Publications by authors named "Kenneth W Spitzer"

38Publications

Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.

J Mol Cell Cardiol 2020 02 23;139:113-123. Epub 2020 Jan 23.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

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February 2020

pH recovery from a proton load in rat cardiomyocytes: effects of chronic exercise.

Am J Physiol Heart Circ Physiol 2018 02 3;314(2):H285-H292. Epub 2017 Nov 3.

Molecular Cardiac Physiology Group, Simon Fraser University , Burnaby, British Columbia , Canada.

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February 2018

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.

Circ Res 2018 01 1;122(1):58-73. Epub 2017 Nov 1.

From the Division of Endocrinology and Metabolism, Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine (K.T., J.S., G.A.J., A.R.T., R.M., H.C.K., Y.Z., R.S., R.O.P., E.D.A.) and Department of Health and Human Physiology (V.A.L.), University of Iowa, Iowa City; Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine (K.T., H.B., A.R.W., J.S., X.X.H., C.L.S., E.D.A.), Nora Eccles Harrison Cardiovascular Research and Training Institute (K.W.S.), and Department of Biochemistry (O.K.), University of Utah School of Medicine, Salt Lake City; Cardiology and Angiology I (H.B.) and Institute for Experimental Cardiovascular Medicine (E.A.R.-Z., P.K.), Heart Center Freiburg University, and Faculty of Medicine (H.B., E.A.R.-Z., P.K.), University of Freiburg, Germany; Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham (A.R.W.); Department of Radiology (T.L.S., K.I.S.) and Diabetic Cardiovascular Disease Center, Cardiovascular Division (J.E.S.), Washington University School of Medicine, St. Louis, MO; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora (G.C.S.); and Department of Biochemistry and Nebraska Redox Biology Center, University of Nebraska, Lincoln (O.K.).

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January 2018

Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart.

Am J Physiol Heart Circ Physiol 2017 Apr 27;312(4):H752-H767. Epub 2017 Jan 27.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.

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April 2017

Na⁺ ions as spatial intracellular messengers for co-ordinating Ca²⁺ signals during pH heterogeneity in cardiomyocytes.

Cardiovasc Res 2015 Feb 16;105(2):171-81. Epub 2014 Dec 16.

Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK

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February 2015

A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived cardiomyocytes.

Am J Physiol Heart Circ Physiol 2014 Nov 29;307(9):H1370-7. Epub 2014 Aug 29.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake City, Utah; Division of Pediatric Cardiology, University of Utah School of Medicine, Salt Lake City, Utah.

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November 2014

Pumping Ca2+ up H+ gradients: a Ca2(+)-H+ exchanger without a membrane.

J Physiol 2014 Aug 10;592(15):3179-88. Epub 2014 Feb 10.

Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK.

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August 2014

A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs.

J Mol Cell Cardiol 2014 Mar 3;68:1-11. Epub 2014 Jan 3.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, 95S 2000E, Salt Lake City, UT 84112, USA; Division of Cardiology, University of Utah, 30N 1900E, Salt Lake City, UT 84132, USA. Electronic address:

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March 2014

Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling.

Proc Natl Acad Sci U S A 2013 May 15;110(22):E2064-73. Epub 2013 May 15.

Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy, and Genetics, Oxford University, Oxford OX1 3PT, United Kingdom.

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May 2013

Modulation of ventricular transient outward K⁺ current by acidosis and its effects on excitation-contraction coupling.

Am J Physiol Heart Circ Physiol 2013 Jun 12;304(12):H1680-96. Epub 2013 Apr 12.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.

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June 2013

Detection of mitochondrial depolarization/recovery during ischaemia--reperfusion using spectral properties of confocally recorded TMRM fluorescence.

J Physiol 2013 Jun 25;591(11):2781-94. Epub 2013 Mar 25.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, 95 S 2000 E, Salt Lake City, UT 84112-5000, USA.

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June 2013

Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes.

Prog Biophys Mol Biol 2012 Oct-Nov;110(2-3):218-25. Epub 2012 Aug 1.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, 95 South 2000 East, Salt Lake City, UT 84112-5000, USA.

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November 2013

Influence of pH on Ca²⁺ current and its control of electrical and Ca²⁺ signaling in ventricular myocytes.

J Gen Physiol 2011 Nov;138(5):537-59

Department of Physiology, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.

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November 2011

Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.

Am J Physiol Heart Circ Physiol 2011 Dec 23;301(6):H2395-401. Epub 2011 Sep 23.

Nora Eccles Harrison Cardiovascular Research and Training Institute, Salt Lake City, Utah, USA.

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December 2011

High-precision recording of the action potential in isolated cardiomyocytes using the near-infrared fluorescent dye di-4-ANBDQBS.

Am J Physiol Heart Circ Physiol 2010 Oct 2;299(4):H1271-81. Epub 2010 Jul 2.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112-5000, USA.

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October 2010

Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heart.

Cell Physiol Biochem 2010 23;25(4-5):419-24. Epub 2010 Mar 23.

Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT 84113, USA.

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June 2010

Modeling calcium waves in cardiac myocytes: importance of calcium diffusion.

Front Biosci (Landmark Ed) 2010 Jan 1;15:661-80. Epub 2010 Jan 1.

Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford OX1 3PT, UK.

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January 2010

Nonanticoagulant heparin reduces myocyte Na+ and Ca2+ loading during simulated ischemia and decreases reperfusion injury.

Am J Physiol Heart Circ Physiol 2010 Jan 23;298(1):H102-11. Epub 2009 Oct 23.

School of Medicine, Division of Cardiology, University of Utah Medical Center, Salt Lake City, UT 84132, USA.

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January 2010