Kerstin Lindblad-Toh

Kerstin Lindblad-Toh

UNVERIFIED PROFILE

Are you Kerstin Lindblad-Toh?   Register this Author

Register author
Kerstin Lindblad-Toh

Kerstin Lindblad-Toh

Publications by authors named "Kerstin Lindblad-Toh"

Are you Kerstin Lindblad-Toh?   Register this Author

100Publications

4242Reads

32Profile Views

Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.

Genome Biol 2020 Jun 9;21(1):127. Epub 2020 Jun 9.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-020-02035-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281935PMC
June 2020

SweHLA: the high confidence HLA typing bio-resource drawn from 1000 Swedish genomes.

Eur J Hum Genet 2020 May 16;28(5):627-635. Epub 2019 Dec 16.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-019-0559-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170882PMC
May 2020

Thoracolumbar meningeal fibrosis in pugs.

J Vet Intern Med 2020 Mar 31;34(2):797-807. Epub 2020 Jan 31.

Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Oslo, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jvim.15716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096664PMC
March 2020

What animals can teach us about evolution, the human genome, and human disease.

Ups J Med Sci 2020 Feb 14;125(1):1-9. Epub 2020 Feb 14.

Department for Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03009734.2020.1722298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054949PMC
February 2020

Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving.

Am J Physiol Regul Integr Comp Physiol 2019 06 20;316(6):R704-R715. Epub 2019 Mar 20.

Anesthesia Center for Critical Care Medicine, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00283.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620652PMC
June 2019

High prevalence of gait abnormalities in pugs.

Vet Rec 2018 02 5;182(6):167. Epub 2018 Feb 5.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://veterinaryrecord.bmj.com/lookup/doi/10.1136/vr.104510
Publisher Site
http://dx.doi.org/10.1136/vr.104510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870464PMC
February 2018

Dissecting evolution and disease using comparative vertebrate genomics.

Nat Rev Genet 2017 10 24;18(10):624-636. Epub 2017 Jul 24.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, Uppsala 75123, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrg.2017.51DOI Listing
October 2017

Comparison of cellular location and expression of Plakophilin-2 in epidermal cells from nonlesional atopic skin and healthy skin in German shepherd dogs.

Vet Dermatol 2017 Aug 6;28(4):377-e88. Epub 2017 Apr 6.

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-75007, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vde.12441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516137PMC
August 2017

Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.

Proc Natl Acad Sci U S A 2016 May 16;113(22):E3091-100. Epub 2016 May 16.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1600084113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896683PMC
May 2016

cgmisc: enhanced genome-wide association analyses and visualization.

Bioinformatics 2015 Dec 6;31(23):3830-1. Epub 2015 Aug 6.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden, Broad Institute of MIT and Harvard, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btv426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653382PMC
December 2015

Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype.

Cell 2015 Nov 12;163(5):1204-1213. Epub 2015 Nov 12.

Human Genome and Stem Cell Center, Biosciences Institute, University of São Paulo, São Paulo 05508-090, Brazil. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2015.10.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668935PMC
November 2015

Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.

PLoS Genet 2015 Jun 9;11(6):e1005248. Epub 2015 Jun 9.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden; Broad Institute, Cambridge, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461293PMC
June 2015

Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds.

BMC Genomics 2015 Jun 23;16:474. Epub 2015 Jun 23.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-015-1702-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477608PMC
June 2015

A simple repeat polymorphism in the MITF-M promoter is a key regulator of white spotting in dogs.

PLoS One 2014 12;9(8):e104363. Epub 2014 Aug 12.

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104363PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130573PMC
April 2015

The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.

Bioinformatics 2014 Dec 28;30(24):3558-60. Epub 2014 Aug 28.

Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK, Broad Institute of MIT and Harvard, Cambridge, MA, USA, Department of Biology, University of Rochester, NY, USA, Vertebrate and Health Genomics, The Genome Analysis Center, Norwich, UK, Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden and Department of Genetics, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btu579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253829PMC
December 2014

Amylase activity is associated with AMY2B copy numbers in dog: implications for dog domestication, diet and diabetes.

