Kenneth S Kosik

Kenneth S Kosik

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Kenneth S Kosik

Publications by authors named "Kenneth S Kosik"

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Microglial microRNAs mediate sex-specific responses to tau pathology.

Nat Neurosci 2020 Feb 23;23(2):167-171. Epub 2019 Dec 23.

Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41593-019-0560-7DOI Listing
February 2020

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.

Neuron 2019 Nov 18;104(3):458-470.e5. Epub 2019 Sep 18.

Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880876PMC
November 2019

Control over single-cell distribution of G1 lengths by WNT governs pluripotency.

PLoS Biol 2019 09 26;17(9):e3000453. Epub 2019 Sep 26.

Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782112PMC
September 2019

iPSCs-derived nerve-like cells from familial Alzheimer's disease PSEN 1 E280A reveal increased amyloid-beta levels and loss of the Y chromosome.

Neurosci Lett 2019 06 20;703:111-118. Epub 2019 Mar 20.

Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Calle 70 No. 52-21, and Calle 62 # 52-59, Building 1, Room 412, SIU Medellin, Colombia. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.03.032DOI Listing
June 2019

In vitro validation of in silico identified inhibitory interactions.

J Neurosci Methods 2019 Jun 6;321:39-48. Epub 2019 Apr 6.

Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA; Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience, University of California, Berkeley, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2019.04.002DOI Listing
June 2019

Non-contact monitoring of extra-cellular field potentials with a multi-electrode array.

Lab Chip 2019 04;19(8):1448-1457

Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1039/c8lc00984hDOI Listing
April 2019

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions.

Elife 2019 04 5;8. Epub 2019 Apr 5.

Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, United States.

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http://dx.doi.org/10.7554/eLife.42571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450672PMC
April 2019

Cell biology in support of neurological research: 2018 highlights.

Authors:
Kenneth S Kosik

Lancet Neurol 2019 Jan;18(1):19-20

Department of Molecular, Cellular and Developmental Biology, Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106-5060, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30462-9DOI Listing
January 2019

Cofactors are essential constituents of stable and seeding-active tau fibrils.

Proc Natl Acad Sci U S A 2018 12 11;115(52):13234-13239. Epub 2018 Dec 11.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106;

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http://dx.doi.org/10.1073/pnas.1810058115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310788PMC
December 2018

Evolution of New miRNAs and Cerebro-Cortical Development.

Annu Rev Neurosci 2018 07 4;41:119-137. Epub 2018 Apr 4.

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1146/annurev-neuro-080317-061822DOI Listing
July 2018

Action potential propagation recorded from single axonal arbors using multielectrode arrays.

J Neurophysiol 2018 07 11;120(1):306-320. Epub 2018 Apr 11.

Neuroscience Research Institute, University of California , Santa Barbara, California.

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http://dx.doi.org/10.1152/jn.00659.2017DOI Listing
July 2018

MEA Viewer: A high-performance interactive application for visualizing electrophysiological data.

PLoS One 2018 9;13(2):e0192477. Epub 2018 Feb 9.

Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192477PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806868PMC
April 2018

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

Sci Rep 2018 04 23;8(1):6382. Epub 2018 Apr 23.

Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA, 93106, USA.

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http://dx.doi.org/10.1038/s41598-018-24904-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913225PMC
April 2018

iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases.

EMBO Mol Med 2017 12;9(12):1742-1762

Laboratory for Neural Stem Cells and Functional Neurogenetics, Division of Neuroimmunology and Multiple Sclerosis, The Ohio State University Wexner Medical Center, Columbus, OH, USA

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http://dx.doi.org/10.15252/emmm.201708191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731211PMC
December 2017

A molecular signature for anastasis, recovery from the brink of apoptotic cell death.

J Cell Biol 2017 10 2;216(10):3355-3368. Epub 2017 Aug 2.

Molecular, Cellular, and Developmental Biology Department, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA

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http://www.jcb.org/lookup/doi/10.1083/jcb.201706134
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http://dx.doi.org/10.1083/jcb.201706134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626555PMC
October 2017

The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation.

