Kerry L Price

The M4 Helix Is Involved in α7 nACh Receptor Function.

Authors:

Ana R G M da Costa Couto Kerry L Price Susanne Mesoy Emily Capes Sarah C R Lummis

ACS Chem Neurosci 2020 05 4;11(10):1406-1412. Epub 2020 May 4.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB 1QW, United Kingdom.

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May 2020

Modulation of the ligand-gated ion channel (ELIC) and the 5-HT receptor via a common vestibule site.

Authors:

Marijke Brams Cedric Govaerts Kumiko Kambara Kerry L Price Radovan Spurny Anant Gharpure Els Pardon Genevieve L Evans Daniel Bertrand Sarah Cr Lummis Ryan E Hibbs Jan Steyaert Chris Ulens

Elife 2020 Jan 28;9. Epub 2020 Jan 28.

Laboratory of Structural Neurobiology, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.

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January 2020

Characterization of a 5-HT-ELIC Chimera Revealing the Sites of Action of Modulators.

Authors:

Kerry L Price Sarah C R Lummis

ACS Chem Neurosci 2018 06 6;9(6):1409-1415. Epub 2018 Mar 6.

Department of Biochemistry , University of Cambridge , Cambridge CB2 1QW , U.K.

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June 2018

The Proton Responsiveness in the Extracellular Domain of GLIC Differs in the Presence of the ELIC Transmembrane Domain.

Authors:

Mona A Alqazzaz Kerry L Price Sarah C R Lummis

Biochemistry 2017 04 6;56(15):2134-2138. Epub 2017 Apr 6.

Department of Biochemistry, University of Cambridge , Cambridge CB2 1QW, U.K.

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April 2017

Subtle Differences among 5-HTAC, 5-HTAD, and 5-HTAE Receptors Are Revealed by Partial Agonists.

Authors:

Kerry L Price Yuri Hirayama Sarah C R Lummis

ACS Chem Neurosci 2017 05 3;8(5):1085-1091. Epub 2017 Apr 3.

Department of Biochemistry, University of Cambridge , Tennis Court Road, Cambridge CB 1QW, United Kingdom.

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May 2017

Crotonic Acid Blocks the Gloeobacter Ligand-Gated Ion Channel (GLIC) via the Extracellular Domain.

Authors:

Mona A Alqazzaz Kerry L Price Sarah C R Lummis

Biochemistry 2016 Oct 14;55(42):5947-5951. Epub 2016 Oct 14.

Department of Biochemistry, University of Cambridge , Cambridge CB2 1QW, U.K.

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October 2016

Palonosetron-5-HT Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.

Authors:

Kerry L Price Reidun K Lillestol Chris Ulens Sarah C R Lummis

ACS Chem Neurosci 2016 12 22;7(12):1641-1646. Epub 2016 Sep 22.

Department of Biochemistry, University of Cambridge , Tennis Court Road, Cambridge CB2 1QW, United Kingdom.

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December 2016

5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems.

Authors:

Jeremias Corradi Andrew J Thompson Ian McGonigle Kerry L Price Cecilia Bouzat Sarah C R Lummis

ACS Chem Neurosci 2015 Jul 7;6(7):1158-64. Epub 2015 May 7.

‡Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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July 2015

Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP.

Authors:

Kerry L Price Reidun K Lillestol Chris Ulens Sarah C R Lummis

ACS Chem Neurosci 2015 Jul 19;6(7):1151-7. Epub 2015 Feb 19.

†Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom.

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July 2015

Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia.

Authors:

Natascha Schaefer Christoph J Kluck Kerry L Price Heike Meiselbach Nadine Vornberger Stephan Schwarzinger Stephanie Hartmann Georg Langlhofer Solveig Schulz Nadja Schlegel Knut Brockmann Bryan Lynch Cord-Michael Becker Sarah C R Lummis Carmen Villmann

J Neurosci 2015 Jan;35(1):422-37

Institute for Clinical Neurobiology, Julius-Maximilians-University of Würzburg, 97078 Würzburg, Germany,

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January 2015

An atypical residue in the pore of Varroa destructor GABA-activated RDL receptors affects picrotoxin block and thymol modulation.

Authors:

Kerry L Price Sarah C R Lummis

Insect Biochem Mol Biol 2014 12 18;55:19-25. Epub 2014 Oct 18.

Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK. Electronic address:

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December 2014

Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function.

Authors:

Andrew J Thompson Mona Alqazzaz Kerry L Price David A Weston Sarah C R Lummis

Biochemistry 2014 Oct 19;53(39):6183-8. Epub 2014 Sep 19.

Department of Biochemistry, University of Cambridge , Cambridge CB2 1QW, U.K.

