Publications by authors named "Khadijeh Haji Naghi Tehrani"

6 Publications

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A study of nerve conduction velocity in diabetic patients and its relationship with tendon reflexes (T-Reflex).

Acta Biomed 2020 09 7;91(3):e2020066. Epub 2020 Sep 7.

Department Neurology, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.

Background And Objective: Neuropathy is one of the most common complications of diabetes mellitus. Neuropathy can cause sensory deficit, neurological disorder, organ ulcers, osteomyelitis, and amputation. Therefore, neurological examinations, determining the nerve conduction velocity and performing sensory and motor tests are important for timely diagnosis and treatment. The present study aimed to investigate the nerve conduction velocity in diabetic patients and its relationship with tendon reflexes.

Materials And Methods: The present study was observational-cross sectional research carried out on 77 diabetic patients who admitted to the EMG / NCV Department of Shariati Hospital in the academic year 1996-1997. In all patients, the medical history of the patient (age, duration of diabetes, gender and age of onset of diabetes), neurological examination, nerve conduction velocity, heat test, vibration test, tendon reflexes, D.L and Amplitude were examined and recorded. Finally, the raw data obtained was entered into the IBM SPSS Statistics software and the important relationships between these variables were analyzed. Moreover, in present study, the statistical significance level (P-value) was considered less than 0.05.

Results: The present study was conducted on a population consisting of 48 women and 29 men with diabetes. The age range of participants was 14-70 years old with an average age of 50.506 ± 7.50. The results of present study showed that the participants with clinical neuropathy (11.2 ± 7.2) had significantly longer duration of diabetes than the normal group and those participants with sub-clinical neuropathy (P-value = 0.12). Statistical analyses indicated that increase in age, increase in the duration of diabetes and the gender of male significantly made the nerve conduction velocity abnormal. The analysis of the response to neural reflexes indicated that the ratio of neurological disorders in the five nerves of the ankle and knee was generally higher in the abnormal group (the patients with nerve conduction disorder) compared to the normal (the patients with normal nerve conduction) and in some cases, such as the ulnar motor nerve of ankle (P-value = 0.010), and the ulnar motor nerve of knee motor -(P-value = 0.002) and also in the peroneal motor nerve of knee (P-value = 0.003) and the sural sensory nerve of knee -(P-value = 0.003), increase in neurological disorders was significant.

Conclusion: Increase in age, increase in the duration of diabetes and the gender of male can significantly make the nerve conduction velocity abnormal.
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http://dx.doi.org/10.23750/abm.v91i3.7288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716994PMC
September 2020

Isolated Oculomotor and Abducens Nerve Palsies as Initial Presentation of Cavernous Sinus Tuberculoma: Case Report and Literature Review.

World Neurosurg 2018 Sep 2;117:413-418. Epub 2018 Jul 2.

Department of Neurology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. Electronic address:

Background: Central nervous system tuberculoma is the most severe manifestation of extrapulmonary tuberculosis with high mortality. Cavernous sinus tuberculoma (CST) is a very rare central nervous system tuberculoma with few cases reported in the literature.

Case Description: A 57-year-old woman was admitted to our clinic with acute diplopia and headache limited to the right side. There was no specific medical history except for migraine, depression, and anxiety, all of which were controlled by oral medications. Physical examination revealed ptosis and mydriasis in the right eye, which indicated right third and sixth cranial nerve palsies. Pituitary magnetic resonance imaging showed a right parasellar lesion at the cavernous sinus wall and ophthalmic nerve. Laboratory examinations and brain computed tomography scan showed negative findings. Initial differential diagnosis included meningioma, sarcoidosis, tuberculoma, and lymphoma. However, results of further studies, including blood and cerebrospinal fluid cultures and Mycobacterium tuberculosis DNA assay, were negative. Biopsy of the cerebral lesion was performed through the subfrontal approach, and histopathologic study confirmed CST. She was treated with a standard antituberculous regimen. After 12 months of follow-up, no cerebral or clinical findings were seen.

Conclusions: CST is a rare presentation of M. tuberculosis, and the diagnosis is a difficult challenge. However, accurate diagnosis and timely treatment of CST can result in complete cure.
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http://dx.doi.org/10.1016/j.wneu.2018.06.203DOI Listing
September 2018

An Investigation of the Prevalence of Subclinical Brain Lesions in MRI Images of Migraine Patients.

