Publications by authors named "Kevin J Harrington"

235Publications

The Changing Landscape of Therapeutic Cancer Vaccines-Novel Platforms and Neoantigen Identification.

Authors:
Jessica Jou Kevin J Harrington Mai-Britt Zocca Eva Ehrnrooth Ezra E W Cohen

Clin Cancer Res 2020 Oct 29. Epub 2020 Oct 29.

Moores Cancer Center, University of California, San Diego Health, La Jolla, California.

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October 2020

Immunomodulatory activity of IR700-labelled affibody targeting HER2.

Authors:
Justyna Mączyńska Chiara Da Pieve Thomas A Burley Florian Raes Anant Shah Jolanta Saczko Kevin J Harrington Gabriela Kramer-Marek

Cell Death Dis 2020 10 20;11(10):886. Epub 2020 Oct 20.

Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.

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October 2020

The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy.

Authors:
Sophie R de Mol van Otterloo John P Christodouleas Erwin L A Blezer Hafid Akhiat Kevin Brown Ananya Choudhury Dave Eggert Beth A Erickson Corinne Faivre-Finn Clifton D Fuller Joel Goldwein Shaista Hafeez Emma Hall Kevin J Harrington Uulke A van der Heide Robert A Huddart Martijn P W Intven Anna M Kirby Susan Lalondrelle Claire McCann Bruce D Minsky Stella Mook Marlies E Nowee Uwe Oelfke Kristina Orrling Arjun Sahgal Jeffrey G Sarmiento Christopher J Schultz Robbert J H A Tersteeg Rob H N Tijssen Alison C Tree Baukelien van Triest William A Hall Helena M Verkooijen

Front Oncol 2020 7;10:1328. Epub 2020 Sep 7.

Division of Imaging, University Medical Center Utrecht, Utrecht, Netherlands.

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September 2020

Head and neck mucosal melanoma: The United Kingdom national guidelines.

Authors:
Pablo Nenclares Derfel Ap Dafydd Izhar Bagwan Donna Begg Cyrus Kerawala Emma King Ken Lingley Vinidh Paleri Gillian Paterson Miranda Payne Priyamal Silva Neil Steven Nancy Turnbull Kent Yip Kevin J Harrington

Eur J Cancer 2020 10 20;138:11-18. Epub 2020 Aug 20.

Royal Marsden Hospital NHS Foundation Trust, London, UK; The Institute of Cancer Research, London, UK.

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October 2020

Further clinical interpretation and implications of KEYNOTE-048 findings - Authors' reply.

Authors:
Barbara Burtness Yayan Zhang Kevin J Harrington Danny Rischin

Lancet 2020 08;396(10248):379-380

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia.

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August 2020

Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer.

Authors:
Eva Crespo-Rodriguez Katharina Bergerhoff Galabina Bozhanova Shane Foo Emmanuel C Patin Harriet Whittock Richard Buus Syed Haider Gareth Muirhead Khin Thway Kate Newbold Robert S Coffin Richard G Vile Dae Kim Martin McLaughlin Alan A Melcher Kevin J Harrington Malin Pedersen

J Immunother Cancer 2020 Aug;8(2)

Translational Immunotherapy Team, The Institute of Cancer Research, London, United Kingdom

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August 2020

Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study.

Authors:
Kevin J Harrington Anthony Kong Nicolas Mach Jason A Chesney Beatriz Castelo Fernandez Danny Rischin Ezra E W Cohen Hoi-Shen Radcliffe Burak Gumuscu Jonathan Cheng Wendy Snyder Lillian L Siu

Clin Cancer Res 2020 Oct 15;26(19):5153-5161. Epub 2020 Jul 15.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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October 2020

Author Correction: STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy.

Authors:
Esther N Arwert Emma L Milford Antonio Rullan Stefanie Derzsi Steven Hooper Takuya Kato David Mansfield Alan Melcher Kevin J Harrington Erik Sahai

Nat Cell Biol 2020 Jul;22(7):908

Tumour Cell Biology Laboratory, Francis Crick Institute, London, UK.

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July 2020

STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy.

Authors:
Esther N Arwert Emma L Milford Antonio Rullan Stefanie Derzsi Steven Hooper Takuya Kato David Mansfield Alan Melcher Kevin J Harrington Erik Sahai

Nat Cell Biol 2020 07 1;22(7):758-766. Epub 2020 Jun 1.

Tumour Cell Biology Laboratory, Francis Crick Institute, London, UK.

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July 2020

RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma.

Authors:
Henry G Smith Kunzah Jamal Jasbani Hs Dayal Tencho Tenev Joan Kyula-Currie Naomi Guppy Patrycja Gazinska Victoria Roulstone Gianmaria Liccardi Emma Davies Ioannis Roxanis Alan A Melcher Andrew J Hayes Gareth J Inman Kevin J Harrington Pascal Meier

EMBO Mol Med 2020 06 18;12(6):e10979. Epub 2020 May 18.

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.

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June 2020

Quality of Life With Pembrolizumab for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma: KEYNOTE-040.

Authors:
Kevin J Harrington Denis Soulières Christophe Le Tourneau Jose Dinis Lisa F Licitra Myung-Ju Ahn Ainara Soria Jean-Pascal H Machiels Nicolas Mach Ranee Mehra Barbara Burtness Misoo C Ellison Jonathan D Cheng Diana Romana Chirovsky Ramona F Swaby Ezra E W Cohen

J Natl Cancer Inst 2020 05 14. Epub 2020 May 14.

