Publications by authors named "Kevin S W Tan"

68Publications

Taming the Sentinels: Microbiome-Derived Metabolites and Polarization of T Cells.

Int J Mol Sci 2020 Oct 19;21(20). Epub 2020 Oct 19.

Immunology Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore.

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http://dx.doi.org/10.3390/ijms21207740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589579PMC
October 2020

Blastocystis.

Trends Parasitol 2020 03 27;36(3):315-316. Epub 2020 Jan 27.

London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1016/j.pt.2019.12.008DOI Listing
March 2020

Antimalarial ,-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships.

ACS Med Chem Lett 2020 Jan 11;11(1):49-55. Epub 2019 Dec 11.

Centre of Excellence for Pharmaceutical Sciences, North-West University, 2531 Potchefstroom, South Africa.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956359PMC
January 2020

Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.

Eur J Med Chem 2019 Dec 7;184:111755. Epub 2019 Oct 7.

Department of Pharmacy, National University of Singapore, 18 Science Drive 4, 117543, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111755DOI Listing
December 2019

Hepatic spheroids used as an in vitro model to study malaria relapse.

Biomaterials 2019 09 22;216:119221. Epub 2019 May 22.

Novartis Institute for Tropical Diseases, 138670, Singapore; Singapore Immunology Network (SIgN), A*STAR, 138648, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.05.032DOI Listing
September 2019

Successful Genetic Transfection of the Colonic Protistan Parasite Blastocystis for Reliable Expression of Ectopic Genes.

Sci Rep 2019 02 28;9(1):3159. Epub 2019 Feb 28.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore, 117545, Singapore.

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http://dx.doi.org/10.1038/s41598-019-39094-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395660PMC
February 2019

Viability Screen of LOPAC Reveals Tyrosine Kinase Inhibitor Tyrphostin A9 as a Novel Partner Drug for Artesunate Combinations To Target the Ring Stage.

Antimicrob Agents Chemother 2019 04 27;63(4). Epub 2019 Mar 27.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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http://aac.asm.org/lookup/doi/10.1128/AAC.02389-18
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http://dx.doi.org/10.1128/AAC.02389-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437515PMC
April 2019

A high content imaging flow cytometry approach to study mitochondria in T cells: MitoTracker Green FM dye concentration optimization.

Methods 2018 02 2;134-135:11-19. Epub 2017 Dec 2.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, and Immunology Programme, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.11.015DOI Listing
February 2018

Proteogenomic Insights into the Intestinal Parasite Blastocystis sp. Subtype 4 Isolate WR1.

Proteomics 2017 Nov 16;17(21). Epub 2017 Oct 16.

Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Centre d'Infection et d'Immunité de Lille, 1 rue du Professeur Calmette, Lille, France.

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http://dx.doi.org/10.1002/pmic.201700211DOI Listing
November 2017

An efficient cumate-inducible system for procyclic and bloodstream form Trypanosoma brucei.

Mol Biochem Parasitol 2017 06 21;214:101-104. Epub 2017 Apr 21.

Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117543, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.molbiopara.2017.04.007DOI Listing
June 2017

BAPTA-AM decreases cellular pH, inhibits acidocalcisome acidification and autophagy in amino acid-starved T. brucei.

Mol Biochem Parasitol 2017 04 6;213:26-29. Epub 2017 Mar 6.

Department of Biological Sciences, National University of Singapore, 117543, Singapore; Centre for BioImaging Sciences, National University of Singapore, 117543, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.molbiopara.2017.03.001DOI Listing
April 2017

Ex Vivo and In Vivo Mice Models to Study Blastocystis spp. Adhesion, Colonization and Pathology: Closer to Proving Koch's Postulates.

PLoS One 2016 10;11(8):e0160458. Epub 2016 Aug 10.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, National University of Singapore, 5 Science Drive 2, Singapore, 117545.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160458PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979897PMC
August 2017

Screening for Drugs Against the Plasmodium falciparum Digestive Vacuole by Imaging Flow Cytometry.

Methods Mol Biol 2016 ;1389:195-205

Department of Microbiology, National University of Singapore, Blk MD4, Level 3, 5 Science Drive 2, Singapore, 117545, Singapore.

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http://dx.doi.org/10.1007/978-1-4939-3302-0_14DOI Listing
September 2017

Pathogenic mechanisms in Blastocystis spp. - Interpreting results from in vitro and in vivo studies.

Parasitol Int 2016 Dec 13;65(6 Pt B):772-779. Epub 2016 May 13.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2016.05.007DOI Listing
December 2016

Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents.

