Publications by authors named "Kevin Mott"

55Publications

Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT.

J Virol 2020 Feb 28;94(6). Epub 2020 Feb 28.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.01798-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158736PMC
February 2020

The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.

Dis Model Mech 2019 07 5;12(7). Epub 2019 Jul 5.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

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http://dx.doi.org/10.1242/dmm.037192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679375PMC
July 2019

The Latency-Associated Transcript Inhibits Apoptosis via Downregulation of Components of the Type I Interferon Pathway during Latent Herpes Simplex Virus 1 Ocular Infection.

J Virol 2019 05 1;93(10). Epub 2019 May 1.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.00103-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498055PMC
May 2019

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.

Breast Cancer Res Treat 2019 Feb 27;174(1):143-155. Epub 2018 Nov 27.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, CB#7264, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10549-018-5061-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418066PMC
February 2019

The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection.

J Virol 2018 02 30;92(4). Epub 2018 Jan 30.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.01599-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790959PMC
February 2018

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice.

PLoS Pathog 2017 May 22;13(5):e1006401. Epub 2017 May 22.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC - SSB3, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456410PMC
May 2017

Interrelationship of Primary Virus Replication, Level of Latency, and Time to Reactivation in the Trigeminal Ganglia of Latently Infected Mice.

J Virol 2016 10 29;90(20):9533-42. Epub 2016 Sep 29.

Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratory, and Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.01373-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044812PMC
October 2016

CD8+ T Cells Play a Bystander Role in Mice Latently Infected with Herpes Simplex Virus 1.

J Virol 2016 05 29;90(10):5059-5067. Epub 2016 Apr 29.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.00255-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859724PMC
May 2016

Mutations within the pathogenic region of herpes simplex virus 1 gK signal sequences alter cell surface expression and neurovirulence.

J Virol 2015 Mar 10;89(5):2530-42. Epub 2014 Dec 10.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.03506-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325753PMC
March 2015

Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells.

Immunobiology 2015 Apr 30;220(4):518-24. Epub 2014 Oct 30.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01712985140021
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http://dx.doi.org/10.1016/j.imbio.2014.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355210PMC
April 2015

Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice.

J Virol 2014 Jul 7;88(14):8016-27. Epub 2014 May 7.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.00913-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097799PMC
July 2014

Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo.

Exp Eye Res 2014 Jun 24;123:8-15. Epub 2014 Apr 24.

Center for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, CA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144835140009
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http://dx.doi.org/10.1016/j.exer.2014.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047190PMC
June 2014

CD8α dendritic cells drive establishment of HSV-1 latency.

PLoS One 2014 2;9(4):e93444. Epub 2014 Apr 2.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093444PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973679PMC
January 2015

Coregulatory interactions among CD8α dendritic cells, the latency-associated transcript, and programmed death 1 contribute to higher levels of herpes simplex virus 1 latency.

J Virol 2014 Jun 26;88(12):6599-610. Epub 2014 Mar 26.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA

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http://dx.doi.org/10.1128/JVI.00590-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054370PMC
June 2014

Overexpression of herpes simplex virus glycoprotein K (gK) alters expression of HSV receptors in ocularly-infected mice.

Invest Ophthalmol Vis Sci 2014 Apr 15;55(4):2442-51. Epub 2014 Apr 15.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, United States.

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http://dx.doi.org/10.1167/iovs.14-14013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989088PMC
April 2014

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.

PLoS One 2014 27;9(1):e87617. Epub 2014 Jan 27.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087617PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903765PMC
September 2014

Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity.

PLoS One 2014 20;9(1):e85360. Epub 2014 Jan 20.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085360PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896391PMC
December 2014

Role of interleukin-2 and herpes simplex virus 1 in central nervous system demyelination in mice.

J Virol 2013 Nov 28;87(22):12102-9. Epub 2013 Aug 28.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1128/JVI.02241-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807926PMC
November 2013

Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation.

