Kevin Booth

Kevin Booth

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Kevin Booth

Kevin Booth

Publications by authors named "Kevin Booth"

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32Publications

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Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids.

Stem Cell Reports 2019 Jul 13;13(1):147-162. Epub 2019 Jun 13.

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626982PMC
July 2019

Genomic Landscape and Mutational Signatures of Deafness-Associated Genes.

Am J Hum Genet 2018 10 20;103(4):484-497. Epub 2018 Sep 20.

Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; The Interdisciplinary Graduate Program in Molecular Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Medical Scientist Training Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Iowa Institute of Human Genetics, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174355PMC
October 2018

Old gene, new phenotype: splice-altering variants in cause recessive non-syndromic hearing impairment.

J Med Genet 2018 08 27;55(8):555-560. Epub 2018 Apr 27.

Molecular Otolaryngology Renal Research Laboratories, Department of Otolaryngology, University of Iowa, Iowa City, Iowa, USA.

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105349
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http://dx.doi.org/10.1136/jmedgenet-2018-105349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060001PMC
August 2018

Intracellular Regulome Variability Along the Organ of Corti: Evidence, Approaches, Challenges, and Perspective.

Front Genet 2018 8;9:156. Epub 2018 May 8.

Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology, University of Iowa, Iowa City, IA, United States.

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http://dx.doi.org/10.3389/fgene.2018.00156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951964PMC
May 2018

Exonic mutations and exon skipping: Lessons learned from DFNA5.

Hum Mutat 2018 03 11;39(3):433-440. Epub 2018 Jan 11.

Department of Otolaryngology-Head Neck Surgery, Molecular Otolaryngology Renal Research Laboratories, University of Iowa, Iowa City, Iowa.

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http://dx.doi.org/10.1002/humu.23384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805621PMC
March 2018

Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab.

Neurology 2018 03 2;90(10):e877-e886. Epub 2018 Feb 2.

From Janssen Research & Development, LLC (E.L.), La Jolla, CA; Janssen Research & Development, LLC (D.W., G.N., S.E.), Titusville, NJ; Brigham and Women's Hospital (R.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Brown University (S.S.), Providence, RI; UCL Institute of Neurology (N.C.F.), London, UK; Clinical Neurochemistry Lab, Department of Neuroscience and Physiology (K.B.), The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden; VUMC (P.S.), Amsterdam, the Netherlands; Janssen Pharmaceuticals (M.E.S., J.S.), NV, Beerse, Belgium; Reference Center for Biological Markers of Dementia (BIODEM) (J.S.), Institute Born-Bunge, University of Antwerp, Belgium; Pfizer, Inc. (K.B.), Collegeville, PA; and Janssen Research & Development, LLC (N.K., H.R.B.), Fremont, CA.

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http://dx.doi.org/10.1212/WNL.0000000000005060DOI Listing
March 2018

Audioprofile Surfaces: The 21st Century Audiogram.

Ann Otol Rhinol Laryngol 2016 May 3;125(5):361-8. Epub 2015 Nov 3.

Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, Iowa, USA Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA.

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http://dx.doi.org/10.1177/0003489415614863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821702PMC
May 2016

Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss.

Hum Genet 2016 Apr 11;135(4):441-450. Epub 2016 Mar 11.

Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology-Head and Neck Surgery, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

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http://dx.doi.org/10.1007/s00439-016-1648-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796320PMC
April 2016

PDZD7 and hearing loss: More than just a modifier.

Am J Med Genet A 2015 Dec 29;167A(12):2957-65. Epub 2015 Sep 29.

Department of Otolaryngology-Head Neck Surgery, Molecular Otolaryngology Renal Research Laboratories, University of Iowa, Iowa City, Iowa.

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http://doi.wiley.com/10.1002/ajmg.a.37274
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http://dx.doi.org/10.1002/ajmg.a.37274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741280PMC
December 2015

Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials.

Neurology 2015 Aug 24;85(8):692-700. Epub 2015 Jul 24.

