Kevin D Read

Kevin D Read

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Kevin D Read

Kevin D Read

Publications by authors named "Kevin D Read"

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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2018 Nov;16(11):714

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1038/s41579-018-0085-1DOI Listing
November 2018

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas' disease.

Bioorg Med Chem Lett 2018 10 3;28(18):3025-3030. Epub 2018 Aug 3.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970618PMC
October 2018

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

ACS Infect Dis 2018 10 10;4(10):1439-1447. Epub 2018 Sep 10.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences , University of Dundee , Dow Street , Dundee . DDI 5EH , U.K.

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http://dx.doi.org/10.1021/acsinfecdis.8b00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189874PMC
October 2018

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1.

Bioorg Med Chem Lett 2018 10 30;28(19):3255-3259. Epub 2018 Jul 30.

The Drug Discovery Unit, Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 4HN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.07.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185871PMC
October 2018

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

J Med Chem 2018 09 12;61(18):8374-8389. Epub 2018 Sep 12.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167002PMC
September 2018

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

ACS Infect Dis 2017 10 2;3(10):718-727. Epub 2017 Oct 2.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.7b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663395PMC
October 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2017 Feb 27;15(4):217-231. Epub 2017 Feb 27.

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/nrmicro.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582623PMC
February 2017

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.

Nat Commun 2016 11 4;7:13312. Epub 2016 Nov 4.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1038/ncomms13312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097156PMC
November 2016

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania.

PLoS Pathog 2016 Nov 3;12(11):e1005971. Epub 2016 Nov 3.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Building, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1005971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094698PMC
November 2016

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.

Elife 2016 05 24;5. Epub 2016 May 24.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.7554/eLife.09744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878867PMC
May 2016

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.

J Med Chem 2015 Oct 29;58(19):7695-706. Epub 2015 Sep 29.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Sir James Black Centre, Dundee, DD1 5EH, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601051PMC
October 2015

Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease.

PLoS Negl Trop Dis 2015 Sep 22;9(9):e0004014. Epub 2015 Sep 22.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0004014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578769PMC
September 2015

In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates.

Planta Med 2014 Feb 22;80(2-3):183-6. Epub 2014 Jan 22.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1055/s-0033-1360262DOI Listing
February 2014

The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.

Antimicrob Agents Chemother 2013 Oct 15;57(10):4699-706. Epub 2013 Jul 15.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00722-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811480PMC
October 2013

Structure-activity relationship studies of pyrrolone antimalarial agents.

ChemMedChem 2013 Sep 5;8(9):1537-44. Epub 2013 Aug 5.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow St, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201300177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963473PMC
September 2013

Synthesis and evaluation of α-thymidine analogues as novel antimalarials.

J Med Chem 2012 Dec 14;55(24):10948-57. Epub 2012 Dec 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1021/jm301328hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530961PMC
December 2012

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

Sci Transl Med 2012 Feb;4(119):119re1

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1126/scitranslmed.3003326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457684PMC
February 2012

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.

ChemMedChem 2012 Jan 8;7(1):95-106. Epub 2011 Dec 8.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/cmdc.201100420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320663PMC
January 2012

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

ChemMedChem 2011 Oct 10;6(10):1832-40. Epub 2011 Aug 10.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229842PMC
October 2011

Characterization of in vivo metabolites of WR319691, a novel compound with activity against Plasmodium falciparum.

Eur J Drug Metab Pharmacokinet 2011 Sep 13;36(3):151-8. Epub 2011 Jul 13.

Department of Medicinal Chemistry, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910-7500, USA,

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http://dx.doi.org/10.1007/s13318-011-0047-8DOI Listing
September 2011

Target validation: linking target and chemical properties to desired product profile.

Curr Top Med Chem 2011 ;11(10):1275-83

Drug Discovery Unit, College of Life Sciences, University of Dundee, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182078PMC
http://dx.doi.org/10.2174/156802611795429185DOI Listing
August 2011

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

ChemMedChem 2011 Feb 29;6(2):302-8. Epub 2010 Dec 29.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, Scotland, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047710PMC
February 2011

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

Biochem Pharmacol 2010 Nov 7;80(10):1478-86. Epub 2010 Aug 7.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bcp.2010.07.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025325PMC
November 2010

Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases.

Chem Biol 2010 Nov;17(11):1250-5

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland.

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http://dx.doi.org/10.1016/j.chembiol.2010.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032886PMC
November 2010

Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.

J Med Chem 2010 Aug;53(16):6071-8

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1021/jm1004754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923871PMC
August 2010

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

Antimicrob Agents Chemother 2010 Jul 3;54(7):2893-900. Epub 2010 May 3.

Division of Biological Chemistry & Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00332-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897277PMC
July 2010

Assessing brain free fraction in early drug discovery.

Expert Opin Drug Metab Toxicol 2010 Mar;6(3):337-44

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1517/17425250903559873DOI Listing
March 2010

The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat.

Epilepsy Res 2009 Jul 28;85(1):96-106. Epub 2009 Mar 28.

epartment of Molecular and Cellular Biology, Neuroscience Centre of Excellence for Drug Discovery, Medicines Research Centre, GlaxoSmithKline S.p.A., Via Fleming 4, Verona 37135, Italy.

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http://dx.doi.org/10.1016/j.eplepsyres.2009.02.018DOI Listing
July 2009

Receptor occupancy and brain free fraction.

Drug Metab Dispos 2009 Apr 21;37(4):753-60. Epub 2009 Jan 21.

Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1124/dmd.108.022814DOI Listing
April 2009

Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model.

Pharm Res 2008 Jul 22;25(7):1531-43. Epub 2008 Feb 22.

The School of Pharmacy, University of Nottingham, University Park, Nottingham NG72RD, UK.

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http://dx.doi.org/10.1007/s11095-008-9550-2DOI Listing
July 2008

Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents.

Eur J Pharm Sci 2005 Jan;24(1):59-66

Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ejps.2004.09.010DOI Listing
January 2005