Anim Genet 2014 Oct 28;45(5):716-22. Epub 2014 Jun 28.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, 75123, Sweden.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/age.12179
Publisher Site
http://dx.doi.org/10.1111/age.12179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329415PMC
October 2014

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma.

Chromosome Res 2014 Sep 6;22(3):305-19. Epub 2014 Mar 6.

Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10577-014-9406-z
Publisher Site
http://dx.doi.org/10.1007/s10577-014-9406-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518683PMC
September 2014

The genomic substrate for adaptive radiation in African cichlid fish.

Nature 2014 Sep 3;513(7518):375-381. Epub 2014 Sep 3.

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353498PMC
September 2014

The dog as a genetic model for immunoglobulin A (IgA) deficiency: identification of several breeds with low serum IgA concentrations.

Vet Immunol Immunopathol 2014 Aug 27;160(3-4):255-9. Epub 2014 May 27.

Division of Clinical Immunology (F79), Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, SE-14186 Huddinge, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetimm.2014.05.010DOI Listing
August 2014

Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization.

Am J Pathol 2014 Apr 11;184(4):985-995. Epub 2014 Feb 11.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00029440140003
Publisher Site
http://dx.doi.org/10.1016/j.ajpath.2013.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969990PMC
April 2014

Genome-wide copy number variant discovery in dogs using the CanineHD genotyping array.

BMC Genomics 2014 Mar 19;15:210. Epub 2014 Mar 19.

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-15-210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234435PMC
March 2014

Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24.

PLoS Genet 2014 Feb 6;10(2):e1003991. Epub 2014 Feb 6.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America ; Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916225PMC
February 2014

Comparative genomics as a tool to understand evolution and disease.

Genome Res 2013 Jul;23(7):1063-8

Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.157503.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698499PMC
July 2013

IgA deficiency in wolves.

Dev Comp Immunol 2013 Jun 22;40(2):180-4. Epub 2013 Jan 22.

Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institute at Karolinska University Hospital Huddinge, SE-14186 Stockholm, Sweden.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0145305X130001
Publisher Site
http://dx.doi.org/10.1016/j.dci.2013.01.005DOI Listing
June 2013

Unsupervised genome-wide recognition of local relationship patterns.

BMC Genomics 2013 May 24;14:347. Epub 2013 May 24.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-14-347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669000PMC
May 2013

Origins of shared genetic variation in African cichlids.

Mol Biol Evol 2013 Apr 28;30(4):906-17. Epub 2012 Dec 28.

School of Biology, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Georgia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/molbev/mss326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603313PMC
April 2013

The ESR1 gene is associated with risk for canine mammary tumours.

BMC Vet Res 2013 Apr 10;9:69. Epub 2013 Apr 10.

Section of Genetics, Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, P,O Box 8146 Dep,, 0033 Oslo, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1746-6148-9-69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637093PMC
April 2013

The African coelacanth genome provides insights into tetrapod evolution.

Nature 2013 Apr;496(7445):311-6

Molecular Genetics Program, Benaroya Research Institute, Seattle, Washington 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633110PMC
April 2013

The genomic signature of dog domestication reveals adaptation to a starch-rich diet.

Nature 2013 Mar 23;495(7441):360-4. Epub 2013 Jan 23.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 75237 Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature11837DOI Listing
March 2013

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.

Genome Res 2012 Jan 17;22(1):51-63. Epub 2011 Oct 17.

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 75237 Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.124123.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246206PMC
January 2012

A high-resolution map of human evolutionary constraint using 29 mammals.

Nature 2011 Oct 12;478(7370):476-82. Epub 2011 Oct 12.

Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature10530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207357PMC
October 2011

LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs.

Vet J 2011 Aug 12;189(2):155-9. Epub 2011 Jul 12.

Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Avenue de l'Hôpital 1, 4000 Liège, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tvjl.2011.06.013DOI Listing
August 2011

Three periods of regulatory innovation during vertebrate evolution.

Science 2011 Aug;333(6045):1019-24

Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95064, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1202702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511857PMC
August 2011

LGI2 truncation causes a remitting focal epilepsy in dogs.

PLoS Genet 2011 Jul 28;7(7):e1002194. Epub 2011 Jul 28.

Department of Veterinary Biosciences, Department of Medical Genetics, Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1002194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145619PMC
July 2011