Publications by authors named "Kevin Talbot"

100Publications

Neurotrophic Properties of C-Terminal Domain of the Heavy Chain of Tetanus Toxin on Motor Neuron Disease.

Toxins (Basel) 2020 Oct 21;12(10). Epub 2020 Oct 21.

Institute of Neurosciences, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain.

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http://dx.doi.org/10.3390/toxins12100666DOI Listing
October 2020

Motor Neuron Disease Register for England, Wales and Northern Ireland-an analysis of incidence in England.

Amyotroph Lateral Scler Frontotemporal Degener 2020 Sep 17:1-8. Epub 2020 Sep 17.

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.

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http://dx.doi.org/10.1080/21678421.2020.1812661DOI Listing
September 2020

Development of LNA Gapmer Oligonucleotide-Based Therapy for ALS/FTD Caused by the C9orf72 Repeat Expansion.

Methods Mol Biol 2020 ;2176:185-208

Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.

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http://dx.doi.org/10.1007/978-1-0716-0771-8_14DOI Listing
January 2020

CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis.

Clin Proteomics 2020 17;17:31. Epub 2020 Aug 17.

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU UK.

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http://dx.doi.org/10.1186/s12014-020-09294-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433176PMC
August 2020

An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress.

Neurobiol Dis 2020 Oct 13;144:105050. Epub 2020 Aug 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom; Lead Contact. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2020.105050DOI Listing
October 2020

Amyotrophic lateral sclerosis with a heterozygous D91A SOD1 variant and classical ALS-TDP neuropathology.

Neurology 2020 09 7;95(13):595-596. Epub 2020 Aug 7.

From the Nuffield Department of Clinical Neurosciences, University of Oxford, UK.

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http://dx.doi.org/10.1212/WNL.0000000000010587DOI Listing
September 2020

CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis.

Ann Clin Transl Neurol 2020 Jul 14. Epub 2020 Jul 14.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/acn3.51114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448184PMC
July 2020

Amyotrophic Lateral Sclerosis: network vulnerability and monosynaptic connections.

Authors:
Kevin Talbot

J Neurol Neurosurg Psychiatry 2020 Sep 14;91(9):906. Epub 2020 Jul 14.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK

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http://dx.doi.org/10.1136/jnnp-2020-323729DOI Listing
September 2020

Quantitative patterns of motor cortex proteinopathy across ALS genotypes.

Acta Neuropathol Commun 2020 07 2;8(1):98. Epub 2020 Jul 2.

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 1, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1186/s40478-020-00961-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331195PMC
July 2020

Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF.

Amyotroph Lateral Scler Frontotemporal Degener 2020 Jun 27:1-9. Epub 2020 Jun 27.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1080/21678421.2020.1752244DOI Listing
June 2020

The use of biotelemetry to explore disease progression markers in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2020 Jun 23:1-11. Epub 2020 Jun 23.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1080/21678421.2020.1773501DOI Listing
June 2020

Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD.

Stem Cell Reports 2020 05 23;14(5):892-908. Epub 2020 Apr 23.

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2020.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220989PMC
May 2020

Primary lateral sclerosis: diagnosis and management.

Pract Neurol 2020 Aug 26;20(4):262-269. Epub 2020 Mar 26.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/practneurol-2019-002300DOI Listing
August 2020

Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.

Cell Rep 2020 03;30(11):3655-3662.e2

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK; Discoveries Centre for Regenerative and Precision Medicine, University College London Campus, London WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.02.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090381PMC
March 2020

Regional callosal integrity and bilaterality of limb weakness in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2020 08 28;21(5-6):396-402. Epub 2020 Feb 28.

Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1080/21678421.2020.1733020DOI Listing
August 2020

Objectively Monitoring Amyotrophic Lateral Sclerosis Patient Symptoms During Clinical Trials With Sensors: Observational Study.

JMIR Mhealth Uhealth 2019 12 20;7(12):e13433. Epub 2019 Dec 20.

Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London, United Kingdom.

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http://dx.doi.org/10.2196/13433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942190PMC
December 2019

Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.

Cell Rep 2019 Oct;29(5):1082-1098.e10

Centre for Discovery Brain Sciences, University of Edinburgh, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.033DOI Listing
October 2019

Wrangling RNA: Antisense oligonucleotides for neurological disorders.

Sci Transl Med 2019 09;11(511)

MDUK Oxford Neuromuscular Centre, University of Oxford, Oxford OX1 3QX, UK.