Eur J Med Chem 2016 Aug 26;119:231-49. Epub 2016 Apr 26.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.04.058DOI Listing
August 2016

Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds.

Antimicrob Agents Chemother 2016 05 22;60(5):3076-89. Epub 2016 Apr 22.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, National University of Singapore, Singapore

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http://dx.doi.org/10.1128/AAC.02476-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862508PMC
May 2016

The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death in .

Microb Cell 2015 Jul 30;2(8):288-298. Epub 2015 Jul 30.

Department of Biological Sciences, National University of Singapore.

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http://dx.doi.org/10.15698/mic2015.08.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349101PMC
July 2015

Cell biology of pathogenic protozoa and their interaction with host cells.

Biomed Res Int 2014 5;2014:143418. Epub 2014 Jun 5.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil ; Instituto Nacional de Metrologia e Qualidade Industrial-Inmetro, Rio de Janeiro, Brazil ; Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens-INBEB, Brazil.

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http://dx.doi.org/10.1155/2014/143418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066675PMC
February 2015

Strain-dependent induction of human enterocyte apoptosis by blastocystis disrupts epithelial barrier and ZO-1 organization in a caspase 3- and 9-dependent manner.

Biomed Res Int 2014 14;2014:209163. Epub 2014 Apr 14.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science, Drive 2, Singapore 117596.

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http://dx.doi.org/10.1155/2014/209163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009109PMC
January 2015

Pleiotropic effects of Blastocystis spp. Subtypes 4 and 7 on ligand-specific toll-like receptor signaling and NF-κB activation in a human monocyte cell line.

PLoS One 2014 14;9(2):e89036. Epub 2014 Feb 14.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089036PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925187PMC
October 2014

Life cycle-dependent cytoskeletal modifications in Plasmodium falciparum infected erythrocytes.

PLoS One 2013 9;8(4):e61170. Epub 2013 Apr 9.

Nano Biomechanics Laboratory, Department of Bioengineering, National University of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061170PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621960PMC
October 2013

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra 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Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

A simplified, sensitive phagocytic assay for malaria cultures facilitated by flow cytometry of differentially-stained cell populations.

PLoS One 2012 4;7(6):e38523. Epub 2012 Jun 4.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366917PMC
October 2012

Statin pleiotropy prevents rho kinase-mediated intestinal epithelial barrier compromise induced by Blastocystis cysteine proteases.

Cell Microbiol 2012 Sep 31;14(9):1474-84. Epub 2012 May 31.

Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, 8A Biomedical Grove, Immunos, Singapore 138648, Singapore.

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http://dx.doi.org/10.1111/j.1462-5822.2012.01814.xDOI Listing
September 2012

Can we teach an old drug new tricks?

Trends Parasitol 2012 Jun 22;28(6):220-4. Epub 2012 Mar 22.

Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/j.pt.2012.02.005DOI Listing
June 2012

Characterization of two cysteine proteases secreted by Blastocystis ST7, a human intestinal parasite.

Parasitol Int 2012 Sep 25;61(3):437-42. Epub 2012 Feb 25.

Clermont Université, Université Blaise Pascal, Laboratoire Microorganismes: Génome et Environnement, BP 10448, F-63000 Clermont-Ferrand, France.

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http://dx.doi.org/10.1016/j.parint.2012.02.007DOI Listing
September 2012

Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids.

Org Lett 2012 Mar 5;14(6):1560-3. Epub 2012 Mar 5.

Department of Chemistry, Faculty of Science, and Medicinal Chemistry Program of the Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.

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March 2012

A metronidazole-resistant isolate of Blastocystis spp. is susceptible to nitric oxide and downregulates intestinal epithelial inducible nitric oxide synthase by a novel parasite survival mechanism.

Infect Immun 2011 Dec 19;79(12):5019-26. Epub 2011 Sep 19.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117596, Singapore.

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http://dx.doi.org/10.1128/IAI.05632-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232666PMC
December 2011

Current Views on the Clinical Relevance of Blastocystis spp.

Curr Infect Dis Rep 2010 Jan;12(1):28-35

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore, 117597, Singapore,

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http://dx.doi.org/10.1007/s11908-009-0073-8DOI Listing
January 2010

A rapid, high-throughput viability assay for Blastocystis spp. reveals metronidazole resistance and extensive subtype-dependent variations in drug susceptibilities.

