Kevin Kit Parker

Kevin Kit Parker

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Kevin Kit Parker

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Porous Biomimetic Hyaluronic Acid and Extracellular Matrix Protein Nanofiber Scaffolds for Accelerated Cutaneous Tissue Repair.

ACS Appl Mater Interfaces 2019 Dec 22;11(49):45498-45510. Epub 2019 Nov 22.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences , Harvard University , Cambridge , Massachusetts 02138 , United States.

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http://dx.doi.org/10.1021/acsami.9b17322DOI Listing
December 2019

Quantifying the effects of engineered nanomaterials on endothelial cell architecture and vascular barrier integrity using a cell pair model.

Nanoscale 2019 Oct;11(38):17878-17893

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/c9nr04981aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779057PMC
October 2019

Muscle tissue engineering in fibrous gelatin: implications for meat analogs.

NPJ Sci Food 2019 21;3:20. Epub 2019 Oct 21.

1Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138 USA.

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http://dx.doi.org/10.1038/s41538-019-0054-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803664PMC
October 2019

Alfalfa Nanofibers for Dermal Wound Healing.

ACS Appl Mater Interfaces 2019 Sep 9;11(37):33535-33547. Epub 2019 Aug 9.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences , Harvard University , Cambridge , Massachusetts 02138 , United States.

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http://dx.doi.org/10.1021/acsami.9b07626DOI Listing
September 2019

Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing.

Lab Chip 2019 Sep;19(18):2993-3010

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Pierce Hall, 29 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/c9lc00253gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814249PMC
September 2019

Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue.

Circulation 2019 Jul 17;140(5):390-404. Epub 2019 Jul 17.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences (S.-J.P., K.Y.L., S.L.K., F.S.P., P.H.C., K.K.P.), Harvard University, Cambridge, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750809PMC
July 2019

Inkjet-Printed Carbon Nanotubes for Fabricating a Spoof Fingerprint on Paper.

ACS Omega 2019 May 16;4(5):8626-8631. Epub 2019 May 16.

Department of Chemistry, Institute of Biological Interfaces, Sogang University, Seoul 04107, Republic of Korea.

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http://dx.doi.org/10.1021/acsomega.9b00936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648154PMC
May 2019

Scatter Enhanced Phase Contrast Microscopy for Discriminating Mechanisms of Active Nanoparticle Transport in Living Cells.

Nano Lett 2019 02 23;19(2):793-804. Epub 2019 Jan 23.

Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering , Harvard University , Cambridge , Massachusetts 02452 , United States.

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http://dx.doi.org/10.1021/acs.nanolett.8b03903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588408PMC
February 2019

Designer Assays for Your Sick, Subdivided Heart.

Authors:
Kevin Kit Parker

Cell 2019 02;176(4):684-685

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.01.028DOI Listing
February 2019

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

Nat Biotechnol 2018 10 20;36(9):865-874. Epub 2018 Aug 20.

Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.4226DOI Listing
October 2018

Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials.

Anal Bioanal Chem 2018 Sep 10;410(24):6141-6154. Epub 2018 May 10.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1007/s00216-018-1106-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230313PMC
September 2018

Traction force microscopy of engineered cardiac tissues.

PLoS One 2018 28;13(3):e0194706. Epub 2018 Mar 28.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194706PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874032PMC
July 2018

Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular system.

Nat Biotechnol 2018 07 28;36(6):530-535. Epub 2018 May 28.

Institute of Biological Interfaces and Department of Chemistry, Sogang University, Seoul, Korea.

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http://www.nature.com/doifinder/10.1038/nbt.4140
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http://dx.doi.org/10.1038/nbt.4140DOI Listing
July 2018

Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing.

Adv Healthc Mater 2018 05 23;7(9):e1701175. Epub 2018 Jan 23.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard University, 29 Oxford St. Pierce Hall, Rm 321, Cambridge, MA, 02138, USA.

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http://doi.wiley.com/10.1002/adhm.201701175
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http://dx.doi.org/10.1002/adhm.201701175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481294PMC
May 2018

Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications.

Biofabrication 2018 01 16;10(2):025004. Epub 2018 Jan 16.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United States of America.

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http://dx.doi.org/10.1088/1758-5090/aa96deDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221195PMC
January 2018

Formation of Multi-Component Extracellular Matrix Protein Fibers.

