Publications by authors named "Kevin J Freise"

30Publications

Semimechanistic Modeling to Guide Venetoclax Coadministration with Ritonavir and Digoxin.

Clin Transl Sci 2020 05 13;13(3):555-562. Epub 2020 Mar 13.

Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.

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May 2020

Power determination during drug development: Is optimizing the sample size based on exposure-response analyses underutilized?

CPT Pharmacometrics Syst Pharmacol 2019 Jan 18. Epub 2019 Jan 18.

Abbvie Inc, 1 North Waukegan Road, North Chicago, IL, 60064.

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January 2019

Are Clinical Therapeutic Protein-Drug Interaction Studies Needed When Disease Modification Is Driving the Potential Interaction?

J Clin Pharmacol 2018 10 21;58(10):1371-1372. Epub 2018 Aug 21.

Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, IL, USA.

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October 2018

Impact of ritonavir dose and schedule on CYP3A inhibition and venetoclax clinical pharmacokinetics.

Eur J Clin Pharmacol 2018 Apr 4;74(4):413-421. Epub 2018 Jan 4.

AbbVie Inc., 1 North Waukegan Road, North Chicago, IL, 60064, USA.

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April 2018

Model-based meta-analysis of progression-free survival in non-Hodgkin lymphoma patients.

Medicine (Baltimore) 2017 Sep;96(35):e7988

AbbVie Inc., North Chicago, IL Current address: Merck and Co., Rahway, NJ Department of Clinical Pharmacy, Ain-Shams University, Cairo, Egypt.

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September 2017

Exposure-response evaluations of venetoclax efficacy and safety in patients with non-Hodgkin lymphoma.

Leuk Lymphoma 2018 04 10;59(4):871-879. Epub 2017 Aug 10.

a Clinical Pharmacology and Pharmacometrics , Abbvie Inc , North Chicago , IL , USA.

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April 2018

Evaluation of the Pharmacokinetic Interaction between Venetoclax, a Selective BCL-2 Inhibitor, and Warfarin in Healthy Volunteers.

Clin Drug Investig 2017 Mar;37(3):303-309

Clinical Pharmacology and Pharmacometrics, AbbVie Inc., 1 North Waukegan Road, North Chicago, IL, 60064, USA.

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March 2017

Venetoclax does not prolong the QT interval in patients with hematological malignancies: an exposure-response analysis.

Cancer Chemother Pharmacol 2016 10 1;78(4):847-53. Epub 2016 Sep 1.

Clinical Pharmacology and Pharmacometrics, Abbvie, 1 North Waukegan Road, North Chicago, IL, 60064, USA.

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October 2016