J Virol 2011 Nov 31;85(21):11448-56. Epub 2011 Aug 31.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery and Regenerative Medicine Institute, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1128/JVI.00678-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194985PMC
November 2011

CD11c controls herpes simplex virus 1 responses to limit virus replication during primary infection.

J Virol 2011 Oct 20;85(19):9945-55. Epub 2011 Jul 20.

Center for Neurobiology and Vaccine Development-SSB3, Regenerative Medicine Institute, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1128/JVI.05208-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196403PMC
October 2011

IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.

PLoS One 2011 Feb 18;6(2):e16820. Epub 2011 Feb 18.

Department of Surgery, Center for Neurobiology and Vaccine Development, Ophthalmology Research, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016820PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041759PMC
February 2011

Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs.

Invest Ophthalmol Vis Sci 2011 Apr 8;52(5):2321-33. Epub 2011 Apr 8.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery and Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1167/iovs.10-6536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080735PMC
April 2011

Ocular infection of mice with an avirulent recombinant HSV-1 expressing IL-4 and an attenuated HSV-1 strain generates virulent recombinants in vivo.

Mol Vis 2010 Oct 26;16:2153-62. Epub 2010 Oct 26.

Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, CSMC Burns & Allen Research Institute, Los Angeles, CA 90048, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994333PMC
October 2010

Immunization with different viral antigens alters the pattern of T cell exhaustion and latency in herpes simplex virus type 1-infected mice.

J Virol 2010 Dec 22;84(23):12315-24. Epub 2010 Sep 22.

Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Department of Surgery, CSMC Burns & Allen Research Institute, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1128/JVI.01600-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976415PMC
December 2010

Involvement of STAT4 in IgG subtype switching and ocular HSV-1 replication in mice.

Mol Vis 2010 Jan 26;16:98-104. Epub 2010 Jan 26.

Department of Surgery, CSMC Burns & Allen Research Institute, Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Los Angeles, CA 90048, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810873PMC
January 2010

Exacerbation of corneal scarring in HSV-1 gK-immunized mice correlates with elevation of CD8+CD25+ T cells in corneas of ocularly infected mice.

Virology 2010 Mar 18;399(1):11-22. Epub 2010 Jan 18.

Center for Neurobiology and Vaccine Development, CSMC Burns and Allen Research Institute, Los Angeles, CA 90048, USA; Ophthalmology Research Laboratories, Department of Surgery, CSMC Burns and Allen Research Institute, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2009.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830294PMC
March 2010

ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection.

J Neuroimmunol 2009 Aug 9;213(1-2):12-9. Epub 2009 Jul 9.

Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2009.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750088PMC
August 2009

A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages.

Virol J 2009 May 13;6:56. Epub 2009 May 13.

Center for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1186/1743-422X-6-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686698PMC
May 2009

Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2.

Invest Ophthalmol Vis Sci 2009 Jul 21;50(7):3275-82. Epub 2009 Feb 21.

Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Center for Neurobiology and Vaccine Development, Los Angeles, California, USA.

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http://dx.doi.org/10.1167/iovs.08-3211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217944PMC
July 2009

The role of a glycoprotein K (gK) CD8+ T-cell epitope of herpes simplex virus on virus replication and pathogenicity.

Invest Ophthalmol Vis Sci 2009 Jun 24;50(6):2903-12. Epub 2009 Jan 24.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1167/iovs.08-2957DOI Listing
June 2009

Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8+ T cells in trigeminal ganglia of latently infected mice.

J Virol 2009 Mar 17;83(5):2246-54. Epub 2008 Dec 17.

Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, CSMC Burns & Allen Research Institute, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1128/JVI.02234-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643740PMC
March 2009

Role of dendritic cells in enhancement of herpes simplex virus type 1 latency and reactivation in vaccinated mice.

Clin Vaccine Immunol 2008 Dec 29;15(12):1859-67. Epub 2008 Oct 29.

Center for Neurobiology and Vaccine Development, D2024, Cedars-Sinai Burns and Allen Research Institute, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1128/CVI.00318-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593179PMC
December 2008

Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency.