Sci Rep 2018 01 30;8(1):1913. Epub 2018 Jan 30.

Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 121-742, Republic of Korea.

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http://www.nature.com/articles/s41598-018-20371-8
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http://dx.doi.org/10.1038/s41598-018-20371-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790006PMC
January 2018

Myofibrils in Cardiomyocytes Tend to Assemble Along the Maximal Principle Stress Directions.

J Biomech Eng 2017 Dec;139(12)

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138 e-mail: .

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http://dx.doi.org/10.1115/1.4037795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691293PMC
December 2017

Fabrication of Millimeter-Long Carbon Tubular Nanostructures Using the Self-Rolling Process Inherent in Elastic Protein Layers.

Adv Mater 2017 Aug 19;29(31). Epub 2017 Jun 19.

Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 04107, South Korea.

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http://dx.doi.org/10.1002/adma.201701732DOI Listing
August 2017

JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement.

Biomaterials 2017 07 18;133:229-241. Epub 2017 Apr 18.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA, 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526340PMC
July 2017

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities.

Lab Chip 2017 06;17(13):2294-2302

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. and Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA and Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1039/c7lc00412eDOI Listing
June 2017

Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - From cardioprotection to functional repair in a translational pig infarction model.

Biomaterials 2017 04 23;122:48-62. Epub 2016 Nov 23.

Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland; Wyss Translational Center Zurich, ETH and University of Zurich, Zurich, Switzerland; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2016.11.029DOI Listing
April 2017

Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip.

J Neurophysiol 2017 03 28;117(3):1320-1341. Epub 2016 Dec 28.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts; and

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http://www.physiology.org/doi/10.1152/jn.00575.2016
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http://dx.doi.org/10.1152/jn.00575.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350271PMC
March 2017

Mechanotransduction and Metabolism in Cardiomyocyte Microdomains.

Biomed Res Int 2016 4;2016:4081638. Epub 2016 Dec 4.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.

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https://www.hindawi.com/journals/bmri/2016/4081638/
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http://dx.doi.org/10.1155/2016/4081638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164897PMC
February 2017

Acute pergolide exposure stiffens engineered valve interstitial cell tissues and reduces contractility in vitro.

Cardiovasc Pathol 2016 Jul-Aug;25(4):316-324. Epub 2016 Apr 25.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10548807163002
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http://dx.doi.org/10.1016/j.carpath.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902741PMC
January 2017

Microenvironmental Control of Adipocyte Fate and Function.

Trends Cell Biol 2016 10 4;26(10):745-755. Epub 2016 Jun 4.

Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788628PMC
October 2016

A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility.

J Cell Biol 2016 Oct 3;215(1):47-56. Epub 2016 Oct 3.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering and Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138

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http://www.jcb.org/lookup/doi/10.1083/jcb.201603111
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http://dx.doi.org/10.1083/jcb.201603111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057287PMC
October 2016

Angiotensin II Induced Cardiac Dysfunction on a Chip.

PLoS One 2016 25;11(1):e0146415. Epub 2016 Jan 25.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725954PMC
July 2016

Phototactic guidance of a tissue-engineered soft-robotic ray.

Science 2016 Jul;353(6295):158-62

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Sogang-Harvard Research Center for Disease Biophysics, Sogang University, Seoul 121-742, Korea.

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http://dx.doi.org/10.1126/science.aaf4292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526330PMC
July 2016

Extracellular matrix protein expression is brain region dependent.

J Comp Neurol 2016 May 1;524(7):1309-36. Epub 2016 Feb 1.

Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, 02138.

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http://dx.doi.org/10.1002/cne.23965DOI Listing
May 2016

Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy.

J Cell Biol 2016 Feb 8;212(4):389-97. Epub 2016 Feb 8.

Disease Biophysics Group, Wyss Institute of Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138

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http://diseasebiophysics.seas.harvard.edu/wp-content/uploads
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http://www.jcb.org/lookup/doi/10.1083/jcb.201508026
Publisher Site
http://dx.doi.org/10.1083/jcb.201508026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754718PMC
February 2016

Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes.

Exp Biol Med (Maywood) 2015 Nov 23;240(11):1543-54. Epub 2015 Apr 23.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

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http://dx.doi.org/10.1177/1535370215583799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778402PMC
November 2015

Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes.

Stem Cell Reports 2013 7;1(5):387-96. Epub 2013 Nov 7.

Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA ; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA ; Wyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(13)0009
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http://linkinghub.elsevier.com/retrieve/pii/S221367111300098
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http://dx.doi.org/10.1016/j.stemcr.2013.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841251PMC
October 2015

Self-organizing large-scale extracellular-matrix protein networks.

Adv Mater 2015 May 31;27(18):2838-45. Epub 2015 Mar 31.

Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 121-742, Republic of Korea.

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http://dx.doi.org/10.1002/adma.201405556DOI Listing
May 2015

Metrics for assessing cytoskeletal orientational correlations and consistency.

PLoS Comput Biol 2015 Apr 7;11(4):e1004190. Epub 2015 Apr 7.

Department of Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America; Department of Chemical Engineering, University of California, Irvine, Irvine, California, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388480PMC
April 2015

Structural phenotyping of stem cell-derived cardiomyocytes.

Stem Cell Reports 2015 Mar 26;4(3):340-7. Epub 2015 Feb 26.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375945PMC
March 2015

Traumatic brain injury and the neuronal microenvironment: a potential role for neuropathological mechanotransduction.

Neuron 2015 Mar;85(6):1177-92

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273150015
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http://dx.doi.org/10.1016/j.neuron.2015.02.041DOI Listing
March 2015

Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury.

Sci Rep 2015 Mar 30;5:9475. Epub 2015 Mar 30.

Mechanobiology &Soft Matter Group, Interfaces and Complex Fluids Laboratory, Research Institute for Biosciences, CIRMAP, University of Mons, 20 Place du Parc B-7000 Mons, Belgium.

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http://dx.doi.org/10.1038/srep09475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377573PMC
March 2015

Effect of solvent evaporation on fiber morphology in rotary jet spinning.

Langmuir 2014 Nov 29;30(44):13369-74. Epub 2014 Oct 29.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Science, Harvard University , Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/la5023104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901524PMC
November 2014

Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation.

Lab Chip 2014 Oct;14(20):3925-36

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering and the School of Engineering and Applied Sciences, Harvard University, 29 Oxford St., Pierce Hall 321, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/c4lc00688gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167568PMC
October 2014

The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function.

Anat Rec (Hoboken) 2014 Sep;297(9):1758-69

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering and the School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/ar.22983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863956PMC
September 2014

Three-dimensional paper-based model for cardiac ischemia.

Adv Healthc Mater 2014 Jul 12;3(7):1036-43. Epub 2014 Feb 12.

Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, Cambridge, MA, 02138, USA; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA, 02138, USA.

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http://dx.doi.org/10.1002/adhm.201300575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107065PMC
July 2014

Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues.

Biomaterials 2014 Jul 14;35(21):5462-71. Epub 2014 Apr 14.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2014.03.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057039PMC
July 2014

Matrix elasticity regulates the optimal cardiac myocyte shape for contractility.

Am J Physiol Heart Circ Physiol 2014 Jun 28;306(11):H1525-39. Epub 2014 Mar 28.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts

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http://ajpheart.physiology.org/content/ajpheart/306/11/H1525
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http://ajpheart.physiology.org/cgi/doi/10.1152/ajpheart.0079
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http://dx.doi.org/10.1152/ajpheart.00799.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042196PMC
June 2014

The structure-function relationships of a natural nanoscale photonic device in cuttlefish chromatophores.

J R Soc Interface 2014 Apr 29;11(93):20130942. Epub 2014 Jan 29.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, , Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1098/rsif.2013.0942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928930PMC
April 2014

Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning.

Biomaterials 2014 Mar 20;35(10):3188-97. Epub 2014 Jan 20.

Disease Biophysics Group, School of Engineering and Applied Sciences Harvard University, 60 Oxford St, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Cir, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2013.12.072DOI Listing
March 2014

Quality metrics for stem cell-derived cardiac myocytes.

Stem Cell Reports 2014 Mar 6;2(3):282-94. Epub 2014 Mar 6.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering and School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22136711140003
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http://dx.doi.org/10.1016/j.stemcr.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964283PMC
March 2014

The contractile strength of vascular smooth muscle myocytes is shape dependent.

Integr Biol (Camb) 2014 Feb;6(2):152-63

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering and the School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/c3ib40230dDOI Listing
February 2014

A potential role for integrin signaling in mechanoelectrical feedback.