Open Access Maced J Med Sci 2018 Jul 14;6(7):1239-1243. Epub 2018 Jul 14.

Department Neurology, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.

Background: The use of the MRI method has opened up a new perspective on pathogenesis, diagnosis and treatment of brain lesions.

Aim: Therefore, this study aimed to evaluate the prevalence of brain subclinical lesions in MRI images of migraine patients.

Methods: This cross-sectional study was conducted on 300 patients with a migraine referred to Baqiyatallah and Amir Al-Momenin Hospitals from 2005 to 2006. We measured the relationship between the results of MRI and the type of brain subclinical lesion by indices such as age, gender, type of a migraine, the number of migraine attacks, blood pressure and heart diseases, cholesterol, diabetes and thyroid diseases. Finally, data were analysed by IBM SPSS statistics software version 23. The significance level in this study was considered as P > 0.05.

Results: From among 300 patients, 87.7% were women in the age range of 13-72 years. Moreover, the results indicated that with increasing age, blood pressure and some migraine attacks, the frequency of abnormal MRI also is increased significantly as well as the ratio of a migraine with aura was significantly higher than a migraine without aura in individuals with abnormal MRI. Also, the ratio of white matter lesions (WML) is higher in a classical migraine (a Migraine with aura). Statistical analyses did not reveal any significant relationship between MRI results on age, diabetes, cholesterol, heart and thyroid diseases.

Conclusion: The prevalence of abnormal MRI in older people and those with high blood pressure and migraine with aura is higher, and the ratio of subclinical lesions in the population of a migraine with aura is more common than a migraine without aura.
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http://dx.doi.org/10.3889/oamjms.2018.263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062284PMC
July 2018

Prevalence of muscular dystrophy in patients with muscular disorders in Tehran, Iran.

Eur J Transl Myol 2018 Apr 18;28(2):7380. Epub 2018 May 18.

Faculty of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.

Muscular dystrophy is a group of diseases that is characterized by progressive muscle wasting and the weakness of variable distribution and severity. On the basis of the distribution of predominant muscle weakness, there are many different kinds of muscular dystrophy. Some dystrophies are especially frequent in certain populations. There are no studies on the prevalence of muscular dystrophy in Iran. This study was aimed to survey the prevalence of muscular dystrophy among Iranian patients with muscular disorders. This analytical cross-sectional study was conducted on 1000 patients with musculoskeletal disorders who visited the dystrophy association of Bou-Ali Hospital (Tehran) from June 2014 to June 2016. Patients' data were extracted using a checklist that included age, gender, age of onset, family history, findings from clinical diagnostic tests and types of muscular dystrophy. The clinical findings were the results of genetic tests; EMG-NCV; para-clinical findings, including LDH and CPK; and pathological findings. All data were analyzed by SPSS V.22 (IBM Inc., NY) with Chi Square and One way ANOVA tests. All analyses were performed with P = 0.05 considered as the threshold of statistical significant. Out of the 337 patients studied, 262 (77.7%) were male and 75 (22.3%) were female. Subjects had a mean (± SD) age of 26.08 (± 11.86) years with an age range of 3 to 59 years. The most common types of muscular dystrophy were found to be Duchenne dystrophy (131 cases, 38.9%), limb-girdle dystrophy (91 cases, 27%), Becker dystrophy (58 cases, 17.2%), FSHD dystrophy (31 cases, 9.2%), and SMA (26 cases, 7.7%), respectively. The results showed that a statistically significant relationship between dystrophy types and gender, age, family history, age of diagnosis, CPK and LDH levels (P < 0.001). There were no statistical relationship between dystrophy types and pathological findings (P = 0.57), EMG-NCV test results (P = 0.062), and genetic findings (P = 0.06). Since muscular dystrophies often appear during the first decade of life, any information in regard to their prevalence can contribute to better planning and provisioning of required services, as well as better treatment or control of the condition. The results also showed that genetic tests, para-clinical tests, pathology analysis, and EMG-NCV tests can serve as good diagnostic tools for different varieties of dystrophy. Thus, facilitation of these diagnostic tests, particularly the genetic tests, can lead to a faster and more accurate diagnosis of dystrophy, especially in people with a family history of the disease.
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http://dx.doi.org/10.4081/ejtm.2018.7385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036313PMC
April 2018

A Study of Nerve Conduction Velocity in Diabetic Patients and its Relationship with Tendon Reflexes (T-Reflex).

