Kevin Talbot

Kevin Talbot

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CSF chitinase proteins in amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2019 Nov 23;90(11):1215-1220. Epub 2019 May 23.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK

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http://dx.doi.org/10.1136/jnnp-2019-320442DOI Listing
November 2019

Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation.

Cell Rep 2019 Oct;29(5):1082-1098.e10

Centre for Discovery Brain Sciences, University of Edinburgh, The Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.033DOI Listing
October 2019

Wrangling RNA: Antisense oligonucleotides for neurological disorders.

Sci Transl Med 2019 Sep;11(511)

MDUK Oxford Neuromuscular Centre, University of Oxford, Oxford OX1 3QX, UK.

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http://dx.doi.org/10.1126/scitranslmed.aay2069DOI Listing
September 2019

Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo.

Hum Mol Genet 2019 Sep 6. Epub 2019 Sep 6.

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1093/hmg/ddz190DOI Listing
September 2019

Tracheostomy in motor neurone disease.

Pract Neurol 2019 Jul 4. Epub 2019 Jul 4.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/practneurol-2018-002109DOI Listing
July 2019

Cerebellar tract alterations in PLS and ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2019 05 21;20(3-4):281-284. Epub 2019 Jan 21.

b Wellcome Centre for Integrative Neuroimaging , University of Oxford , Oxford , UK.

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https://www.tandfonline.com/doi/full/10.1080/21678421.2018.1
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http://dx.doi.org/10.1080/21678421.2018.1562554DOI Listing
May 2019

Regional thalamic MRI as a marker of widespread cortical pathology and progressive frontotemporal involvement in amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2018 12 26;89(12):1250-1258. Epub 2018 Jul 26.

Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK

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http://dx.doi.org/10.1136/jnnp-2018-318625DOI Listing
December 2018

UFLC-Derived CSF Extracellular Vesicle Origin and Proteome.

Proteomics 2018 12 10;18(24):e1800257. Epub 2018 Dec 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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http://doi.wiley.com/10.1002/pmic.201800257
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http://dx.doi.org/10.1002/pmic.201800257DOI Listing
December 2018

Towards a TDP-43-Based Biomarker for ALS and FTLD.

Mol Neurobiol 2018 Oct 19;55(10):7789-7801. Epub 2018 Feb 19.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/s12035-018-0947-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132775PMC
October 2018

Amyotrophic lateral sclerosis: the complex path to precision medicine.

J Neurol 2018 Oct 27;265(10):2454-2462. Epub 2018 Jul 27.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s00415-018-8983-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182683PMC
October 2018

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Acta Neuropathol Commun 2018 09 24;6(1):99. Epub 2018 Sep 24.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/s40478-018-0600-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151931PMC
September 2018

Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis.

Clin Neurophysiol 2018 07 6;129(7):1479-1489. Epub 2018 Apr 6.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2018.03.019DOI Listing
July 2018

Advances in therapy for spinal muscular atrophy: promises and challenges.

Nat Rev Neurol 2018 04 9;14(4):214-224. Epub 2018 Feb 9.

Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/nrneurol.2018.4DOI Listing
April 2018

Increased cerebral functional connectivity in ALS: A resting-state magnetoencephalography study.

Neurology 2018 04 21;90(16):e1418-e1424. Epub 2018 Mar 21.

From the Nuffield Department of Clinical Neurosciences (M.P., K.T., M.R.T.), and Oxford Centre for Human Brain Activity (M.P., G.L.C., A.Q., A.C.N., M.W.W., M.R.T.), University of Oxford, UK; and Miller School of Medicine (J.W., M.B.), University of Miami, FL.

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http://dx.doi.org/10.1212/WNL.0000000000005333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902786PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis.

Ann Neurol 2018 02 9;83(2):258-268. Epub 2018 Feb 9.

Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.

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http://dx.doi.org/10.1002/ana.25143DOI Listing
February 2018

Genetic screening in sporadic ALS and FTD.