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http://dx.doi.org/10.1126/scitranslmed.aay2069DOI Listing
September 2019

Tracheostomy in motor neurone disease.

Pract Neurol 2019 Dec 4;19(6):467-475. Epub 2019 Jul 4.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/practneurol-2018-002109DOI Listing
December 2019

CSF chitinase proteins in amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2019 11 23;90(11):1215-1220. Epub 2019 May 23.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK

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http://dx.doi.org/10.1136/jnnp-2019-320442DOI Listing
November 2019

Cerebellar tract alterations in PLS and ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2019 05 21;20(3-4):281-284. Epub 2019 Jan 21.

b Wellcome Centre for Integrative Neuroimaging , University of Oxford , Oxford , UK.

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https://www.tandfonline.com/doi/full/10.1080/21678421.2018.1
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http://dx.doi.org/10.1080/21678421.2018.1562554DOI Listing
May 2019

UFLC-Derived CSF Extracellular Vesicle Origin and Proteome.

Proteomics 2018 12 10;18(24):e1800257. Epub 2018 Dec 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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http://doi.wiley.com/10.1002/pmic.201800257
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http://dx.doi.org/10.1002/pmic.201800257DOI Listing
December 2018

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Acta Neuropathol Commun 2018 09 24;6(1):99. Epub 2018 Sep 24.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/s40478-018-0600-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151931PMC
September 2018

Amyotrophic lateral sclerosis: the complex path to precision medicine.

J Neurol 2018 Oct 27;265(10):2454-2462. Epub 2018 Jul 27.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s00415-018-8983-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182683PMC
October 2018

Regional thalamic MRI as a marker of widespread cortical pathology and progressive frontotemporal involvement in amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2018 12 26;89(12):1250-1258. Epub 2018 Jul 26.

Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK

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http://dx.doi.org/10.1136/jnnp-2018-318625DOI Listing
December 2018

Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis.

Clin Neurophysiol 2018 07 6;129(7):1479-1489. Epub 2018 Apr 6.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2018.03.019DOI Listing
July 2018

Increased cerebral functional connectivity in ALS: A resting-state magnetoencephalography study.

Neurology 2018 04 21;90(16):e1418-e1424. Epub 2018 Mar 21.

From the Nuffield Department of Clinical Neurosciences (M.P., K.T., M.R.T.), and Oxford Centre for Human Brain Activity (M.P., G.L.C., A.Q., A.C.N., M.W.W., M.R.T.), University of Oxford, UK; and Miller School of Medicine (J.W., M.B.), University of Miami, FL.

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http://dx.doi.org/10.1212/WNL.0000000000005333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902786PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Towards a TDP-43-Based Biomarker for ALS and FTLD.

Mol Neurobiol 2018 Oct 19;55(10):7789-7801. Epub 2018 Feb 19.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/s12035-018-0947-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132775PMC
October 2018

Advances in therapy for spinal muscular atrophy: promises and challenges.

Nat Rev Neurol 2018 04 9;14(4):214-224. Epub 2018 Feb 9.

Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/nrneurol.2018.4DOI Listing
April 2018

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis.

Ann Neurol 2018 02 9;83(2):258-268. Epub 2018 Feb 9.

Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1002/ana.25143DOI Listing
February 2018

Spinal muscular atrophy: antisense oligonucleotide therapy opens the door to an integrated therapeutic landscape.

Hum Mol Genet 2017 10;26(R2):R151-R159

Department of Physiology, Anatomy and Genetics, University of Oxford OX1 3QX, Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddx215DOI Listing
October 2017

Fundus fluorescein angiography in Susac's syndrome.

Pract Neurol 2017 Dec 17;17(6):472-473. Epub 2017 Aug 17.

Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1136/practneurol-2017-001727DOI Listing
December 2017

Therapeutic strategies for spinal muscular atrophy: SMN and beyond.

Dis Model Mech 2017 08;10(8):943-954

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.030148
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http://dx.doi.org/10.1242/dmm.030148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560066PMC
August 2017

Genetic screening in sporadic ALS and FTD.

J Neurol Neurosurg Psychiatry 2017 12 22;88(12):1042-1044. Epub 2017 Jun 22.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2017-315995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740553PMC
December 2017

Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis.

Acad Radiol 2017 10 29;24(10):1187-1194. Epub 2017 May 29.

Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Oxford University Centre for Magnetic Resonance Research, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.acra.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605225PMC
October 2017

Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by mutations.

