Kevin M Brown

Kevin M Brown

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Sex specific associations in genome wide association analysis of renal cell carcinoma.

Authors:
Ruhina S Laskar David C Muller Peng Li Mitchell J Machiela Yuanqing Ye Valerie Gaborieau Matthieu Foll Jonathan N Hofmann Leandro Colli Joshua N Sampson Zhaoming Wang Delphine Bacq-Daian Anne Boland Behnoush Abedi-Ardekani Geoffroy Durand Florence Le Calvez-Kelm Nivonirina Robinot Helene Blanche Egor Prokhortchouk Konstantin G Skryabin Laurie Burdett Meredith Yeager Sanja Radojevic-Skodric Slavisa Savic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Stefan Rascu Anush Mukeria David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Beata Świątkowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Antonia Trichopoulou Elio Riboli Kim Overvad Salvatore Panico Borje Ljungberg Raviprakash T Sitaram Graham G Giles Roger L Milne Gianluca Severi Fiona Bruinsma Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard D Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Wong-Ho Chow Lee E Moore Toni K Choueiri Christopher Wood Mattias Johansson James D McKay Kevin M Brown Nathaniel Rothman Mark G Lathrop Jean-Francois Deleuze Xifeng Wu Paul Brennan Stephen J Chanock Mark P Purdue Ghislaine Scelo

Eur J Hum Genet 2019 Jun 23. Epub 2019 Jun 23.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.doi.org/10.1038/s41431-019-0455-9DOI Listing
June 2019

A Dynamic -Regulation Pattern Underlying Epithelial Ovarian Cancer Susceptibility.

Cancer Res 2019 Feb;79(3):439-440

Laboratory of Translational Genomics, Division of Cancer Epidemiology & Genetics, NCI, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3938DOI Listing
February 2019

Secretory Microneme Proteins Induce T-Cell Recall Responses in Mice Chronically Infected with Toxoplasma gondii.

mSphere 2019 02 27;4(1). Epub 2019 Feb 27.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/mSphere.00711-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393730PMC
February 2019

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.

Authors:
Mattias Johansson Robert Carreras-Torres Ghislaine Scelo Mark P Purdue Daniela Mariosa David C Muller Nicolas J Timpson Philip C Haycock Kevin M Brown Zhaoming Wang Yuanqing Ye Jonathan N Hofmann Matthieu Foll Valerie Gaborieau Mitchell J Machiela Leandro M Colli Peng Li Jean-Guillaume Garnier Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Sanja Radojevic-Skodric Simona Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Elisabete Weiderpass Börje Ljungberg Raviprakash Tumkur Sitaram Christel Häggström Fiona Bruinsma Susan J Jordan Gianluca Severi Ingrid Winship Kristian Hveem Lars J Vatten Tony Fletcher Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Gabriella Andreotti Laura E Beane Freeman Stella Koutros Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Kathryn M Wilson J Michael Gaziano Howard D Sesso Neal D Freedman Alexander S Parker Jeanette E Eckel-Passow Wen-Yi Huang Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Timothy Eisen Marc Henrion James Larkin Poulami Barman Bradley C Leibovich Toni K Choueiri G Mark Lathrop Jean-Francois Deleuze Marc Gunter James D McKay Xifeng Wu Richard S Houlston Stephen J Chanock Caroline Relton J Brent Richards Richard M Martin George Davey Smith Paul Brennan

PLoS Med 2019 01 3;16(1):e1002724. Epub 2019 Jan 3.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.doi.org/10.1371/journal.pmed.1002724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317776PMC
January 2019

Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase.

Cell Host Microbe 2018 12 15;24(6):804-816.e6. Epub 2018 Nov 15.

Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128183055
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http://dx.doi.org/10.1016/j.chom.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292738PMC
December 2018

Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.

Genome Res 2018 11 17;28(11):1621-1635. Epub 2018 Oct 17.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.233304.117
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http://dx.doi.org/10.1101/gr.233304.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211648PMC
November 2018

Corrigendum re "Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma" [Eur Urol 2017;72:747-54].