Sci Rep 2017 10 17;7(1):13307. Epub 2017 Oct 17.

Department of Mechanical Engineering, University of California, Santa Barbara, Santa Barbara, CA, USA.

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http://dx.doi.org/10.1038/s41598-017-13731-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645312PMC
October 2017

Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury.

Cell Rep 2017 08;20(5):1136-1147

Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565222PMC
August 2017

RNA stores tau reversibly in complex coacervates.

PLoS Biol 2017 Jul 6;15(7):e2002183. Epub 2017 Jul 6.

Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2002183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500003PMC
July 2017

A microRNA-mRNA expression network during oral siphon regeneration in .

Development 2017 05 21;144(10):1787-1797. Epub 2017 Apr 21.

Department of Molecular, Cell and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA

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http://dev.biologists.org/lookup/doi/10.1242/dev.144097
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http://dx.doi.org/10.1242/dev.144097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450834PMC
May 2017

Life at Low Copy Number: How Dendrites Manage with So Few mRNAs.

Authors:
Kenneth S Kosik

Neuron 2016 Dec;92(6):1168-1180

Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA 93106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.11.002DOI Listing
December 2016

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Stem Cell Reports 2016 09 1;7(3):325-340. Epub 2016 Sep 1.

Department of Neurology, Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032560PMC
September 2016

Detection of Prokaryotic Genes in the Amphimedon queenslandica Genome.

PLoS One 2016 9;11(3):e0151092. Epub 2016 Mar 9.

Neuroscience Research Institute and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151092PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784904PMC
August 2016

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA.

Neuron 2016 06 2;90(6):1174-1188. Epub 2016 Jun 2.

Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911262PMC
June 2016

Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways.

Hum Mol Genet 2016 Apr 10;25(7):1294-306. Epub 2016 Jan 10.

Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, Biomolecular Science and Engineering Program,

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http://dx.doi.org/10.1093/hmg/ddw010DOI Listing
April 2016

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease.

Anal Chem 2016 Apr 7;88(7):3704-14. Epub 2016 Mar 7.

F. M. Kirby Neurobiology Center, Boston Children's Hospital , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b04509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808556PMC
April 2016

Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate.

Cell 2016 Apr 24;165(2):410-20. Epub 2016 Mar 24.

Department of Molecular Cellular Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.02.014DOI Listing
April 2016

Tracking Down Mutations Cell by Cell.

Authors:
Kenneth S Kosik

Neuron 2016 Mar;89(6):1126-1127

Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106-5060, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.02.042DOI Listing
March 2016

β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.

Front Cell Neurosci 2015 8;9:498. Epub 2016 Jan 8.

Cellular and Molecular Neurobiology Area, Viral Vector Core and Gene Therapy, University of Antioquia Medellin, Antioquia, Colombia.

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http://dx.doi.org/10.3389/fncel.2015.00498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705306PMC
January 2016

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.

Cell Rep 2015 Sep 20;12(9):1414-29. Epub 2015 Aug 20.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558300PMC
September 2015

Tau-er of Power.

Authors:
Kenneth S Kosik

Cerebrum 2015 May-Jun;2015. Epub 2015 May 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564233PMC
September 2015

Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs.

Neural Dev 2015 Sep 17;10:20. Epub 2015 Sep 17.

Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, 93106, USA.

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http://dx.doi.org/10.1186/s13064-015-0047-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574169PMC
September 2015

Personalized medicine for effective Alzheimer disease treatment.

Authors:
Kenneth S Kosik

JAMA Neurol 2015 May;72(5):497-8

Neuroscience Research Institute, University of California, Santa Barbara.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2014.3445DOI Listing
May 2015

Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation.

Chem Biol 2015 Apr 9;22(4):472-482. Epub 2015 Apr 9.

USR3151-CNRS/UPMC, Protein Phosphorylation and Disease Laboratory, Station Biologique de Roscoff, CS 90074, 29688 Roscoff, Bretagne, France. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.03.009DOI Listing
April 2015

Tau immunization: a cautionary tale?

