Keqiang Ye

Keqiang Ye

UNVERIFIED PROFILE

Are you Keqiang Ye?   Register this Author

Register author
Keqiang Ye

Keqiang Ye

Publications by authors named "Keqiang Ye"

Are you Keqiang Ye?   Register this Author

100Publications

2014Reads

39Profile Views

Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology.

Prog Neurobiol 2020 Feb 25;185:101730. Epub 2019 Nov 25.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pneurobio.2019.101730DOI Listing
February 2020

C/EBPβ/δ-secretase signaling mediates Parkinson's disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB.

Mol Psychiatry 2020 Feb 21. Epub 2020 Feb 21.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41380-020-0687-7DOI Listing
February 2020

Initiation of Parkinson's disease from gut to brain by δ-secretase.

Cell Res 2020 Jan 24;30(1):70-87. Epub 2019 Oct 24.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41422-019-0241-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951265PMC
January 2020

Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.

J Clin Invest 2020 Jan;130(1):422-437

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI130513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934194PMC
January 2020

δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities.

Transl Neurodegener 2020 6;9. Epub 2020 Jan 6.

2Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40035-019-0179-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943888PMC
January 2020

Developing Insulin and BDNF Mimetics for Diabetes Therapy.

Curr Top Med Chem 2019 ;19(24):2188-2204

Department of Pathology and Laboratory Medicine, Emory University of School of Medicine, Atlanta, GA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1568026619666191010160643DOI Listing
December 2019

Mcl-1 Interacts with Akt to Promote Lung Cancer Progression.

Cancer Res 2019 Dec 29;79(24):6126-6138. Epub 2019 Oct 29.

Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, Georgia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-19-0950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911632PMC
December 2019

Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control.

Proc Natl Acad Sci U S A 2019 12 20;116(49):24852-24860. Epub 2019 Nov 20.

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, 16419 Suwon, Korea;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1916306116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900500PMC
December 2019

Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease.

J Neurosci 2019 Sep 29;39(37):7291-7305. Epub 2019 Jul 29.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0625-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759025PMC
September 2019

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.

Cell Rep 2019 Jul;28(3):655-669.e5

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.06.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684282PMC
July 2019

Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression.

EMBO Rep 2019 06 13;20(6). Epub 2019 May 13.

Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

View Article

Download full-text PDF

Source
http://embor.embopress.org/lookup/doi/10.15252/embr.20184720
Publisher Site
http://dx.doi.org/10.15252/embr.201847202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549025PMC
June 2019

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2019 May 4;46(5):1152-1163. Epub 2019 Jan 4.

Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00259-018-4242-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451715PMC
May 2019

Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.

Proc Natl Acad Sci U S A 2019 04 19;116(18):9094-9102. Epub 2019 Apr 19.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1901348116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500177PMC
April 2019

Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation.

Cell Death Dis 2019 03 4;10(3):222. Epub 2019 Mar 4.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-019-1452-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399291PMC
March 2019

NQO1 Is Regulated by PTEN in Glioblastoma, Mediating Cell Proliferation and Oxidative Stress.

Oxid Med Cell Longev 2018 25;2018:9146528. Epub 2018 Nov 25.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/9146528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286748PMC
February 2019

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.

J Exp Med 2018 12 29;215(12):3038-3056. Epub 2018 Oct 29.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20180539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279401PMC
December 2018

Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer's disease.

Proc Natl Acad Sci U S A 2018 12 10;115(52):E12427-E12434. Epub 2018 Dec 10.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1815915115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310855PMC
December 2018

TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.

Front Cell Neurosci 2018 20;12:485. Epub 2018 Dec 20.

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fncel.2018.00485
Publisher Site
http://dx.doi.org/10.3389/fncel.2018.00485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306470PMC
December 2018

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle.

Metabolism 2018 10 20;87:113-122. Epub 2018 Jun 20.

School of Biological Sciences, the University of Hong Kong, Hong Kong, SAR, China; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, SAR, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.metabol.2018.06.007DOI Listing
October 2018

BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.

Proc Natl Acad Sci U S A 2018 04 26;115(15):3954-3959. Epub 2018 Mar 26.

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1800498115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899489PMC
April 2018

Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.

Sci Transl Med 2018 04;10(435)

Department of Pathology, Harvard Medical School, Dana-Farber/Harvard Cancer Center; Department of Laboratory Medicine, Children's Hospital Boston, Karp Family Research Building, Room 10214, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aal4045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435359PMC
April 2018

CK2 Phosphorylating I/SET Mediates Tau Pathology and Cognitive Impairment.

Front Mol Neurosci 2018 30;11:146. Epub 2018 Apr 30.

Key Laboratory of Education Ministry of China for Neurological Disorders, Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2018.00146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936753PMC
April 2018

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.

Proc Natl Acad Sci U S A 2018 01 2;115(3):578-583. Epub 2018 Jan 2.

College of Biosystems Engineering and Food Science, Zhejiang University, Zhejiang 310058, China;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1718683115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777001PMC
January 2018

TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease.

Proc Natl Acad Sci U S A 2017 10 18;114(40):10773-10778. Epub 2017 Sep 18.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1713969114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635931PMC
October 2017

Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.