Authors:
Mitchell J Machiela Jonathan N Hofmann Robert Carreras-Torres Kevin M Brown Mattias Johansson Zhaoming Wang Matthieu Foll Peng Li Nathaniel Rothman Sharon A Savage Valerie Gaborieau James D McKay Yuanqing Ye Marc Henrion Fiona Bruinsma Susan Jordan Gianluca Severi Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Mannisto Stephanie Weinstein Peter E Clark Todd E Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard S Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Leandro M Colli Joshua N Sampson Celine Besse Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Mirjana Mijuskovic Miodrag Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot H B As Bueno-de-Mesquita Federico Canzian Eric J Duell Börje Ljungberg Raviprakash T Sitaram Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen James Larkin Toni K Choueiri G Mark Lathrop Bin Tean Teh Jean-Francois Deleuze Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock Ghislaine Scelo Mark P Purdue

Eur Urol 2018 09 28;74(3):e85-e86. Epub 2018 May 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183036
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http://dx.doi.org/10.1016/j.eururo.2018.05.017DOI Listing
September 2018

CRISPR-mediated Tagging with BirA Allows Proximity Labeling in .

Bio Protoc 2018 Mar;8(6)

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.21769/BioProtoc.2768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890295PMC
March 2018

Conditional Knockdown of Proteins Using Auxin-inducible Degron (AID) Fusions in .

Bio Protoc 2018 Feb;8(4)

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.

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https://bio-protocol.org/e2728
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http://dx.doi.org/10.21769/BioProtoc.2728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890294PMC
February 2018

Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor.

Eur J Cancer 2018 01 12;89:90-101. Epub 2017 Dec 12.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.11.011DOI Listing
January 2018

Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Authors:
Mitchell J Machiela Jonathan N Hofmann Robert Carreras-Torres Kevin M Brown Mattias Johansson Zhaoming Wang Matthieu Foll Peng Li Nathaniel Rothman Sharon A Savage Valerie Gaborieau James D McKay Yuanqing Ye Marc Henrion Fiona Bruinsma Susan Jordan Gianluca Severi Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Mannisto Stephanie Weinstein Peter E Clark Todd E Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard S Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Leandro M Colli Joshua N Sampson Celine Besse Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Mirjana Mijuskovic Miodrag Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot H Bas Bueno-de-Mesquita Federico Canzian Eric J Duell Börje Ljungberg Raviprakash T Sitaram Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen James Larkin Toni K Choueiri G Mark Lathrop Bin Tean Teh Jean-Francois Deleuze Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock Ghislaine Scelo Mark P Purdue

Eur Urol 2017 11 7;72(5):747-754. Epub 2017 Aug 7.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838173063
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http://dx.doi.org/10.1016/j.eururo.2017.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641242PMC
November 2017

Genome-wide association study identifies multiple risk loci for renal cell carcinoma.

Authors:
Ghislaine Scelo Mark P Purdue Kevin M Brown Mattias Johansson Zhaoming Wang Jeanette E Eckel-Passow Yuanqing Ye Jonathan N Hofmann Jiyeon Choi Matthieu Foll Valerie Gaborieau Mitchell J Machiela Leandro M Colli Peng Li Joshua N Sampson Behnoush Abedi-Ardekani Celine Besse Helene Blanche Anne Boland Laurie Burdette Amelie Chabrier Geoffroy Durand Florence Le Calvez-Kelm Egor Prokhortchouk Nivonirina Robinot Konstantin G Skryabin Magdalena B Wozniak Meredith Yeager Gordana Basta-Jovanovic Zoran Dzamic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Laura Baglietto Heiner Boeing Kay-Tee Khaw Elisabete Weiderpass Borje Ljungberg Raviprakash T Sitaram Fiona Bruinsma Susan J Jordan Gianluca Severi Ingrid Winship Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard D Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen Marc Henrion James Larkin Poulami Barman Bradley C Leibovich Toni K Choueiri G Mark Lathrop Nathaniel Rothman Jean-Francois Deleuze James D McKay Alexander S Parker Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock

Nat Commun 2017 06 9;8:15724. Epub 2017 Jun 9.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms15724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472706PMC
June 2017

Plasma Membrane Association by N-Acylation Governs PKG Function in .

MBio 2017 05 2;8(3). Epub 2017 May 2.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/mBio.00375-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414004PMC
May 2017

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii.

PLoS Pathog 2017 May 5;13(5):e1006379. Epub 2017 May 5.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis. Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435356PMC
May 2017

Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma.

Cancer Res 2017 04 20;77(7):1649-1661. Epub 2017 Jan 20.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0919DOI Listing
April 2017

A melanin-bleaching methodology for molecular and histopathological analysis of formalin-fixed paraffin-embedded tissue.

Lab Invest 2016 10 22;96(10):1116-27. Epub 2016 Aug 22.

Experimental Pathology Laboratory, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/labinvest.2016.90DOI Listing
October 2016

The genomic landscape of cutaneous melanoma.

