Kevin Mayo

Kevin Mayo

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Kevin Mayo

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Corrigendum to "An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature" [Vaccine 36(21) 3054-3060].

Vaccine 2019 Jun 12. Epub 2019 Jun 12.

Angiogenesis Laboratory, Cancer Center Amsterdam, Department of Medical Oncology, VU University Medical Center, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2019.06.010DOI Listing
June 2019

NMR-based insight into galectin-3 binding to endothelial cell adhesion molecule CD146: evidence for non-canonical interactions with the lectin's CRD β-sandwich F-face.

Glycobiology 2019 May 16. Epub 2019 May 16.

Department of Biochemistry, Molecular Biology & Biophysics, 6-155 Jackson Hall, University of Minnesota, Minneapolis, Minnesota 55455 USA.

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http://dx.doi.org/10.1093/glycob/cwz036DOI Listing
May 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Galectin-3 binds selectively to the terminal, non-reducing end of β(1→4)-galactans, with overall affinity increasing with chain length.

Glycobiology 2019 01;29(1):74-84

Department of Biochemistry, Molecular Biology & Biophysics, 6-155 Jackson Hall, University of Minnesota, Minneapolis, MN, USA.

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https://academic.oup.com/glycob/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/glycob/cwy085DOI Listing
January 2019

Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose.

Biosci Rep 2018 12 14;38(6). Epub 2018 Dec 14.

Jilin Province Key Laboratory for Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University, Changchun 130024, China

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http://dx.doi.org/10.1042/BSR20181787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294630PMC
December 2018

Preparation of individual galactan oligomers, their prebiotic effects, and use in estimating galactan chain length in pectin-derived polysaccharides.

Carbohydr Polym 2018 Nov 17;199:526-533. Epub 2018 Jul 17.

Jilin Province Key Laboratory for Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University, Changchun, 130024, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01448617183083
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http://dx.doi.org/10.1016/j.carbpol.2018.07.048DOI Listing
November 2018

An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature.

Vaccine 2018 05 11;36(21):3054-3060. Epub 2018 Apr 11.

Angiogenesis Laboratory, Cancer Center Amsterdam, Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2018.03.064DOI Listing
May 2018

Adhesion/growth-regulatory galectins tested in combination: evidence for formation of hybrids as heterodimers.

Biochem J 2018 03 15;475(5):1003-1018. Epub 2018 Mar 15.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, U.S.A.

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http://dx.doi.org/10.1042/BCJ20170658DOI Listing
March 2018

Galectins as Molecular Targets for Therapeutic Intervention.

Int J Mol Sci 2018 Mar 19;19(3). Epub 2018 Mar 19.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://www.mdpi.com/1422-0067/19/3/905
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http://dx.doi.org/10.3390/ijms19030905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877766PMC
March 2018

Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008.

J Exp Clin Cancer Res 2018 Mar 27;37(1):67. Epub 2018 Mar 27.

Department of Systems Biology, Beckman Research Institute City of Hope, Monrovia, CA, USA.

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http://dx.doi.org/10.1186/s13046-018-0721-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870532PMC
March 2018

Novel polysaccharide binding to the N-terminal tail of galectin-3 is likely modulated by proline isomerization.

Glycobiology 2017 11;27(11):1038-1051

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1093/glycob/cwx071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881736PMC
November 2017

Macromolecular assemblies of complex polysaccharides with galectin-3 and their synergistic effects on function.

Biochem J 2017 11 9;474(22):3849-3868. Epub 2017 Nov 9.

Jilin Province Key Laboratory for Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University, Changchun 130024, PR China

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http://dx.doi.org/10.1042/BCJ20170143DOI Listing
November 2017

Chemokines from a Structural Perspective.

Int J Mol Sci 2017 Oct 2;18(10). Epub 2017 Oct 2.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.3390/ijms18102088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666770PMC
October 2017

Probing Functional Heteromeric Chemokine Protein-Protein Interactions through Conformation-Assisted Oxime Ligation.

Angew Chem Int Ed Engl 2016 11 27;55(48):14963-14966. Epub 2016 Oct 27.

Department of Biochemistry, University of Maastricht, Cardiovascular Research Institute Maastricht (CARIM), Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/anie.201607036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132021PMC
November 2016

Binding of polysaccharides to human galectin-3 at a noncanonical site in its carbohydrate recognition domain.

Glycobiology 2016 Jan;26(1):88-99

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA

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http://dx.doi.org/10.1093/glycob/cwv073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851716PMC
January 2016

Evaluation of 111In-labeled Anginex as Potential SPECT Tracer for Imaging of Tumor Angiogenesis.

