Publications by authors named "Kevin T Bush"

53Publications

Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease.

JCI Insight 2020 04 9;5(7). Epub 2020 Apr 9.

Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1172/jci.insight.133817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205256PMC
April 2020

The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology.

Clin Pharmacol Ther 2020 Jul 11;108(1):40-53. Epub 2020 Apr 11.

Division of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1002/cpt.1818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292762PMC
July 2020

Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.

J Biol Chem 2020 02 2;295(7):1829-1842. Epub 2020 Jan 2.

Department of Pediatrics, University of California San Diego, La Jolla, California 92093-0693

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http://dx.doi.org/10.1074/jbc.RA119.010729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029110PMC
February 2020

A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis.

Sci Rep 2019 08 15;9(1):11879. Epub 2019 Aug 15.

Departments of Pediatrics, University of California at San Diego, La Jolla, CA, 92093-0693, USA.

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http://dx.doi.org/10.1038/s41598-019-47798-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695406PMC
August 2019

Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.

Nat Rev Nephrol 2019 05;15(5):301-316

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41581-019-0111-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619437PMC
May 2019

Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development.

Am J Med Genet A 2019 01 13;179(1):71-77. Epub 2018 Nov 13.

Division of Pediatric Cardiology, University of California San Diego School of Medicine, San Diego, California.

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http://dx.doi.org/10.1002/ajmg.a.40481DOI Listing
January 2019

Elucidation of Drug Combination Synergy in Treatment of Pancreatic Ductal Adenocarcinoma.

Anticancer Res 2018 04;38(4):1967-1977

CureMatch, Inc., San Diego, CA, U.S.A.

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http://dx.doi.org/10.21873/anticanres.12434DOI Listing
April 2018

The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis.

J Biol Chem 2017 09 1;292(38):15789-15803. Epub 2017 Aug 1.

From the Departments of Pediatrics,

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http://dx.doi.org/10.1074/jbc.M117.796516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612110PMC
September 2017

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes.

Sci Rep 2017 07 10;7(1):4939. Epub 2017 Jul 10.

Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

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http://www.nature.com/articles/s41598-017-04949-2
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http://dx.doi.org/10.1038/s41598-017-04949-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504054PMC
July 2017

Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.

J Pharmacol Exp Ther 2016 10 3;359(1):215-29. Epub 2016 Aug 3.

Departments of Bioengineering (H.C.L.), Pediatrics (A.G., Y.C., C.L., K.T.B., S.K.N.), Medicine (W.W., S.K.N.), Cellular and Molecular Medicine (S.K.N.), and Pharmacology (R.A.), and the San Diego Supercomputer Center (N.B., P.R.), University of California San Diego, La Jolla, California

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034704PMC
http://dx.doi.org/10.1124/jpet.116.232660DOI Listing
October 2016

Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers.

Drug Metab Dispos 2016 07 4;44(7):1050-60. Epub 2016 Apr 4.

Department of Pediatrics (G.M., K.T.B., S.K.N.), Department of Medicine, Division of Nephrology and Hypertension, (S.K.N.), and Department of Cellular and Molecular Medicine (S.K.N.), University of California, San Diego, La Jolla, California

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http://dx.doi.org/10.1124/dmd.115.068254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931883PMC
July 2016

Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters.

Clin J Am Soc Nephrol 2015 Nov 21;10(11):2039-49. Epub 2015 Oct 21.

Division of Family & Preventative Medicine, University of California-San Diego, La Jolla, California;

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http://cjasn.asnjournals.org/cgi/doi/10.2215/CJN.02440314
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http://dx.doi.org/10.2215/CJN.02440314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633783PMC
November 2015

Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors.

Drug Metab Dispos 2015 Dec 10;43(12):1855-63. Epub 2015 Sep 10.

Departments of Pediatrics (K.T.B., S.K.N.), Medicine (Division of Nephrology and Hypertension)(W.W., S.K.N.), Bioengineering (H.C.L.), Biomedical Sciences (C.Z.), School of Pharmacy/Pharmaceutical Science (R.A.), and Cellular and Molecular Medicine (S.K.N.), University of California, San Diego, La Jolla, California

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http://dx.doi.org/10.1124/dmd.115.065250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658493PMC
December 2015

The organic anion transporter (OAT) family: a systems biology perspective.

Physiol Rev 2015 Jan;95(1):83-123

Departments of Pediatrics, Medicine, Cellular and Molecular Medicine, Bioengineering, and Family and Preventative Medicine, University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.1152/physrev.00025.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281586PMC
January 2015

Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease.

Curr Opin Organ Transplant 2014 Apr;19(2):153-61

aDepartment of Pediatrics bDepartment of Biomedical Sciences cDepartment of Medicine dDepartment of Cellular & Molecular Medicine eDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.

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http://pdfs.journals.lww.com/co-transplantation/2014/04000/R
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOT.0000000000000053DOI Listing
April 2014

Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis.

Pediatr Nephrol 2014 Apr 2;29(4):727-35. Epub 2014 Feb 2.

Department of Medicine, University of California, La Jolla, San Diego, CA, 92093-0693, USA,

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http://dx.doi.org/10.1007/s00467-013-2725-zDOI Listing
April 2014

GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling.

Biol Open 2013 30;2(9):952-9. Epub 2013 Jul 30.

Department of Medicine, University of California , San Diego, La Jolla, CA 92093-0693 , USA ; Present address: Department of Pediatrics, University of Calgary and Alberta Children's Hospital, Calgary, AB T3B 6A8, Canada.

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http://dx.doi.org/10.1242/bio.20135595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773342PMC
October 2013

Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.

Drug Metab Dispos 2013 Oct 6;41(10):1825-34. Epub 2013 Aug 6.

