Publications by authors named "Kevin Brindle"

100Publications

Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T.

Sci Rep 2020 Oct 16;10(1):17563. Epub 2020 Oct 16.

Department of Radiology, University of Cambridge, Cambridge Biomedical Campus, Box 218, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1038/s41598-020-74462-6DOI Listing
October 2020

Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER Breast Cancer.

Cancer Cell 2020 Oct 24;38(4):516-533.e9. Epub 2020 Sep 24.

Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Cancer Centre, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.08.016DOI Listing
October 2020

Probing hepatic metabolism of [2-C]dihydroxyacetone in vivo with H-decoupled hyperpolarized C-MR.

MAGMA 2020 Sep 10. Epub 2020 Sep 10.

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/s10334-020-00884-yDOI Listing
September 2020

Hyperpolarized C MRI of Tumor Metabolism Demonstrates Early Metabolic Response to Neoadjuvant Chemotherapy in Breast Cancer.

Radiol Imaging Cancer 2020 Jul 31;2(4):e200017. Epub 2020 Jul 31.

Departments of Radiology (R.W., A.B.G., J.T.G., A.J.P., S.U., F.Z., M.L., M.C.L., S.H., A.F., L.B., L.R., E.S., M.J.G., F.J.G., F.A.G.), Oncology (J.K., H.B., E.H., B.B., R.B., J.E.A., C.C.), and Biochemistry (K.M.B.), the Cambridge Breast Cancer Research Unit (E.P., J.K., H.B., E.H., R.B., J.E.A., C.C.), University of Cambridge, Cambridge, England; Departments of Radiology (A.J.P., I.P., R.S., M.J.G., F.J.G., F.A.G.) and Histopathology (E.P.), Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England; Cancer Research UK Cambridge Centre, Cambridge, England (R.W., M.A.M., E.P., T.T., L.B., L.R., E.S., J.E.A., C.C., K.M.B., F.A.G.); Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria (R.W., L.B.); Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, England (M.A.M., T.T., C.C., K.M.B.); and RAPID Biomedical, Rimpar, Germany (T.L.).

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http://dx.doi.org/10.1148/rycan.2020200017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398116PMC
July 2020

Lectins in Cervical Screening.

Cancers (Basel) 2020 Jul 16;12(7). Epub 2020 Jul 16.

Wolfson Institute of Preventive Medicine, Centre for Cancer Prevention, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.3390/cancers12071928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409129PMC
July 2020

A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarized C imaging.

Magn Reson Med 2020 Oct 15;84(4):1895-1908. Epub 2020 Mar 15.

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/mrm.28248DOI Listing
October 2020

Spectroscopic measurements of metabolic fluxes.

Nat Biomed Eng 2020 03;4(3):254-256

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41551-020-0535-8DOI Listing
March 2020

Increasing the sensitivity of hyperpolarized [ N ]urea detection by serial transfer of polarization to spin-coupled protons.

Magn Reson Med 2020 Oct 10;84(4):1844-1856. Epub 2020 Mar 10.

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/mrm.28241DOI Listing
October 2020

Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized C MRI.

Circ Res 2020 03 5;126(6):725-736. Epub 2020 Feb 5.

From the Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine (O.J.R., A.A., J.J.J.J.M., J.Y.C.L., A.J.M.L., M.A.P., C.T., S.N., D.J.T.), University of Oxford, United Kingdom.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077975PMC
March 2020

Measuring Tumor Glycolytic Flux in Vivo by Using Fast Deuterium MRI.

Radiology 2020 02 10;294(2):289-296. Epub 2019 Dec 10.

From the Cancer Research UK Cambridge Institute (F.K., A.J.W., F.H., M.F., E.H., K.M.B.) and Department of Biochemistry (K.M.B.), University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, England.

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http://dx.doi.org/10.1148/radiol.2019191242DOI Listing
February 2020

Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized C-methylglyoxal.

Commun Biol 2018 21;1:232. Epub 2018 Dec 21.

4University of Cambridge, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/s42003-018-0241-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303249PMC
December 2018

Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized C MR with Photosensitive Metabolic Substrates.

J Am Chem Soc 2018 10 22;140(43):14455-14463. Epub 2018 Oct 22.

Cancer Research UK Cambridge Institute, University of Cambridge , Li Ka Shin Center, Robinson Way, Cambridge CB2 0RE , U.K.

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http://dx.doi.org/10.1021/jacs.8b09326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217999PMC
October 2018

Emerging Technologies to Image Tissue Metabolism.

Cell Metab 2019 03 27;29(3):518-538. Epub 2018 Sep 27.

