Publications by authors named "Kevser Harmandar"

2 Publications

  • Page 1 of 1

BSA/DNA binding behavior and the photophysicochemical properties of novel water soluble zinc(II)phthalocyanines directly substituted with piperazine groups.

J Biol Inorg Chem 2021 Jun 4;26(4):455-465. Epub 2021 May 4.

Department of Chemistry, Gebze Technical University, 41400, Gebze, Kocaeli, Turkey.

In the current research, two novel zinc(II) phthalocyanines (ZnPcs) (1 and 2) directly connecting with 4-(4-methylpiperazin-1-yl)phenyl groups have been synthesized through the Suzuki-Miyaura coupling reaction. These ZnPcs 1 and 2 were converted to their water-soluble derivatives (1Q and 2Q) by quaternization. The photochemical and photophysical properties were determined in DMSO for the non-ionic zinc(II) phthalocyanines (1 and 2) and in both DMSO and aqueous solutions for the quaternized cationic derivatives (1Q and 2Q) to establish their photosensitizer capabilities in photodynamic therapy (PDT). The spectrofluorometric and spectrophotometric techniques were employed for the determination of interaction between water-soluble ZnPcs (1Q and 2Q) and BSA or ct-DNA. The binding constants of these compounds to BSA were found in the order of 10 M. The binding constant of the ct-DNA interaction with 2Q (1.09 × 10 M) was found higher than 1Q (6.87 × 10 M). The thermodynamic constants were determined for both 1Q and 2Q. The endothermic and spontaneous nature of interaction was observed with ct-DNA. Besides, the thermal denaturation and viscosity studies proved the non-intercalative mode of binding for both compounds to ct-DNA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00775-021-01868-6DOI Listing
June 2021

Alkali Phosphonate Metal-Organic Frameworks.

Chemistry 2019 Aug 4;25(48):11214-11217. Epub 2019 Jul 4.

Lebensmittelchemie und Toxikologie, Technische Universität Berlin, Gustav-Meyer-Allee-25, Berlin, 13355, Germany.

A new family of porous metal-organic frameworks (MOFs), namely alkali phosphonate MOFs, is reported. [Na Cu(H TPPA)]⋅(NH (CH ) ) (GTUB-1) was synthesized using the tetratopic 5,10,15,20-tetrakis[p-phenylphosphonic acid] porphyrin (H -TPPA) linker with planar X-shaped geometrical core. GTUB-1 is composed of rectangular void channels with BET surface area of 697 m  g . GTUB-1 exhibits exceptional thermal stability. The toxicity analysis of the (H -TPPA) linker indicates that it is well tolerated by an intestinal cell line, suggesting its suitability for creating phosphonate MOFs for biological applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201902207DOI Listing
August 2019