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October 2014

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

Authors:

Radovan Spurny Bert Billen Rebecca J Howard Marijke Brams Sarah Debaveye Kerry L Price David A Weston Sergei V Strelkov Jan Tytgat Sonia Bertrand Daniel Bertrand Sarah C R Lummis Chris Ulens

J Biol Chem 2013 Mar 30;288(12):8355-64. Epub 2013 Jan 30.

Laboratory of Structural Neurobiology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, PB 601, B-3000 Leuven, Belgium.

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March 2013

GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.

Authors:

Jamie A Ashby Ian V McGonigle Kerry L Price Netta Cohen Federico Comitani Dennis A Dougherty Carla Molteni Sarah C R Lummis

Biophys J 2012 Nov 20;103(10):2071-81. Epub 2012 Nov 20.

Department of Biochemistry, Cambridge, UK.

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November 2012

Cys-loop receptor channel blockers also block GLIC.

Authors:

Mona Alqazzaz Andrew J Thompson Kerry L Price Hans-Georg Breitinger Sarah C R Lummis

Biophys J 2011 Dec 20;101(12):2912-8. Epub 2011 Dec 20.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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December 2011

A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.

Authors:

Stephan A Pless Ariele P Hanek Kerry L Price Joseph W Lynch Henry A Lester Dennis A Dougherty Sarah C R Lummis

Mol Pharmacol 2011 Apr 25;79(4):742-8. Epub 2011 Jan 25.

School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.

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April 2011

Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.

Authors:

Mariana Bartos Kerry L Price Sarah C R Lummis Cecilia Bouzat

J Biol Chem 2009 Aug 8;284(32):21478-87. Epub 2009 Jun 8.

Instituto de Investigaciones Bioquímicas, UNS-CONICET, Bahía Blanca 8000, Argentina.

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August 2009

A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.

Authors:

Kerry L Price Kiowa S Bower Andrew J Thompson Henry A Lester Dennis A Dougherty Sarah C R Lummis

Biochemistry 2008 Jun 22;47(24):6370-7. Epub 2008 May 22.

Department of Biochemistry, University of Cambridge, UK.

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June 2008

5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.

Authors:

Kiowa S Bower Kerry L Price Laura E C Sturdee Mariza Dayrell Dennis A Dougherty Sarah C R Lummis

Eur J Pharmacol 2008 Feb 17;580(3):291-7. Epub 2007 Nov 17.

California Institute of Technology, Pasadena, California, USA.

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February 2008

Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors.

Authors:

Kerry L Price Katherine S Millen Sarah C R Lummis

J Biol Chem 2007 Aug 2;282(35):25623-30. Epub 2007 Jul 2.

Department of Biochemistry, University of Cambridge and Neurobiology Division, MRC-LMB, Hills Rd., Cambridge CB2 2QH, United Kingdom.

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August 2007

Exploring the binding of serotonin to the 5-HT3 receptor by density functional theory.

Authors:

Claudio Melis P-L Chau Kerry L Price Sarah C R Lummis Carla Molteni

J Phys Chem B 2006 Dec;110(51):26313-9

Physics Department, King's College London, Strand, London WC2R 2LS, United Kingdom.

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December 2006

Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor.

Authors:

Nora L Sullivan Andrew J Thompson Kerry L Price Sarah C R Lummis

Mol Membr Biol 2006 Sep-Oct;23(5):442-51

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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January 2007

FlexStation examination of 5-HT3 receptor function using Ca2+ - and membrane potential-sensitive dyes: advantages and potential problems.

Authors:

Kerry L Price Sarah C R Lummis

J Neurosci Methods 2005 Dec 20;149(2):172-7. Epub 2005 Jul 20.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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December 2005

Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding.

Authors:

Andrew J Thompson Kerry L Price David C Reeves S Ling Chan P-L Chau Sarah C R Lummis

J Biol Chem 2005 May 21;280(21):20476-82. Epub 2005 Mar 21.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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May 2005

Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis.

Authors:

Darren L Beene Kerry L Price Henry A Lester Dennis A Dougherty Sarah C R Lummis

J Neurosci 2004 Oct;24(41):9097-104

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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October 2004

The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.

Authors:

Kerry L Price Sarah C R Lummis

J Biol Chem 2004 May 3;279(22):23294-301. Epub 2004 Mar 3.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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May 2004

Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.

Authors:

David C Reeves Muhammed F R Sayed Pak-Lee Chau Kerry L Price Sarah C R Lummis

Biophys J 2003 Apr;84(4):2338-44

Department of Biochemistry, University of Cambridge, Cambridge CB2 1AG, United Kingdom.

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April 2003

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