J Neurol Neurosurg Psychiatry 2017 12 22;88(12):1042-1044. Epub 2017 Jun 22.

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2017-315995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740553PMC
December 2017

Fundus fluorescein angiography in Susac's syndrome.

Pract Neurol 2017 Dec 17;17(6):472-473. Epub 2017 Aug 17.

Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1136/practneurol-2017-001727DOI Listing
December 2017

The ALSFRS as an outcome measure in therapeutic trials and its relationship to symptom onset.

Amyotroph Lateral Scler Frontotemporal Degener 2016 Jul-Aug;17(5-6):414-25. Epub 2016 Feb 11.

a Nuffield Department of Clinical Neuroscience , University of Oxford and.

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http://dx.doi.org/10.3109/21678421.2016.1140786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950444PMC
October 2017

Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis.

Acad Radiol 2017 10 29;24(10):1187-1194. Epub 2017 May 29.

Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK; Oxford University Centre for Magnetic Resonance Research, John Radcliffe Hospital, West Wing Level 6, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.acra.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605225PMC
October 2017

Spinal muscular atrophy: antisense oligonucleotide therapy opens the door to an integrated therapeutic landscape.

Hum Mol Genet 2017 10;26(R2):R151-R159

Department of Physiology, Anatomy and Genetics, University of Oxford OX1 3QX, Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddx215DOI Listing
October 2017

Therapeutic strategies for spinal muscular atrophy: SMN and beyond.

Dis Model Mech 2017 08;10(8):943-954

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.030148
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http://dx.doi.org/10.1242/dmm.030148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560066PMC
August 2017

A risk stratifying tool to facilitate safe late-stage percutaneous endoscopic gastrostomy in ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 19;18(3-4):243-248. Epub 2017 Jan 19.

a Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1080/21678421.2016.1274330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425625PMC
May 2017

Sweet food preference in amyotrophic lateral sclerosis.

Pract Neurol 2017 Apr 10;17(2):128-129. Epub 2017 Jan 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/practneurol-2016-001554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520252PMC
April 2017

ADCY5-related dyskinesia presenting as familial myoclonus-dystonia.

Neurogenetics 2017 Apr 22;18(2):111-117. Epub 2017 Feb 22.

Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Level G, Mailpoint 627, Princess Anne Hospital, Coxford Road, Southampton, SO16 5YA, UK.

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http://dx.doi.org/10.1007/s10048-017-0510-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359383PMC
April 2017

Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by mutations.

Proc Natl Acad Sci U S A 2017 04 28;114(16):E3324-E3333. Epub 2017 Mar 28.

Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1614557114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402433PMC
April 2017

A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2017 02 31;18(1-2):1-9. Epub 2016 Aug 31.

a Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, & Academic Directorate of Neurosciences, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield.

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http://dx.doi.org/10.1080/21678421.2016.1221433DOI Listing
February 2017

Clinical tool for predicting survival in ALS: do we need one?

Authors:
Kevin Talbot

J Neurol Neurosurg Psychiatry 2016 12 4;87(12):1275. Epub 2016 Jul 4.

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http://dx.doi.org/10.1136/jnnp-2016-313683DOI Listing
December 2016

Psychiatric disorders prior to amyotrophic lateral sclerosis.

Ann Neurol 2016 12 14;80(6):935-938. Epub 2016 Nov 14.

Oxford University Nuffield Department of Population Health, Old Road Campus, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/ana.24801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215396PMC
December 2016

What is the role of TDP-43 in C9orf72-related amyotrophic lateral sclerosis and frontemporal dementia?

Brain 2016 12;139(Pt 12):3057-3059

Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford, OX3 9DU, UK

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http://dx.doi.org/10.1093/brain/aww264DOI Listing
December 2016

Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks.

Amyotroph Lateral Scler Frontotemporal Degener 2015 27;17(1-2):101-11. Epub 2015 Aug 27.

a Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.