J Virol 2008 Oct 30;82(20):9870-9. Epub 2008 Jul 30.

Center for Neurobiology and Vaccine Development, D2024, Cedars-Sinai Burns and Allen Research Institute, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1128/JVI.00566-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566288PMC
October 2008

Macrophages are important determinants of acute ocular HSV-1 infection in immunized mice.

Invest Ophthalmol Vis Sci 2007 Dec;48(12):5605-15

Center for Neurobiology and Vaccine Development, Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1167/iovs.07-0894DOI Listing
December 2007

The corneas of naive mice contain both CD4+ and CD8+ T cells.

Mol Vis 2007 Sep 28;13:1802-12. Epub 2007 Sep 28.

Center for Neurobiology & Vaccine Development, Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, CA 90272, USA.

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September 2007

A recombinant herpes simplex virus type 1 expressing two additional copies of gK is more pathogenic than wild-type virus in two different strains of mice.

J Virol 2007 Dec 26;81(23):12962-72. Epub 2007 Sep 26.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC-D2024, 8700 Beverly Blvd., Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1128/JVI.01442-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169076PMC
December 2007

Epitope mapping of HSV-1 glycoprotein K (gK) reveals a T cell epitope located within the signal domain of gK.

Virus Res 2007 Sep 11;128(1-2):71-80. Epub 2007 May 11.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.virusres.2007.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020453PMC
September 2007

Role of anti-glycoproteins D (anti-gD) and K (anti-gK) IgGs in pathology of herpes stromal keratitis in humans.

Invest Ophthalmol Vis Sci 2007 May;48(5):2185-93

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Cedars-Sinai Medical Center Burns and Allen Research Institute, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1167/iovs.06-1276DOI Listing
May 2007

A mutant deleted for most of the herpes simplex virus type 1 (HSV-1) UOL gene does not affect the spontaneous reactivation phenotype in rabbits.

J Neurovirol 2006 Feb;12(1):5-16

Department of Ophthalmology, University of California at Irvine, School of Medicine, Irvine, California, USA.

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http://dx.doi.org/10.1080/13550280500516401DOI Listing
February 2006

Herpes simplex virus type 1 immediate-early protein ICP0 diffuses out of infected rabbit corneas.

J Gen Virol 2005 Nov;86(Pt 11):2979-2988

Department of Ophthalmology, School of Medicine, University of California at Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1099/vir.0.81246-0DOI Listing
November 2005

Identification of a protein encoded in the herpes simplex virus type 1 latency associated transcript promoter region.

Virus Res 2005 Mar;108(1-2):101-10

Department of Ophthalmology, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.virusres.2004.08.011DOI Listing
March 2005

Glycoprotein C of herpes simplex virus type 1 is required to cause keratitis at low infectious doses in intact rabbit corneas.

Curr Eye Res 2004 Aug-Sep;29(2-3):181-9

Department of Ophthalmology, UC Irvine College of Medicine, Irvine, CA, USA.

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http://dx.doi.org/10.1080/02713680490504542DOI Listing
January 2005

Regional variation in wound contraction of mohs surgery defects allowed to heal by second intention.

Dermatol Surg 2003 Jul;29(7):712-22

Mohs Surgery Unit, Hawaii Skin Cancer and Photodamage Center, Honolulu, Hawaii 96813, USA.

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http://dx.doi.org/10.1046/j.1524-4725.2003.29180.xDOI Listing
July 2003

Herpes simplex virus type 1 mutants containing the KOS strain ICP34.5 gene in place of the McKrae ICP34.5 gene have McKrae-like spontaneous reactivation but non-McKrae-like virulence.

J Gen Virol 2002 Dec;83(Pt 12):2933-2942

Department of Ophthalmology, School of Medicine, University of California Irvine, Medical Center, Building 55, Room 204, Orange, CA 92868, USA1.

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http://dx.doi.org/10.1099/0022-1317-83-12-2933DOI Listing
December 2002