Publications by authors named "Kerry S Campbell"

71Publications

Impacts of pembrolizumab therapy on immune phenotype in patients with high-grade neuroendocrine neoplasms.

Cancer Immunol Immunother 2021 Jan 4. Epub 2021 Jan 4.

Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.

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January 2021

Immune phenotype of patients with stage IV metastatic inflammatory breast cancer.

Breast Cancer Res 2020 Dec 2;22(1):134. Epub 2020 Dec 2.

Blood Cell Development and Function Program, Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA, 19111, USA.

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December 2020

TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic.

Oncotarget 2020 Oct 20;11(42):3753-3769. Epub 2020 Oct 20.

Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medical Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

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October 2020

The need for cell lines from diverse ethnic backgrounds for prostate cancer research.

Nat Rev Urol 2019 12;16(12):691-692

Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

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December 2019

Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA.

Cancer Immunol Res 2019 07 4;7(7):1120-1134. Epub 2019 Jun 4.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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July 2019

Conformational Changes in the Cytoplasmic Region of KIR3DL1 upon Interaction with SHP-2.

Structure 2019 04 14;27(4):639-650.e2. Epub 2019 Feb 14.

Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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April 2019

Evidence That Combination Therapy With CD16-Bearing NK-92 Cells and FDA-Approved Alefacept Can Selectively Target the Latent HIV Reservoir in CD4+ CD2hi Memory T Cells.

Front Immunol 2018 5;9:2552. Epub 2018 Nov 5.

Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.

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September 2019

Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma.

Front Immunol 2018 5;9:2551. Epub 2018 Nov 5.

Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States.

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September 2019

Splice variants of human natural cytotoxicity receptors: novel innate immune checkpoints.

Cancer Immunol Immunother 2018 Dec 20;67(12):1871-1883. Epub 2017 Dec 20.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Goldman Building, Room 143, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel.

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December 2018

Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures.

Oncotarget 2017 Sep 5;8(40):66747-66757. Epub 2017 Aug 5.

Department of Hematology/Oncology and Molecular Therapeutics Program, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA.

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September 2017

Regulation of the Functions of Natural Cytotoxicity Receptors by Interactions with Diverse Ligands and Alterations in Splice Variant Expression.

Front Immunol 2017 30;8:369. Epub 2017 Mar 30.

Blood Cell Development and Function Program, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA.

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March 2017

Expression of NKp46 Splice Variants in Nasal Lavage Following Respiratory Viral Infection: Domain 1-Negative Isoforms Predominate and Manifest Higher Activity.

Front Immunol 2017 15;8:161. Epub 2017 Feb 15.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel; National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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February 2017

NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint.

Oncotarget 2016 Oct;7(43):70912-70923

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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October 2016

Suppressing the killer instinct.

Authors:
Kerry S Campbell

Sci Signal 2016 05 24;9(429):fs8. Epub 2016 May 24.

Blood Cell Development and Function Program, Institute for Cancer Research, Fox Chase Cancer Center (FCCC), Philadelphia, PA 19111, USA.

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May 2016

Survival in acute myeloid leukemia is associated with NKp44 splice variants.

Oncotarget 2016 May;7(22):32933-45

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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May 2016

Central nervous system acute lymphoblastic leukemia: role of natural killer cells.

Blood 2015 May 20;125(22):3420-31. Epub 2015 Apr 20.

Childhood Leukemia Research Section, Department of Pediatric Oncology and the Cancer Research Center, Edmond and Lily Safra Children Hospital and Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel;

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May 2015

Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner.

J Biol Chem 2015 May 16;290(19):11833-42. Epub 2015 Mar 16.

From the Departments of Microbiology and Immunology and

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May 2015

Regulation of natural cytotoxicity receptors by heparan sulfate proteoglycans in -cis: A lesson from NKp44.

Eur J Immunol 2015 Apr 21;45(4):1180-91. Epub 2015 Jan 21.

The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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April 2015

The ap-2 clathrin adaptor mediates endocytosis of an inhibitory killer cell Ig-like receptor in human NK cells.

J Immunol 2014 Nov 19;193(9):4675-83. Epub 2014 Sep 19.

Immune Cell Development and Host Defense Program, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111;

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November 2014

Carbohydrate-mediated modulation of NK cell receptor function: structural and functional influences of heparan sulfate moieties expressed on NK cell surface.

Front Oncol 2014 16;4:185. Epub 2014 Jul 16.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev , Beer-Sheva , Israel ; National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev , Beer-Sheva , Israel.

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July 2014

The Ca2+ sensor S100A1 modulates neuroinflammation, histopathology and Akt activity in the PSAPP Alzheimer's disease mouse model.