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http://www.tandfonline.com/doi/full/10.3109/21678421.2015.10
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http://dx.doi.org/10.3109/21678421.2015.1054292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127416PMC
October 2016

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Pathogenesis of FUS-associated ALS and FTD: insights from rodent models.

Acta Neuropathol Commun 2016 09 6;4(1):99. Epub 2016 Sep 6.

Neuropathology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s40478-016-0358-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011941PMC
September 2016

The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2015 29;16(7-8):456-63. Epub 2015 Jun 29.

a Nuffield Department of Clinical Neuroscience , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.3109/21678421.2015.1053490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720042PMC
August 2016

Nutritional pathway for people with motor neurone disease.

Br J Community Nurs 2016 Jul;21(7):360-3

Consultant Neurologist, Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford.

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http://dx.doi.org/10.12968/bjcn.2016.21.7.360DOI Listing
July 2016

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk.

J Neurol Neurosurg Psychiatry 2016 06 5;87(6):580-8. Epub 2016 Jan 5.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2015-311945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893149PMC
June 2016

Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers.

Nat Rev Neurol 2016 06 13;12(6):346-57. Epub 2016 May 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1038/nrneurol.2016.68DOI Listing
June 2016

ABN news.

Pract Neurol 2016 Jun;16(3):252

Association of British Neurologists, London, UK.

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http://dx.doi.org/10.1136/practneurol-2016-001439DOI Listing
June 2016

Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2016 Mar 10;87(3):244-6. Epub 2015 Aug 10.

Nuffield Department of Population Health, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2015-311157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789816PMC
March 2016

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Stem Cell Reports 2016 Mar 18;6(3):342-56. Epub 2016 Feb 18.

Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788783PMC
March 2016

Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy.

Ann Neurol 2016 Feb 13;79(2):217-30. Epub 2016 Jan 13.

Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.

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http://dx.doi.org/10.1002/ana.24549DOI Listing
February 2016

Improving access to medicines: empowering patients in the quest to improve treatment for rare lethal diseases.

J Med Ethics 2015 Dec 9;41(12):987-9. Epub 2013 Jul 9.

Neurosciences Department, Barwon Health, The Geelong Hospital, Geelong, Victoria, Australia.

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http://dx.doi.org/10.1136/medethics-2013-101427DOI Listing
December 2015

Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology.

Hum Mol Genet 2015 Aug 13;24(15):4397-406. Epub 2015 May 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK,

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http://dx.doi.org/10.1093/hmg/ddv176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492401PMC
August 2015

CSF neurofilament light chain reflects corticospinal tract degeneration in ALS.

Ann Clin Transl Neurol 2015 Jul 25;2(7):748-55. Epub 2015 May 25.

Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom.

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http://dx.doi.org/10.1002/acn3.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531057PMC
July 2015

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.

Neurology 2015 Jun 1;84(22):2247-57. Epub 2015 May 1.

From the Centre for Neuroscience & Trauma (C.-H.L., G.G., J.K., A.M.), Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; Sobell Department of Motor Neuroscience and Movement Disorders (C.-H.L., L.G.), Departments of Neuroinflammation (A.P.), Neurodegenerative Disease (P.F.), Molecular Neuroscience (K.S.), and Clinical Neuroscience (R.O.), and MRC Centre for Neuromuscular Diseases (R.O., L.G.), UCL Institute of Neurology, London; MRC Integrative Epidemiology Unit (C.M.-W.), University of Bristol; Nuffield Department of Clinical Neurosciences (E.G., K.T., M.R.T.), University of Oxford; Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, London, UK; UmanDiagnostics (N.N.), Umeå, Sweden; Medicine Clinical Trial Unit (M.F.), Musgrove Park Hospital, Taunton, UK; National Hospital for Neurology and Neurosurgery (R.O., R.H., A.M.), London, UK; Neurology (J.K.), University Hospital Basel, Switzerland; North-East London and Essex MND Care and Research Centre (A.M.), London; and Basildon and Thurrock University Hospitals NHS Foundation Trust (A.M.), Basildon, UK.