Anticancer Res 2015 Nov;35(11):5945-54

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands Oncology Solutions, Philips Research, Eindhoven, the Netherlands

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November 2015

Structural significance of galectin design: impairment of homodimer stability by linker insertion and partial reversion by ligand presence.

Protein Eng Des Sel 2015 Jul 21;28(7):199-210. Epub 2015 Mar 21.

Institut für Physiologische Chemie, Tierärztliche Fakultät, Ludwig-Maximilians Universität, Veterinär-straße 13, 80539 München, Germany.

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http://dx.doi.org/10.1093/protein/gzv014DOI Listing
July 2015

Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: synthesis, activity screening, and HSQC-based NMR analysis.

Chembiochem 2015 Jan 18;16(1):126-39. Epub 2014 Nov 18.

PharmaQAM, Department of Chemistry, Université du Québec à Montréal, P. O. Box 8888, Succ. Centre-ville, Montréal, QC, H3C 3P8 (Canada).

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http://dx.doi.org/10.1002/cbic.201402474DOI Listing
January 2015

Peptides derived from human galectin-3 N-terminal tail interact with its carbohydrate recognition domain in a phosphorylation-dependent manner.

Biochem Biophys Res Commun 2014 Jan 22;443(1):126-31. Epub 2013 Nov 22.

Chemical and Physical Biology Department, Centro de Investigaciones Biológicas, CSIC, 28040 Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X130195
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http://dx.doi.org/10.1016/j.bbrc.2013.11.063DOI Listing
January 2014

Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer.

Invest New Drugs 2013 Oct 8;31(5):1142-50. Epub 2013 Feb 8.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/s10637-013-9932-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242102PMC
October 2013

Bacterial membrane disrupting dodecapeptide SC4 improves survival of mice challenged with Pseudomonas aeruginosa.

Biochim Biophys Acta 2013 Jun 9;1830(6):3454-7. Epub 2013 Feb 9.

Department of Biochemistry, University of Minnesota Health Science Center, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.bbagen.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545587PMC
June 2013

Structure-based optimization of angiostatic agent 6DBF7, an allosteric antagonist of galectin-1.

J Pharmacol Exp Ther 2013 Mar 11;344(3):589-99. Epub 2012 Dec 11.

Department of Biochemistry, University of Minnesota, 321 Church Street, Minneapolis, MN 55455, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.112.19964
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http://dx.doi.org/10.1124/jpet.112.199646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583509PMC
March 2013

Protein lysine-Nζ alkylation and O-phosphorylation mediated by DTT-generated reactive oxygen species.

Protein Sci 2013 Mar 27;22(3):327-46. Epub 2013 Jan 27.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1002/pro.2214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595463PMC
March 2013

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin.

Biomol NMR Assign 2012 Oct 7;6(2):127-9. Epub 2011 Sep 7.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, 6-155 Jackson Hall, 321 Church St., Minneapolis, MN 55455, USA.

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http://link.springer.com/10.1007/s12104-011-9339-9
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http://dx.doi.org/10.1007/s12104-011-9339-9DOI Listing
October 2012

Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding.

J Med Chem 2012 Jun 30;55(11):5121-9. Epub 2012 May 30.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/jm300014qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242090PMC
June 2012

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease.

J Alzheimers Dis 2012 ;28(2):377-87

MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.3233/JAD-2011-110824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118466PMC
May 2012

Structural features for α-galactomannan binding to galectin-1.

Glycobiology 2012 Apr 7;22(4):543-51. Epub 2011 Dec 7.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

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https://academic.oup.com/glycob/article-lookup/doi/10.1093/g
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http://dx.doi.org/10.1093/glycob/cwr173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287016PMC
April 2012

Dual-targeting of αvβ3 and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo.

J Control Release 2012 Mar 30;158(2):207-14. Epub 2011 Oct 30.

Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1016/j.jconrel.2011.10.032DOI Listing
March 2012

Structural aspects of binding of α-linked digalactosides to human galectin-1.

