Publications by authors named "Kevin Jon Williams"

65Publications

CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features.

Mod Pathol 2020 Sep 5. Epub 2020 Sep 5.

Departments of Pathology and Dermatology, Virginia Commonwealth University School of Medicine, 1200 East Marshall Street, Richmond, VA, 23298, USA.

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http://dx.doi.org/10.1038/s41379-020-00672-yDOI Listing
September 2020

An oxide transport chain essential for balanced insulin action.

Atherosclerosis 2020 04 13;298:42-51. Epub 2020 Feb 13.

Section of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA; Department of Molecular and Clinical Medicine, Sahlgrenska Academy of the University of Gothenburg, Göteborg, 413 45, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.02.006DOI Listing
April 2020

Diabetes-Related Fracture Risk Is Different in African Americans Compared With Hispanics and Caucasians.

J Clin Endocrinol Metab 2019 11;104(11):5729-5736

Section of Endocrinology, Diabetes, and Metabolism, Pritzker School of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1210/jc.2019-00931DOI Listing
November 2019

Accelerated atherosclerotic cardiovascular risk in type 1 diabetes mellitus: Time for a new idea?

Atherosclerosis 2019 07 14;286:150-153. Epub 2019 Apr 14.

Department of Molecular and Clinical Medicine, Sahlgrenska Academy of the University of Gothenburg, Göteborg, 413 45, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.04.207DOI Listing
July 2019

Blood plasma versus serum: which is right for sampling circulating membrane microvesicles in human subjects?

Ann Rheum Dis 2020 06 20;79(6):e73. Epub 2019 Apr 20.

Section of Endocrinology, Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1136/annrheumdis-2019-215505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957763PMC
June 2020

Novel Insights into How Overnutrition Disrupts the Hypothalamic Actions of Leptin.

Front Endocrinol (Lausanne) 2018 26;9:89. Epub 2018 Mar 26.

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.3389/fendo.2018.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879088PMC
March 2018

Suppression of Hepatic FLOT1 (Flotillin-1) by Type 2 Diabetes Mellitus Impairs the Disposal of Remnant Lipoproteins via Syndecan-1.

Arterioscler Thromb Vasc Biol 2018 01 21;38(1):102-113. Epub 2017 Nov 21.

From the School of Public Health (K.C., Q.W., C.Y.) and Department of Surgery, The First Affiliated Hospital (K.H.), Anhui Medical University, Hefei, China; Section of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (K.C., X.W., P.C., K.J.W.); and Department of Molecular and Clinical Medicine, Sahlgrenska Academy of the University of Gothenburg, Sweden (K.J.W.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982506PMC
January 2018

The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity.

Curr Opin Lipidol 2016 10;27(5):473-83

aDepartment of Molecular and Clinical Medicine, University of Gothenburg bSahlgrenska University Hospital, Gothenburg, Sweden cSection of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOL.0000000000000330DOI Listing
October 2016

Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward.

Atherosclerosis 2016 Apr 13;247:225-82. Epub 2016 Feb 13.

Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.02.004DOI Listing
April 2016

Translocation of Endogenous Danger Signal HMGB1 From Nucleus to Membrane Microvesicles in Macrophages.

J Cell Physiol 2016 11 9;231(11):2319-26. Epub 2016 Mar 9.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.25352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021294PMC
November 2016

How an artery heals.

Circ Res 2015 Nov;117(11):909-13

From the Section of Endocrinology, Diabetes, & Metabolism, Temple University School of Medicine, Philadelphia, PA (K.J.W.); Department of Molecular and Clinical Medicine, Sahlgrenska Academy of the University of Gothenburg, Göteborg, Sweden (K.J.W.); Departments of Medicine, Pathology & Cell Biology, and Physiology, Columbia University Medical Center, New York, NY (I.T.); and Department of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and The Center for the Prevention of Cardiovascular Disease, NYU School of Medicine, New York, NY (E.A.F.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663458PMC
November 2015

Liraglutide in Weight Management.

N Engl J Med 2015 10;373(18):1782

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http://dx.doi.org/10.1056/NEJMc1509759DOI Listing
October 2015

Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms.

Thromb Haemost 2015 Nov 17;114(6):1165-74. Epub 2015 Sep 17.

Dr. Ming-Lin Liu, Tel.: +46739435823, Fax: +46 13 14 91 06, E-mail:

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http://dx.doi.org/10.1160/TH14-10-0899DOI Listing
November 2015

Another Agent for Obesity--Will This Time Be Different?