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http://dx.doi.org/10.1212/WNL.0000000000001642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456658PMC
June 2015

Identification of distinct circulating exosomes in Parkinson's disease.

Ann Clin Transl Neurol 2015 Apr 6;2(4):353-61. Epub 2015 Feb 6.

Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom ; Oxford Parkinson's Disease Centre, University of Oxford Oxford, United Kingdom.

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http://dx.doi.org/10.1002/acn3.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402081PMC
April 2015

Linking compensation to payment incentives. A new challenge for healthcare.

Healthc Exec 2014 Jul-Aug;29(4):58-60

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March 2015

Autosomal dominant inheritance of rapidly progressive amyotrophic lateral sclerosis due to a truncation mutation in the fused in sarcoma (FUS) gene.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Dec 5;15(7-8):557-62. Epub 2014 Jun 5.

Nuffield Department of Clinical Neurosciences, University of Oxford.

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http://dx.doi.org/10.3109/21678421.2014.920033DOI Listing
December 2014

An eye-tracking version of the trail-making test.

PLoS One 2013 18;8(12):e84061. Epub 2013 Dec 18.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084061PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867477PMC
October 2014

FTLD-ALS of TDP-43 type and SCA2 in a family with a full ataxin-2 polyglutamine expansion.

Acta Neuropathol 2014 Oct 10;128(4):597-604. Epub 2014 Apr 10.

Department of Neuropathology, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1007/s00401-014-1277-zDOI Listing
October 2014

Advances in the clinical science of the motor unit: from motor neuron to neuromuscular junction.

Curr Opin Neurol 2014 Oct;27(5):503-5

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1097/WCO.0000000000000139DOI Listing
October 2014

Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis.

Brain 2014 Sep 20;137(Pt 9):2546-55. Epub 2014 Jun 20.

1 Oxford Centre for Functional Magnetic Resonance of the Brain, University of Oxford, UK2 Nuffield Department of Clinical Neurosciences, University of Oxford, UK5 Oxford Centre for Magnetic Resonance Imaging Research, University of Oxford, UK

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September 2014

Swallowing and oropharyngeal dysphagia.

Clin Med (Lond) 2014 Aug;14(4):456

Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4952855PMC
August 2014

Should all patients with ALS have genetic testing?

Authors:
Kevin Talbot

J Neurol Neurosurg Psychiatry 2014 May 18;85(5):475. Epub 2013 Jul 18.

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http://dx.doi.org/10.1136/jnnp-2013-305727DOI Listing
May 2014

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease.

J Neurol Neurosurg Psychiatry 2014 May 1;85(5):560-6. Epub 2013 Nov 1.

Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2013-306104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995329PMC
May 2014

T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.

J Cereb Blood Flow Metab 2014 May 5;34(5):785-93. Epub 2014 Feb 5.

CR-UK/MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/jcbfm.2014.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013759PMC
May 2014

Comprehensive morphometry of subcortical grey matter structures in early-stage Parkinson's disease.

Hum Brain Mapp 2014 Apr 16;35(4):1681-90. Epub 2013 Jul 16.

FMRIB Centre, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom; Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/hbm.22282DOI Listing
April 2014

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.

Neurobiol Aging 2014 Apr 24;35(4):906-15. Epub 2013 Oct 24.

MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919158PMC
April 2014

Predictors of cognitive impairment in an early stage Parkinson's disease cohort.

Mov Disord 2014 Mar 6;29(3):351-9. Epub 2014 Jan 6.

Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, United Kingdom; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom; Oxford Parkinson's Disease Centre, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/mds.25748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235340PMC
March 2014

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.

Hum Mol Genet 2014 Feb 25;23(4):855-69. Epub 2013 Sep 25.