Glycobiology 2011 Dec 28;21(12):1627-41. Epub 2011 Jun 28.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1093/glycob/cwr083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219418PMC
December 2011

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Authors:
Paul Hollingworth Denise Harold Rebecca Sims Amy Gerrish Jean-Charles Lambert Minerva M Carrasquillo Richard Abraham Marian L Hamshere Jaspreet Singh Pahwa Valentina Moskvina Kimberley Dowzell Nicola Jones Alexandra Stretton Charlene Thomas Alex Richards Dobril Ivanov Caroline Widdowson Jade Chapman Simon Lovestone John Powell Petroula Proitsi Michelle K Lupton Carol Brayne David C Rubinsztein Michael Gill Brian Lawlor Aoibhinn Lynch Kristelle S Brown Peter A Passmore David Craig Bernadette McGuinness Stephen Todd Clive Holmes David Mann A David Smith Helen Beaumont Donald Warden Gordon Wilcock Seth Love Patrick G Kehoe Nigel M Hooper Emma R L C Vardy John Hardy Simon Mead Nick C Fox Martin Rossor John Collinge Wolfgang Maier Frank Jessen Eckart Rüther Britta Schürmann Reiner Heun Heike Kölsch Hendrik van den Bussche Isabella Heuser Johannes Kornhuber Jens Wiltfang Martin Dichgans Lutz Frölich Harald Hampel John Gallacher Michael Hüll Dan Rujescu Ina Giegling Alison M Goate John S K Kauwe Carlos Cruchaga Petra Nowotny John C Morris Kevin Mayo Kristel Sleegers Karolien Bettens Sebastiaan Engelborghs Peter P De Deyn Christine Van Broeckhoven Gill Livingston Nicholas J Bass Hugh Gurling Andrew McQuillin Rhian Gwilliam Panagiotis Deloukas Ammar Al-Chalabi Christopher E Shaw Magda Tsolaki Andrew B Singleton Rita Guerreiro Thomas W Mühleisen Markus M Nöthen Susanne Moebus Karl-Heinz Jöckel Norman Klopp H-Erich Wichmann V Shane Pankratz Sigrid B Sando Jan O Aasly Maria Barcikowska Zbigniew K Wszolek Dennis W Dickson Neill R Graff-Radford Ronald C Petersen Cornelia M van Duijn Monique M B Breteler M Arfan Ikram Anita L DeStefano Annette L Fitzpatrick Oscar Lopez Lenore J Launer Sudha Seshadri Claudine Berr Dominique Campion Jacques Epelbaum Jean-François Dartigues Christophe Tzourio Annick Alpérovitch Mark Lathrop Thomas M Feulner Patricia Friedrich Caterina Riehle Michael Krawczak Stefan Schreiber Manuel Mayhaus S Nicolhaus Stefan Wagenpfeil Stacy Steinberg Hreinn Stefansson Kari Stefansson Jon Snaedal Sigurbjörn Björnsson Palmi V Jonsson Vincent Chouraki Benjamin Genier-Boley Mikko Hiltunen Hilkka Soininen Onofre Combarros Diana Zelenika Marc Delepine Maria J Bullido Florence Pasquier Ignacio Mateo Ana Frank-Garcia Elisa Porcellini Olivier Hanon Eliecer Coto Victoria Alvarez Paolo Bosco Gabriele Siciliano Michelangelo Mancuso Francesco Panza Vincenzo Solfrizzi Benedetta Nacmias Sandro Sorbi Paola Bossù Paola Piccardi Beatrice Arosio Giorgio Annoni Davide Seripa Alberto Pilotto Elio Scarpini Daniela Galimberti Alexis Brice Didier Hannequin Federico Licastro Lesley Jones Peter A Holmans Thorlakur Jonsson Matthias Riemenschneider Kevin Morgan Steven G Younkin Michael J Owen Michael O'Donovan Philippe Amouyel Julie Williams

Nat Genet 2011 May 3;43(5):429-35. Epub 2011 Apr 3.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/ng.803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084173PMC
May 2011

Tumour thermotolerance, a physiological phenomenon involving vessel normalisation.

Int J Hyperthermia 2011 4;27(1):42-52. Epub 2011 Jan 4.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, MN, USA.

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http://dx.doi.org/10.3109/02656736.2010.510495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086848PMC
April 2011

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

PLoS One 2010 Nov 15;5(11):e13950. Epub 2010 Nov 15.

Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981526PMC
November 2010

Lactose binding to galectin-1 modulates structural dynamics, increases conformational entropy, and occurs with apparent negative cooperativity.

J Mol Biol 2010 Apr 23;397(5):1209-30. Epub 2010 Feb 23.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.jmb.2010.02.033DOI Listing
April 2010

p16(INK4a) Peptide mimetics identified via virtual screening.

Bioorg Med Chem Lett 2010 Jan 15;20(1):403-5. Epub 2009 Oct 15.

Research Service, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.10.046DOI Listing
January 2010

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

Nat Genet 2009 Oct 6;41(10):1088-93. Epub 2009 Sep 6.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1038/ng.440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845877PMC
October 2009

The alpha-galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain.