Department of Biochemistry, University of Cambridge, Old Addenbrooke's Site, Cambridge CB2 1GA, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183056
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http://dx.doi.org/10.1016/j.cmet.2018.09.004DOI Listing
March 2019

Hyperpolarized C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.

NMR Biomed 2018 11 10;31(11):e4004. Epub 2018 Sep 10.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1002/nbm.4004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220795PMC
November 2018

[F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.

Theranostics 2018 1;8(14):3991-4002. Epub 2018 Jul 1.

Cancer Research UK - Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.7150/thno.23709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071532PMC
August 2019

Magnetic resonance imaging of cancer metabolism with hyperpolarized C-labeled cell metabolites.

Curr Opin Chem Biol 2018 08 13;45:187-194. Epub 2018 Jul 13.

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2018.03.004DOI Listing
August 2018

Sub-minute kinetics of human red cell fumarase: H spin-echo NMR spectroscopy and C rapid-dissolution dynamic nuclear polarization.

NMR Biomed 2018 03 8;31(3). Epub 2018 Jan 8.

School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/nbm.3870DOI Listing
March 2018

A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1- C]pyruvate and [1- C]lactate.

NMR Biomed 2018 02 7;31(2). Epub 2017 Dec 7.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.

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http://doi.wiley.com/10.1002/nbm.3866
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http://dx.doi.org/10.1002/nbm.3866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814908PMC
February 2018

Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent.

Clin Cancer Res 2017 Nov 18;23(22):6893-6903. Epub 2017 Aug 18.

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1029DOI Listing
November 2017

Brain Tumor Imaging.

J Clin Oncol 2017 Jul 22;35(21):2432-2438. Epub 2017 Jun 22.

Kevin M. Brindle, Richard J. Mair, and Alan J. Wright, Cancer Research UK Cambridge Institute, Cambridge; David Y. Lewis, Cancer Research UK Beatson Institute, Glasgow, United Kingdom; José L. Izquierdo-García, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III and Centro de Investigación Biomédica en Red Enfermedades Respiratorias, Madrid, Spain.

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http://dx.doi.org/10.1200/JCO.2017.72.7636DOI Listing
July 2017

Dynamic H imaging of hyperpolarized [1- C]lactate in vivo using a reverse INEPT experiment.

Magn Reson Med 2018 02 5;79(2):741-747. Epub 2017 May 5.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/mrm.26725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811914PMC
February 2018

Dynamic nuclear polarisation: The future of imaging in oncology?

Porto Biomed J 2017 May-Jun;2(3):71-75. Epub 2017 Feb 10.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1016/j.pbj.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806983PMC
February 2017

Site-Selective Modification of Proteins with Oxetanes.

Chemistry 2017 May 29;23(27):6483-6489. Epub 2017 Mar 29.

Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.

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http://dx.doi.org/10.1002/chem.201700745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434895PMC
May 2017

Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I.

J Nucl Med 2017 06 16;58(6):881-887. Epub 2017 Feb 16.

Cancer Research United Kingdom Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom; and.

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http://dx.doi.org/10.2967/jnumed.116.183004DOI Listing
June 2017

Imaging biomarker roadmap for cancer studies.

Nat Rev Clin Oncol 2017 03 11;14(3):169-186. Epub 2016 Oct 11.

CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/nrclinonc.2016.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378302PMC
March 2017

Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.

Clin Cancer Res 2016 Nov 8;22(21):5196-5203. Epub 2016 Sep 8.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321522PMC
November 2016

Following Metabolism in Living Microorganisms by Hyperpolarized (1)H NMR.

J Am Chem Soc 2016 09 6;138(37):12278-86. Epub 2016 Sep 6.

Klinik und Poliklinik für Nuklearmedizin, Technische Universität München , München 81675, Germany.

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http://dx.doi.org/10.1021/jacs.6b07483DOI Listing
September 2016

Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.

J Biomed Opt 2016 08;21(8):84001

University of Cambridge, Department of Physics, JJ Thomson Avenue, Cambridge CB3 0HE, United KingdombUniversity of Cambridge, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom.

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http://dx.doi.org/10.1117/1.JBO.21.8.084001DOI Listing
August 2016

Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

NMR Biomed 2016 08 16;29(8):1048-55. Epub 2016 Jun 16.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1002/nbm.3568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973679PMC
August 2016

Detection of colorectal dysplasia using fluorescently labelled lectins.

Sci Rep 2016 Apr 13;6:24231. Epub 2016 Apr 13.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/srep24231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829854PMC
April 2016

Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate.

