx.doi.org/10.1016/j.bioorg.2015.11.001DOI Listing
February 2016

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.

Bioorg Med Chem Lett 2016 Jan 1;26(2):406-412. Epub 2015 Dec 1.

Pharmacology Department, Faculty of Veterinary, Cairo University, Cairo, Egypt.

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http://dx.doi.org/10.1016/j.bmcl.2015.11.105DOI Listing
January 2016

1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents.

Bioorg Chem 2015 Dec 8;63:13-23. Epub 2015 Sep 8.

Pharmacology Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

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http://dx.doi.org/10.1016/j.bioorg.2015.09.002DOI Listing
December 2015

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.

Bioorg Med Chem Lett 2015 Dec 19;25(24):5787-91. Epub 2015 Oct 19.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

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http://dx.doi.org/10.1016/j.bmcl.2015.10.047DOI Listing
December 2015

Synthesis and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing an aminosulphonyl pharmacophore.

Arch Pharm Res 2015 Nov 23;38(11):1932-42. Epub 2015 Apr 23.

Department of Pharmacology, Faculty of Veterinary, Cairo University, Cairo, Egypt.

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http://dx.doi.org/10.1007/s12272-015-0606-7DOI Listing
November 2015

Synthesis, characterization and biological evaluation of novel 4'-fluoro-2'-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents.

J Enzyme Inhib Med Chem 2015 Jun 8;30(3):484-91. Epub 2014 Sep 8.

Department of Pharmaceutical Organic Chemistry, Beni-Suef University , Beni-Suef , Egypt .

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http://dx.doi.org/10.3109/14756366.2014.949255DOI Listing
June 2015

Synthesis of new 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles: a search for novel nitric oxide donor anti-inflammatory agents.

Bioorg Med Chem Lett 2014 Nov 16;24(21):5015-21. Epub 2014 Sep 16.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada.

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http://dx.doi.org/10.1016/j.bmcl.2014.09.024DOI Listing
November 2014

Design, synthesis and pharmacological evaluation of novel pyrrolizine derivatives as potential anticancer agents.

Bioorg Chem 2014 Apr 4;53:1-7. Epub 2014 Jan 4.

Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2014.01.001DOI Listing
April 2014

Synthesis and anticancer activity of some new pyrazolo[3,4-d]pyrimidin-4-one derivatives.

Molecules 2014 Mar 18;19(3):3297-309. Epub 2014 Mar 18.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

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http://www.mdpi.com/1420-3049/19/3/3297
Publisher Site
http://dx.doi.org/10.3390/molecules19033297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270843PMC
March 2014

Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues.

Bioorg Med Chem Lett 2013 Sep 26;23(17):4960-3. Epub 2013 Jun 26.

Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.

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http://dx.doi.org/10.1016/j.bmcl.2013.06.056DOI Listing
September 2013

Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors.

Bioorg Med Chem Lett 2011 Feb 23;21(4):1195-8. Epub 2010 Dec 23.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8.

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http://dx.doi.org/10.1016/j.bmcl.2010.12.091DOI Listing
February 2011

Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.

Bioorg Med Chem Lett 2010 Oct 3;20(19):5776-80. Epub 2010 Aug 3.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta, Canada.

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http://dx.doi.org/10.1016/j.bmcl.2010.07.132DOI Listing
October 2010

Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.

Bioorg Med Chem Lett 2010 Apr 13;20(7):2168-73. Epub 2010 Feb 13.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8.

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http://dx.doi.org/10.1016/j.bmcl.2010.02.040DOI Listing
April 2010

Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Bioorg Med Chem Lett 2008 Dec 7;18(23):6138-41. Epub 2008 Oct 7.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta., Canada T6G 2N8.

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http://dx.doi.org/10.1016/j.bmcl.2008.10.009DOI Listing
December 2008

Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: a search for novel nitric oxide donor anti-inflammatory agents.

Bioorg Med Chem 2008 Oct 29;16(19):8882-8. Epub 2008 Aug 29.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta., Canada T6G2N8.

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http://dx.doi.org/10.1016/j.bmc.2008.08.059DOI Listing
October 2008

Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.

Bioorg Med Chem Lett 2008 Jul 22;18(14):4195-8. Epub 2008 May 22.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta., Canada T6G 2N8.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0800579
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http://dx.doi.org/10.1016/j.bmcl.2008.05.071DOI Listing
July 2008

Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.

Bioorg Med Chem 2008 Mar 8;16(6):3302-8. Epub 2007 Dec 8.

Dentistry Pharmacy Centre, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 3-118 Edmonton, Alta., Canada T6G 2N8.

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http://dx.doi.org/10.1016/j.bmc.2007.12.006DOI Listing
March 2008

Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.

Bioorg Med Chem 2008 Feb 5;16(4):1948-56. Epub 2007 Nov 5.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta., Canada T6G 2N8.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960700970
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http://dx.doi.org/10.1016/j.bmc.2007.11.003DOI Listing
February 2008

Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.

Bioorg Med Chem 2007 Nov 22;15(21):6796-801. Epub 2007 Aug 22.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, ALTA, Canada.

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http://dx.doi.org/10.1016/j.bmc.2007.07.021DOI Listing
November 2007