Glycobiology 2009 Sep 18;19(9):1034-45. Epub 2009 Jun 18.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Health Sciences Center, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1093/glycob/cwp084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720280PMC
September 2009

NF-kappaB activation in endothelial cells is critical for the activity of angiostatic agents.

Mol Cancer Ther 2009 Sep 25;8(9):2645-54. Epub 2009 Aug 25.

Angiogenesis Laboratory, Department of Pathology, Research, School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherland.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0383DOI Listing
September 2009

Reflections on a community and university research collaboration.

Australas Psychiatry 2009 Aug;17 Suppl 1:S68-71

School of Indigenous Australian Studies, James Cook University, Cairns, QLD, Australia.

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http://journals.sagepub.com/doi/10.1080/10398560902948712
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August 2009

Using pulse field gradient NMR diffusion measurements to define molecular size distributions in glycan preparations.

Carbohydr Res 2009 Jul 17;344(10):1205-12. Epub 2009 Apr 17.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.carres.2009.04.010DOI Listing
July 2009

The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin-glycan interactions at the cell surface.

Biochem J 2009 Jun 26;421(2):211-21. Epub 2009 Jun 26.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

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http://biochemj.org/lookup/doi/10.1042/BJ20090265
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708933PMC
June 2009

The research dance: university and community research collaborations at Yarrabah, North Queensland, Australia.

Health Soc Care Community 2009 Mar 17;17(2):133-40. Epub 2008 Sep 17.

School of Indigenous Australian Studies, James Cook University, Cairns, Queensland, Australia.

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http://doi.wiley.com/10.1111/j.1365-2524.2008.00805.x
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March 2009

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.

Neurogenetics 2009 Feb 24;10(1):13-7. Epub 2008 Sep 24.

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/s10048-008-0150-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726757PMC
February 2009

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 29 kDa human galectin-1 protein dimer.

Biomol NMR Assign 2008 Dec 27;2(2):203-5. Epub 2008 Sep 27.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

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http://link.springer.com/10.1007/s12104-008-9121-9
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December 2008

Probing structure-activity relationships in bactericidal peptide betapep-25.

Biochem J 2008 Aug;414(1):143-50

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1042/BJ20080506DOI Listing
August 2008

CXC and CC chemokines form mixed heterodimers: association free energies from molecular dynamics simulations and experimental correlations.

J Biol Chem 2008 Aug 12;283(35):24155-66. Epub 2008 Jun 12.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 321 Church Street, Minneapolis, MN 55455, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M803308200
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527121PMC
August 2008

Identification of novel drug targets for angiostatic cancer therapy; it takes two to tango.

Curr Pharm Des 2007 ;13(35):3576-83

Angiogenesis Laboratory, Department of Pathology, Maastricht University & University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands.

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February 2008

Galectins: From Theory to Therapy. 23 November 2007, Maastricht, the Netherlands.

Authors:
Kevin H Mayo

IDrugs 2008 Feb;11(2):97-100

University of Minnesota, 312 Church St SE, Minneapolis, MN 55455, USA.

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February 2008

A journey in structure-based drug discovery: from designed peptides to protein surface topomimetics as antibiotic and antiangiogenic agents.

Acc Chem Res 2007 Oct 28;40(10):1057-65. Epub 2007 Jul 28.

Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://pubs.acs.org/doi/abs/10.1021/ar700086k
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October 2007

Clearance of amyloid-beta by circulating lipoprotein receptors.

Nat Med 2007 Sep 12;13(9):1029-31. Epub 2007 Aug 12.

Frank P. Smith Laboratory for Neuroscience and Neurosurgical Research, Department of Neurosurgery, University of Rochester Medical School, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1038/nm1635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936449PMC
September 2007

Anginex-conjugated liposomes for targeting of angiogenic endothelial cells.

Bioconjug Chem 2007 May-Jun;18(3):785-90. Epub 2007 Mar 23.

Angiogenesis Laboratory, Research Institute Growth and Development (GROW), Department of Pathology, Maastricht University & University Hospital, Maastricht, The Netherlands.

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http://dx.doi.org/10.1021/bc060316hDOI Listing
August 2007

Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP).

Am J Med Genet B Neuropsychiatr Genet 2007 Jun;144B(4):469-74

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/ajmg.b.30485DOI Listing
June 2007

Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation.

Ann Neurol 2007 May;61(5):446-53

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/ana.21099DOI Listing
May 2007

NMR solution structure of the angiostatic peptide anginex.