J Med Chem 2017 09 18;60(17):7244-7255. Epub 2017 Aug 18.

Department of Pathology and Laboratory Medicine ‡Department of Pharmacology, Emory Chemical Biology Discovery Center Emory University School of Medicine Atlanta, Georgia 30322, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.7b00228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871875PMC
September 2017

Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.

Mol Cell 2017 Sep 17;67(5):812-825.e5. Epub 2017 Aug 17.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA; Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2017.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753427PMC
September 2017

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life.

Proc Natl Acad Sci U S A 2017 08 8;114(34):9188-9193. Epub 2017 Aug 8.

Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China 200092;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1706069114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576812PMC
August 2017

Sex differences in brain-derived neurotrophic factor signaling and functions.

J Neurosci Res 2017 01;95(1-2):328-335

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jnr.23863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271179PMC
January 2017

α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.

Proc Natl Acad Sci U S A 2017 01 17;114(5):1183-1188. Epub 2017 Jan 17.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1618627114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293033PMC
January 2017

Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway.

Brain Behav Immun 2016 Oct 21;57:314-325. Epub 2015 Sep 21.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2015.09.012DOI Listing
October 2016

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.

Expert Opin Ther Targets 2016 Oct 13;20(10):1237-45. Epub 2016 May 13.

b Department of Pathology and Laboratory Medicine , Emory University School of Medicine , Atlanta , GA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14728222.2016.1182990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315368PMC
October 2016

Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats.

Mol Neurobiol 2016 09 2;53(7):4772-86. Epub 2015 Sep 2.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-015-9393-xDOI Listing
September 2016

Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling.

Proc Natl Acad Sci U S A 2016 06 13;113(26):E3773-81. Epub 2016 Jun 13.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong JS 226001, China

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1604519113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932970PMC
June 2016

Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist.

Exp Neurol 2016 May 2;279:178-186. Epub 2016 Mar 2.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Geriatric Research, Education, and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886163004
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2016.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933026PMC
May 2016

7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents.

Neurosci Lett 2016 05 24;620:43-9. Epub 2016 Mar 24.

Department of Biology, Sundia MediTech Company Ltd., 388 Jialilve Road, Zhangjiang Hightech Park, Shanghai 201203, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2016.03.042DOI Listing
May 2016

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin.

Oncotarget 2016 Apr;7(14):17356-68

Department of Pathophysiology, School of Basic Medicine and The Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.7861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951217PMC
April 2016

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins.

Sci Rep 2016 Apr 21;6:24756. Epub 2016 Apr 21.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep24756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838862PMC
April 2016

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders.

Transl Neurodegener 2016 6;5. Epub 2016 Jan 6.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40035-015-0048-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702337PMC
January 2016

Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents.

Neuropharmacology 2015 Dec 14;99:448-58. Epub 2015 Aug 14.

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2015.08.016DOI Listing
December 2015

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease.

Nat Commun 2015 Nov 9;6:8762. Epub 2015 Nov 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms9762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659940PMC
November 2015

NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury.

Proc Natl Acad Sci U S A 2015 Oct 12;112(43):13354-9. Epub 2015 Oct 12.

Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1510194112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629318PMC
October 2015

Norepinephrine Protects against Amyloid-β Toxicity via TrkB.

J Alzheimers Dis 2015 ;44(1):251-60

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-141062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714587PMC
September 2015

Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability.

Proc Natl Acad Sci U S A 2015 Jun 26;112(23):7255-60. Epub 2015 May 26.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322;

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1505917112
Publisher Site
http://dx.doi.org/10.1073/pnas.1505917112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466726PMC
June 2015

Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO.

Proc Natl Acad Sci U S A 2015 Jan 5;112(3):899-904. Epub 2015 Jan 5.

Divisions of Molecular Medicine and Cardiology, Departments of Anesthesiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1420695112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311801PMC
January 2015

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination.

Proc Natl Acad Sci U S A 2014 Nov 5;111(46):16586-91. Epub 2014 Nov 5.

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Division of Neurodegenerative Disorders, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, JS 226001, China

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1417548111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246270PMC
November 2014

N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain.

Adv Exp Med Biol 2014 ;801:765-71

Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4614-3209-8_96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069859PMC
July 2014

Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.

Cell Res 2014 Mar 10;24(3):344-58. Epub 2014 Jan 10.

1] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2] iHuman Institute, ShanghaiTech University, Shanghai 201210, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cr.2014.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945893PMC
March 2014

7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.

Neuropsychopharmacology 2014 Feb 11;39(3):638-50. Epub 2013 Sep 11.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/npp.2013.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895241PMC
February 2014

O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity.

Pharmacology 2013 21;91(3-4):185-200. Epub 2013 Feb 21.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000346920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793717PMC
December 2013

Novel small molecule activators of the Trk family of receptor tyrosine kinases.

Biochim Biophys Acta 2013 Oct 6;1834(10):2213-8. Epub 2012 Sep 6.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbapap.2012.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602283PMC
October 2013

Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves.