Pigment Cell Melanoma Res 2016 May 4;29(3):266-83. Epub 2016 Mar 4.

Oncogenomics Laboratory, QIMR Berghofer Medical Research Institute, Herston, Qld, Australia.

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http://dx.doi.org/10.1111/pcmr.12459DOI Listing
May 2016

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.

Cell Rep 2016 05 19;15(9):1884-92. Epub 2016 May 19.

Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.04.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889472PMC
May 2016

Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii.

J Biol Chem 2016 Apr 1;291(18):9554-65. Epub 2016 Mar 1.

From the Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

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http://dx.doi.org/10.1074/jbc.M115.700518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850294PMC
April 2016

An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations.

Proteomics 2016 Feb 8;16(3):417-26. Epub 2016 Jan 8.

Radboud Institute of Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/pmic.201500327DOI Listing
February 2016

The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release.

PLoS One 2014 19;9(6):e99950. Epub 2014 Jun 19.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063779PMC
October 2015

Computational and human observer image quality evaluation of low dose, knowledge-based CT iterative reconstruction.

Med Phys 2015 Oct;42(10):6098-111

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 and Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106.

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http://dx.doi.org/10.1118/1.4929973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592430PMC
October 2015

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

Nat Genet 2015 Sep 3;47(9):987-995. Epub 2015 Aug 3.

Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1038/ng.3373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557485PMC
September 2015

Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma.

J Natl Cancer Inst 2015 Feb 13;107(2). Epub 2014 Dec 13.

Affiliations of authors: QIMR Berghofer Medical Research Institute, Brisbane, Australia (LGA, ALP, MG, PJ, JMP, JS, VB, SW, KDR, MSS, GWM, NGM, NKH); Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK (CDRE, TMK, DJA); Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark (KW, AMG); Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK (MH, HSn, DTB, JANB); Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (JC, KMB); Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología del Principado de Asturias (IUOPA) Universidad de Oviedo, Oviedo, Spain (VQ, AJR, CLO); Cancer Genomics Research Laboratory, NCI Frederick, SAIC-Frederick Inc., Frederick MD (XZ, KJ); Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands (RvD, NAG); Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Lund, Sweden (HO, CI, ÅB, GJ); Translational Genomics Institute, Phoenix, AZ (JMT); University of Sydney at Westmead Millennium Institute, Westmead, Sydney, NSW, Australia (EAH, HSc, GJM); Melanoma Institute Australia, North Sydney, NSW, Australia (EAH, HSc, GJM).

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http://dx.doi.org/10.1093/jnci/dju408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334787PMC
February 2015

The effect on melanoma risk of genes previously associated with telomere length.

J Natl Cancer Inst 2014 Oct 17;106(10). Epub 2014 Sep 17.

Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds, Leeds, UK (MMI, DTB, JCT, MHa, JRM, JANB, JHB); Oncogenomics (NKH), Genetic Epidemiology (NGM), Inflammatory Bowel Diseases Laboratory (GLRS), Cancer Control Group (DCW), Statistical Genetics (SM, MHL), and Molecular Epidemiology (GWM), QIMR Berghofer Medical Research Institute, Brisbane, Australia; INSERM, UMR-946, Genetic Variation and Human Diseases Unit, Paris, France (MB, FD); Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France (MB, FD); Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney, Australia (AEC); Department of Oncology, University of Cambridge, Cambridge, UK (AMD, PDPP); Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (JEL); Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley, Australia (EKM, SVW); Centre for Cancer Biomarkers CCBIO (LAA) and Gade Laboratory for Pathology (AM), Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Pathology, Haukeland University Hospital, Bergen, Norway (LAA); Department of Pathology, Molecular Pathology (PAA) and Department of Dermatology (PH), Oslo University Hospital, Rikshospitalet, Oslo, Norway; Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes, Paris, France (MFA); Department of Dermatology (EA) and Oncogenics Unit (EA, EF), Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv, Israel (EA); Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy (GBS, EFPG); Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital, Genoa, Italy (GBS, EFPG); Division of Cancer Epidemiology and Gene

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https://genepi.qimr.edu.au/contents/p/staff/IlesMM_JNCI_EPUB
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/dju267
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http://dx.doi.org/10.1093/jnci/dju267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196080PMC
October 2014

Identification of a melanoma susceptibility locus and somatic mutation in TET2.

Carcinogenesis 2014 Sep 30;35(9):2097-101. Epub 2014 Jun 30.