Prog Biophys Mol Biol 2012 Oct-Nov;110(2-3):196-203. Epub 2012 Jul 20.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA 02138, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00796107120004
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http://dx.doi.org/10.1016/j.pbiomolbio.2012.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807692PMC
November 2013

Design standards for engineered tissues.

Biotechnol Adv 2013 Sep-Oct;31(5):632-7. Epub 2012 Dec 23.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1016/j.biotechadv.2012.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644329PMC
October 2013

Microfluidic heart on a chip for higher throughput pharmacological studies.

Lab Chip 2013 Sep;13(18):3599-608

Disease Biophysics Group, Wyss Institute of Biologically Inspired Engineering, Harvard Stem Cell Institute, School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall Rm 321, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/c3lc50350jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786400PMC
September 2013

Micropatterning Alginate Substrates for Cardiovascular Muscle on a Chip.

Adv Funct Mater 2013 Aug;23(30):3738-3746

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall 321, Cambridge, MA (USA).

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http://dx.doi.org/10.1002/adfm.201203319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511503PMC
August 2013

Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip.

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9770-5. Epub 2013 May 28.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1304913110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683774PMC
June 2013

The contribution of cellular mechanotransduction to cardiomyocyte form and function.

Biomech Model Mechanobiol 2012 Nov 7;11(8):1227-39. Epub 2012 Jul 7.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Pierce Hall Rm. 321, 29 Oxford St., Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1007/s10237-012-0419-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786397PMC
November 2012

Differential contributions of conformation extension and domain unfolding to properties of fibronectin nanotextiles.

Nano Lett 2012 Nov 8;12(11):5587-92. Epub 2012 Oct 8.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/nl302643gDOI Listing
November 2012

Muscle on a chip: in vitro contractility assays for smooth and striated muscle.

J Pharmacol Toxicol Methods 2012 May-Jun;65(3):126-35. Epub 2012 Apr 12.

Disease Biophysics Group, Wyss Institute of Biologically Inspired Engineering, Harvard Stem Cell Institute, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10568719120004
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http://dx.doi.org/10.1016/j.vascn.2012.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184427PMC
October 2012

Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture.

Biomaterials 2012 Aug 15;33(23):5732-41. Epub 2012 May 15.

Disease Biophysics Group, Harvard Stem Cell Institute, Wyss Institute of Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2012.04.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026933PMC
August 2012

A tissue-engineered jellyfish with biomimetic propulsion.

Nat Biotechnol 2012 Aug;30(8):792-7

Division of Biology, California Institute of Technology, Pasadena, California, USA.

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http://dx.doi.org/10.1038/nbt.2269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026938PMC
August 2012

Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle.

Proc Natl Acad Sci U S A 2012 Jun 6;109(25):9881-6. Epub 2012 Jun 6.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1203007109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382528PMC
June 2012

Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior.

J Biomech 2012 Mar 10;45(5):832-41. Epub 2012 Jan 10.

School of Engineering and Applied Science, Harvard University, Cambridge, MA, United States.

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http://dx.doi.org/10.1016/j.jbiomech.2011.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294204PMC
March 2012

A possible role for integrin signaling in diffuse axonal injury.

PLoS One 2011 22;6(7):e22899. Epub 2011 Jul 22.

Disease Biophysics Group, School of Engineering and Applied Sciences, Wyss Institute of Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022899PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142195PMC
December 2011

Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip.

Lab Chip 2011 Dec 10;11(24):4165-73. Epub 2011 Nov 10.

Disease Biophysics Group, Wyss Institute of Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, 29 Oxford St, Pierce Hall Rm 321, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/c1lc20557aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038963PMC
December 2011

Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve.

Proc Natl Acad Sci U S A 2011 Dec 28;108(50):19943-8. Epub 2011 Nov 28.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1106954108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250145PMC
December 2011

Vascular smooth muscle contractility depends on cell shape.

Integr Biol (Camb) 2011 Nov 12;3(11):1063-70. Epub 2011 Oct 12.

Disease Biophysics Group, Harvard Stem Cell Institute, Wyss Institute of Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/c1ib00061fDOI Listing
November 2011

Blast-induced phenotypic switching in cerebral vasospasm.

Proc Natl Acad Sci U S A 2011 Aug 15;108(31):12705-10. Epub 2011 Jul 15.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard School of Engineering and Applied Science, Pierce Hall #321, 29 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.1105860108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150891PMC
August 2011

Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function.