From Janssen Alzheimer Immunotherapy Research & Development, LLC (E.L., R.M., P.C., K.M.G., J.D., Y.L., I.C.T., S.B., E.Y., H.R.B.), South San Francisco, CA; Janssen Pharmaceutical (M.E.S.), Beerse, NV; Brigham & Women's Hospital (R.S.), Boston, MA; University of Michigan (R.K.), Ann Arbor; University of Pittsburgh (N.S.M., W.E.K., C.A.M.), PA; Butler Hospital (S.S.), Providence, RI; UCL Institute of Neurology (N.C.F.), London, UK; IXICO plc (D.L.H., A.S.L.), London, UK; Pfizer Inc. (B.T.W.), Groton, CT; Pfizer Inc. (K.B.), Collegeville, PA; Global R&D Partners, LLC (M.G.), San Diego, CA; and University of California (M.G.), San Diego.

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http://dx.doi.org/10.1212/WNL.0000000000001877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553028PMC
August 2015

USH2 caused by GPR98 mutation diagnosed by massively parallel sequencing in advance of the occurrence of visual symptoms.

Ann Otol Rhinol Laryngol 2015 May 5;124 Suppl 1:123S-8S. Epub 2015 Mar 5.

Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan

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http://dx.doi.org/10.1177/0003489415574070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441826PMC
May 2015

Hearing loss caused by a P2RX2 mutation identified in a MELAS family with a coexisting mitochondrial 3243AG mutation.

Ann Otol Rhinol Laryngol 2015 May 18;124 Suppl 1:177S-83S. Epub 2015 Mar 18.

Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan

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http://dx.doi.org/10.1177/0003489415575045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441871PMC
May 2015

Novel PTPRQ mutations identified in three congenital hearing loss patients with various types of hearing loss.

Ann Otol Rhinol Laryngol 2015 May 18;124 Suppl 1:184S-92S. Epub 2015 Mar 18.

Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan

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http://journals.sagepub.com/doi/10.1177/0003489415575041
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http://dx.doi.org/10.1177/0003489415575041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441868PMC
May 2015

De novo mutation in X-linked hearing loss-associated POU3F4 in a sporadic case of congenital hearing loss.

Ann Otol Rhinol Laryngol 2015 May 19;124 Suppl 1:169S-76S. Epub 2015 Mar 19.

Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan

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http://dx.doi.org/10.1177/0003489415575042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441833PMC
May 2015

Mutations in LOXHD1 gene cause various types and severities of hearing loss.

Ann Otol Rhinol Laryngol 2015 May 19;124 Suppl 1:135S-41S. Epub 2015 Mar 19.

Department of Otolaryngology, Shinshu University School of Medicine, Matsumoto, Japan Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan

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http://dx.doi.org/10.1177/0003489415574067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441841PMC
May 2015

HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice.

PLoS Genet 2015 Mar 27;11(3):e1005137. Epub 2015 Mar 27.

Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology University of Iowa, Iowa City, Iowa, United States of America; Interdepartmental PhD Program in Genetics, University of Iowa, Iowa City, Iowa, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376867PMC
March 2015

Utilizing ethnic-specific differences in minor allele frequency to recategorize reported pathogenic deafness variants.

Am J Hum Genet 2014 Oct 25;95(4):445-53. Epub 2014 Sep 25.

Molecular Otolaryngology & Renal Research Labs, Department of Otolaryngology-Head and Neck Surgery, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Interdepartmental PhD Program in Genetics, University of Iowa, Iowa City, IA 52242, USA; Department of Molecular Physiology & Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185121PMC
October 2014

TBC1D24 mutation causes autosomal-dominant nonsyndromic hearing loss.

Hum Mutat 2014 Jul 6;35(7):819-23. Epub 2014 May 6.

