Publications by authors named "Kenneth Macleod"

103Publications

Integrative analysis of multi-platform reverse-phase protein array data for the pharmacodynamic assessment of response to targeted therapies.

Authors:
Adam Byron Stephan Bernhardt Bérèngere Ouine Aurélie Cartier Kenneth G Macleod Neil O Carragher Vonick Sibut Ulrike Korf Bryan Serrels Leanne de Koning

Sci Rep 2020 12 15;10(1):21985. Epub 2020 Dec 15.

Department of Translational Research, Institut Curie, PSL Research University, 26 rue d'Ulm, 75005, Paris, France.

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December 2020

The Effect of Estrogen on Intracellular Ca and Na Regulation in Heart Failure.

Authors:
Jahn M Firth Hsiang-Yu Yang Alice J Francis Najah Islam Kenneth T MacLeod

JACC Basic Transl Sci 2020 Sep 2;5(9):901-912. Epub 2020 Sep 2.

National Heart and Lung Institute, Imperial College, Hammersmith Hospital, London, United Kingdom.

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September 2020

Brain microenvironment-driven resistance to immune and targeted therapies in acral melanoma.

Authors:
Rebecca Jane Lee Garima Khandelwal Franziska Baenke Alessio Cannistraci Kenneth Macleod Piyushkumar Mundra Garry Ashton Amit Mandal Amaya Viros Gabriela Gremel Elena Galvani Matthew Smith Neil Carragher Nathalie Dhomen Crispin Miller Paul Lorigan Richard Marais

ESMO Open 2020 08;5(4)

Molecular Oncology Group, CRUK Manchester Institute, The University of Manchester, Nether Alderley, Macclesfield, UK

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August 2020

Differential lymphatic versus portal vein uptake of the synthetic pyrethroids deltamethrin and cis-permethrin in rats.

Authors:
Larry G Higgins Lynsey R Chatham Sara L Tomczynski A Kenneth MacLeod Marjory Moreau Harvey J Clewell Miyoung Yoon Moire R Creek Thomas G Osimitz Brian G Lake

Toxicology 2020 10 14;443:152563. Epub 2020 Aug 14.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

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October 2020

Approaches to High-Throughput Analysis of Cardiomyocyte Contractility.

Authors:
Peter T Wright Sharmane F Tsui Alice J Francis Kenneth T MacLeod Steven B Marston

Front Physiol 2020 8;11:612. Epub 2020 Jul 8.

Myocardial Function, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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July 2020

Metabolism of bifenthrin, β-cyfluthrin, λ-cyhalothrin, cyphenothrin and esfenvalerate by rat and human cytochrome P450 and carboxylesterase enzymes.

Authors:
Laura Hedges Susan Brown A Kenneth MacLeod Marjory Moreau Miyoung Yoon Moire R Creek Thomas G Osimitz Brian G Lake

Xenobiotica 2020 Dec 22;50(12):1434-1442. Epub 2020 Jul 22.

Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.

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December 2020

Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma.

Authors:
Priya Sriskandarajah Alexis De Haven Brandon Kenneth MacLeod Neil O Carragher Vladimir Kirkin Martin Kaiser Steven R Whittaker

BMC Cancer 2020 Mar 30;20(1):269. Epub 2020 Mar 30.

Division of Cancer Therapeutics, The Institute of Cancer Research, London, SW7 3RP, UK.

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March 2020

Lung clearance index and steroid response in pediatric severe asthma.

Authors:
Samantha Irving Louise Fleming Fatima Ahmad Elizabeth Biggart Yvvone Bingham James Cook Pippa Hall Angela Jamalzadeh Prasad Nagakumar Cara Bossley Atul Gupta Kenneth Macleod Sejal Saglani Andrew Bush

Pediatr Pulmonol 2020 04 6;55(4):890-898. Epub 2020 Feb 6.

Royal Brompton and Harefield NHS Foundation Trust, London, UK.

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April 2020

N-cadherin stabilises neural identity by dampening anti-neural signals.

Authors:
Karolina Punovuori Rosa P Migueles Mattias Malaguti Guillaume Blin Kenneth G Macleod Neil O Carragher Tim Pieters Frans van Roy Marc P Stemmler Sally Lowell

Development 2019 11 8;146(21). Epub 2019 Nov 8.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh EH16 4UU, UK

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November 2019

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging.

Authors:
Mandy Johnstone Navneet A Vasistha Miruna C Barbu Owen Dando Karen Burr Edward Christopher Sophie Glen Christelle Robert Rana Fetit Kenneth G Macleod Matthew R Livesey David St Clair Douglas H R Blackwood Kirsty Millar Neil O Carragher Giles E Hardingham David J A Wyllie Eve C Johnstone Heather C Whalley Andrew M McIntosh Stephen M Lawrie Siddharthan Chandran

Mol Psychiatry 2019 02 6;24(2):294-311. Epub 2018 Nov 6.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

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February 2019

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.