Front Oncol 2016 11;6:59. Epub 2016 Mar 11.

Li Ka Shing Centre, Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.3389/fonc.2016.00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786548PMC
March 2016

Single shot three-dimensional pulse sequence for hyperpolarized C MRI.

Magn Reson Med 2017 02 24;77(2):740-752. Epub 2016 Feb 24.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/mrm.26168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297976PMC
February 2017

31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

J Appl Physiol (1985) 2016 Mar 7;120(6):649-56. Epub 2016 Jan 7.

Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, United Kingdom; and Department of Musculoskeletal Biology and MRC - Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing, Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1152/japplphysiol.00871.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796179PMC
March 2016

Development of Timd2 as a reporter gene for MRI.

Magn Reson Med 2016 Apr 15;75(4):1697-707. Epub 2015 May 15.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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https://www.repository.cam.ac.uk/bitstream/handle/1810/24860
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http://doi.wiley.com/10.1002/mrm.25750
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http://dx.doi.org/10.1002/mrm.25750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832381PMC
April 2016

Imaging metabolism with hyperpolarized (13)C-labeled cell substrates.

Authors:
Kevin M Brindle

J Am Chem Soc 2015 May 15;137(20):6418-27. Epub 2015 May 15.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, U.K.

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http://pubs.acs.org/doi/10.1021/jacs.5b03300
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http://dx.doi.org/10.1021/jacs.5b03300DOI Listing
May 2015

Imaging tumor metabolism using positron emission tomography.

Cancer J 2015 Mar-Apr;21(2):129-36

From the Cancer Research UK-Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1097/PPO.0000000000000105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413031PMC
December 2015

Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells.

Magn Reson Med 2015 Dec 17;74(6):1543-7. Epub 2014 Dec 17.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/mrm.25561DOI Listing
December 2015

Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

EMBO J 2014 Jun 16;33(12):1365-82. Epub 2014 May 16.

Prostate Cancer Research Group, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership University of Oslo and Oslo University Hospital, Oslo, Norway Department of Cancer Prevention and Urology, Institute of Cancer Research and Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.15252/embj.201386874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194125PMC
June 2014

(13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.

Magn Reson Med 2015 May 6;73(5):1733-40. Epub 2014 May 6.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK; Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1002/mrm.25286DOI Listing
May 2015

Oatp1 enhances bioluminescence by acting as a plasma membrane transporter for D-luciferin.

Mol Imaging Biol 2014 Oct;16(5):626-34

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK, CB2 1QW,

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http://dx.doi.org/10.1007/s11307-014-0741-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161938PMC
October 2014

Late Imaging with [1-(11)C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET.

J Nucl Med 2014 Jul 28;55(7):1144-9. Epub 2014 Apr 28.

Cancer Research United Kingdom-Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; and

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http://dx.doi.org/10.2967/jnumed.113.134437DOI Listing
July 2014

Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy.

J Natl Cancer Inst 2014 Apr 28;106(5). Epub 2014 Apr 28.

Affiliations of authors: MRC Cancer Unit, Cambridge, UK (C-AJO, CSR-I, MO, CEW, AN, RCF); Cancer Research UK Cambridge Institute, Cambridge, UK (NBS, OMR, D-eH, MIK, CC, KB); UK Cambridge Esophagogastric Centre, Addenbrooke's Hospital, Cambridge, UK (RHH).

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http://dx.doi.org/10.1093/jnci/dju050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112924PMC
April 2014

Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

Magn Reson Med 2015 Apr 14;73(4):1401-6. Epub 2014 Apr 14.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/mrm.25254DOI Listing
April 2015

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.

Contrast Media Mol Imaging 2014 Mar-Apr;9(2):182-6

Department of Biochemistry, University of Cambridge and Cancer Research UK, Cambridge Research Institute, Cambridge, UK.

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http://dx.doi.org/10.1002/cmmi.1556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265858PMC
October 2014

Imaging cell death.

J Nucl Med 2014 Jan;55(1):1-4

Cancer Research United Kingdom Cambridge Institute, Li-Ka Shing Centre, Cambridge, United Kingdom; and.

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http://dx.doi.org/10.2967/jnumed.112.114264DOI Listing
January 2014

Dual-modality gene reporter for in vivo imaging.

Proc Natl Acad Sci U S A 2014 Jan 17;111(1):415-20. Epub 2013 Dec 17.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1319000111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890795PMC
January 2014

CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.

J Biophotonics 2014 Nov 17;7(11-12):906-13. Epub 2013 Dec 17.

