Kevin R Brown

Kevin R Brown

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Kevin R Brown

Kevin R Brown

Publications by authors named "Kevin R Brown"

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Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.

Am J Physiol Renal Physiol 2019 Dec 30;317(6):F1593-F1604. Epub 2019 Sep 30.

Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1152/ajprenal.00195.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962514PMC
December 2019

Pooled CRISPR-Based Genetic Screens in Mammalian Cells.

J Vis Exp 2019 Sep 4(151). Epub 2019 Sep 4.

Donnelly Centre, University of Toronto; Department of Molecular Genetics, University of Toronto; Institute for Biomaterials and Biomedical Engineering, University of Toronto;

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http://dx.doi.org/10.3791/59780DOI Listing
September 2019

CRISPR screens are feasible in TP53 wild-type cells.

Mol Syst Biol 2019 08;15(8):e8679

Donnelly Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.15252/msb.20188679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686785PMC
August 2019

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.

Cell Rep 2019 04;27(2):599-615.e12

Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Canadian Institute for Advanced Research, Toronto, ON, Canada; Institute for Biomaterials and BioMedical Engineering, University of Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.041DOI Listing
April 2019

Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response.

J Biol Chem 2019 01 6;294(4):1396-1409. Epub 2018 Dec 6.

From the Banting and Best Department of Medical Research and Department of Medical Genetics, The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.004420
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http://dx.doi.org/10.1074/jbc.RA118.004420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349115PMC
January 2019

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.

Cell Rep 2017 03;18(10):2343-2358

Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medicine, University of Toronto, Toronto, ON M5G 2C4, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Rheumatology, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.028DOI Listing
March 2017

An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.

Oncotarget 2017 Jan;8(3):4484-4500

Princess Margaret Cancer Centre, University Health Network, Toronto Medical Discovery Tower, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.18632/oncotarget.13152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354848PMC
January 2017

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

Mol Cell 2016 Apr 3;62(1):121-36. Epub 2016 Mar 3.

Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, ON M5S3E1, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Cir, Toronto, ON M5S1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988125PMC
April 2016

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.

Cell 2016 Jan;164(1-2):293-309

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Laura and Isaac Perlmutter Cancer Centre, NYU-Langone Medical Center, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.11.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724865PMC
January 2016

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Cell 2015 Dec 25;163(6):1515-26. Epub 2015 Nov 25.

Donnelly Centre, 160 College Street, Toronto, ON M5S3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S1A1, Canada; Canadian Institute for Advanced Research, Toronto, ON M5G1Z8, Canada. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)01495-6.pdf
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http://www.cell.com/cms/attachment/2042476803/2055463631/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501495
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http://dx.doi.org/10.1016/j.cell.2015.11.015DOI Listing
December 2015

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

Cancer Res 2015 Oct 21;75(19):4211-23. Epub 2015 Aug 21.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

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http://cancerres.aacrjournals.org/content/early/2015/08/21/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-15-1107DOI Listing
October 2015

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics.

Mol Syst Biol 2014 Jul 1;10:733. Epub 2014 Jul 1.

Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299491PMC
http://dx.doi.org/10.15252/msb.20145216DOI Listing
July 2014

Miniature short hairpin RNA screens to characterize antiproliferative drugs.

G3 (Bethesda) 2013 Aug 7;3(8):1375-87. Epub 2013 Aug 7.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1534/g3.113.006437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737177PMC
August 2013

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.

Hum Mol Genet 2012 Sep 29;21(17):3785-94. Epub 2012 May 29.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/hmg/dds206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412378PMC
September 2012

COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines.

Nucleic Acids Res 2012 Jan 18;40(Database issue):D957-63. Epub 2011 Nov 18.

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada M5G 0A3.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkr959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245009PMC
January 2012

NAViGaTOR: Network Analysis, Visualization and Graphing Toronto.

Bioinformatics 2009 Dec 16;25(24):3327-9. Epub 2009 Oct 16.

Division of Signaling Biology, Ontario Cancer Institute and University Health Network, Toronto, ON.

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http://dx.doi.org/10.1093/bioinformatics/btp595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788933PMC
December 2009

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

Sci Signal 2009 12 22;2(102):ra84. Epub 2009 Dec 22.

Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University School of Medicine, Frankfurt (Main), Germany.

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http://dx.doi.org/10.1126/scisignal.2000576DOI Listing
December 2009

Unequal evolutionary conservation of human protein interactions in interologous networks.

Genome Biol 2007 ;8(5):R95

Department of Medical Biophysics, University of Toronto, Toronto, Canada M5G 1L7.

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http://dx.doi.org/10.1186/gb-2007-8-5-r95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929159PMC
September 2007

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

Proteomics 2007 Jun;7(11):1775-85

Department of Biochemistry and the Siebens-Drake Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1002/pmic.200601006DOI Listing
June 2007

Online predicted human interaction database.

Bioinformatics 2005 May 18;21(9):2076-82. Epub 2005 Jan 18.

Division of Cancer Informatics, Ontario Cancer Institute, University of Toronto, Canada.

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http://dx.doi.org/10.1093/bioinformatics/bti273DOI Listing
May 2005

High-throughput mapping of a dynamic signaling network in mammalian cells.

Science 2005 Mar;307(5715):1621-5

Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.

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http://dx.doi.org/10.1126/science.1105776DOI Listing
March 2005

A nuclear 3'-5' exonuclease proofreads for the exonuclease-deficient DNA polymerase alpha.

DNA Repair (Amst) 2002 Oct;1(10):795-810

Division of Experimental Therapeutics, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada.

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http://dx.doi.org/10.1016/s1568-7864(02)00115-5DOI Listing
October 2002