Antimicrob Agents Chemother 2011 Feb 22;55(2):637-48. Epub 2010 Nov 22.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1128/AAC.00900-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028762PMC
February 2011

Automatic area classification in peripheral blood smears.

IEEE Trans Biomed Eng 2010 Aug 1;57(8):1982-90. Epub 2010 Mar 1.

Institute for Infocomm Research, Agency for Science Technology and Research, and the Image and Pervasive Access Laboratory (UMI 2955, French National Center for Scientific Research), Singapore 138632.

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http://dx.doi.org/10.1109/TBME.2010.2043841DOI Listing
August 2010

Staurosporine-induced programmed cell death in Blastocystis occurs independently of caspases and cathepsins and is augmented by calpain inhibition.

Microbiology (Reading) 2010 May 7;156(Pt 5):1284-1293. Epub 2010 Jan 7.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore.

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http://dx.doi.org/10.1099/mic.0.034025-0DOI Listing
May 2010

Autophagy is involved in starvation response and cell death in Blastocystis.

Microbiology (Reading) 2010 Mar 12;156(Pt 3):665-677. Epub 2009 Nov 12.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore.

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http://dx.doi.org/10.1099/mic.0.033944-0DOI Listing
March 2010

Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites.

Angew Chem Int Ed Engl 2009 ;48(44):8293-7

Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.

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http://dx.doi.org/10.1002/anie.200903747DOI Listing
February 2010

New insights on classification, identification, and clinical relevance of Blastocystis spp.

Authors:
Kevin S W Tan

Clin Microbiol Rev 2008 Oct;21(4):639-65

Department of Microbiology, Laboratory of Molecular and Cellular Parasitology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.

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http://dx.doi.org/10.1128/CMR.00022-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570156PMC
October 2008

Blastocystis exhibits inter- and intra-subtype variation in cysteine protease activity.

Parasitol Res 2009 Jan 10;104(2):355-61. Epub 2008 Oct 10.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Kent Ridge 117597, Singapore.

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http://dx.doi.org/10.1007/s00436-008-1203-1DOI Listing
January 2009

Biochemical characterization of a mitochondrial-like organelle from Blastocystis sp. subtype 7.

Microbiology (Reading) 2008 Sep;154(Pt 9):2757-2766

Department of Chemistry and Physical Sciences, Pace University, New York, NY 10038, USA.

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http://dx.doi.org/10.1099/mic.0.2008/017897-0DOI Listing
September 2008

Complete circular DNA in the mitochondria-like organelles of Blastocystis hominis.

Int J Parasitol 2008 Oct 23;38(12):1377-82. Epub 2008 Jul 23.

Laboratoire Microorganismes, Génome et Environnement, UMR CNRS 6023, Université Blaise Pascal, 63177 Aubière Cedex, France.

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http://dx.doi.org/10.1016/j.ijpara.2008.06.001DOI Listing
October 2008

Blastocystis ratti contains cysteine proteases that mediate interleukin-8 response from human intestinal epithelial cells in an NF-kappaB-dependent manner.

Eukaryot Cell 2008 Mar 21;7(3):435-43. Epub 2007 Dec 21.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 5 Science Drive 2, Singapore 117597.

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http://dx.doi.org/10.1128/EC.00371-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268520PMC
March 2008

Predominance of subtype 3 among Blastocystis isolates from a major hospital in Singapore.

Parasitol Res 2008 Mar 7;102(4):663-70. Epub 2007 Dec 7.

Laboratory of Molecular and Cellular Parasitology, National University of Singapore, Singapore 5 Science Drive 2, Singapore 117597, Singapore.

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http://dx.doi.org/10.1007/s00436-007-0808-0DOI Listing
March 2008

Ultrastructural and phylogenetic studies on Blastocystis isolates from cockroaches.

J Eukaryot Microbiol 2007 Jan-Feb;54(1):33-7

Department of Biological Sciences, Faculty of Science, Nara Women's University, Kitauoya-Nishimachi, Nara 630-8506, Japan.

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http://dx.doi.org/10.1111/j.1550-7408.2006.00141.xDOI Listing
September 2007

Terminology for Blastocystis subtypes--a consensus.

Trends Parasitol 2007 Mar 22;23(3):93-6. Epub 2007 Jan 22.

Laboratory of Parasitology, Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark.

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http://dx.doi.org/10.1016/j.pt.2007.01.004DOI Listing
March 2007

MalariaCount: an image analysis-based program for the accurate determination of parasitemia.