Neurobiol Aging 2015 Mar 30;36(3):1316-32. Epub 2014 Dec 30.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.11.022DOI Listing
March 2015

The outer subventricular zone and primate-specific cortical complexification.

Neuron 2015 Feb;85(4):683-94

Neuroscience Research Institute and Dept Cellular Molecular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273140116
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http://dx.doi.org/10.1016/j.neuron.2014.12.060DOI Listing
February 2015

Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation.

Neurology 2015 Jan 3;84(2):206-8. Epub 2014 Dec 3.

From the Neuroscience Research Institute (K.S.K., M.L.A.), University of California, Santa Barbara; Grupo de Neurociencias de Antioquia (C.M., L.L., G.G., L.M., S.M., S.R.R., H.L., M.G., F.L.), Universidad de Antioquia, Medellín, Colombia; Banner Alzheimer's Institute (J.B.L., P.N.T., E.M.R.), Phoenix, AZ; and Genentech (W.C., S.S., C.H.), South San Francisco, CA.

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http://dx.doi.org/10.1212/WNL.0000000000001130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336083PMC
January 2015

SMN regulates axonal local translation via miR-183/mTOR pathway.

Hum Mol Genet 2014 Dec 4;23(23):6318-31. Epub 2014 Jul 4.

Department of Neurology, The F. M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA,

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http://dx.doi.org/10.1093/hmg/ddu350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271102PMC
December 2014

MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.

Cell Rep 2014 Dec 20;9(5):1729-1741. Epub 2014 Nov 20.

Cell and Developmental Biology, Roy J. Carver Biotechnology Center, University of Illinois-Urbana Champaign, Urbana, IL 61801, USA; College of Medicine, Roy J. Carver Biotechnology Center, University of Illinois-Urbana Champaign, Urbana, IL 61801, USA; Neuroscience Program, Roy J. Carver Biotechnology Center, University of Illinois-Urbana Champaign, Urbana, IL 61801, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.10.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268400PMC
December 2014

Synaptic dysregulation in a human iPS cell model of mental disorders.

Nature 2014 Nov 17;515(7527):414-8. Epub 2014 Aug 17.

1] Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [3] Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [4] The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature13716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501856PMC
November 2014

Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells.

Stem Cells 2014 Oct;32(10):2616-25

Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, California, USA.

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http://dx.doi.org/10.1002/stem.1764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165656PMC
October 2014

Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.

Front Aging Neurosci 2014 10;6:243. Epub 2014 Sep 10.

Cellular and Molecular Neurobiology Area, Neuroscience Group of Antioquia, Faculty of Medicine, University Research Headquarters, University of Antioquia Medellín Colombia.

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http://dx.doi.org/10.3389/fnagi.2014.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159979PMC
October 2014

A quantitative framework to evaluate modeling of cortical development by neural stem cells.

Neuron 2014 Jul;83(1):69-86

Neurogenetics Program, Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277209PMC
July 2014

Parallel discovery of Alzheimer's therapeutics.

Sci Transl Med 2014 Jun;6(241):241cm5

Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1126/scitranslmed.3008228DOI Listing
June 2014

Particle display: a quantitative screening method for generating high-affinity aptamers.

Angew Chem Int Ed Engl 2014 May 18;53(19):4796-801. Epub 2014 Mar 18.

Department of Mechanical Engineering, Materials and Institute for Collaborative Biotechnologies, University of California, Santa Barbara, CA 93106 (USA).

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http://doi.wiley.com/10.1002/anie.201309334
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http://dx.doi.org/10.1002/anie.201309334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065591PMC
May 2014

Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns.

Neuron 2014 Mar 27;81(6):1255-1262. Epub 2014 Feb 27.

Neuroscience Research Institute and Department Cellular Molecular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273140002
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http://dx.doi.org/10.1016/j.neuron.2014.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020629PMC
March 2014

Diseases: Study neuron networks to tackle Alzheimer's.

Authors:
Kenneth S Kosik

Nature 2013 Nov;503(7474):31-2

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http://dx.doi.org/10.1038/503031aDOI Listing
November 2013

Statistical analysis of dendritic spine distributions in rat hippocampal cultures.