Biochim Biophys Acta 2007 May 24;1774(5):645-51. Epub 2007 Mar 24.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.bbapap.2007.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986776PMC
May 2007

Early in vivo assessment of angiostatic therapy efficacy by molecular MRI.

FASEB J 2007 Feb 3;21(2):378-83. Epub 2007 Jan 3.

Biomedical NMR, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.

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http://dx.doi.org/10.1096/fj.06-6791comDOI Listing
February 2007

Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening.

J Med Chem 2007 Feb;50(3):462-71

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Health Science Center, 6-155 Jackson Hall, 321 Church Street, Minneapolis, Minnesota 55455, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm0609824
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February 2007

Antiangiogenesis therapy using a novel angiogenesis inhibitor, anginex, following radiation causes tumor growth delay.

Int J Clin Oncol 2007 Feb 25;12(1):42-7. Epub 2007 Feb 25.

Department of Radiology, Kakegawa City General Hospital, 1-1-1 Minami Sugiya, Kakegawa, Shizuoka 436-8502, Japan.

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http://dx.doi.org/10.1007/s10147-006-0625-yDOI Listing
February 2007

Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease.

BMC Genet 2007 Jan 31;8. Epub 2007 Jan 31.

Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.

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http://dx.doi.org/10.1186/1471-2156-8-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800865PMC
January 2007

Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications.

Cancer Res 2006 Nov;66(22):10770-7

Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology, Maastricht University and University Hospital, The Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1609DOI Listing
November 2006

Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature.

Blood 2006 Oct 22;108(7):2339-48. Epub 2006 Jun 22.

Angiogenesis Laboratory, Department of Pathology, University Hospital Maastricht, PO Box 5800, 6202AZ Maastricht, The Netherlands.

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http://dx.doi.org/10.1182/blood-2006-02-004291DOI Listing
October 2006

Anti-angiogenesis and anti-tumor activity of recombinant anginex.

Biochem Biophys Res Commun 2006 Oct 5;349(3):1073-8. Epub 2006 Sep 5.

Angiogenesis Laboratory, Research Institute Growth and Development GROW, Department of Pathology, Maastricht University and University Hospital, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.bbrc.2006.08.154DOI Listing
October 2006

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.

Proc Natl Acad Sci U S A 2006 Oct 16;103(43):15975-80. Epub 2006 Oct 16.

Angiogenesis Laboratory, Research Institute for Growth and Development (GROW), Department of Pathology, University Maastricht, 6202A2 Maastricht, The Netherlands.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0603883103
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635112PMC
October 2006

Design of nonpeptidic topomimetics of antiangiogenic proteins with antitumor activities.

J Natl Cancer Inst 2006 Jul;98(13):932-6

Department of Biochemistry, 6-155 Jackson Hall, University of Minnesota, 321 Church Street, Minneapolis, MN 55455, USA

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http://dx.doi.org/10.1093/jnci/djj247DOI Listing
July 2006

Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors.

FASEB J 2006 Apr;20(6):621-30

Angiogenesis Laboratory, Research Institute for Growth and Development (GROW), Department of Internal Medicine, Maastricht University & University Hospital, Maastricht, The Netherlands.

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http://dx.doi.org/10.1096/fj.05-4493comDOI Listing
April 2006

Integrating preferences into health status assessment for amyotrophic lateral sclerosis: the ALS Utility Index.

Amyotroph Lateral Scler Other Motor Neuron Disord 2005 Sep;6(3):169-76

MEDTAP International, Bethesda, Maryland 20814, USA.

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http://www.tandfonline.com/doi/full/10.1080/1466082041002133
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http://dx.doi.org/10.1080/14660820410021339DOI Listing
September 2005

Cloning an artificial gene encoding angiostatic anginex: From designed peptide to functional recombinant protein.

Biochem Biophys Res Commun 2005 Aug;333(4):1261-8

Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology, Maastricht University and University Hospital, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.bbrc.2005.06.029DOI Listing
August 2005

Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells.

Int J Cancer 2005 Jun;115(2):312-9

Department of Biochemistry, University of Minnesota Academic Health Center, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1002/ijc.20850DOI Listing
June 2005

Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane.

Fertil Steril 2005 Mar;83(3):793-5

Department of Obstetrics and Gynaecology, Research Institute Growth and Development (GROW), Maastricht University and University Hospital, Maastricht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S001502820403022
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http://dx.doi.org/10.1016/j.fertnstert.2004.06.080DOI Listing
March 2005

Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level.

J Biol Chem 2005 Feb 5;280(6):4948-58. Epub 2004 Nov 5.

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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February 2005