Proc Natl Acad Sci U S A 2017 04 28;114(16):E3324-E3333. Epub 2017 Mar 28.

Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1614557114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402433PMC
April 2017

ADCY5-related dyskinesia presenting as familial myoclonus-dystonia.

Neurogenetics 2017 Apr 22;18(2):111-117. Epub 2017 Feb 22.

Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Level G, Mailpoint 627, Princess Anne Hospital, Coxford Road, Southampton, SO16 5YA, UK.

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http://dx.doi.org/10.1007/s10048-017-0510-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359383PMC
April 2017

A risk stratifying tool to facilitate safe late-stage percutaneous endoscopic gastrostomy in ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 19;18(3-4):243-248. Epub 2017 Jan 19.

a Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1080/21678421.2016.1274330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425625PMC
May 2017

Sweet food preference in amyotrophic lateral sclerosis.

Pract Neurol 2017 Apr 10;17(2):128-129. Epub 2017 Jan 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/practneurol-2016-001554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520252PMC
April 2017

What is the role of TDP-43 in C9orf72-related amyotrophic lateral sclerosis and frontemporal dementia?

Brain 2016 12;139(Pt 12):3057-3059

Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford, OX3 9DU, UK

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http://dx.doi.org/10.1093/brain/aww264DOI Listing
December 2016

Psychiatric disorders prior to amyotrophic lateral sclerosis.

Ann Neurol 2016 12 14;80(6):935-938. Epub 2016 Nov 14.

Oxford University Nuffield Department of Population Health, Old Road Campus, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/ana.24801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215396PMC
December 2016

Pathogenesis of FUS-associated ALS and FTD: insights from rodent models.

Acta Neuropathol Commun 2016 09 6;4(1):99. Epub 2016 Sep 6.

Neuropathology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s40478-016-0358-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011941PMC
September 2016

A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2017 02 31;18(1-2):1-9. Epub 2016 Aug 31.

a Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, & Academic Directorate of Neurosciences, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield.

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http://dx.doi.org/10.1080/21678421.2016.1221433DOI Listing
February 2017

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Nutritional pathway for people with motor neurone disease.

Br J Community Nurs 2016 Jul;21(7):360-3

Consultant Neurologist, Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford.

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http://dx.doi.org/10.12968/bjcn.2016.21.7.360DOI Listing
July 2016

Clinical tool for predicting survival in ALS: do we need one?

Authors:
Kevin Talbot

J Neurol Neurosurg Psychiatry 2016 12 4;87(12):1275. Epub 2016 Jul 4.

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http://dx.doi.org/10.1136/jnnp-2016-313683DOI Listing
December 2016

ABN news.

Pract Neurol 2016 Jun;16(3):252

Association of British Neurologists, London, UK.

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http://dx.doi.org/10.1136/practneurol-2016-001439DOI Listing
June 2016

Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers.

Nat Rev Neurol 2016 06 13;12(6):346-57. Epub 2016 May 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1038/nrneurol.2016.68DOI Listing
June 2016

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Stem Cell Reports 2016 Mar 18;6(3):342-56. Epub 2016 Feb 18.

Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788783PMC
March 2016

The ALSFRS as an outcome measure in therapeutic trials and its relationship to symptom onset.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Jul-Aug;17(5-6):414-25. Epub 2016 Feb 11.

a Nuffield Department of Clinical Neuroscience , University of Oxford and.

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http://dx.doi.org/10.3109/21678421.2016.1140786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950444PMC
October 2017

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk.

J Neurol Neurosurg Psychiatry 2016 06 5;87(6):580-8. Epub 2016 Jan 5.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2015-311945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893149PMC
June 2016

Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy.

Ann Neurol 2016 Feb 13;79(2):217-30. Epub 2016 Jan 13.

Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.

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http://dx.doi.org/10.1002/ana.24549DOI Listing
February 2016

Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks.

Amyotroph Lateral Scler Frontotemporal Degener 2015 27;17(1-2):101-11. Epub 2015 Aug 27.

a Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.3109/21678421.2015.1054292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127416PMC
October 2016

CSF neurofilament light chain reflects corticospinal tract degeneration in ALS.

Ann Clin Transl Neurol 2015 Jul 25;2(7):748-55. Epub 2015 May 25.

Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom.

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http://dx.doi.org/10.1002/acn3.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531057PMC
July 2015

Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2016 Mar 10;87(3):244-6. Epub 2015 Aug 10.