Molecular Otolaryngology & Renal Research Laboratories, Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

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http://doi.wiley.com/10.1002/humu.22557
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http://dx.doi.org/10.1002/humu.22557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267685PMC
July 2014

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

Authors:
Catherine A Brownstein Alan H Beggs Nils Homer Barry Merriman Timothy W Yu Katherine C Flannery Elizabeth T DeChene Meghan C Towne Sarah K Savage Emily N Price Ingrid A Holm Lovelace J Luquette Elaine Lyon Joseph Majzoub Peter Neupert David McCallie Peter Szolovits Huntington F Willard Nancy J Mendelsohn Renee Temme Richard S Finkel Sabrina W Yum Livija Medne Shamil R Sunyaev Ivan Adzhubey Christopher A Cassa Paul I W de Bakker Hatice Duzkale Piotr Dworzyński William Fairbrother Laurent Francioli Birgit H Funke Monica A Giovanni Robert E Handsaker Kasper Lage Matthew S Lebo Monkol Lek Ignaty Leshchiner Daniel G MacArthur Heather M McLaughlin Michael F Murray Tune H Pers Paz P Polak Soumya Raychaudhuri Heidi L Rehm Rachel Soemedi Nathan O Stitziel Sara Vestecka Jochen Supper Claudia Gugenmus Bernward Klocke Alexander Hahn Max Schubach Mortiz Menzel Saskia Biskup Peter Freisinger Mario Deng Martin Braun Sven Perner Richard J H Smith Janeen L Andorf Jian Huang Kelli Ryckman Val C Sheffield Edwin M Stone Thomas Bair E Ann Black-Ziegelbein Terry A Braun Benjamin Darbro Adam P DeLuca Diana L Kolbe Todd E Scheetz Aiden E Shearer Rama Sompallae Kai Wang Alexander G Bassuk Erik Edens Katherine Mathews Steven A Moore Oleg A Shchelochkov Pamela Trapane Aaron Bossler Colleen A Campbell Jonathan W Heusel Anne Kwitek Tara Maga Karin Panzer Thomas Wassink Douglas Van Daele Hela Azaiez Kevin Booth Nic Meyer Michael M Segal Marc S Williams Gerard Tromp Peter White Donald Corsmeier Sara Fitzgerald-Butt Gail Herman Devon Lamb-Thrush Kim L McBride David Newsom Christopher R Pierson Alexander T Rakowsky Aleš Maver Luca Lovrečić Anja Palandačić Borut Peterlin Ali Torkamani Anna Wedell Mikael Huss Andrey Alexeyenko Jessica M Lindvall Måns Magnusson Daniel Nilsson Henrik Stranneheim Fulya Taylan Christian Gilissen Alexander Hoischen Bregje van Bon Helger Yntema Marcel Nelen Weidong Zhang Jason Sager Lu Zhang Kathryn Blair Deniz Kural Michael Cariaso Greg G Lennon Asif Javed Saloni Agrawal Pauline C Ng Komal S Sandhu Shuba Krishna Vamsi Veeramachaneni Ofer Isakov Eran Halperin Eitan Friedman Noam Shomron Gustavo Glusman Jared C Roach Juan Caballero Hannah C Cox Denise Mauldin Seth A Ament Lee Rowen Daniel R Richards F Anthony San Lucas Manuel L Gonzalez-Garay C Thomas Caskey Yu Bai Ying Huang Fang Fang Yan Zhang Zhengyuan Wang Jorge Barrera Juan M Garcia-Lobo Domingo González-Lamuño Javier Llorca Maria C Rodriguez Ignacio Varela Martin G Reese Francisco M De La Vega Edward Kiruluta Michele Cargill Reece K Hart Jon M Sorenson Gholson J Lyon David A Stevenson Bruce E Bray Barry M Moore Karen Eilbeck Mark Yandell Hongyu Zhao Lin Hou Xiaowei Chen Xiting Yan Mengjie Chen Cong Li Can Yang Murat Gunel Peining Li Yong Kong Austin C Alexander Zayed I Albertyn Kym M Boycott Dennis E Bulman Paul M K Gordon A Micheil Innes Bartha M Knoppers Jacek Majewski Christian R Marshall Jillian S Parboosingh Sarah L Sawyer Mark E Samuels Jeremy Schwartzentruber Isaac S Kohane David M Margulies

Genome Biol 2014 Mar 25;15(3):R53. Epub 2014 Mar 25.

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http://dx.doi.org/10.1186/gb-2014-15-3-r53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073084PMC
March 2014