Moores Cancer Center at UC San Diego Health, University of California San Diego, La Jolla, CA, USA.

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May 2020

Changing paradigms in the treatment of residual/recurrent head and neck cancer: implications for dysphagia management.

Authors:
Grainne C Brady John C Hardman Vinidh Paleri Kevin J Harrington Justin W G Roe

Curr Opin Otolaryngol Head Neck Surg 2020 Jun;28(3):165-171

Department of Speech, Voice and Swallowing, The Royal Marsden NHS Foundation Trust.

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June 2020

Impact of antibiotic use during curative treatment of locally advanced head and neck cancers with chemotherapy and radiotherapy.

Authors:
Pablo Nenclares Sheerang A Bhide Helena Sandoval-Insausti Pierre Pialat Lucinda Gunn Alan Melcher Kate Newbold Christopher M Nutting Kevin J Harrington

Eur J Cancer 2020 05 2;131:9-15. Epub 2020 Apr 2.

Head and Neck Unit, Royal Marsden Hospital, London, United Kingdom; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.

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May 2020

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

Authors:
Lorenzo Galluzzi Ilio Vitale Sarah Warren Sandy Adjemian Patrizia Agostinis Aitziber Buqué Martinez Timothy A Chan George Coukos Sandra Demaria Eric Deutsch Dobrin Draganov Richard L Edelson Silvia C Formenti Jitka Fucikova Lucia Gabriele Udo S Gaipl Sofia R Gameiro Abhishek D Garg Encouse Golden Jian Han Kevin J Harrington Akseli Hemminki James W Hodge Dewan Md Sakib Hossain Tim Illidge Michael Karin Howard L Kaufman Oliver Kepp Guido Kroemer Juan Jose Lasarte Sherene Loi Michael T Lotze Gwenola Manic Taha Merghoub Alan A Melcher Karen L Mossman Felipe Prosper Øystein Rekdal Maria Rescigno Chiara Riganti Antonella Sistigu Mark J Smyth Radek Spisek John Stagg Bryan E Strauss Daolin Tang Kazuki Tatsuno Stefaan W van Gool Peter Vandenabeele Takahiro Yamazaki Dmitriy Zamarin Laurence Zitvogel Alessandra Cesano Francesco M Marincola

J Immunother Cancer 2020 03;8(1)

Refuge Biotechnologies, Menlo Park, California, USA.

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March 2020

Inflammatory microenvironment remodelling by tumour cells after radiotherapy.

Authors:
Martin McLaughlin Emmanuel C Patin Malin Pedersen Anna Wilkins Magnus T Dillon Alan A Melcher Kevin J Harrington

Nat Rev Cancer 2020 04 11;20(4):203-217. Epub 2020 Mar 11.

Targeted Therapy Team, The Institute of Cancer Research, London, UK.

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April 2020

The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism.

Authors:
Martin McLaughlin Malin Pedersen Victoria Roulstone Katharina F Bergerhoff Henry G Smith Harriet Whittock Joan N Kyula Magnus T Dillon Hardev S Pandha Richard Vile Alan A Melcher Kevin J Harrington

Mol Ther Oncolytics 2020 Mar 17;16:238-249. Epub 2020 Jan 17.

The Institute of Cancer Research, London, UK.

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March 2020

Cost-effectiveness analysis of nivolumab for the treatment of squamous cell carcinoma of the head and neck in the United States.

Authors:
Robert Haddad Ezra E W Cohen Meena Venkatachalam Kate Young Prianka Singh James W Shaw Beata Korytowsky Pranav Abraham Kevin J Harrington

J Med Econ 2020 May 29;23(5):442-447. Epub 2020 Jan 29.

Royal Marsden NHS Foundation Trust, The Institute of Cancer Research, London, UK.

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May 2020

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment.

Authors:
Maria Esperanza Rodriguez-Ruiz Ilio Vitale Kevin J Harrington Ignacio Melero Lorenzo Galluzzi

Nat Immunol 2020 02 23;21(2):120-134. Epub 2019 Dec 23.

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

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February 2020

Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study.

Authors:
Barbara Burtness Kevin J Harrington Richard Greil Denis Soulières Makoto Tahara Gilberto de Castro Amanda Psyrri Neus Basté Prakash Neupane Åse Bratland Thorsten Fuereder Brett G M Hughes Ricard Mesía Nuttapong Ngamphaiboon Tamara Rordorf Wan Zamaniah Wan Ishak Ruey-Long Hong René González Mendoza Ananya Roy Yayan Zhang Burak Gumuscu Jonathan D Cheng Fan Jin Danny Rischin

Lancet 2019 11 1;394(10212):1915-1928. Epub 2019 Nov 1.

Peter MacCallum Cancer Centre, Melbourne, VIC, Austrialia; University of Melbourne, Melbourne, VIC, Australia.

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November 2019

Patritumab or placebo, with cetuximab plus platinum therapy in recurrent or metastatic squamous cell carcinoma of the head and neck: A randomised phase II study.

Authors:
Martin D Forster Magnus T Dillon Judit Kocsis Éva Remenár Gabor Pajkos Frederic Rolland Jonathan Greenberg Kevin J Harrington

Eur J Cancer 2019 12 21;123:36-47. Epub 2019 Oct 21.

Head and Neck Unit, Royal Marsden Hospital/Institute of Cancer Research, National Institute of Health Research Biomedical Research Center, London, UK. Electronic address:

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December 2019