Cavendish Laboratory, University of Cambridge, J. J. Thomson Avenue, Cambridge, CB3 0HE, UK; Institute of Life Sciences, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.

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http://dx.doi.org/10.1002/jbio.201300110DOI Listing
November 2014

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

Nat Med 2014 Jan 8;20(1):93-7. Epub 2013 Dec 8.

1] Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. [2] Department of Biochemistry, University of Cambridge, Cambridge, UK. [3].

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http://dx.doi.org/10.1038/nm.3416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886895PMC
January 2014

Versatile and enhanced tumour modelling in mice via somatic cell transduction.

J Pathol 2014 Mar;232(4):449-57

Department of Molecular Imaging, CRUK Cambridge Institute, University of Cambridge, UK.

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http://dx.doi.org/10.1002/path.4313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288983PMC
March 2014

Dual-sugar imaging using isonitrile and azido-based click chemistries.

Org Biomol Chem 2013 Nov;11(42):7297-300

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1039/c3ob41805gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246059PMC
November 2013

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

NMR Biomed 2013 Dec 15;26(12):1696-704. Epub 2013 Aug 15.

Department of Biochemistry, University of Cambridge, UK, and Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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http://dx.doi.org/10.1002/nbm.3005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238807PMC
December 2013

Imaging mouse cancer models in vivo using reporter transgenes.

Cold Spring Harb Protoc 2013 Aug 1;2013(8):685-99. Epub 2013 Aug 1.

Department of Molecular Imaging, CRUK Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom.

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http://dx.doi.org/10.1101/pdb.top069864DOI Listing
August 2013

Metabolic glycan imaging by isonitrile-tetrazine click chemistry.

Chembiochem 2013 Jun 13;14(9):1063-7. Epub 2013 May 13.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://dx.doi.org/10.1002/cbic.201300130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743162PMC
June 2013

Imaging cell surface glycosylation in vivo using "double click" chemistry.

Bioconjug Chem 2013 Jun 16;24(6):934-41. Epub 2013 May 16.

Cancer Research U.K., Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1021/bc300621nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687584PMC
June 2013

Investigation of transcriptional responses of juvenile mouse bone marrow to power frequency magnetic fields.

Mutat Res 2013 May-Jun;745-746:40-5. Epub 2013 Mar 20.

Health Protection Agency Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire, UK.

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http://dx.doi.org/10.1016/j.mrfmmm.2013.03.005DOI Listing
August 2013

Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

Magn Reson Med 2014 Jan 25;71(1):402-10. Epub 2013 Feb 25.

Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK; Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, UK.

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http://doi.wiley.com/10.1002/mrm.24644
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http://dx.doi.org/10.1002/mrm.24644DOI Listing
January 2014

Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.

Magn Reson Med 2013 Nov 27;70(5):1200-9. Epub 2012 Dec 27.

Cancer Research UK Cambridge Research Institute, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1002/mrm.24591
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http://dx.doi.org/10.1002/mrm.24591DOI Listing
November 2013

Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.

Proc Natl Acad Sci U S A 2012 Aug 26;109(33):13374-9. Epub 2012 Jul 26.

Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1205539109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421192PMC
August 2012

What do magnetic resonance-based measurements of Pi→ATP flux tell us about skeletal muscle metabolism?

Diabetes 2012 Aug;61(8):1927-34

Department of Musculoskeletal Biology and Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.2337/db11-1725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402329PMC
August 2012

Direct enhancement of nuclear singlet order by dynamic nuclear polarization.

J Am Chem Soc 2012 May 25;134(18):7668-71. Epub 2012 Apr 25.

School of Chemistry, Southampton University, Southampton SO17 1BJ, UK.

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http://dx.doi.org/10.1021/ja302814eDOI Listing
May 2012

Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate.

J Am Chem Soc 2012 Mar 1;134(10):4969-77. Epub 2012 Mar 1.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1021/ja300222eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303201PMC
March 2012

Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.

Cancer Res 2012 Feb 5;72(4):854-64. Epub 2012 Jan 5.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378497PMC
February 2012

Exploring isonitrile-based click chemistry for ligation with biomolecules.

Org Biomol Chem 2011 Nov 13;9(21):7303-5. Epub 2011 Sep 13.

University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, UK CB2 1EW.

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http://dx.doi.org/10.1039/c1ob06424jDOI Listing
November 2011

Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry.

J Nucl Med 2011 Sep 17;52(9):1333-6. Epub 2011 Aug 17.

Cancer Research United Kingdom Cambridge Research Institute, Cambridge, United Kingdom.

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September 2011