N Engl J Med 2015 Jul;373(1):82-3

From the Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia (E.S.S., K.J.W.); and the Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden (K.J.W.).

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http://dx.doi.org/10.1056/NEJMe1506236DOI Listing
July 2015

Decreased secretion of adiponectin through its intracellular accumulation in adipose tissue during tobacco smoke exposure.

Nutr Metab (Lond) 2015 9;12:15. Epub 2015 May 9.

Section of Endocrinology, Diabetes & Metabolic Diseases, Temple University School of Medicine, Philadelphia, PA USA.

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http://dx.doi.org/10.1186/s12986-015-0011-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465313PMC
June 2015

Biglycan deficiency: increased aortic aneurysm formation and lack of atheroprotection.

J Mol Cell Cardiol 2014 Oct 2;75:174-80. Epub 2014 Aug 2.

Division of Endocrinology and Molecular Medicine, Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA; Department of Veterans Affairs, Lexington, KY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169288PMC
October 2014

Insulin regulates the unfolded protein response in human adipose tissue.

Diabetes 2014 Mar 15;63(3):912-22. Epub 2013 Oct 15.

Division of Endocrinology/Diabetes/Metabolism, Temple University School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.2337/db13-0906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931405PMC
March 2014

Molecular mediators for raft-dependent endocytosis of syndecan-1, a highly conserved, multifunctional receptor.

J Biol Chem 2013 May 22;288(20):13988-99. Epub 2013 Mar 22.

Division of Endocrinology, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1074/jbc.M112.444737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656258PMC
May 2013

Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke.

Am J Pathol 2013 May 13;182(5):1552-62. Epub 2013 Mar 13.

Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.ajpath.2013.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644720PMC
May 2013

Decreased body fat, elevated plasma transforming growth factor-β levels, and impaired BMP4-like signaling in biglycan-deficient mice.

Connect Tissue Res 2013 23;54(1):5-13. Epub 2012 Aug 23.

Division of Endocrinology and Molecular Medicine, Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536-0200, USA.

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http://dx.doi.org/10.3109/03008207.2012.715700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557867PMC
June 2013

Cholesterol-induced membrane microvesicles as novel carriers of damage-associated molecular patterns: mechanisms of formation, action, and detoxification.

Arterioscler Thromb Vasc Biol 2012 Sep 19;32(9):2113-21. Epub 2012 Jul 19.

Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, 3322 North Broad Street, Medical Office Building, room 212, Philadelphia, PA 19140, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.112.255471
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http://dx.doi.org/10.1161/ATVBAHA.112.255471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568119PMC
September 2012

What does HDL do? A new mechanism to slow atherogenesis--but a new problem in type 2 diabetes mellitus.

Atherosclerosis 2012 Nov 22;225(1):36-8. Epub 2012 Jun 22.

Section of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Temple University School of Medicine, 3322 North Broad Street, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2012.06.023DOI Listing
November 2012

The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia.

Curr Opin Lipidol 2012 Aug;23(4):334-44

Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1097/MOL.0b013e3283544424DOI Listing
August 2012

NOX4 pathway as a source of selective insulin resistance and responsiveness.

Arterioscler Thromb Vasc Biol 2012 May 9;32(5):1236-45. Epub 2012 Feb 9.

Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1161/ATVBAHA.111.244525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398464PMC
May 2012

Microvesicles: potential markers and mediators of endothelial dysfunction.

Curr Opin Endocrinol Diabetes Obes 2012 Apr;19(2):121-7

Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1097/MED.0b013e32835057e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031554PMC
April 2012

Globular warming: how fat gets to the furnace.

Nat Med 2011 Feb;17(2):157-9

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http://dx.doi.org/10.1038/nm0211-157DOI Listing
February 2011

Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins.

Hepatology 2010 Dec 3;52(6):1957-67. Epub 2010 Nov 3.

Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1002/hep.23916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991429PMC
December 2010

Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages.

Arterioscler Thromb Vasc Biol 2010 Sep 17;30(9):1818-24. Epub 2010 Jun 17.

Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1161/ATVBAHA.110.209577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939448PMC
September 2010

Recent insights into factors affecting remnant lipoprotein uptake.

Curr Opin Lipidol 2010 Jun;21(3):218-28

Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1097/MOL.0b013e328338cabcDOI Listing
June 2010

Molecular processes that handle -- and mishandle -- dietary lipids.

J Clin Invest 2008 Oct;118(10):3247-59

Division of Endocrinology, Diabetes, and Metabolic Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5005, USA.