J Microbiol Methods 2007 Jan 11;68(1):11-8. Epub 2006 Jul 11.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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January 2007

Blastocystis ratti induces contact-independent apoptosis, F-actin rearrangement, and barrier function disruption in IEC-6 cells.

Infect Immun 2006 Jul;74(7):4114-23

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore.

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http://dx.doi.org/10.1128/IAI.00328-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489721PMC
July 2006

Observations on the internal and surface morphology of malaria infected blood cells using optical and atomic force microscopy.

J Microbiol Methods 2006 Sep 7;66(3):434-9. Epub 2006 Mar 7.

Nano Biomechanics Laboratory, Division of Bioengineering and Department of Mechanical Engineering, National University of Singapore, Singapore 117576.

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http://dx.doi.org/10.1016/j.mimet.2006.01.009DOI Listing
September 2006

Protease activity of Blastocystis hominis.

Parasitol Res 2006 Jul 4;99(2):126-30. Epub 2006 Mar 4.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore.

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http://dx.doi.org/10.1007/s00436-006-0131-1DOI Listing
July 2006

Systematic study of sequence motifs for RNA trans splicing in Trypanosoma brucei.

Mol Cell Biol 2005 Nov;25(21):9586-94

Laboratory of Molecular Parasitology, Box 185, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1128/MCB.25.21.9586-9594.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265811PMC
November 2005

Protozoan programmed cell death--insights from Blastocystis deathstyles.

Trends Parasitol 2005 Dec 11;21(12):547-50. Epub 2005 Oct 11.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597.

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http://dx.doi.org/10.1016/j.pt.2005.09.006DOI Listing
December 2005

Degradation of human secretory immunoglobulin A by Blastocystis.

Parasitol Res 2005 Nov 7;97(5):386-9. Epub 2005 Sep 7.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597.

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http://dx.doi.org/10.1007/s00436-005-1461-0DOI Listing
November 2005

Programmed cell death in Blastocystis hominis occurs independently of caspase and mitochondrial pathways.

Biochimie 2005 Jun 8;87(6):489-97. Epub 2005 Apr 8.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.biochi.2005.03.003DOI Listing
June 2005

Plasmodium falciparum: a simplified technique for obtaining singly infected erythrocytes.

Parasitol Res 2005 Feb 23;95(3):176-8. Epub 2004 Dec 23.

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, 117597, Singapore.

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http://dx.doi.org/10.1007/s00436-004-1266-6DOI Listing
February 2005

Blastocystis in humans and animals: new insights using modern methodologies.

Authors:
Kevin S W Tan

Vet Parasitol 2004 Dec;126(1-2):121-44

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, S 117597 Singapore, Singapore.

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http://dx.doi.org/10.1016/j.vetpar.2004.09.017DOI Listing
December 2004

Caspase-3-like protease influences but is not essential for DNA fragmentation in Blastocystis undergoing apoptosis.

Eur J Cell Biol 2004 Sep;83(9):477-82

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1078/0171-9335-00411DOI Listing
September 2004

Isolation and characterization of the mitochondrion-like organelle from Blastocystis hominis.

J Microbiol Methods 2004 Jul;58(1):101-9

Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, 117597 Singapore.

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http://dx.doi.org/10.1016/j.mimet.2004.03.008DOI Listing
July 2004

Metronidazole induces programmed cell death in the protozoan parasite Blastocystis hominis.

Microbiology (Reading) 2004 Jan;150(Pt 1):33-43

Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597.

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http://dx.doi.org/10.1099/mic.0.26496-0DOI Listing
January 2004

Multiple reproductive processes in Blastocystis: proceed with caution.

Trends Parasitol 2003 Jul;19(7):290-1; author reply 291-2

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http://dx.doi.org/10.1016/s1471-4922(03)00119-3DOI Listing
July 2003

Trypanosoma brucei MRE11 is non-essential but influences growth, homologous recombination and DNA double-strand break repair.

Mol Biochem Parasitol 2002 Nov-Dec;125(1-2):11-21

Laboratory of Molecular Parasitology, The Rockefeller University, Box 185, 1230 York Avenue, New York, NY 10021-6399, USA.

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http://dx.doi.org/10.1016/s0166-6851(02)00165-2DOI Listing
March 2003

Recent advances in Blastocystis hominis research: hot spots in terra incognita.

Int J Parasitol 2002 Jun;32(7):789-804

Department of Microbiology, Faculty of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597.

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http://dx.doi.org/10.1016/s0020-7519(02)00005-xDOI Listing
June 2002