Proc Natl Acad Sci U S A 2013 Oct 16;110(40):16217-22. Epub 2013 Sep 16.

Departments of Cell Biology and Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1303646110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791704PMC
October 2013

The roles of PIKE in tumorigenesis.

Authors:
Qi Qi Keqiang Ye

Acta Pharmacol Sin 2013 Aug 17;34(8):991-7. Epub 2013 Jun 17.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/aps.2013.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733165PMC
August 2013

Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists.

J Neurosci 2013 Aug;33(32):13042-52

Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China 100730.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0854-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735884PMC
August 2013

Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth.

Acta Pharmacol Sin 2013 Jul 27;34(7):930-8. Epub 2013 May 27.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/aps.2013.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002615PMC
July 2013

Blockade of glioma proliferation through allosteric inhibition of JAK2.

Sci Signal 2013 Jul 9;6(283):ra55. Epub 2013 Jul 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.2003900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772155PMC
July 2013

Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.

Hum Mol Genet 2013 Jun 27;22(12):2462-70. Epub 2013 Feb 27.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddt098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658168PMC
June 2013

Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.

Mol Cell Biol 2013 May 25;33(9):1797-808. Epub 2013 Feb 25.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01410-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624174PMC
May 2013

Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate.

Proc Natl Acad Sci U S A 2013 May 22;110(19):7726-31. Epub 2013 Apr 22.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 30020, China.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1302906110
Publisher Site
http://dx.doi.org/10.1073/pnas.1302906110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651495PMC
May 2013

N-acetylserotonin: neuroprotection, neurogenesis, and the sleepy brain.

Neuroscientist 2012 Dec 14;18(6):645-53. Epub 2012 May 14.

Morehouse School of Medicine, Atlanta, GA 30310, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1073858412446634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422380PMC
December 2012

Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils.

Immunity 2012 Dec 15;37(6):1037-49. Epub 2012 Nov 15.

Department of Pathology, Harvard Medical School and Department of Lab Medicine, Children's Hospital Boston and Dana-Farber/Harvard Cancer Center, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2012.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525814PMC
December 2012

SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.

J Neurosci 2012 Nov;32(48):17262-72

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3300-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518045PMC
November 2012

Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression.

J Med Chem 2012 Oct 3;55(19):8524-37. Epub 2012 Oct 3.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm301099xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491656PMC
October 2012

Asparaginyl endopeptidase cleaves TDP-43 in brain.

Proteomics 2012 Aug;12(15-16):2455-63

Department of Neurology, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201200006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787696PMC
August 2012

Inhibition of IκB kinase in Notch signaling activates FOXO3a.

Authors:
Keqiang Ye

Cell Cycle 2012 Jul 1;11(13):2417. Epub 2012 Jul 1.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.21067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404869PMC
July 2012

7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo.

Biochem Biophys Res Commun 2012 Jun 7;422(3):387-92. Epub 2012 May 7.

Department of Otolaryngology Head & Neck Surgery, Beijing Tongren Hospital Capital Medical University, #1 Dong Jiao Min Xiang Street, Beijing 100730, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2012.04.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388121PMC
June 2012

7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome.

J Appl Physiol (1985) 2012 Mar 22;112(5):704-10. Epub 2011 Dec 22.

Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.01361.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643819PMC
March 2012

Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases.

J Biol Chem 2012 Feb 3;287(9):6113-27. Epub 2012 Jan 3.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.293605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307261PMC
February 2012

N-acetyl serotonin derivatives as potent neuroprotectants for retinas.

Proc Natl Acad Sci U S A 2012 Feb 13;109(9):3540-5. Epub 2012 Feb 13.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/content/109/9/3540.full.pdf
Web Search
http://www.pnas.org/cgi/doi/10.1073/pnas.1119201109
Publisher Site
http://dx.doi.org/10.1073/pnas.1119201109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295250PMC
February 2012

Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?

Rev Neurosci 2012 Jan 26;23(2):153-61. Epub 2012 Jan 26.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/revneuro-2011-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760202PMC
January 2012

Loss of tumor suppressor Merlin in advanced breast cancer is due to post-translational regulation.

J Biol Chem 2011 Nov 30;286(46):40376-85. Epub 2011 Sep 30.

Department of Oncologic Sciences, Mitchell Cancer Institute, Mobile, Alabama 36604, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.250035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220570PMC
November 2011

What we have learnt about PIKE from the knockout mice.

Int J Biochem Mol Biol 2011 7;2(3):228-39. Epub 2011 Jun 7.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine Atlanta, GA USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193289PMC
November 2011

Identification of a molecular activator for insulin receptor with potent anti-diabetic effects.

J Biol Chem 2011 Oct 9;286(43):37379-88. Epub 2011 Sep 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.247387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199485PMC
October 2011

PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression.

EMBO J 2011 Aug 16;30(20):4274-86. Epub 2011 Aug 16.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emboj.2011.281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199380PMC
August 2011

The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity.

EMBO Rep 2011 Jul 1;12(8):847-54. Epub 2011 Jul 1.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, Georgia 30322, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/embor.2011.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147257PMC
July 2011