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http://dx.doi.org/10.1172/JCI35206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556568PMC
October 2008

Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression.

Arterioscler Thromb Vasc Biol 2008 Oct 31;28(10):1723-30. Epub 2008 Jul 31.

Department of Medicine, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1161/ATVBAHA.108.173344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562252PMC
October 2008

Autophagy of an oxidized, aggregated protein beyond the ER: a pathway for remarkably late-stage quality control.

Autophagy 2008 Jul 27;4(5):721-3. Epub 2008 May 27.

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.4161/auto.6346DOI Listing
July 2008

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control.

Proc Natl Acad Sci U S A 2008 Apr 7;105(15):5862-7. Epub 2008 Apr 7.

Departments of Medicine, Leon H. Charney Division of Cardiology, and Cell Biology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1073/pnas.0707460104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311371PMC
April 2008

Rapid regression of atherosclerosis: insights from the clinical and experimental literature.

Nat Clin Pract Cardiovasc Med 2008 Feb;5(2):91-102

Department of Medicine/Division of Endocrinology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1038/ncpcardio1086DOI Listing
February 2008

Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications.

Circulation 2007 Oct;116(16):1832-44

Department of Medicine, Columbia University Medical Center, 630 W 168th St, New York, NY 10032, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.676890DOI Listing
October 2007

Decorin deficiency enhances progressive nephropathy in diabetic mice.

Am J Pathol 2007 Nov 20;171(5):1441-50. Epub 2007 Sep 20.

Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.2353/ajpath.2007.070079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043506PMC
November 2007

Cellular and molecular mechanisms for rapid regression of atherosclerosis: from bench top to potentially achievable clinical goal.

Curr Opin Lipidol 2007 Aug;18(4):443-50

Department of Medicine/Division of Endocrinology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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https://insights.ovid.com/crossref?an=00041433-200708000-000
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http://dx.doi.org/10.1097/MOL.0b013e32823bcb15DOI Listing
August 2007

Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles.

Arterioscler Thromb Vasc Biol 2007 Feb 7;27(2):430-5. Epub 2006 Dec 7.

Dorrance H. Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1161/01.ATV.0000254674.47693.e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568121PMC
February 2007

Properties of a versatile nanoparticle platform contrast agent to image and characterize atherosclerotic plaques by magnetic resonance imaging.

Nano Lett 2006 Oct;6(10):2220-4

Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://pubs.acs.org/doi/abs/10.1021/nl061498r
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http://dx.doi.org/10.1021/nl061498rDOI Listing
October 2006

Lipoprotein retention--and clues for atheroma regression.

Arterioscler Thromb Vasc Biol 2005 Aug;25(8):1536-40

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http://dx.doi.org/10.1161/01.ATV.0000174795.62387.d3DOI Listing
August 2005

Loss of heparan N-sulfotransferase in diabetic liver: role of angiotensin II.

Diabetes 2005 Apr;54(4):1116-22

Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.2337/diabetes.54.4.1116DOI Listing
April 2005

Oxidation, lipoproteins, and atherosclerosis: which is wrong, the antioxidants or the theory?

Curr Opin Clin Nutr Metab Care 2005 Mar;8(2):139-46

Division of Endocrinology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/00075197-200503000-00006DOI Listing
March 2005

Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques.

J Am Chem Soc 2004 Dec;126(50):16316-7

Imaging Science Laboratories, Department of Radiology, Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1021/ja044911aDOI Listing
December 2004

The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity.

Virology 2004 Dec;330(2):481-6

The Dorrance H. Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.virol.2004.10.011DOI Listing
December 2004

Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production.

J Clin Invest 2004 May;113(9):1277-87

The Zena and Michael A. Wiener Cardiovascular Institute and the Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI19197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC398425PMC
May 2004

Human immunodeficiency virus type 1 enters primary human brain microvascular endothelial cells by a mechanism involving cell surface proteoglycans independent of lipid rafts.

J Virol 2003 Nov;77(22):12140-51

The Dorrance H. Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC254292PMC
http://dx.doi.org/10.1128/jvi.77.22.12140-12151.2003DOI Listing
November 2003

Atherosclerosis and inflammation.

Science 2002 Jul;297(5581):521-2

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http://dx.doi.org/10.1126/science.297.5581.521DOI Listing
July 2002

Editorial: The mystery--and importance--of diabetic atherosclerotic vascular disease.

J Clin Endocrinol Metab 2002 Jan;87(1):33-4

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http://dx.doi.org/10.1210/jcem.87.1.8264DOI Listing
January 2002