BMC Bioinformatics 2013 Oct 2;14:287. Epub 2013 Oct 2.

Department of Electrical and Computer Engineering, University of California Santa Barbara, Santa Barbara, CA, USA.

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http://dx.doi.org/10.1186/1471-2105-14-287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871014PMC
October 2013

Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models.

J Biol Chem 2013 Jul 4;288(30):22042-56. Epub 2013 Jun 4.

Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1074/jbc.M112.436402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724657PMC
July 2013

Molecular biology: Circles reshape the RNA world.

Authors:
Kenneth S Kosik

Nature 2013 Mar 27;495(7441):322-4. Epub 2013 Feb 27.

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http://dx.doi.org/10.1038/nature11956DOI Listing
March 2013

Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers.

Hum Mutat 2012 Dec 10;33(12):1630-4. Epub 2012 Aug 10.

Neuroscience Research Institute, University of California at Santa Barbara, CA, USA.

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http://dx.doi.org/10.1002/humu.22167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496074PMC
December 2012

Deep annotation of mouse iso-miR and iso-moR variation.

Nucleic Acids Res 2012 Jul 19;40(13):5864-75. Epub 2012 Mar 19.

Neuroscience Research Institute and Department of Cellular Molecular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1093/nar/gks247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401436PMC
July 2012

Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

J Gerontol A Biol Sci Med Sci 2012 Jun 20;67(7):741-6. Epub 2012 Apr 20.

Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, USA.

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http://dx.doi.org/10.1093/gerona/gls110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009730PMC
June 2012

Functionalization of a protosynaptic gene expression network.

Proc Natl Acad Sci U S A 2012 Jun 20;109 Suppl 1:10612-8. Epub 2012 Jun 20.

Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1073/pnas.1201890109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386881PMC
June 2012

Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions.

BMC Genomics 2012 May 30;13:209. Epub 2012 May 30.

Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1186/1471-2164-13-209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447736PMC
May 2012

NMDA mediated contextual conditioning changes miRNA expression.

PLoS One 2011 12;6(9):e24682. Epub 2011 Sep 12.

Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024682PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171446PMC
February 2012

Identification of piRNAs in the central nervous system.

RNA 2011 Jun 22;17(6):1090-9. Epub 2011 Apr 22.

Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1261/rna.2565011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096041PMC
June 2011

PhDs: what's left if science abdicates?

Authors:
Kenneth S Kosik

Nature 2011 May;473(7347):284

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http://dx.doi.org/10.1038/473284bDOI Listing
May 2011

Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.

Bioorg Med Chem Lett 2011 Apr 3;21(7):2098-101. Epub 2011 Feb 3.

Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.01.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062192PMC
April 2011

MicroRNA regulation of neural stem cells and neurogenesis.

J Neurosci 2010 Nov;30(45):14931-6

Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4280-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071711PMC
November 2010

Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology.

PLoS Comput Biol 2010 Nov 11;6(11):e1000997. Epub 2010 Nov 11.

Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978700PMC
November 2010

MicroRNAs and cellular phenotypy.

Authors:
Kenneth S Kosik

Cell 2010 Oct;143(1):21-6

Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1016/j.cell.2010.09.008DOI Listing
October 2010

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice.

J Neurosci 2010 Oct;30(42):13966-76

Cellular and Molecular Neurobiology Area, Viral Vector Core and Gene Therapy, Group of Neuroscience of Antioquia, Faculty of Medicine, Sede de Investigación Universitaria, University of Antioquia, AA 1226 Medellin, Colombia.

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http://dx.doi.org/10.1523/JNEUROSCI.3637-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003593PMC
October 2010

A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation.

Neuron 2009 Dec;64(6):871-84

Neuroscience Research Institute and Department of Cellular Molecular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1016/j.neuron.2009.11.023DOI Listing
December 2009

MicroRNAs potentiate neural development.

Neuron 2009 Nov;64(3):303-9

Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242 USA.

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http://dx.doi.org/10.1016/j.neuron.2009.10.020DOI Listing
November 2009

MicroRNAs tell an evo-devo story.