Authors:
Ali J Chakera Paul S Hurst Gill Spyer Emmanuel O Ogunnowo-Bada William J Marsh Christine H Riches Chen-Yu Yueh S Pauliina Markkula Jeffrey W Dalley Roger D Cox Ian A Macdonald Stephanie A Amiel Kenneth M MacLeod Lora K Heisler Andrew T Hattersley Mark L Evans

Mol Metab 2018 11 13;17:17-27. Epub 2018 Aug 13.

Wellcome Trust/ MRC Institute of Metabolic Science and Department of Medicine, University of Cambridge, United Kingdom. Electronic address:

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November 2018

Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes.

Authors:
Laura Hedges Susan Brown A Kenneth MacLeod Audrey Vardy Edward Doyle Gina Song Marjory Moreau Miyoung Yoon Thomas G Osimitz Brian G Lake

Xenobiotica 2019 May 4;49(5):521-527. Epub 2018 Jun 4.

a Concept Life Sciences (formerly CXR Biosciences Ltd.) , Dundee , UK.

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May 2019

Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy.

Authors:
A Kenneth MacLeod De Lin Jeffrey T-J Huang Lesley A McLaughlin Colin J Henderson C Roland Wolf

Clin Cancer Res 2018 05 6;24(9):2138-2147. Epub 2018 Feb 6.

Division of Cancer Research, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.

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May 2018

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation.

Authors:
Jennifer M Felton Christopher D Lucas David A Dorward Rodger Duffin Tiina Kipari Sonja Vermeren Calum T Robb Kenneth G MacLeod Bryan Serrels Jürgen Schwarze Christopher Haslett Ian Dransfield Adriano G Rossi

J Allergy Clin Immunol 2018 12 8;142(6):1884-1893.e6. Epub 2018 Feb 8.

MRC Centre for Inflammation Research, the Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

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December 2018

Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis.

Authors:
Laurie J Smith Kenneth A Macleod Guilhem J Collier Felix C Horn Helen Sheridan Ina Aldag Chris J Taylor Steve Cunningham Jim M Wild Alex Horsley

PLoS One 2017 27;12(11):e0188275. Epub 2017 Nov 27.

Respiratory Research Group, Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom.

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December 2017

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.

Authors:
Jonathan Berrout Eleni Kyriakopoulou Lavanya Moparthi Alexandra S Hogea Liza Berrout Cristina Ivan Mihaela Lorger John Boyle Chris Peers Stephen Muench Jacobo Elies Gomez Xin Hu Carolyn Hurst Thomas Hall Sujanitha Umamaheswaran Laura Wesley Mihai Gagea Michael Shires Iain Manfield Margaret A Knowles Simon Davies Klaus Suhling Yurema Teijeiro Gonzalez Neil Carragher Kenneth Macleod N Joan Abbott George A Calin Nikita Gamper Peter M Zygmunt Zahra Timsah

Nat Commun 2017 10 16;8(1):947. Epub 2017 Oct 16.

School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.

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October 2017

Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies.

Authors:
Markus B Sikkel Darrel P Francis James Howard Fabiana Gordon Christina Rowlands Nicholas S Peters Alexander R Lyon Sian E Harding Kenneth T MacLeod

Cardiovasc Res 2017 Dec;113(14):1743-1752

Myocardial Function Section, Fourth Floor, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

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December 2017

Age- and strain-related aberrant Ca release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy.

Authors:
Christina T Rowlands Thomas Owen Saheed Lawal Shuangyi Cao Samata S Pandey Hsiang-Yu Yang Weihua Song Ross Wilkinson Anita Alvarez-Laviada Katja Gehmlich Steven B Marston Kenneth T MacLeod

Am J Physiol Heart Circ Physiol 2017 12 8;313(6):H1213-H1226. Epub 2017 Sep 8.

National Heart & Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College, Hammersmith Hospital , London , United Kingdom.

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December 2017

Reverse Phase Protein Arrays and Drug Discovery.

Authors:
Kenneth G Macleod Bryan Serrels Neil O Carragher

Methods Mol Biol 2017 ;1647:153-169

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.

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April 2018

Effect of ovariectomy on intracellular Ca regulation in guinea pig cardiomyocytes.

Authors:
Hsiang-Yu Yang Jahn M Firth Alice J Francis Anita Alvarez-Laviada Kenneth T MacLeod

Am J Physiol Heart Circ Physiol 2017 Nov 4;313(5):H1031-H1043. Epub 2017 Aug 4.

National Heart and Lung Institute, Imperial College London, London, United Kingdom; and

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November 2017