Nuffield Department of Population Health, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2015-311157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789816PMC
March 2016

The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2015 29;16(7-8):456-63. Epub 2015 Jun 29.

a Nuffield Department of Clinical Neuroscience , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.3109/21678421.2015.1053490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720042PMC
August 2016

Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology.

Hum Mol Genet 2015 Aug 13;24(15):4397-406. Epub 2015 May 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK,

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http://dx.doi.org/10.1093/hmg/ddv176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492401PMC
August 2015

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.

Neurology 2015 Jun 1;84(22):2247-57. Epub 2015 May 1.

From the Centre for Neuroscience & Trauma (C.-H.L., G.G., J.K., A.M.), Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; Sobell Department of Motor Neuroscience and Movement Disorders (C.-H.L., L.G.), Departments of Neuroinflammation (A.P.), Neurodegenerative Disease (P.F.), Molecular Neuroscience (K.S.), and Clinical Neuroscience (R.O.), and MRC Centre for Neuromuscular Diseases (R.O., L.G.), UCL Institute of Neurology, London; MRC Integrative Epidemiology Unit (C.M.-W.), University of Bristol; Nuffield Department of Clinical Neurosciences (E.G., K.T., M.R.T.), University of Oxford; Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, London, UK; UmanDiagnostics (N.N.), Umeå, Sweden; Medicine Clinical Trial Unit (M.F.), Musgrove Park Hospital, Taunton, UK; National Hospital for Neurology and Neurosurgery (R.O., R.H., A.M.), London, UK; Neurology (J.K.), University Hospital Basel, Switzerland; North-East London and Essex MND Care and Research Centre (A.M.), London; and Basildon and Thurrock University Hospitals NHS Foundation Trust (A.M.), Basildon, UK.

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http://dx.doi.org/10.1212/WNL.0000000000001642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456658PMC
June 2015

Identification of distinct circulating exosomes in Parkinson's disease.

Ann Clin Transl Neurol 2015 Apr 6;2(4):353-61. Epub 2015 Feb 6.

Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom ; Oxford Parkinson's Disease Centre, University of Oxford Oxford, United Kingdom.

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http://dx.doi.org/10.1002/acn3.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402081PMC
April 2015

Linking compensation to payment incentives. A new challenge for healthcare.

Healthc Exec 2014 Jul-Aug;29(4):58-60

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March 2015

Advances in the clinical science of the motor unit: from motor neuron to neuromuscular junction.

Curr Opin Neurol 2014 Oct;27(5):503-5

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1097/WCO.0000000000000139DOI Listing
October 2014

Swallowing and oropharyngeal dysphagia.

Clin Med (Lond) 2014 Aug;14(4):456

Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.7861/clinmedicine.14-4-456aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952855PMC
August 2014

Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis.

Brain 2014 Sep 20;137(Pt 9):2546-55. Epub 2014 Jun 20.

1 Oxford Centre for Functional Magnetic Resonance of the Brain, University of Oxford, UK2 Nuffield Department of Clinical Neurosciences, University of Oxford, UK5 Oxford Centre for Magnetic Resonance Imaging Research, University of Oxford, UK

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http://brain.oxfordjournals.org/content/brain/137/9/2546.ful
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September 2014

Autosomal dominant inheritance of rapidly progressive amyotrophic lateral sclerosis due to a truncation mutation in the fused in sarcoma (FUS) gene.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Dec 5;15(7-8):557-62. Epub 2014 Jun 5.

Nuffield Department of Clinical Neurosciences, University of Oxford.

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December 2014

FTLD-ALS of TDP-43 type and SCA2 in a family with a full ataxin-2 polyglutamine expansion.

Acta Neuropathol 2014 Oct 10;128(4):597-604. Epub 2014 Apr 10.

Department of Neuropathology, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s00401-014-1277-zDOI Listing
October 2014

T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.

J Cereb Blood Flow Metab 2014 May 5;34(5):785-93. Epub 2014 Feb 5.

CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/jcbfm.2014.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013759PMC
May 2014

Advances in motor neurone disease.

J R Soc Med 2014 Jan;107(1):14-21

Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1177/0141076813511451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883149PMC
January 2014

Predictors of cognitive impairment in an early stage Parkinson's disease cohort.

Mov Disord 2014 Mar 6;29(3):351-9. Epub 2014 Jan 6.

Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, United Kingdom; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom; Oxford Parkinson's Disease Centre, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/mds.25748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235340PMC
March 2014