Departments of Pediatrics (H.C.L., K.T.B., S.K.N.), Medicine, Division of Nephrology and Hypertension (W.W., S.A.E., S.K.N.), Cellular and Molecular Medicine (S.K.N.), and Bioengineering (N.J., B.O.P., S.K.N.), University of California, San Diego, La Jolla, California.

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http://dx.doi.org/10.1124/dmd.113.052647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781372PMC
October 2013

N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.

J Biol Chem 2012 Dec 11;287(50):42064-70. Epub 2012 Oct 11.

Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA.

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http://www.jbc.org/content/287/50/42064.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M112.423327
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http://dx.doi.org/10.1074/jbc.M112.423327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516752PMC
December 2012

In vitro culture of embryonic kidney rudiments and isolated ureteric buds.

Methods Mol Biol 2012 ;886:13-21

Pediatrics Department, University of California, San Diego, CA, USA.

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http://link.springer.com/content/pdf/10.1007/978-1-61779-851
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http://link.springer.com/10.1007/978-1-61779-851-1_2
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http://dx.doi.org/10.1007/978-1-61779-851-1_2DOI Listing
September 2012

Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury.

J Biol Chem 2011 Jul 7;286(30):26391-5. Epub 2011 Jun 7.

Farmacología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, 2000 Rosario, Argentina.

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http://dx.doi.org/10.1074/jbc.M111.249292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143602PMC
July 2011

Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate.

Dev Biol 2011 Aug 11;356(1):19-27. Epub 2011 May 11.

Department of Medicine (Division of Nephrology and Hypertension), University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130836PMC
August 2011

Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.

Dev Biol 2011 Jul 7;355(2):394-403. Epub 2011 May 7.

Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.ydbio.2011.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118867PMC
July 2011

Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice.

PLoS One 2010 May 18;5(5):e10691. Epub 2010 May 18.

Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872662PMC
May 2010

Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching.

Dev Biol 2010 Mar 6;339(2):354-65. Epub 2010 Jan 6.

Department of Medicine, University of California, San Diego, CA 92093-0693, USA.

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http://dx.doi.org/10.1016/j.ydbio.2009.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834281PMC
March 2010

Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function.

Am J Physiol Renal Physiol 2009 Jul 13;297(1):F210-7. Epub 2009 May 13.

Department of Pediatrics, University of California, La Jolla, California 92093-0693, USA.

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http://dx.doi.org/10.1152/ajprenal.90260.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711709PMC
July 2009

Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members.

Physiol Genomics 2009 Jul 5;38(2):116-24. Epub 2009 May 5.

Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093-0693, USA.

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http://dx.doi.org/10.1152/physiolgenomics.90309.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712220PMC
July 2009

Organogenesis forum lecture: In vitro kidney development, tissue engineering and systems biology.

Organogenesis 2008 Jul;4(3):137-43

Department of Medicine, School of Medicine; University of California; San Diego, La Jolla, California USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634587PMC
http://dx.doi.org/10.4161/org.4.3.6498DOI Listing
July 2008

Analysis of metagene portraits reveals distinct transitions during kidney organogenesis.

Sci Signal 2008 Dec 9;1(49):ra16. Epub 2008 Dec 9.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0505, USA.

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http://dx.doi.org/10.1126/scisignal.1163630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016920PMC
December 2008

Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues.

Nat Clin Pract Nephrol 2007 Aug;3(8):443-8

University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1038/ncpneph0558DOI Listing
August 2007

Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development.

Differentiation 2006 Dec;74(9-10):638-47

Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1111/j.1432-0436.2006.00102.xDOI Listing
December 2006

The developmental nephrome: systems biology in the developing kidney.

Curr Opin Nephrol Hypertens 2007 Jan;16(1):3-9

Department of Medicine, Nephrology Division, Federal University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1097/MNH.0b013e3280118a5aDOI Listing
January 2007

Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system.

Dev Biol 2006 Oct 12;298(2):571-84. Epub 2006 Jul 12.

Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, and Urological Diseases Research Center, Department of Urology, Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.07.006DOI Listing
October 2006

Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia.

J Biol Chem 2005 Dec 23;280(51):42181-7. Epub 2005 Sep 23.

Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M507962200DOI Listing
December 2005

Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells.

Biochem Biophys Res Commun 2004 Sep;322(1):223-31

Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0401608
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http://dx.doi.org/10.1016/j.bbrc.2004.07.097DOI Listing
September 2004

Branching morphogenesis and kidney disease.

Development 2004 Apr;131(7):1449-62

Department of Pediatrics, University of California, San Diego, CA 92093-0693, USA.

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http://dx.doi.org/10.1242/dev.01089DOI Listing
April 2004

The molecular pharmacology of organic anion transporters: from DNA to FDA?

Mol Pharmacol 2004 Mar;65(3):479-87

Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1124/mol.65.3.479DOI Listing
March 2004

TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud.

Dev Biol 2004 Feb;266(2):285-98

Department of Medicine, Pediatrics and Cellular Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0693, USA.

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http://dx.doi.org/10.1016/j.ydbio.2003.10.023DOI Listing
February 2004

Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development.

Kidney Int 2003 Dec;64(6):1997-2008

Department of Medicine, University of California, San Diego, California, USA.

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http://dx.doi.org/10.1046/j.1523-1755.2003.00383.xDOI Listing
December 2003

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis.

Nature 2003 Nov;426(6964):247-54

Howard Hughes Medical Institute, School and Department of Medicine, UCSD, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA.

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http://dx.doi.org/10.1038/nature02083DOI Listing
November 2003

A strategy for in vitro propagation of rat nephrons.

Kidney Int 2002 Dec;62(6):1958-65

Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1046/j.1523-1755.2002.00694.xDOI Listing
December 2002