Department of Physiology, Anatomy and Genetics, MRC Functional Genomics Unit, University of Oxford, South Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1093/hmg/ddt477DOI Listing
February 2014

Progressive hemiparesis (Mills syndrome) with aphasia in amyotrophic lateral sclerosis.

Neurology 2014 Feb 20;82(5):457-8. Epub 2013 Dec 20.

From Oxford University, John Radcliffe Hospital (D.B., R.A.L.M., K.T., M.H., M.R.T.); Milton Keynes Hospital NHS Trust (R.B.), Buckinghamshire; and Oxford University, Warneford Hospital (R.A.L.M.), UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917681PMC
February 2014

Amyotrophic lateral sclerosis: cell vulnerability or system vulnerability?

Authors:
Kevin Talbot

J Anat 2014 Jan 8;224(1):45-51. Epub 2013 Sep 8.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/joa.12107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867886PMC
January 2014

The influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.

Parkinsonism Relat Disord 2014 Jan 12;20(1):99-105. Epub 2013 Oct 12.

Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, United Kingdom; Oxford Parkinson Disease Centre, University of Oxford, Oxford, United Kingdom; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2013.09.025DOI Listing
January 2014

Expanding the genetics of huntingtonism.

Neurology 2014 Jan 20;82(4):286-7. Epub 2013 Dec 20.

From the Center for Neurosciences (A.F.), The Feinstein Institute for Medical Research, Manhasset, NY; and the Nuffield Department of Clinical Neurosciences (K.T.), University of Oxford, UK.

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http://dx.doi.org/10.1212/WNL.0000000000000067DOI Listing
January 2014

Advances in motor neurone disease.

J R Soc Med 2014 Jan;107(1):14-21

Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1177/0141076813511451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883149PMC
January 2014

Management of sialorrhoea in motor neuron disease: a survey of current UK practice.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Dec 7;14(7-8):521-7. Epub 2013 May 7.

Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, & Academic Directorate of Neurosciences, Royal Hallamshire Hospital , Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield.

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http://dx.doi.org/10.3109/21678421.2013.790452DOI Listing
December 2013

Myelin imaging in amyotrophic and primary lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Dec 16;14(7-8):562-73. Epub 2013 May 16.

Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford.

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http://dx.doi.org/10.3109/21678421.2013.794843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837681PMC
December 2013

The impact of fatigue and psychosocial variables on quality of life for patients with motor neuron disease.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Dec 31;14(7-8):537-45. Epub 2013 May 31.

The Walton Centre for Neurology and Neurosurgery , Liverpool.

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http://dx.doi.org/10.3109/21678421.2013.799700DOI Listing
December 2013

Assessing social isolation in motor neurone disease: a Rasch analysis of the MND Social Withdrawal Scale.

J Neurol Sci 2013 Nov 9;334(1-2):112-8. Epub 2013 Aug 9.

The Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, UK; NIHR Collaboration for Leadership in Applied Health Research and Care for Greater Manchester, Centre for Primary Care, University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2013.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837185PMC
November 2013

Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study.

Neurology 2013 Oct 14;81(14):1222-5. Epub 2013 Aug 14.

From the Oxford University Nuffield Department of Clinical Neurosciences (M.R.T., K.T.), John Radcliffe Hospital; Oxford University Unit of Health-Care Epidemiology (R.G., M.J.G.), Department of Public Health; and Oxford University Department of Physiology, Anatomy and Genetics (S.R.), Oxford, UK.

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http://dx.doi.org/10.1212/WNL.0b013e3182a6cc13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795611PMC
October 2013

Mimics and chameleons in motor neurone disease.

Pract Neurol 2013 Jun 24;13(3):153-64. Epub 2013 Apr 24.

University of Oxford Nuffield Department of Clinical Neurosciences, Oxford, UK.

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http://dx.doi.org/10.1136/practneurol-2013-000557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664389PMC
June 2013