Cell Calcium 2014 Aug 26;56(2):68-80. Epub 2014 May 26.

Center for Biomolecular Therapeutics, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

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August 2014

Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity.

Eur J Immunol 2014 Aug 5;44(8):2331-9. Epub 2014 Jun 5.

Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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August 2014

Combination immune therapies to enhance anti-tumor responses by NK cells.

Front Immunol 2013 Dec 23;4:481. Epub 2013 Dec 23.

Immune Cell Development and Host Defense Program, The Research Institute at Fox Chase Cancer Center , Philadelphia, PA , USA.

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December 2013

Natural killer cell biology: an update and future directions.

J Allergy Clin Immunol 2013 Sep 30;132(3):536-544. Epub 2013 Jul 30.

Immune Cell Development and Host Defense Program, the Research Institute at Fox Chase Cancer Center, Philadelphia, Pa.

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September 2013

Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.

J Immunol 2013 Jan 12;190(2):723-36. Epub 2012 Dec 12.

Integrated Biomedical Science Graduate Program, The Ohio State University, Columbus, OH 43210, USA.

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January 2013

Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity.

J Clin Invest 2012 Oct 24;122(10):3769-80. Epub 2012 Sep 24.

Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.

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October 2012

A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen.

Oncoimmunology 2012 Jul;1(4):572-574

The Shraga Segal Department of Microbiology and Immunology; Faculty of Health Sciences; Ben-Gurion University of the Negev; Beer Sheva, Israel.

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July 2012

B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.

Proc Natl Acad Sci U S A 2012 Jan 20;109(1):267-72. Epub 2011 Dec 20.

Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA.

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January 2012

[Natural killer cells and cancer. Regulation by the killer cell Ig-like receptors (KIR)].

Zhongguo Fei Ai Za Zhi 2010 Jul;13(7):731-6

Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA, USA.

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July 2010

Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations.

Immunology 2011 Mar 7;132(3):315-25. Epub 2011 Jan 7.

Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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March 2011

Introduction of shRNAs into human NK-like cell lines with retrovirus.

Methods Mol Biol 2010 ;612:223-31

Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA.

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February 2010

Expression of cDNAs in human Natural Killer cell lines by retroviral transduction.

Methods Mol Biol 2010 ;612:199-208

Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA.

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February 2010

Measuring intracellular calcium signaling in murine NK cells by flow cytometry.

Methods Mol Biol 2010 ;612:149-57

Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA.

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February 2010

Natural killer cells and cancer: regulation by the killer cell Ig-like receptors (KIR).

Cancer Biol Ther 2009 Dec 28;8(23):2211-20. Epub 2009 Dec 28.

Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA, USA.

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December 2009

SHP-2 expression negatively regulates NK cell function.

J Immunol 2009 Dec 13;183(11):7234-43. Epub 2009 Nov 13.

Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA.

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December 2009

Immunotherapy of cancer.

Eur J Pharmacol 2009 Dec 20;625(1-3):41-54. Epub 2009 Oct 20.

Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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December 2009

Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy.

J Immunol 2008 May;180(9):6392-401

Department of Medical Oncology and Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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May 2008

Enhanced NK-cell development and function in BCAP-deficient mice.

Blood 2008 Jul 12;112(1):131-40. Epub 2008 Mar 12.

Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111-2497, USA.

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July 2008

KIR2DL4 differentially signals downstream functions in human NK cells through distinct structural modules.

J Immunol 2008 Mar;180(5):2922-32

Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111, USA.

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March 2008

Protein kinase C regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells.

J Immunol 2007 Oct;179(8):5281-90

Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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October 2007

Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor.

J Immunol 2007 Sep;179(5):2766-73

Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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September 2007

Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44.

Biochemistry 2007 Jun 31;46(25):7426-36. Epub 2007 May 31.

The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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June 2007

Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein.

J Immunol 2005 Apr;174(7):3859-63

Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA.

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April 2005

KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2).

J Immunol 2004 Jun;172(12):7385-92

Division of Basic Science, Fox Chase Cancer Center, Institute for Cancer Research, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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June 2004

NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence.

J Immunol 2004 Jan;172(2):899-906

Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA.

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January 2004

KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production.

J Immunol 2003 Oct;171(7):3415-25

Fox Chase Cancer Center, Division of Basic Science, Institute for Cancer Research, Philadelphia, PA 19111, USA.

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October 2003

Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells.

J Immunol 2003 May;170(9):4539-47

Division of Basic Science, Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111, USA.

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May 2003

SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells.

J Immunol 2002 May;168(10):5047-57

Division of Basic Science, Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA.

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May 2002