Pflugers Arch 2011 Jul 19;462(1):89-104. Epub 2011 Apr 19.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.

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http://link.springer.com/10.1007/s00424-011-0951-4
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July 2011

Hierarchical architecture influences calcium dynamics in engineered cardiac muscle.

Exp Biol Med (Maywood) 2011 Mar 17;236(3):366-73. Epub 2011 Feb 17.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering & Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1258/ebm.2010.010239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501496PMC
March 2011

Self-organization of muscle cell structure and function.

PLoS Comput Biol 2011 Feb 24;7(2):e1001088. Epub 2011 Feb 24.

Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America.

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https://dx.plos.org/10.1371/journal.pcbi.1001088
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044763PMC
February 2011

A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis.

J Theor Biol 2010 Aug 4;265(3):433-42. Epub 2010 May 4.

Department of Mechanical Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.jtbi.2010.04.023DOI Listing
August 2010

Surface-initiated assembly of protein nanofabrics.

Nano Lett 2010 Jun;10(6):2184-91

Disease Biophysics Group, Wyss Institute for Biologically-Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://pubs.acs.org/doi/abs/10.1021/nl100998p
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June 2010

Nanofiber assembly by rotary jet-spinning.

Nano Lett 2010 Jun;10(6):2257-61

Disease Biophysics Group, Wyss Institute for Biologically-Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/nl101355xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704151PMC
June 2010

Optimization of electroactive hydrogel actuators.

ACS Appl Mater Interfaces 2010 Feb;2(2):343-6

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http://dx.doi.org/10.1021/am900755wDOI Listing
February 2010

Control of myocyte remodeling in vitro with engineered substrates.

In Vitro Cell Dev Biol Anim 2009 Jul-Aug;45(7):343-50. Epub 2009 Feb 28.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1007/s11626-009-9182-9DOI Listing
November 2009

Generation of functional ventricular heart muscle from mouse ventricular progenitor cells.

Science 2009 Oct;326(5951):426-9

Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza, CPZN 3200, 185 Cambridge Street, Boston, MA 02114-2790, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1177350
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895998PMC
October 2009

Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy.

Circ Cardiovasc Genet 2009 Apr 18;2(2):116-24. Epub 2009 Feb 18.

Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.108.806935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731432PMC
April 2009

Cardiogenesis and the complex biology of regenerative cardiovascular medicine.

Science 2008 Dec;322(5907):1494-7

MGH Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1163267
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December 2008

Sarcomere alignment is regulated by myocyte shape.

Cell Motil Cytoskeleton 2008 Aug;65(8):641-51

Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.

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http://doi.wiley.com/10.1002/cm.20290
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http://dx.doi.org/10.1002/cm.20290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492320PMC
August 2008

Myofibrillar architecture in engineered cardiac myocytes.

Circ Res 2008 Aug 17;103(4):340-2. Epub 2008 Jul 17.

Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA. kkparker@ seas.harvard.edu

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.108.18246
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http://dx.doi.org/10.1161/CIRCRESAHA.108.182469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910252PMC
August 2008

Dynamic control of protein-protein interactions.

Langmuir 2008 Jan 4;24(1):316-22. Epub 2007 Dec 4.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://pubs.acs.org/doi/abs/10.1021/la702041g
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http://dx.doi.org/10.1021/la702041gDOI Listing
January 2008

Muscular thin films for building actuators and powering devices.

Science 2007 Sep;317(5843):1366-70

Disease Biophysics Group, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1146885DOI Listing
September 2007

Multidimensional detection and analysis of Ca2+ sparks in cardiac myocytes.

Biophys J 2007 Jun 16;92(12):4433-43. Epub 2007 Mar 16.

Disease Biophysics Group, Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1529/biophysj.106.089359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1877778PMC
June 2007

Stretch-induced ventricular arrhythmias during acute ischemia and reperfusion.

J Appl Physiol (1985) 2004 Jul;97(1):377-83

Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1152/japplphysiol.01235.2001DOI Listing
July 2004

Analytical model for predicting mechanotransduction effects in engineered cardiac tissue.

Tissue Eng 2003 Apr;9(2):283-9

Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 48309, USA.

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https://www.liebertpub.com/doi/10.1089/107632703764664747
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April 2003