Open Access Maced J Med Sci 2018 Jun 17;6(6):1072-1076. Epub 2018 Jun 17.

Department Neurology, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.

Background: Neuropathy is one of the most common complications of diabetes mellitus. Neuropathy can cause the sensory deficit, neurological disorder, limb ulcers, osteomyelitis, and amputation. Therefore, neurological examinations, determining the nerve conduction velocity and performing sensory and motor tests are important for timely diagnosis and treatment.

Aim: The present study aimed to investigate the nerve conduction velocity in diabetic patients and its relationship with tendon reflexes.

Material And Methods: The present study was observational-cross sectional research carried out on 77 diabetic patients who were admitted into the EMG/NCV Department of Shariati Hospital in the academic year 1996-1997. In all patients, the medical history of the patient (age, duration of diabetes, gender and age of onset of diabetes), neurological examination, nerve conduction velocity, heat test, vibration test, tendon reflexes, D.L and Amplitude were examined and recorded. Finally, the raw data obtained were entered into the IBM SPSS Statistics software, and the important relationships between these variables were analysed. Moreover, in the present study, the statistical significance level (P-value) was considered less than 0.05.

Results: The present study was conducted on a population consisting of 48 women and 29 men with diabetes. The age range of participants was 14-70 years old with an average age of 50.506 ± 7.50. The results of present study showed that the participants with clinical neuropathy (11.2 ± 7.2) had a significantly longer duration of diabetes than the normal group and those participants with sub-clinical neuropathy (P-value = 0.12). Statistical analyses indicated that increase in age, increase in the duration of diabetes and the gender of male significantly made the nerve conduction velocity abnormal. The analysis of the response to neural reflexes indicated that the ratio of neurological disorders in the five nerves of the ankle and knee was generally higher in the abnormal group (the patients with nerve conduction disorder) compared to the normal (the patients with normal nerve conduction) and in some cases, such as the ulnar motor nerve of ankle (P-value = 0.010), and the ulnar motor nerve of knee motor (P-value = 0.002) and also in the peroneal motor nerve of knee (P-value = 0.003) and the sural sensory nerve of knee (P-value = 0.003), increase in neurological disorders was significant.

Conclusion: Increase in age, increase in the duration of diabetes, and the male gender can significantly increase the risk of abnormal nerve conduction velocity.
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http://dx.doi.org/10.3889/oamjms.2018.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026439PMC
June 2018

Evaluation prevalence of Pompe disease in Iranian patients with myopathies of unknown etiology.

Electron Physician 2017 Jul 25;9(7):4886-4889. Epub 2017 Jul 25.

Pharm.D., Graduated from Tehran University of Medical Science (TUMS), Tehran, Iran.

Background: Pompe disease is a rare but potentially treatable metabolic disorder having an estimated worldwide incidence of one in forty thousand live births. While the introduction of enzyme replacement therapy (ERT) has considerably increased the awareness of the disease, the delay in diagnosis is still consistent and most patients go undetected.

Objective: This study aimed to determine the prevalence of late-onset Pompe disease (LOPD) in a high-risk population, using dried blood spot (DBS) as a main screening tool.

Methods: This cross-sectional study was performed on the 93 patients who attended to the neuromuscular center of Bu-ali hospital in Tehran, Iran, during 2014-2015. Inclusion criteria were: 1) age ≥1 years, 2) proximal myopathies of unknown etiology in lower limbs or symptoms of limb girdle muscle weakness (LGMW), and 3) unexplained elevated CPK (>174). Acid α-glucosidase (GAA) activity was measured separately on DBS by fluorometric method. For the final diagnosis, GAA deficiency was confirmed by a biochemical assay in skeletal muscle, whereas genotype was assessed by GAA molecular analysis. All statistical tests were performed using the SPSS version 16. Results are presented as mean (SD) or median (IQR), as appropriate.

Results: In a 12-month period, we studied 93 cases: 5 positive samples (5.3%) were detected by DBS screening, biochemical and molecular genetic studies finally confirmed LOPD diagnosis in 3 cases (3.22%). Among the 93 patients, 100% showed hyperCKemia, 89 patients (95.7%) showed LGMW and 4 patients had symptoms of proximal myopathies in the lower limb.

Conclusions: Results from the LOPED study suggest that GAA activity requires accurate screening by DBS in all patients referred for hyperCKemia and/or LGMW.
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http://dx.doi.org/10.19082/4886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587008PMC
July 2017