Department of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, Channing Division of Network Medicine and Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA, Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN 46202, USA, Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA and Department of Dermatology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA

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http://dx.doi.org/10.1093/carcin/bgu140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146422PMC
September 2014

Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases.

PLoS Pathog 2014 Jun 12;10(6):e1004180. Epub 2014 Jun 12.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America; Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055737PMC
June 2014

Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9.

MBio 2014 May 13;5(3):e01114-14. Epub 2014 May 13.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/mBio.01114-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030483PMC
May 2014

Whole genome profiling of spontaneous and chemically induced mutations in Toxoplasma gondii.

BMC Genomics 2014 May 10;15:354. Epub 2014 May 10.

Department of Biology, Boston College, Higgins Hall 355, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.

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http://dx.doi.org/10.1186/1471-2164-15-354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035079PMC
May 2014

A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers.

PLoS One 2013 19;8(8):e72144. Epub 2013 Aug 19.

Oncogenomics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia ; University of Queensland, Brisbane, Queensland, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072144PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747051PMC
April 2014

Selective deletion of the endothelial sphingosine-1-phosphate 1 receptor exacerbates kidney ischemia-reperfusion injury.

Kidney Int 2014 Apr 11;85(4):807-23. Epub 2013 Sep 11.

Department of Anesthesiology, Anesthesiology Research Laboratories, College of Physicians and Surgeons of Columbia University, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/ki.2013.345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952061PMC
April 2014

Critical role of interleukin-11 in isoflurane-mediated protection against ischemic acute kidney injury in mice.

Anesthesiology 2013 Dec;119(6):1389-401

* Postdoctoral Research Scientist, † Research Associate, ‡ Research Student, ‖ Professor, Department of Anesthesiology, § Professor, Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York.

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http://dx.doi.org/10.1097/ALN.0b013e3182a950daDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867581PMC
December 2013

The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury.

Kidney Int 2013 Jul 20;84(1):90-103. Epub 2013 Feb 20.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, Anesthesiology Research Laboratories, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/ki.2013.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676468PMC
July 2013

A variant in FTO shows association with melanoma risk not due to BMI.

Nat Genet 2013 Apr 3;45(4):428-32, 432e1. Epub 2013 Mar 3.

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St. James's University Hospital, Leeds, UK.

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https://genepi.qimr.edu.au/contents/p/staff/Iles_etal_Nature
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640814PMC
April 2013

A low dose simulation tool for CT systems with energy integrating detectors.

Med Phys 2013 Mar;40(3):031102

Philips Healthcare, Cleveland, Ohio 44143, USA.

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http://doi.wiley.com/10.1118/1.4789628
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March 2013

Critical role of interleukin-17A in murine intestinal ischemia-reperfusion injury.

Am J Physiol Gastrointest Liver Physiol 2013 Jan 1;304(1):G12-25. Epub 2012 Nov 1.

Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032-3784, USA.

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http://dx.doi.org/10.1152/ajpgi.00201.2012DOI Listing
January 2013

Paneth cell-mediated multiorgan dysfunction after acute kidney injury.

J Immunol 2012 Dec 29;189(11):5421-33. Epub 2012 Oct 29.

Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1200581
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504173PMC
December 2012

A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma.

Pigment Cell Melanoma Res 2012 Nov 1;25(6):815-8. Epub 2012 Oct 1.

Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/pcmr.12006DOI Listing
November 2012

Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.

Kidney Int 2012 Oct 13;82(8):878-91. Epub 2012 Jun 13.

Department of Anesthesiology, Columbia University, New York, New York 10032-3784, USA.

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http://dx.doi.org/10.1038/ki.2012.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443517PMC
October 2012

Interleukin-11 protects against renal ischemia and reperfusion injury.

Am J Physiol Renal Physiol 2012 Oct 1;303(8):F1216-24. Epub 2012 Aug 1.

Department of Anesthesiology, Anesthesiology Research Laboratories, Columbia University, West 168th St., New York, NY 10032-3784, USA.

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http://dx.doi.org/10.1152/ajprenal.00220.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469680PMC
October 2012

'Melt welt' mechanism of extreme weakening of gabbro at seismic slip rates.

Nature 2012 Aug;488(7413):638-41

Institute of Geophysics and Planetary Physics, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature11370DOI Listing
August 2012

The Skp1 protein from Toxoplasma is modified by a cytoplasmic prolyl 4-hydroxylase associated with oxygen sensing in the social amoeba Dictyostelium.

J Biol Chem 2012 Jul 30;287(30):25098-110. Epub 2012 May 30.

Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1074/jbc.M112.355446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408163PMC
July 2012

Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury.

J Am Soc Nephrol 2012 Feb 17;23(2):266-80. Epub 2011 Nov 17.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032-3784, USA.

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http://dx.doi.org/10.1681/ASN.2011050503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269189PMC
February 2012

Genome-wide association study identifies three new melanoma susceptibility loci.

Nat Genet 2011 Oct 9;43(11):1108-13. Epub 2011 Oct 9.

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James’s University Hospital, Leeds, UK.

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http://dx.doi.org/10.1038/ng.959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251256PMC
October 2011

Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury.

Hepatology 2011 May;53(5):1662-75

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1002/hep.24253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082595PMC
May 2011

Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy.

Lab Invest 2011 Jan 9;91(1):63-84. Epub 2010 Aug 9.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032-3784, USA.

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http://www.nature.com/articles/labinvest2010151
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991383PMC
January 2011

Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation.

Lab Invest 2010 Aug 10;90(8):1209-24. Epub 2010 May 10.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032-3784, USA.

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http://www.nature.com/articles/labinvest2010102
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007623PMC
August 2010

Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.

J Biol Chem 2010 Aug 25;285(35):26852-60. Epub 2010 Jun 25.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

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http://dx.doi.org/10.1074/jbc.M110.147041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930684PMC
August 2010

A versatile gene-based test for genome-wide association studies.

Am J Hum Genet 2010 Jul;87(1):139-45

Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia.

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http://dx.doi.org/10.1016/j.ajhg.2010.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896770PMC
July 2010

Protection against acute kidney injury via A(1) adenosine receptor-mediated Akt activation reduces liver injury after liver ischemia and reperfusion in mice.

J Pharmacol Exp Ther 2010 Jun 22;333(3):736-47. Epub 2010 Mar 22.

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032-3784, USA.

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http://dx.doi.org/10.1124/jpet.110.166884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879934PMC
June 2010

The role of DNA microarrays in Toxoplasma gondii research, the causative agent of ocular toxoplasmosis.

J Ocul Biol Dis Infor 2009 Dec 12;2(4):214-222. Epub 2009 Dec 12.

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73034 USA.

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http://dx.doi.org/10.1007/s12177-009-9040-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816810PMC
December 2009

Human heat shock protein 27 overexpressing mice are protected against hepatic ischemia and reperfusion injury.

Transplantation 2009 May;87(10):1478-87

Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032-3784, USA.

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http://dx.doi.org/10.1097/TP.0b013e3181a3c691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726263PMC
May 2009

Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung.

Dev Comp Immunol 2008 18;32(9):1088-98. Epub 2008 Mar 18.

Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, 1110 N. Stonewall Avenue, Oklahoma City, OK 73117, USA.

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http://dx.doi.org/10.1016/j.dci.2008.02.005DOI Listing
July 2008

Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment.

Cancer Res 2005 Nov;65(22):10164-9

Children's Memorial Research Center and Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, IL 60614, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2497DOI Listing
November 2005

Inter-platform comparability of microarrays in acute lymphoblastic leukemia.

BMC Genomics 2004 Sep 23;5:71. Epub 2004 Sep 23.

Research Center for Genetic Medicine, Children's National Medical Center, Institute of Biomedical Sciences, George Washington University Medical Center, Washington, D.C. 20037, USA.

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http://dx.doi.org/10.1186/1471-2164-5-71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522810PMC
September 2004

Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure.

Invest Ophthalmol Vis Sci 2004 Apr;45(4):1247-58

Laboratory of Molecular and Developmental Biology, National Eye Institute, Bethesda, Maryland 20814-9692, USA.

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http://dx.doi.org/10.1167/iovs.03-1123DOI Listing
April 2004

The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma.

Pediatr Neurosurg 2003 Jul;39(2):68-74

Department of Pediatrics, Children's National Medical Center, Washington, DC 20010, USA.

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http://dx.doi.org/10.1159/000071317DOI Listing
July 2003

Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling.

Cancer Res 2003 Apr;63(8):1865-70

Center for Cancer Research, Children's Research Institute, Washington, DC 20010, USA.

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April 2003

Qualitative research in a cross-cultural context: Fijian experiences.

Qual Health Res 2003 Mar;13(3):333-42

School of Social and International Studies, Deakin University, Melbourne, Australia.

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http://journals.sagepub.com/doi/10.1177/1049732302250129
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March 2003

Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function.

Cancer Res 2002 May;62(9):2654-9

Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC 20007-2197, USA.

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May 2002