Authors:
Kenneth S Kosik

Nat Rev Neurosci 2009 10 9;10(10):754-9. Epub 2009 Sep 9.

Neuroscience Research Institute and the Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1038/nrn2713DOI Listing
October 2009

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.

Cell 2009 May 30;137(4):647-58. Epub 2009 Apr 30.

Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, The University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1016/j.cell.2009.02.038DOI Listing
May 2009

MicroRNA-124: micromanager of neurogenesis.

Cell Stem Cell 2009 May;4(5):375-6

Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1016/j.stem.2009.04.007DOI Listing
May 2009

Exploring the early origins of the synapse by comparative genomics.

Authors:
Kenneth S Kosik

Biol Lett 2009 Feb;5(1):108-11

Neuroscience Research Institute, University of California, Santa Barbara, CA 93106-5060, USA.

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http://dx.doi.org/10.1098/rsbl.2008.0594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657765PMC
February 2009

The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

J Neurosci 2009 Feb;29(7):2151-61

Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4660-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768429PMC
February 2009

Regulation of AMPA receptor trafficking by delta-catenin.

Mol Cell Neurosci 2008 Dec 17;39(4):499-507. Epub 2008 Jun 17.

Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.

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http://dx.doi.org/10.1016/j.mcn.2008.06.002DOI Listing
December 2008

A delta-catenin signaling pathway leading to dendritic protrusions.

J Biol Chem 2008 Nov 22;283(47):32781-91. Epub 2008 Sep 22.

Neuroscience Research Institute, and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1074/jbc.M804688200DOI Listing
November 2008

MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.

Cancer Res 2008 Oct;68(19):8164-72

Department of Molecular, Cellular and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1305DOI Listing
October 2008

MUC1* mediates the growth of human pluripotent stem cells.

PLoS One 2008 Oct 3;3(10):e3312. Epub 2008 Oct 3.

Center for Stem Cell Biology and Engineering, University of California Santa Barbara, Santa Barbara, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003312PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553196PMC
October 2008

Noncoding RNAs in Long-Term Memory Formation.

Neuroscientist 2008 Oct;14(5):434-45

Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1177/1073858408319187DOI Listing
October 2008

Heterogeneous dysregulation of microRNAs across the autism spectrum.

Neurogenetics 2008 Jul 19;9(3):153-61. Epub 2008 Jun 19.

Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA.

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http://link.springer.com/10.1007/s10048-008-0133-5
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http://dx.doi.org/10.1007/s10048-008-0133-5DOI Listing
July 2008

Genetic testing must recognize impact of bad news on recipient.

Nature 2008 Jul;454(7201):158-9

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http://dx.doi.org/10.1038/454158cDOI Listing
July 2008

Reconstructing ancestral genome content based on symmetrical best alignments and Dollo parsimony.

Bioinformatics 2008 Mar 9;24(5):606-12. Epub 2008 Jan 9.

Department of Computer Science, University of California, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1093/bioinformatics/btn005DOI Listing
March 2008

New approaches to the discovery of cdk5 inhibitors.

Curr Alzheimer Res 2007 Dec;4(5):547-9

Laboratory for Drug Discovery for Neurodegeneration, Harvard Center for Neurodegeneration and Repair, Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, USA.

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http://dx.doi.org/10.2174/156720507783018181DOI Listing
December 2007

Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR.

RNA 2007 Aug 25;13(8):1224-34. Epub 2007 Jun 25.

Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA 93106, USA.

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http://www.rnajournal.org/cgi/doi/10.1261/rna.480407
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http://dx.doi.org/10.1261/rna.480407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924896PMC
August 2007

Detection of a microRNA signal in an in vivo expression set of mRNAs.

PLoS One 2007 Aug 29;2(8):e804. Epub 2007 Aug 29.

Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, California, United States of America; Department of Molecular, Cellular and Developmental Biology, University of California at Santa Barbara, Santa Barbara, California, United States of America.

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http://dx.plos.org/10.1371/journal.pone.0000804
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000804PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950084PMC
August 2007